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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 3 | Liver transplant recipients with portal vein thrombosis:a single center retrospective study显示文摘BACKGROUND:Portal vein thrombosis(PVT)used to be a contraindication for liver transplantation(LT).This obstacle has been delt with following the improvement of LT-related techniques and therapeutic approaches to thrombosis. But the effect of PVT on LT outcomes is still controversial. We reviewed retrospectively the outcome of LT patients with PVT as well as risk factors and surgical management according to PVT grades. METHODS:A total of 465 adult LTs were performed from December 2002 through December 2006.Operative findings and the result of preoperative ultrasonography and imaging were reviewed for PVT grading(Yerdel grading).Comparison of risk factors,variables associated with perioperative period and prognosis between recipients with and without PVT is based on the grades. RESULTS:In the 465 LTs,42 were operatively confirmed to have PVT(9.0%)(19 recipients with grade 1,14 with grade 2,7 with grade 3,and 2 with grade 4).Increased age and treatment of portal hypertension were associated with PVT.Grade 1 or 2 PVT was treated by direct anastomosis or single thrombectomy.In grade 3 PVT patients,the donor PV was directly anastomosed to the dilated branch of the recipient portal venous system or to the distal open superior mesenteric vein through an interposition vein graft if needed.Grade 4 PVT was managed by our modified cavoportal hemitransposition technique.The comparison between PVT patients and controls showed no significant difference in operative duration and blood transfusion(P>0.05).The flow rate of the PV was lower in the PVT patients(48.881±12.788 cm/s)than in the controls(57.172±21.715 cm/s,P<0.05).The PVT patients had such postoperative complications as renal failure and PV rethrombosis(P<0.05).The 1-year survival rates in PVT and non-PVT patients were 78.6%and 76.4%respectively (P>0.05);the 3-year survival rates were 58.8%and 56.4% respectively(P>0.05). CONCLUSIONS:PVT is not contraindicated for LT if it is graded.PVT recipients may have post-transplantation complications like renal failure and PV rethrombosis,and operative difficulty and patient survival are similar to those in recipients without PVT.Development of therapeutic approaches and accumulation of experience in dealing with PVT further improve the outcomes of LT in PVT recipients. | Tao, Yi-Feng Teng, Fei Wang, Zheng-Xin Guo, Wen-Yuan Shi, Xiao-Min Wang, Gui-Hua Ding, Guo-Shan Fu, Zhi-Ren | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，1： | 14 |
| 4 | Isolation and culture of adult Sertoli cells and their effects on the function of co-cultured allogeneic islets in vitro显示文摘Background Globally, 180 million people suffer from diabetes mellitus. Islet transplantation is believed to be an almost ideal therapy for insulin-dependent patients. How to maintain the viability and the function of isolated human islets is a challenge in clinical practice. Sertoli cells are considered ‘nurse cells’in the seminiferous tubules and have been used in cell graft protocols for neurodegenerative diseases and diabetes in many studies. Many researchers have used immature murine testes as the primarily source of Sertoli cells in islet transplantation because they are easily purified. Mature human Sertoli cells have been seldom investigated. In the present study, we developed a method for the isolation and culture of Sertoli cells derived from adult human testes, and investigated their effects on the function of allogeneic islets when they were cultured together in vitro. Methods Adult Sertoli cells were prepared successfully by two-step enzyme digestion with trypsin, collagenase and hyaluronidase. They were identified by morphological characteristics and their activity was determined by MTT colorimetry over a 28-day culture time in vitro. A glucose-stimulated insulin secretion test was performed to detect the effects of Sertoli cells on allogeneic islets’ function when they were co-cultured for 21 days in vitro. Results In cultured cells, mature human Sertoli cells accounted for more than 90% of total cells. The activity of Sertoli cells reached 95% and they remained highly cytoactive for a long time in vitro (P>0.05). Compared with the islets cultured alone, the co-cultured islets with allogeneic Sertoli cells maintained higher sensitivity to glucose stimulation for the duration of the experiment (P<0.01). Conclusions A method of isolation and culture of Sertoli cells from adult testes has been established. Sertoli cells could enhance allogeneic islets’ function when they were co-cultured in vitro. They could be a helper cell in islet transplantation. | TENG Yan XUE Wu-jun DING Xiao-ming FENG Xin-shun XIANG He-li JIANG Ya-zhuo TIAN Pu-xun | 2005 | Chinese Medical Journal2005，，22： | 13 |
| 5 | Chemical vapor deposition growth of large-scale hexagonal boron nitride with controllable orientation显示文摘有一致厚度的大域的六角形的硼氮化物(h-BN ) 的化学蒸汽免职(CVD ) 合成是很挑战性的,主要由于这材料的极其高的成核密度。此处,我们报导晶片规模的成功的生长,有大单人赛水晶的领域尺寸的高质量的 h-BN 单层电影,吗直到~ 72 ??????????????????????????慮潮档湡敮獬???????慮潮畴敢??洠獥灯牯???? ?? | Xiuju Song Junfeng Gao Yufeng Nie Teng Gao Jingyu Sun Donglin Ma Qiucheng Li Yubin Chen Chuanhong Jin Alicja Bachmatiuk Mark H. Rummeli Feng Ding Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，10： | 12 |
| 6 | Failure of hepatocyte marker-expressing hematopoietic progenitor cells to efficiently convert into hepatocytes in vitro显示文摘 | Lian G Wang C Teng C Zhang C Du L Zhong Q Miao C Ding M Deng H | 2006 | 中国生物学文摘2006，20，5： | 11 |
| 7 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules显示文摘Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, powered congression of those chromosomes, their segregation in anaphase, and assembly of a spindle midzone at mitotic exit. The centromere-associated kinesin motor CENP-E, whose binding partner is BubR1, has been implicated in congression of misaligned chromosomes and the transition from lateral kinetochore-microtubule association to end-on capture. Although previously proposed to be a pseudokinase, here we report the structure of the kinase domain of Drosophila melanogaster BubR1, revealing its folding into a conformation predicted to be catalytically active. BubR1 is shown to be a bona fide kinase whose phosphorylation of CENP-E switches it from a laterally attached microtubule motor to a plus-end microtubule tip tracker. Computational modeling is used to identify bubristatin as a selective BubR1 kinase antagonist that targets the αN1 helix of N-terminal extension and αC helix of the BubR1 kinase domain. Inhibition of CENP-E phosphorylation is shown to prevent proper microtubule capture at kinetochores and, surprisingly, proper assembly of the central spindle at mitotic exit. Thus, BubR1-mediated CENP-E phosphorylation produces a temporal switch that enables transition from lateral to end-on microtubule capture and organization of microtubules into stable midzone arrays. | Yuejia Huang Lin Lin Xing Liu Sheng Ye Phil Y. Yao Wenwen Wang Fengrui Yang Xinjiao Gao Junying Li Yin Zhang Jiancun Zhang Zhihong Yang Xu Liu Zhenye Yang Jianye Zang Maikun Teng Zhiyong Wang Ke Ruan Xia Ding Lin Li Don W. Cleveland Rongguang Zhang Xuebiao Yao | 2019 | Cell Research2019，29，7： | 8 |
| 8 | High Resolution Radar Real-Time Signal and Information Processing显示文摘Radar is an electronic device that uses radio waves to determine the range, angle, or velocity of objects. Real-time signal and information processor is an important module for real-time positioning, imaging, detection and recognition of targets. With the development of ultra-wideband technology, synthetic aperture technology, signal and information processing technology, the radar coverage, detection accuracy and resolution have been greatly improved, especially in terms of one-dimensional(1D) high-resolution radar detection, tracking, recognition, and two-dimensional(2D) synthetic aperture radar imaging technology. Meanwhile, for the application of radar detection and remote sensing with high resolution and wide swath, the amount of data has been greatly increased. Therefore, the radar is required to have low-latency and real-time processing capability under the constraints of size, weight and power consumption. This paper systematically introduces the new technology of high resolution radar and real-time signal and information processing. The key problems and solutions are discussed, including the detection and tracking of 1D high-resolution radar, the accurate signal modeling and wide-swath imaging for geosynchronous orbit synthetic aperture radar, and real-time signal and information processing architecture and efficient algorithms. Finally, the latest research progress and representative results are presented, and the development trends are prospected. | Teng Long Tao Zeng Cheng Hu Xichao Dong Liang Chen Quanhua Liu Yizhuang Xie Zegang Ding Yang Li Yanhua Wang Yan Wang | 2019 | China Communications2019，16，2： | 7 |
| 9 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 10 | In vivo evaluation of urokinase-loaded hollow nanogels for sonothrombolysis on suture embolization-induced acute ischemic stroke rat model显示文摘The urokinase-type plasminogen activator(uPA)loaded hollow nanogels(nUK)were synthesized by a one-step reaction of glycol chitosan and aldehyde capped poly(ethylene oxide).The resultant formulation is sensitive to diagnostic ultrasound(US)of 2 MHz.Herein,we evaluated the in vivo sonothrombolysis performance of the nUK on acute ischemic stroke rat model which was established by suture embolization of middle cerebral artery(MCA).Via intravenous(i.v.)administration,the experimental data prove a controlled release of the therapeutic protein around the clots under ultrasound stimulation,leading to enhanced thrombolysis efficiency of the nUK,evidenced from smaller infarct volume and better clinical scores when compared to the i.v.dose of free uPA no matter with or without US intervention.Meanwhile,the preservation ability of the nanogels not only prolonged the circulation duration of the protein,but also resulted in the better blood-brain barrier protection of the nUK formulation,showing no increased risk on the hemorrhagic transformation than the controls.This work suggests that the nUK is a safe sonothrombolytic formulation for the treatment of acute ischemic stroke. | Yuming Teng Haiqiang Jin Ding Nan Mengnan Li Chenghe Fan Yuanyuan Liu Pu Lv Wei Cui Yongan Sun Hongjun Hao Xiaozhong Qu Zhenzhong Yang Yining Huang | 2018 | Bioactive Materials2018，3，1： | 7 |
| 11 | Milling Force Model for Aviation Aluminum Alloy: Academic Insight and Perspective Analysis显示文摘Aluminum alloy is the main structural material of aircraft,launch vehicle,spaceship,and space station and is processed by milling.However,tool wear and vibration are the bottlenecks in the milling process of aviation aluminum alloy.The machining accuracy and surface quality of aluminum alloy milling depend on the cutting parameters,material mechanical properties,machine tools,and other parameters.In particular,milling force is the crucial factor to determine material removal and workpiece surface integrity.However,establishing the prediction model of milling force is important and difficult because milling force is the result of multiparameter coupling of process system.The research progress of cutting force model is reviewed from three modeling methods:empirical model,finite element simulation,and instantaneous milling force model.The problems of cutting force modeling are also determined.In view of these problems,the future work direction is proposed in the following four aspects:(1)high-speed milling is adopted for the thin-walled structure of large aviation with large cutting depth,which easily produces high residual stress.The residual stress should be analyzed under this particular condition.(2)Multiple factors(e.g.,eccentric swing milling parameters,lubrication conditions,tools,tool and workpiece deformation,and size effect)should be considered comprehensively when modeling instantaneous milling forces,especially for micro milling and complex surface machining.(3)The database of milling force model,including the corresponding workpiece materials,working condition,cutting tools(geometric figures and coatings),and other parameters,should be established.(4)The effect of chatter on the prediction accuracy of milling force cannot be ignored in thin-walled workpiece milling.(5)The cutting force of aviation aluminum alloy milling under the condition of minimum quantity lubrication(mql)and nanofluid mql should be predicted. | Zhenjing Duan Changhe Li Wenfeng Ding Yanbin Zhang Min Yang Teng Gao Huajun Cao Xuefeng Xu Dazhong Wang Cong Mao Hao Nan Li Gupta Munish Kumar Zafar Said Sujan Debnath Muhammad Jamil Hafiz Muhammad Ali | 2021 | Chinese Journal of Mechanical Engineering2021，34，1： | 7 |
| 12 | Immunotherapy in liver transplantation for hepatocellular carcinoma:Pros and cons显示文摘Liver transplantation(LT)has emerged as a curative strategy for hepatocellular carcinoma(HCC),but contributes to a higher predisposition to HCC recurrence in the immunosuppression context,especially for tumors beyond the Milan criteria.Although immunotherapy has dramatically improved survival for immunocompetent patients and has become the standard of care for a variety of tumors,including HCC,it is mainly used outside the scope of organ transplantation owing to potentially fatal allograft rejection.Nevertheless,accumulative evidence has expanded the therapeutic paradigms of immunotherapy for HCC,from downstaging or bridging management in the pretransplant setting to the salvage or adjuvant strategy in the posttransplant setting.Generally,immunotherapy mainly includes immune checkpoint inhibitors(ICIs),adoptive cell transfer(ACT)and vaccine therapy.ICIs,followed by ACT,have been most investigated in LT,with some promising results.Because of the complex tumor microenvironment and immunoreactivity when immunosuppressants are combined with immunotherapy,it is difficult to reach formulations for immunosuppressant adjustment and the optimal selection of immunotherapy as well as patients.In addition,the absence of effective biomarkers for identifying rejection and tumor response is still an unresolved barrier to successful clinical immunotherapy applications for LT.In this review,we comprehensively summarize the available evidence of immunotherapy used in LT that is specific to HCC.Moreover,we discuss clinically concerning issues regarding the concurrent goals of graft protection and antitumor response. | Yi Luo Fei Teng Hong Fu Guo-Shan Ding | 2022 | World Journal of Gastrointestinal Oncology2022，14，1： | 7 |
| 13 | An improved motion compensation method for high resolution UAV SAR imaging显示文摘The polynomial and sinusoidal motion errors always exist in the unmanned aero vehicle(UAV)SAR due to the small size and low velocity of the platform,causing serious spectrum compressing/stretching and significant spectral replicas of the azimuth signal.The motion errors induce serious blurring of the SAR image and'ghost targets',and can hardly be precisely estimated by the conventional motion compensation(MOCO)method.In this paper,an improved MOCO method is proposed to estimate and eliminate the motion errors in the high resolution UAV SAR without high precision inertial navigation system(INS)data.The time domain range walk correction(RWC)operation in the coarse phase error estimation process of the proposed MOCO method is the key operation that ensures the estimation accuracy of the whole MOCO method.Finally,the validity of the improved MOCO method is verified by computer simulations and real UAV SAR data processing. | FAN BangKui DING ZeGang GAO WenBin LONG Teng | 2014 | Science China(Information Sciences)2014，57，12： | 6 |
| 14 | Two-in-one:A pooled analysis of primary hepatic neuroendocrine carcinoma combine d/collide d with hepatocellular carcinoma显示文摘To the Editor:Primary hepatic neuroendocrine carcinoma(PHNEC)combined/collided with hepatocellular carcinoma(HCC)is a rare and intriguing disease with characteristics of two histologically different cancers.Usually,a combined type refers to the cases in which hepatic neuroendocrine carcinoma(HNEC)and HCC components intermingle with each other and cannot be clearly separated in the transitional areas,while a collision type refers to those in which the two distinct cancers occurred simultaneously and independently.Sometimes it is difficult to readily distinguish these two types.We searched PubMed,Medline,China Science Periodical Database,and VIP Database with the publication from January 1980 to January 2019,using the keywords(“hepatic neuroendocrine carcinoma”or“HNEC”)and(“hepatocellular carcinoma”or“HCC”).After manually excluding records on secondary HNEC and other types of liver cancer,a total of 28 cases in 24 reports[1–24]were identified and summarized in Table 1. | Jia-Xi Mao Fei Teng Ke-Yan Sun Cong Liu Guo-Shan Ding Wen-Yuan Guo | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，4： | 6 |
| 15 | Two case reports and literature review for hepatic epithelioid angiomyolipoma: Pitfall of misdiagnosis显示文摘BACKGROUND Hepatic epithelioid angiomyolipoma(HEAML) is a rare liver disease and is easily misdiagnosed. Enhanced recognition of HEAML is beneficial to the differential diagnosis of rare liver diseases.CASE SUMMARY We presented two cases of HEAML in Changzheng Hospital, Naval Medical University, and then collected and analyzed all reports about HEAML recorded in PubMed, MEDLINE, China Science Periodical Database, and VIP database from January 2000 to March 2018. A total of 409 cases of HEAML in 97 reports were collected, with a ratio of men to women of 1:4.84 and an age range from 12 years to 80 years(median 44 years). Among the patients with clinical symptoms mentioned, 61.93%(205/331) were asymptomatic, 34.74%(115/331) showed upper or right upper quadrant abdomen discomfort, while a few of them showed abdominal mass, gastrointestinal symptoms, low fever, or weight loss. The misdiagnosis rate of HEAML was as high as 40.34%(165/409) due to its nonspecific imaging findings. Most of the tumors were solitary and round in morphology, with clear boundaries. Ultrasound scan indicated low echo with internal nonuniformity and rich blood supply in most cases. Computer tomography/magnetic resonance imaging enhanced scan showed varied characteristics. The ratio of fast wash-in and fast wash-out, fast wash-in and slow wash-out, and delayed enhancement was roughly 4:5:1. A definite diagnosis of HEAML depended on the pathological findings of the epithelioid cells in lesions and the expression of human melanoma black 45, smooth muscle actin,melanoma antigen, and actin by immunohistochemical staining. HEAML had a relatively low malignant rate of 3.91%. However, surgical resection was the main treatment for HEAML, due to the difficulty diagnosing before operation.CONCLUSION HEAML is a rare and easily misdiagnosed disease, and it should be diagnosed carefully, taking into account clinical course, imaging, pathological,and immunohistochemical findings. | Jia-Xi Mao Fei Teng Cong Liu Hang Yuan Ke-Yan Sun You Zou Jia-Yong Dong Jun-Song Ji Jun-Feng Dong Hong Fu Guo-Shan Ding Wen-Yuan Guo | 2019 | World Journal of Clinical Cases2019，7，8： | 6 |
| 16 | An optimization method for metamorphic mechanisms based on multidisciplinary design optimization显示文摘The optimization of metamorphic mechanisms is different from that of the conventional mechanisms for its characteristics of multi-configuration. There exist complex coupled design variables and constraints in its multiple different configuration optimization models. To achieve the compatible optimized results of these coupled design variables, an optimization method for metamorphic mechanisms is developed in the paper based on the principle of multidisciplinary design optimization(MDO). Firstly, the optimization characteristics of the metamorphic mechanism are summarized distinctly by proposing the classification of design variables and constraints as well as coupling interactions among its different configuration optimization models. Further, collaborative optimization technique which is used in MDO is adopted for achieving the overall optimization performance. The whole optimization process is then proposed by constructing a two-level hierarchical scheme with global optimizer and configuration optimizer loops. The method is demonstrated by optimizing a planar five-bar metamorphic mechanism which has two configurations,and results show that it can achieve coordinated optimization results for the same parameters in different configuration optimization models. | Zhang Wuxiang Wu Teng Ding Xilun | 2014 | Chinese Journal of Aeronautics2014，27，6： | 6 |
| 17 | Eogenetic Karst in Interbedded Carbonates and Evaporites and Its Impact on Hydrocarbon Reservoir: A New Case from Middle Triassic Leikoupo Formation in Sichuan Basin, Southwest China显示文摘Karst in interbedded carbonates and evaporites has been reported to have important and complex impacts on reservoir. It is significant for exploration and karst geology. Here, we report such a new case from Middle Triassic Leikoupo Formation of Sichuan Basin, Southwest China. Stratigraphic incompleteness and the occurrence of unconformity provide evidence for the presence of eogenetic karst. Under the impact of this eogenetic karst, residual weathered and solution-collapse breccia, solution pores and silicification and dedolomitization have been observed. Classic stratigraphic zonation of karst is not readily distinguishable, which is ascribed to the stratigraphic collapse of carbonate rocks resulting from the dissolution of evaporites by lateral subsurface fluid flow. In terms of impact on reservoir quality, karst can generally improve the initial physical property of the porous layers in theory. However, subsurface fluid flow dissolved the evarporitic beds and facilitated the collapse of overlying strata. As a consequence, the lateral continuity of the reservoirs would be destroyed, and relatively high-quality reservoirs can only be developed with little collapse of overlying strata, reflecting reservoir heterogeneities. This may be a general feature of reservoir formation under the impact of karst in interbedded carbonates and evaporites. | Hong Liu Xiucheng Tan Ling Li Xiong Ding Jian Cao Guang Yang Teng Ma | 2019 | Journal of Earth Science2019，30，5： | 5 |
| 18 | Electrical and optical properties of ZnO:Al films with different hydrogen contents in sputtering gas显示文摘Aluminum-doped zinc oxide(Zn O:Al) films were deposited by direct current magnetron sputtering in incorporating hydrogen in sputtering gas at room temperature. The influences of hydrogen content in sputtering gas on the structural, optical, and electrical properties of Zn O:Al films were systematically investigated. It is found that hydrogen incorporated into Zn O lattice forms shallow donors in Zn O:Al films and plays an important role in the properties of Zn O:Al films. The electrical conductivity and infrared(IR) reflectance are improved due to the increase of electron carrier concentration, and the average transmittance decreases, which is ascribed to the strong scattering from the hydrogen incorporated and oxygen vacancies in Zn O:Al films. In this study,the resistivity of 5.5×10^(-4) Ω·cm is obtained, the average transmittance of the wavelength in the range of 400–900 nm is almost 86%, and the IR reflectance reaches 75% at 2,500 nm,which is higher than that of reported TCO films. The band gap determined by optical absorption is a result of competition between Burstein–Moss effect and many-body perturbation effect. However, the hydrogen content in sputtering gas is above 10%, and the optical band gap shift is independent of hydrogen content in sputtering gas. | Fei Qu Teng Zhang Hong-Wei Gu Qing-Quan Qiu Fa-Zhu Ding Xing-Yu Peng Hong-Yan Wang | 2015 | Rare Metals2015，34，3： | 5 |
| 19 | Apoptosis induced by preoperative oral 5′-DFUR administration in gastric adenocarcinoma and its mechanism of action显示文摘瞄准:为了学习, apoptosis 在胃的腺癌和它行动的机制由外科手术前的口头的 5'-DFUR 管理导致了。方法:六十个胃的癌症病人在手术前随机被划分成三个组(20 每组) :在为 3 的 800-1200 mg/d 的剂量的组 one:5'-DFUR 口服 - 5 d,组织二:500 mg 5-FU + 200 mg/d CF 由静脉为 3 滴下 - 5 d,组三(控制组) 。在化疗以后的一或二天,病人被操作。Fas/FasL, PD-ECGF 和 PCNA 被免疫组织化学检验, apoptotic 肿瘤房间被原位 TUNEL 方法检测。54 个病人收到了胃切除术,包括 12 辩解的切除术和 42 激进的切除术。六个病人被排除。最后,在 5'-DFUR 组,在 CF+5-FU 组的 16 个盒子,和在控制组的 20 个盒子的 18 个盒子被分析。结果:在耐心的吝啬的年龄没有有效差量,性,白血房间计数, haematoglobin (HB ) ,凝血致活酶,在三之中的复杂并发症发生,基或减轻切除术,侵略深度(T) , lymphonode 参与(N) ,转移(M) 和 TNM 阶段组织的起作用的仙子。然而, PCNA 索引(PI ) 在 5'-DFUR,组(40.51+/-12.62 ) 和 5-FU+CF 组(41.12+/-15.26 ) 在控制组(58.33+/-15.69 ) 是比那显著地低的(F=9.083, P=0.000 ) 。在 5'-DFUR 组(14.39+/-9.49 ) 和 5-FU+CF 组(14.11+/-9.68 ) 的 apoptotic 索引(AI ) 在控制组(6.88+/-7.37 ) 比那显著地高(F=4.409, P=0.017 ) 。船边交货和 FasL 在的表示率组一和组三是 66.7%(12/18 ) 并且 50%(9/18 ) , 43.8%(7/16 ) 并且 81.3%(13/16 ) , 45.0%(9/20 ) 并且 85%(17/20 ) 分别地。在 5'-DFUR 组的 FasL 的表示率在另外的二个组是比那显著地低的(chi2=6.708, P=0.035 ) 。同时, PD-ECGF 的表示率比在 CF+5-FU 组(9/16,56.3%) 和控制组(13/20,65.0%) 在 5'-DFUR 组(4/18,28.6%) 是显著地更低的(chi2=7.542, P=0.023 ) 。船边交货表示的频率显著地与辩解或激进的切除术被相关(chi2=7.651, P=0.006 ) ,侵略深度(chi2=8.927, P=0.003 ) ,淋巴的传播(chi2=4.488, P=0.034 ) 并且 UICC 阶段(chi2=8.063, P=0.045 ) 分别地。在 3 月 2005,45 日底,病人们被跟随起来。0.5- , 1- , 2- ,分别地, 3 年的幸存率是 96%,73%,60%,48% 它与 T, N, M 和船边交货表示,然而并非与 PD-ECGF 和 FasL 表示是相关的。结论:外科手术前的口头的 5'-DFUR 管理可以导致胃的癌房间和减少肿瘤房间增长索引的 apoptosis,但是不能与 FasL 和 PD-ECGF 表示的胃的 cancer.Down 规定改进病人的预后由 5'-DFUR 调停了可以是它的反癌症机制之一。有胃的癌的前进的船边交货表示相互关联并且可以是一个有效预示的因素。 | Wen-He Zhao Shi-Fu Wang Wei Ding Jian-Ming Sheng Zhi-Min Ma Li-Song Teng Min Wang Fu-Sheng Wu Bing Luo | 2006 | World Journal of Gastroenterology2006，12，9： | 5 |
| 20 | Clonality and allelotype analyses of focal nodular hyperplasia compared with hepatocellular adenoma and carcinoma显示文摘AIM: To identify clonality and genetic alterations in focal nodular hyperplasia (FNH) and the nodules derived from it. METHODS: Twelve FNH lesions were examined. Twelve hepatocellular adenomas (HCAs) and 22 hepatocellular carcinomas (HCCs) were used as references. Nodules of different types were identified and isolated from FNH by microdissection. An X-chromosome inactivation assay was employed to describe their clonality status. Loss of heterozygosity (LOH) was detected, using 57 markers, for genetic alterations.RESULTS: Nodules of altered hepatocytes (NAH), the putative precursors of HCA and HCC, were found in all the FNH lesions. Polyclonality was revealed in 10 FNH lesions from female patients, and LOH was not detected in any of the six FNH lesions examined, the results apparently showing their polyclonal nature. In contrast, monoclonality was demonstrated in all the eight HCAs and in four of the HCCs from females, and allelic imbalances were found in the HCAs (9/9) and HCCs (15/18), with chromosomal arms 11p, 13q and 17p affected in the former, and 6q, 8p, 11p, 16q and 17p affected in the latter lesions in high frequencies (≥ 30%). Monoclonality was revealed in 21 (40%) of the 52 microdissected NAH, but was not found in any of the f ive ordinary nodules. LOH was found in all of the 13 NAH tested, being highly frequent at six loci on 8p, 11p, 13q and 17p. CONCLUSION: FNH, as a whole, is polyclonal, but some of the NAH lesions derived from it are already neoplastic and harbor similar allelic imbalances as HCAs. | Yi-Ran Cai Li Gong Xiao-Ying Teng Hong-Tu Zhang Cheng-Feng Wang Guo-Lian Wei Lei Guo Fang Ding Zhi-Hua Liu Qin-Jing Pan Qin Su | 2009 | World Journal of Gastroenterology2009，15，37： | 5 |
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