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1Petawatt and exawatt class lasers worldwide显示文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development.Colin N.Danson Constantin Haefner Jake Bromage Thomas Butcher Jean-Christophe FChanteloup Enam A.Chowdhury Almantas Galvanauskas Leonida A.Gizzi Joachim Hein David I.Hillier Nicholas W.Hopps Yoshiaki Kato Efim A.Khazanov Ryosuke Kodama Georg Korn Ruxin Li Yutong Li Jens Limpert Jingui Ma Chang Hee Nam David Neely Dimitrios Papadopoulos Rory R.Penman Liejia Qian Jorge J.Rocca andrey A.Shaykin Craig W.Siders Christopher Spindloe Sándor Szatmári Raoul M.G.M.Trines Jianqiang Zhu Ping Zhu Jonathan D.Zuegel 2019High Power Laser Science and Engineering2019,7,3:33
226mA cm^(-2) J_(sc) from organic solar cells with a low-bandgap nonfullerene acceptor显示文摘Nonfullerene-based organic solar cells(NFOSCs)have received great interest recently due to their higher performance and greater potential compared with fullerene-based solar cells[1].Power conversion efficiencies(PCEs)over 13% have been realized in single-junction NFOSCs[2].Compared with traditional fullerene acceptors,the greatest advantage of nonfullerene acceptors is their stronger light-harvesting capability in the visible andZuo Xiao Xue Jia Dan Li Shizhe Wang Xinjian Geng Feng Liu Junwu Chen Shangfeng Yang Thomas P.Russell Liming Ding 2017Science Bulletin2017,62,22:28
3DUF221 proteins are a family of osmosensitive calciumpermeable cation channels conserved across eukaryotes显示文摘Congcong Hou Wang Tian Thomas Klelst Kai He Veder Garcia Fenglin Bai Yanli Hao Sheng Luan Legong Li 2014Cell Research2014,24,5:22
4Chinese Atherosclerosis Risk Evaluation(CARE II)study:a novel cross-sectional,multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events-design and rationale显示文摘Background:Carotid atherosclerotic plaque is identified as one of the main sources of ischaemic stroke.However,the prevalence of carotid high-risk atherosclerotic plaque in Chinese patients with ischaemic cerebrovascular events has been inconsistently reported and needs to be investigated in a large population.Objectives:The primary objective of CARE II study was to determine the prevalence and characteristics of high-risk features of atherosclerotic plaques in the carotid arteries in Chinese patients with recent ischaemic stroke or transient ischaemia attack(TIA).The relationship between carotid plaque features and cerebral infarcts,the differences of carotid plaque patterns among different regions of China and the gender specific characteristics of carotid plaque will be also determined.Study design:The CARE II study will enrol 1000 patients with recent ischaemic stroke or TIA and carotid plaque from 13 hospitals and medical centres across China.In this cross-sectional,non-randomised,observational,multicentre study,all patients will undergo carotid artery MRI of bilateral carotid arteries and routine brain MRI with standardised protocols.The MRI will be interpreted at core reading centres to evaluate the characteristics of morphology and compositions of carotid plaque.Conclusions:This is a cross-sectional,multicentre study to investigate the prevalence and characteristics of high-risk atherosclerotic carotid plaque in Chinese patients with stroke and TIA by using high-resolution MRI of vessel wall.This trial is sufficiently powered to demonstrate the prevalence of carotid high-risk plaque and to explore regional differences in Chinese patients who suffered stroke.Xihai Zhao Rui Li Daniel S Hippe Thomas S Hatsukami Chun Yuan CARE-II Investigators 2017Stroke & Vascular Neurology2017,2,1:21
5Synergistic effect of fluorination on both donor and acceptor materials for high performance non-fullerene polymer solar cells with 13.5% efficiency显示文摘A high performance polymer solar cells(PSCs) based on polymer donor PM6 containing fluorinated thienyl benzodithiophene unit and n-type organic semiconductor acceptor IT-4 F containing fluorinated end-groups were developed. In addition to complementary absorption spectra(300–830 nm) with IT-4 F, the PM6 also has a deep HOMO(the highest occupied molecular) level(-5.50 e V), which will lower the open-circuit voltage(V_(oc)) sacrifice and reduce the E_(loss) of the IT-4 F-based PSCs. Moreover, the strong crystallinity of PM6 is beneficial to form favorable blend morphology and hence to suppress recombination. As a result, in comparison with the PSCs based on a non-fluorinated D/A pair of PBDB-T:ITIC with a medium PCE of 11.2%, the PM6:IT-4 Fbased PSCs yielded an impressive PCE of 13.5% due to the synergistic effect of fluorination on both donor and acceptor, which is among the highest values recorded in the literatures for PSCs to date. Furthermore, a PCE of 12.2% was remained with the active layer thickness of up to 285 nm and a high PCE of 11.4% was also obtained with a large device area of 1 cm^2. In addition, the devices also showed good storage, thermal and illumination stabilities with respect to the efficiency. These results indicate that fluorination is an effective strategy to improve the photovoltaic performance of materials, as well as the both fluorinated donor and acceptor pair-PM6:IT-4 F is an ideal candidate for the large scale roll-to-roll production of efficient PSCs in the future.Qunping Fan Wenyan Su Yan Wang Bing Guo Yufeng Jiang Xia Guo Feng Liu Thomas P.Russell Maojie Zhang Yongfang Li 2018Science China Chemistry2018,61,5:18
6Multichannel vectorial holographic display and encryption显示文摘Since its invention,holography has emerged as a powerful tool to fully reconstruct the wavefronts of light including all the fundamental properties(amplitude,phase,polarization,wave vector,and frequency).For exploring the full capability for information storage/display and enhancing the encryption security of metasurface holograms,smart multiplexing techniques together with suitable metasurface designs are highly demanded.Here,we integrate multiple polarization manipulation channels for various spatial phase profiles into a single birefringent vectorial hologram by completely avoiding unwanted cross-talk.Multiple independent target phase profiles with quantified phase relations that can process significantly different information in different polarization states are realized within a single metasurface.For our metasurface holograms,we demonstrate high fidelity,large efficiency,broadband operation,and a total of twelve polarization channels.Such multichannel polarization multiplexing can be used for dynamic vectorial holographic display and can provide triple protection for optical security.The concept is appealing for applications of arbitrary spin to angular momentum conversion and various phase modulation/beam shaping elements.Ruizhe Zhao Basudeb Sain Qunshuo Wei Chengchun Tang Xiaowei Li Thomas Weiss Lingling Huang Yongtian Wang Thomas Zentgraf 2018Light(Science & Applications)2018,7,1:15
7No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer.Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li 2009World Journal of Gastroenterology2009,15,18:11
8The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment.ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart 2019Science China(Physics,Mechanics & Astronomy)2019,62,2:11
9A theoretical prediction of chemical zonation in early oceans(>520 Ma)显示文摘Early oceans(>520 Ma) were characterized by widespread water-column anoxia, stratification, and limited oxidant availability, which are comparable to the chemical characteristics of modern marine sedimentary pore-waters in productive continental margins. Based on this similarity and our current understanding of the formation mechanism of early Earth ocean chemistry, we propose an idealized chemical zonation model for early oceans that includes the following redox zones(from shallow nearshore to deep offshore regions): oxic, nitrogenous(NO3?-NO2?-enriched), manganous-ferruginous(Mn2+ or Fe2+-enriched), sulfidic(H2S-enriched), methanic(CH4-enriched), and ferruginous(Fe2+-enriched). These zones were dynamically maintained by a combination of processes including surface-water oxygenation by atmospheric free oxygen, nitrate reduction beneath the chemocline, nearshore manganese-iron reduction, sulfate reduction, methanogenesis, and hydrothermal Fe2+ inputs from the deep ocean. Our modified 'euxinic wedge' model expands on previous versions of this model, providing a more complete theoretical framework for the chemical zonation of early Earth oceans that helps to explain observations of unusual Mo-S-C isotope patterns. This model may provide a useful foundation for future studies of ocean chemistry evolution and elemental biogeochemical cycles in early Earth history.LI Chao CHENG Meng Thomas J.ALGEO XIE ShuCheng 2015Science China Earth Sciences2015,58,11:11
10Personalized targeted therapy for esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma continues to heavily burden clinicians worldwide. Researchers have discovered the genomic landscape of esophageal squamous cell carcinoma, which holds promise for an era of personalized oncology care. One of the most pressing problems facing this issue is to improve the understanding of the newly available genomic data, and identify the driver-gene mutations, pathways, and networks. The emergence of a legion of novel targeted agents has generated much hope and hype regarding more potent treatment regimens, but the accuracy of drug selection is still arguable. Other problems, such as cancer heterogeneity, drug resistance, exceptional responders, and side effects, have to be surmounted. Evolving topics in personalized oncology, such as interpretation of genomics data, issues in targeted therapy, research approaches for targeted therapy, and future perspectives, will be discussed in this editorial.Xiaozheng Kang Keneng Chen Yicheng Li Jianying Li Thomas A D'Amico Xiaoxin Chen 2015World Journal of Gastroenterology2015,21,25:10
11Nature:揭示干细胞惊人异质性显示文摘论文作者George Daley教授说:"这是一项非常基础的研究,但它阐明了多能性状态广泛性。我们捕获了干细胞不同状态的详细分子谱。"研究人员通过采用多种变量如不同的化学物质、培养环境和遗传敲除来扰乱多能干细胞,研究人员探究了它们的发育景观。随后,他们分析了每个细胞的遗传组成,观察了每个细胞多能状态的微小波动。他们发现内部、化学和环境信号影响干细胞方式的许多细微差异,揭示出了复杂的发育调控因子"决策"回路。Roshan M.Kumar Patrick Cahan Alex K.Shalek Rahul Satija A.Jay Daley Keyser Hu Li Jin Zhang Keith Pardee David Gennert John J.Trombetta Thomas C.Ferrante Aviv Regev George Q.Daley James J. Collins 2014岭南现代临床外科2014,14,6:10
1211.2% Efficiency all-polymer solar cells with high open-circuit voltage显示文摘Herein,we fabricated all-polymer solar cells(all-PSCs)based on a fluorinated wide-bandgap p-type conjugated polymer PM6 as the donor,and a narrow bandgap n-type conjugated polymer PZ1 as the acceptor.In addition to the complementary absorption and matching energy levels,the optimized blend films possess high cystallinity,predominantly face-on stacking,and a suitable phase separated morphology.With this active layer,the devices exhibited a high Vocof 0.96 V,a superior Jscof 17.1 mA cm^-2,a fine fill factor(FF)of 68.2%,and thus an excellent power conversion efficiency(PCE)of 11.2%,which is the highest value reported to date for single-junction all-PSCs.Furthermore,the devices showed good storage stability.After 80 d of storage in the N2-filled glovebox,the PCE still remained over 90%of the original value.Large-area devices(1.1 cm^2)also demonstrated an outstanding performance with a PCE of 9.2%,among the highest values for the reported large-area all-PSCs.These results indicate that the PM6:PZ1 blend is a promising candidate for scale-up production of large area high-performance all-PSCs.Yuan Meng Jingnan Wu Xia Guo Wenyan Su Lei Zhu Jin Fang Zhi-Guo Zhang Feng Liu Maojie Zhang Thomas P. Russell Yongfang Li 2019Science China Chemistry2019,62,7:9
13TWISTED DWARF 1 Associates with BRASSINOSTEROID-INSENSITIVE 1 to Regulate Early Events of the Brassinosteroid Signaling Pathway显示文摘为异种证明改变的 brassinosteroid (BR ) 敏感或象 bri1 一样显型导致了扭曲的矮子 1 的二新变异的等位基因(TWD1 ) 的鉴定的一幅染色体宽的屏幕, twd1-4,和 twd1-5。以前的研究显示了那 TWD1,也作为 ULTRACURVATA 2 或 FKBP42 说出,与植物生长素流出 transporters 联系并且为他们的生物功能是必要的。尽管更早的报告证明 BR 发信号是在 twd1 的 downregulated, TWD1 怎么集成于 BR 发信号,没被阐明。这里,我们提供证明 TWD1 以一种 BR 独立的方式与 BR 受体 BRI1 invivo 交往的基因、生物化学的证据。进一步的分析显示 TWD1 不由改变调制 BR 信号 transduction 嗯质量控制或蛋白质许多 BRI1;相反, TWD1 看起来在 BRI1 和它的合作受体的导致 BR 的相互作用批评这二蛋白质的 BAK1,以及导致 BR 的 phosphorylation。这些结果提供表明小径的 BR 的早事件的更好的理解。Baolin Zhao Minghui Lv Zengxiu Feng Thomas Campbell Emmanuel Liscum Jia Li 2016Molecular Plant2016,9,4:8
14Developing More Effective Enhanced Biochar Fertilisers for Improvement of Pepper Yield and Quality显示文摘Utilization of biochar at high application rates can increase soil C and crop yields, decrease greenhouse gas emissions and reduce nutrient run-off from soils. However, the high application rate of 10 t ha-1may not return a profit to the farmer due to the high cost of biochar. In this study biochar was modified through pre-treating the biomass and post-treating with phosphoric acid, minerals and different chemical fertilisers to study the effects of two new enhanced biochar fertilisers on the yield and quality of green pepper in a field experiment with 5 fertilisation treatments and 3 replications. The two new biochar fertilisers significantly(P < 0.05) increased the yield of green pepper(11.33–11.47 t ha-1), compared with the conventional chemical fertiliser(9.72 t ha-1). The biochar fertiliser treatments improved the vitamin C content of green pepper from 236.99 to 278.28 mg kg-1, and also significantly(P < 0.05) reduced the nitrate content from 132.32 to 101.92 mg kg-1, compared with chemical fertiliser. This study indicated that, compared to the use of conventional chemical fertiliser, all of the biochar fertiliser treatments could significantly improve the yield and quality of green pepper.YAO Chunxue Stephen JOSEPH LI Lianqing PAN Genxing Yun LIN Paul MUNROE Ben PACE Sarasadat TAHERYMOOSAVI Lukas VAN ZWIETEN Torsten THOMAS Shaun NIELSEN Jun YE Scott DONNE 2015Pedosphere2015,25,5:8
15Strategies to anode protection in lithium metal battery:A review显示文摘Lithium metal batteries(LMBs)are considered the most promising energy stor-age devices for applications such as electrical vehicles owing to its tremendous theoretical capacity(3860 mAh g−1).However,the serious safety issues and poor cycling performance caused by the dendritic crystal growth during deposi-tion are concerned for any rechargeable batteries with a lithium metal anode.To make widespread adoption a possibility,considerable efforts have been devoted to suppressing lithium(Li)dendrite growth.In this review,the recent strategies to developing dendrite free Li anode,including constructing an artifi-cial solid electrolyte interface,current collector modification,separator film improvement,and electrolyte additive,are summarized.The merits and short-comings for different strategies are reviewed and a general summary and per-spective on the next generation rechargeable batteries are presented.Jiawei Li Zhao Kong Xiaoxi Liu Bocong Zheng Qi Hua Fan Elias Garratt Thomas Schuelke Keliang Wang Hui Xu Hong Jin 2021InfoMat2021,3,12:8
16Recruitment of CCR6-expressing Thl7 cells by CCL20 secreted from plasmin-stimulated macrophages显示文摘在现在的学习,导出单核白血球的人的巨噬细胞被区分开来与 buffy 上衣。Na ? 用 anti-CD4 从外部血 mononuclear 房间充实的 ve CD4+T 房间磁性的祷告和 autoMACS 分离系统在 T 助手下面被极化 17 (Th17 ) 支持条件 6 天得到 Th17 房间。Th17 房间区别和 Th17 房间上的 C-C chemokine 受体类型 6 的表示(CCR6 ) 的频率被流动 cytometry 调查。巨噬细胞的被触发胞质素的正式就职煽动性的 protein-3alpha/C-C chemokine ligand 20 (CCL20 ) 在巨噬细胞的基因被反向的抄写聚合酶链反应估计,并且分泌了蛋白质层次被连接酶的 immunosorbent 测量试金。从刺激胞质素的巨噬细胞分泌的 CCL20 导致的 Th17 房间移植被趋化性用一个 transwell 系统在 vitro 测试。这些结果证明那胞质素在人的导出单核白血球的巨噬细胞触发 chemokine CCL20 送信人 RNA 的表示和 CCL20 蛋白质的版本,它极其取决于胞质素的解朊的活动和 p38 的激活表明小径的激活 mitogen 的蛋白质 kinase 和原子 factor-kappaB。CCR6 的表示在 87.23 牡挠祲映潲上被检测吗?Qun Li Yves Laumonnier Tatiana Syrovets Thomas Simmet 2013Acta Biochimica et Biophysica Sinica2013,45,7:8
17Metasurface interferometry toward quantum sensors显示文摘Optical metasurfaces open new avenues for the precise wavefront control of light for integrated quantum technology.Here,we demonstrate a hybrid integrated quantum photonic system that is capable of entangling and disentangling two-photon spin states at a dielectric metasurface.Via the interference of single-photon pairs at a nanostructured dielectric metasurface,a path-entangled two-photon NOON state with circular polarization that exhibits a quantum HOM interference visibility of 86±4% is generated.Furthermore,we demonstrate nonclassicality andphase sensitivity in a metasurface-based interferometer with a fringe visibility of 86.8±1.1%in the coincidence counts.This high visibility proves the metasurface-induced path entanglement inside the interferometer.Our findings provide a promising way to develop hybrid-integrated quantum technology operating in the high-dimensional mode space in various applications,such as imaging,sensing,and computing.Philip Georgi Marcello Massaro Kai-Hong Luo Basudeb Sain Nicola Montaut Harald Herrmann Thomas Weiss Guixin Li Christine Silberhorn Thomas Zentgraf 2019Light(Science & Applications)2019,8,1:7
18A GmNINa-miR172c-NNC1 Regulatory Network Coordinates the Nodulation and Autoregulation of Nodulation Pathways in Soybean显示文摘Symbiotic root nodules are root lateral organs of plants in which nitrogen-fixing bacteria(rhizobia)convert atmospheric nitrogen to ammonia.The formation and number of nodules in legumes are precisely controlled by a rhizobia-induced signal cascade and host-controlled autoregulation of nodulation(AON).However,how these pathways are integrated and their underlying mechanisms are unclear.Here,we report that microRNA172c(miR172c)activates soybean(Glycine max)R hizobia-induced CLE1(GmRICI)and GmRIC2 by removing the transcriptional repression of these genes by Nodule Number Control 1(NNC1),leading to the activation of the AON pathway.NNC1 interacts with GmNINa,the soybean ortholog of Lotus NODULE INCEPTION(NIN),and hampers its transcriptional activation o i G m RICI and GmRIC2.Importantly,GmNINa acts as a transcriptional activator of miR172c.Intriguingly,NNC1 can transcriptionally repress miR172c expression,adding a negative feedback loop into the NNC1 regulatory network.Moreover,GmNINa interacts with NNC1 and can relieve the NNC1-mediated repression of miR172c transcription.Thus,the GmNINa-miR172c-NNC1 network is a master switch that coordinately regulates and optimizes NF and AON signaling,supporting the balance between nodulation and AON in soybean.Lixiang Wang Zhengxi Sun Chao Su Yongliang Wang Qiqi Yan Jiahuan Chen Thomas Ott Xia Li 2019Molecular Plant2019,12,9:7
19Non-transgenic Plant Genome Editing Using Purified Sequence-Specific Nucleases显示文摘Dear Editor, Sequence-specific nucleases,including zinc-finger nucleases,meganucleases,TAL effector nucleases (TALENs),and CRISPR/ Cas systems,have been used to introduce targeted mutations in a wide range of plant species (Voytas,2013;Baltes and Voytas,2015).However,delivery of these nucleases using traditional transformation methods (e.g.,particle bombardment,Agrobacterium or protoplast transformation) may result in undesired genetic alterations due to random insertion of nucleaseencoding DNA intothe host genome.Song Luo Jin Li Thomas J. Stoddard Nicholas J. Baltes Zachary L. Demorest Benjamin M. Clasen Andrew Coffman Adam Retterath Luc Mathis Daniel F. Voytas Feng Zhang 2015Molecular Plant2015,8,9:7
20Experimental evaluation of thermolysis-driven gas emissions from LiPF6-carbonate electrolyte used in lithium-ion batteries显示文摘This paper performs an experimental evaluation of thermolysis-driven gases generated by the thermal decomposition of 1 M LiPF6+EC/DMC=1/1 v/v electrolytes at various decomposition temperatures,pyrolysis durations,and oxygen concentrations.Carried out in a home-built autoclave filled with pure helium,the experiment reveals that as the decomposition temperature increases,more types and larger quantities of gases will be released.Specifically,the experimental results demonstrate trends of logistic growth in the volume concentration of CO2,C2H6O,C2H4,CO,and C2H4O2 with the increase of decomposition temperature.With a prolonged pyrolysis duration,while volume concentrations of certain gases,such as CO2,C2H6O,C2H5F,and CO would increase,the concentration of C2H4O2 actually decreases.Moreover,concentrations of both C2H4 and C2H5F will first decrease and reach their minimum values at 1%v/v oxygen concentration,and then they would quickly climb back at higher oxygen concentrations,while the concentrations of C2H6 and C2H3F would decrease monotonically.It is envisioned that the detailed experimental results and findings on the gas generation pattern of 1 M LiPF6+EC/DMC=1/1 v/v electrolytes can facilitate the development of an early warning mechanism of thermal runaway based on gas sensing technology,which can be effectively applied to monitor the potential thermal failures of lithium-ion batteries with the same type of electrolyte and thus promote the thermal safety of battery packs in safety-critical applications.Zhenghai Liao Shen Zhang Yikun Zhao Zongjia Qiu Kang Li Dong Han Guoqiang Zhang Thomas G.Habetler 2020Journal of Energy Chemistry2020,29,10:7
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