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| 1 | Enhanced efficiency of generating induced pluripotent stem (iPS) cells from human somatic cells by a combination of six transcription factors显示文摘 | Jing Liao Zhao Wu Ying Wang Lu Cheng Chun Cui Yuan Gao Taotao Chen Lingjun Rao Siye Chen Nannan Jia Huiming Dai Shunmei Xin Jiuhong Kang Gang Pei Lei Xiao | 2008 | Cell Research2008，18，5： | 61 |
| 2 | Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells显示文摘导致的 pluripotent 干细胞(iPSCs ) 的产生为心疾病,屏蔽的药和潜在的自体同源的心脏的新生的调查打开了新大街。然而,他们的申请被导出 iPSC 的 cardiomyocytes (iPS 厘米) 的低效的心脏的区别,高写在行间可变性,和差的成熟妨碍。为 iPSCs 的心脏的区别和成熟识别有效 inducers 并且阐明机制,我们系统地在各种各样的鼠科的(m) iPSCs 上屏蔽了十六 cardiomyocyte inducers 并且发现没有自发的心脏性的潜力,仅仅维生素酸(AA ) 一致地并且要用体力地包括八提高了十一根线的心脏的区别。我们然后优化了治疗条件并且表明了那区别天 2-6,为心脏的祖先房间(CPC ) 的说明的经期,是一批评时间让 AA 生效。这被 AA 增加了表示的事实进一步证实心血管然而并非 mesodermal 标记。显著, AA 处理导致了近似 7.3 褶层(miPSCs ) 和 30.2 褶层(人的 iPSCs ) 在 iPS 厘米的收益扩充。如此的效果经由 MEK-ERK1/2 小径被归因于 CPC 的增长的特定的增加由通过支持骨胶原合成。另外,导致 AA 的 cardiomyocytes 显示出更好的 sarcomeric 组织并且提高了行动潜力和钙 transients 的回答到 β肾上腺素能并且 muscarinic 刺激。这些调查结果证明 AA 是合适的 cardiomyocyte inducer 让 iPSCs 普遍,简单地改进心脏的区别和成熟。这些调查结果也强调由在指导 pluripotent 干细胞的心脏的区别操作细胞外的微型环境刺激 CPC 增长的重要性。 | Nan Cao Zumei Liu Zhongyan Chen Jia Wang Taotao Chen Xiaoyang Zhao Yu Ma Lianju Qin Jiuhong Kang Bin Wei Liu Wang Ying Jin Huang-Tian Yang | 2012 | Cell Research2012，22，1： | 28 |
| 3 | Normal Structure and Function of Endothecium Chloroplasts Maintained by ZmMs33-Mediated Lipid Biosynthesis in Tapetal Cells Are Critical for Anther Development in Maize显示文摘Genic male sterility(GMS)is critical for heterosis utilization and hybrid seed production.Although GMS mutants and genes have been studied extensively in plants,it has remained unclear whether chloroplast-associated photosynthetic and metabolic activities are involved in the regulation of anther development.In this study,we characterized the function of ZmMs33/ZmGPAT6,which encodes a member of the glycerol-3-phosphate acyltransferase(GPAT)family that catalyzes the first step of the glycerolipid synthetic pathway.We found that normal structure and function of endothecium(En)chloroplasts maintained by ZmMs33-mediated lipid biosynthesis in tapetal cells are crucial for maize anther development.ZmMs33 is expressed mainly in the tapetum at early anther developmental stages and critical for cell proliferation and expansion at late stages.Chloroplasts in En cells of wild-type anthers function as starch storage sites before stage 10 but as photosynthetic factories since stage 10 to enable starch metabolism and carbohydrate supply.Loss of ZmMs33 function inhibits the biosynthesis of glycolipids and phospholipids,which are major components of En chloroplast membranes,and disrupts the development and function of En chloroplasts,resulting in the formation of abnormal En chloroplasts containing numerous starch granules.Further analyses reveal that starch synthesis during the day and starch degradation at night are greatly suppressed in the mutant anthers,leading to carbon starvation and low energy status,as evidenced by low trehalose-6-phosphate content and a reduced ATP/AMP ratio.The energy sensor and inducer of autophagy,SnRK1,was activated to induce early and excessive autophagy,premature PCD,and metabolic reprogramming in tapetal cells,finally arresting the elongation and development of mutant anthers.Taken together,our results not only show that ZmMs33 is required for normal structure and function of En chloroplasts but also reveal that starch metabolism and photosynthetic activities of En chloroplasts at different developmental stages are essential for normal anther development.These findings provide novel insights for understanding how lipid biosynthesis in the tapetum,the structure and function of En chloroplasts,and energy and substance metabolism are coordinated to maintain maize anther development. | Taotao Zhu Ziwen Li Xueli An Yan Long Xiaofeng Xue Ke Xie Biao Ma Danfeng Zhang Yijian Guan Canfang Niu Zhenying Dong Quancan Hou Lina Zhao Suowei Wu Jinping Li Weiwei Jin Xiangyuan Wan | 2020 | Molecular Plant2020，13，11： | 9 |
| 4 | In situ observation of C_(60)(C(COOH)_(2))_(2) interacting with living cells using fluorescence microscopy显示文摘The interactions between nanoparticles and living cells were investigated by an imaging technique of fluorescence microscopy. For this pur- pose, the C60 derivative C60(C(COOH)2)2, a thera- peutic agent for degeneration diseases of central nervous system, was synthesized, purified and characterized. Its interaction with the living cell and penetration of the cellular membrane were in situ studied using the real time imaging technique, and its potential cytotoxicity was also examined by flow cy- tometry. The results indicate that C60(C(COOH)2)2 can easily enter cells, and is mainly located in cytoplasm by fluorescein labeling. Furthermore, C60(C(COOH)2)2 can carry the molecule that cannot cross cellular membranes into cells, because fluo- rescein compound itself cannot enter the cell or ad- here to membrane. At concentrations ranging from 1×10?2 to 1×102 mg/L, C60(C(COOH)2)2 does not show any detectable cytotoxicity. | YE Chang CHEN Chunying CHEN Zhen MENG Huan XING Li JIANG Yaxin YUAN Hui XING Gengmei ZHAO Feng ZHAO Yuliang CHAI Zhifang FANG Xiaohong HAN Dong CHEN Long WANG Chen WEI Taotao | 2006 | Chinese Science Bulletin2006，51，9： | 4 |
| 5 | Microwave-assisted hydroxylation of benzene to phenol with H_2O_2 over FeSO_4/SiO_2显示文摘Hydroxyl radicals HO are generated under Fenton-like (Fe2++H2O2→HO?+OH?+Fe3+) catalytic conditions upon microwave irradiation. Liquid-phase direct catalytic oxidation of benzene to phenol was obtained using FeSO4 supported on silica gel as a solid catalyst and hydrogen peroxide as the oxidant. The effects of various parameters, such as the different solvents, the amount of solvent used, the amount of catalyst used, the reaction time, the reaction temperature and the amount of hydrogen peroxide used on the yield of phenol were studied to identify optimum reaction conditions. Conventionally heated reaction gives a phenol yield of 0.6%. A higher phenol yield of 13.9% with a selectivity of 100% is obtained when the reaction mixture was irradiated with micro-wave energy. It is concluded that microwave irradiation offers more effective control of energy input for hydroxyl radical generation that is appropriate for various synthetic reactions. | LIU Tong WEI Xianyong ZHAO Jianjun XIE Hengsen WANG Taotao ZONG Zhimin | 2010 | Mining Science and Technology2010，20，1： | 4 |
| 6 | Lysosomal chymotrypsin induces mitochondrial fission in apoptotic cells by proteolytic activation of calcineurin显示文摘 | Qianqian Chen Juan Zhang Kai Zhao Wei Li Qi Miao Yang Sun Xingyu Zhao Taotao Wei Fuyu Yang | 2014 | Protein & Cell2014，5，8： | 2 |
| 7 | Influence of channel/back-barrier thickness on the breakdown of AlGaN/GaN MIS-HEMTs显示文摘The leakage current and breakdown voltage of Al Ga N/Ga N/Al Ga N high electron mobility transistors on silicon with different Ga N channel thicknesses were investigated.The results showed that a thin Ga N channel was beneficial for obtaining a high breakdown voltage,based on the leakage current path and the acceptor traps in the Al Ga N back-barrier.The breakdown voltage of the device with an 800 nm-thick Ga N channel was 926 V@1 m A/mm,and the leakage current increased slowly between 300 and 800 V.Besides,the raising conduction band edge of the Ga N channel by the Al Ga N back-barrier lead to little degradation for sheet 2-D electron gas density,especially,in the thin Ga N channel.The transfer and output characteristics were not obviously deteriorated for the samples with different Ga N channel thickness.Through optimizing the Ga N channel thickness and designing the Al GaN back-barrier,the lower leakage current and higher breakdown voltage would be possible. | Jie Zhao Yanhui Xing Kai Fu Peipei Zhang Liang Song Fu Chen Taotao Yang Xuguang Deng Sen Zhang Baoshun Zhang | 2018 | Journal of Semiconductors2018，39，9： | 2 |
| 8 | Author Correction:Evolutionarily conservative and non-conservative regulatory networks during primate interneuron development revealed by single-cell RNA and ATAC sequencing显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfsckp5fnnoknok695f.ffgz.tsg.suse.edu.cn/10.1038/s41422-022-00635-9,published online 10 March 2022 We found that the information in the original Supplementary Figs.S2–S4 was not fully displayed due to an error in the image upload.The correct images are shown below for better display.These corrections do not affect the description of the results or the conclusion of this work.No change of the original figure legends is needed.We apologize for the mistake.The original article has been corrected. | Ziqi Zhao Dan Zhang Fuqiang Yang Mingrui Xu Shaoli Zhao Taotao Pan Chuanyu Liu Yongjie Liu Qingfeng Wu Qiang Tu Ping Zhou Rong Li Jia Kang Lan Zhu Fei Gao Yaqing Wang Zhiheng Xu | 2023 | Cell Research2023，33，7： | 1 |
| 9 | Synthesis of light hydrocarbons over Fe/AC catalysts显示文摘A series of Fe/AC catalysts for catalytic hydrogenation of CO to light hydrocarbons(LHCs) were prepared by decomposing Fe(CO)5 in an autoclave.The catalysts activities were tested in a high-pressure micro reactor.The results show that both CO conversion and LHCs selectivity were significantly affected by the amount of Fe loaded onto the catalysts.The optimum Fe content was determined to be 10% by weight of the catalyst.Over the corresponding catalyst(i.e.,10% Fe/C catalyst),the conversion of CO and the selectivity of LHCs were 94.8% and 59.2%,respectively,at 360 °C.Based on various catalyst characterization techniques,such as XRD,BET and SEM,the catalysts surface areas and pore volume decreased and the smaller particles agglomerated at the edges and corners in the outer region of the support with the increasing Fe content.The agglomerated particles increased greatly when the iron content of the catalyst was higher than 10%.The decrease of catalyst activity can be due to the agglomerated particles. | Zhao Jianjun Zong Zhimin Wang Taotao Liu Tong Wei Xianyong | 2012 | International Journal of Mining Science and Technology2012，22，2： | 1 |
| 10 | Nitric oxide damages neuronal mitochondria and induces apoptosis in neurons显示文摘The cytotoxic effect of nitric oxide on primarily cultured rat cerebellar granule cells was stuatea, and the mechanisms were discussed. The results showed that nitric oxide donor S-nitroso-N-acetyl-penicillamine (SNAP; 500 (imol/L) could induce apoptosis in immature cultures of cerebellar granule cells. Flow cytometry and HPLC analyses revealed that after treatment with SNAP, the mitochondrial transmembrane potential and the cellular ATP content decreased significantly. Nitric oxide scavenger hemoglobin could effectively prevent the neuronal mitochondria from dysfunction and attenuate apoptosis. The results suggested that nitric oxide activated the apoptotic program by inhibiting the activity of mitochondrial respiratory chain and thus decreasing the cellular ATP content. | Taotao Wei Chang Chen Jingwu Hou Baolu Zhao Wenjuan Xin | 2000 | Chinese Science Bulletin2000，45，5： | 1 |
| 11 | Utilization of novel ester-containing quaternary ammonium surfactant as cationic collector for iron ore flotation显示文摘 | WENG Xiaoqing MEI Guangjun ZHAO Taotao | 2013 | Separation and Purification Technology2013，103，： | 1 |
| 12 | Rapamycin and other longevity‐promoting compounds enhance the generation of mouse induced pluripotent stem cells显示文摘 | Taotao Chen Li Shen Jie Yu Hongjiang Wan Ao Guo Jiekai Chen Yuan Long Jian Zhao Gang Pei | 2011 | Aging Cell2011，，5： | 1 |
| 13 | Pregnancy outcomes and relative risk factors among Chinese women with congenital heart disease显示文摘 | Hua Liu Taotao Huang Weixiu Zhao Yao Shen Jianhua Lin | 2012 | International Journal of Gynecology and Obstetrics2012，，： | 1 |
| 14 | Removal of an- ionic azo dyes from aqueous solution by functional ionic liquid cross-linked polymer显示文摘 | Gao Hejun Kan Taotao Zhao Siyuan | 2013 | J Hazard Mater2013，261，： | 1 |
| 15 | Highly selective oxidation of amines to imines by Mn2O3 catalyst under eco-friendly conditions显示文摘Enhancing the selectivity of imines for the oxidative self-coupling of primary amines was found to be challenging in the heterogeneous catalysis.Three different manganese oxides(M-3,M-4,M-5) were synthesized by controlling the calcination temperature using a simple template-free oxalate route.The prepared manganese oxides were systematically characterized using XRD,N2 sorption,SEM,TEM,XPS,H2-TPR techniques.M-4 gave 96.2% selectivity of imine at 100% conversion of benzylamine,which was far more superior than other existing protocols.Mn^3+/Mn^4+ ratio was found to affect the selectivity of the imines.The probable reaction pathway for amines oxidation catalyzed by manganese oxides was proposed for the first time. | Fushan Chen Tao Yang Songlin Zhao Taotao Jiang Lu Yu Houfeng Xiong Chuankun Guo Yufang Rao Yan Liu Liu Liu Jian Zhou Pengxiang Tu Jun Ni Qunfeng Zhang Xiaonian Li | 2019 | Chinese Chemical Letters2019，30，12： | 1 |
| 16 | Synthesis of light hydrocarbons from CO hydrogenation over Co_xMn_(0.06)/SiO_2显示文摘A series of CoxMn0.06/SiO2 catalysts were prepared by an impregnation method for catalytic hydrogenation of CO to Light Hydrocarbons(LHCs).The catalysts were characterized by XRD,SEM,N2 adsorption and NH3-TPD techniques.Catalyst activities were evaluated in a high-pressure micro reactor.The results show that the performance of the catalysts was significantly affected by the amount of Co loaded onto the substrate.The activity of the Co0.10Mn0.06/SiO2 catalyst was stable with time-on-stream.The CO conversion and LHCs selectivity were 95.3% and 98.1%,respectively,for this catalyst at 400 °C. | ZHAO, Jianjun ZONG, Zhimin XIE, Hengsen LIU, Tong LI, Jianjun WANG, Taotao WEI, Xianyong | 2010 | Mining Science and Technology2010，20，2： | 1 |
| 17 | Scientific objectives of the Hot Universe Baryon Surveyor(HUBS) mission显示文摘The Hot Universe Baryon Surveyor(HUBS) is a proposed space-based X-ray telescope for detecting X-ray emissions from the hot gas content in our universe. With its unprecedented spatially-resolved high-resolution spectroscopy and large field of view,the HUBS mission will be uniquely qualified to measure the physical and chemical properties of the hot gas in the interstellar medium, the circumgalactic medium, the intergalactic medium, and the intracluster medium. These measurements will be valuable for two key scientific goals of HUBS, namely to unravel the AGN and stellar feedback physics that governs the formation and evolution of galaxies, and to probe the baryon budget and multi-phase states from galactic to cosmological scales. In addition to these two goals, the HUBS mission will also help us solve some problems in the fields of galaxy clusters, AGNs, difuse X-ray backgrounds, supernova remnants, and compact objects. This paper discusses the perspective of advancing these fields using the HUBS telescope. | Joel Bregman Renyue Cen Yang Chen Wei Cui Taotao Fang Fulai Guo Edmund Hodges-Kluck Rui Huang Luis C.Ho Li Ji Suoqing Ji Xi Kang Xiaoyu Lai Hui Li Jiangtao Li Miao Li Xiangdong Li Yuan Li Zhaosheng Li Guiyun Liang Helei Liu Wenhao Liu Fangjun Lu Junjie Mao Gabriele Ponti Zhijie Qu Chenxi Shan Lijing Shao Fangzheng Shi Xinwen Shu Lei Sun Mouyuan Sun Hao Tong Junfeng Wang Junxian Wang Q.Daniel Wang Song Wang Tinggui Wang Weiyang Wang Zhongxiang Wang Dandan Xu Haiguang Xu Heng Xu Renxin Xu Xiaojie Xu Yongquan Xue Hang Yang Feng Yuan Shuinai Zhang Yuning Zhang Zhongli Zhang Yuanyuan Zhao Enping Zhou Ping Zhou | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 1 |
| 18 | Utilization of no- vel ester-containing quaternary ammonium surfactant as cationic collector for iron ore flotation 显示文摘 | Wcug Xiaoqing Mei Guangun Zhao Taotao ct al | 2013 | Separation and Purification Tech- nology2013，105，1： | 1 |
| 19 | Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin显示文摘 | Xin Zhao Yong Wang Shijun Yang Wentong Zhang Chengzhe Zu Taotao Zhang Binghua Tang Baochun Zhang Guozhang Li Bo Deng Dayong Cai Bhushan Patwardhan | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
| 20 | Utilization of novel es- ter-containing quaternary ammonium surfactant as cationic collector for iron ore flotation 显示文摘 | Weng Xiaoqir)g Mei Guangjun Zhao Taotao | 2013 | Separation and Purification Technology2013，103，： | 1 |
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