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| 1 | Inhibition of corneal fibrosis by Smad7 in rats after photorefractive keratectomy显示文摘 | WANG Ti ZHOU Xing-tao YU Yan ZHU Jing-yin DAI Jin-hui QU Xiao-mei LE Qi-hua CHU Ren-yuan | 2013 | Chinese Medical Journal2013，，8： | 8 |
| 2 | Expression of Smad7 inhibits fibrogenic responses of keratocytes to transforming growth factor β2显示文摘背景转变生长因素(TGF ) 是在纤维变性的发展的最重要的生长因素之一并且在角膜上结疤。Smad7,禁止的 Smad,能禁止 TGF 信号办理。在最近的年里,一些机关上的纤维变性的抑制上的调停 lentiviral 的 Smad7 的效果被学习了,当很少在角膜上对效果被知道时。试图在 TGF 2 在 vitro.Methods Keratocytes 导致的 keratocyte 增长和纤维变性上决定调停 lentiviral 的 Smad7 基因表示的效果的这研究从与表示 lentiviral 向量(Lv-Smad7 ) 或非工作的控制向量(Lv 空白) 的 Smad7 从 Sprague-Dawley (SD ) 老鼠和 transfected 孤立的 comeal 织物是有教养的。跟随暴露到 TGF2, keratocytes 被处理让 immunoblotting 估计 TGF/Smad 发信号的 Smad2 同样下游的事件的 phosphorylation。fibrotic 标记的表示光滑的肌肉肌动朊(-SMA), 类型骨胶原(骨胶原) 被西方的弄污和量的实时聚合酶链反应(PCR ) 测量。全面房间增长被 3-(4,5-dimethyl-thiazol-2-yl ) 决定 -2,5-dipheny1tetrazolium 溴化物(MTT ) 试金和房间的表示在 Smad7 基因转移压制了 TGF/Smad 由 Smad2 的下面调整的 phosphorylation 在 keratocytes 发信号的 mRNA 和蛋白质 levels.Results 的周期相关的标记 Ki67。包括 Ki67 的房间增长和纤维变性的标记, -SMA, 骨胶原被 Smad 7 的介绍禁止进 TGF 暴露的 keratocytes。因而,房间增长的率是 attenuated.Conclusion Smad7 基因转移到 TGF2 的 keratocytes 的禁止的 fibrogenic 回答。 | WANG Ti ZHOU Xing-tao YU Yan DAI Jin-hui QU Xiao-mei LE Qi-hua CHU Ren-yuan | 2011 | Chinese Medical Journal2011，，13： | 6 |
| 3 | P-Loop-Dependent NLR SNC1 Can Oligomerize and Activate Immunity in the Nucleus显示文摘 | Fang Xu Yu Ti Cheng Paul Kapos Yan Huang Xin Li | 2014 | Molecular Plant2014，7，12： | 6 |
| 4 | Human fused NKG2D-IL-15 protein controls xenografted human gastric cancer through the recruitment and activation of NK cells显示文摘Interleukin (IL )-15 在生来的杀手(NK ) 和 CD8+T 房间增长和功能起一个重要作用并且是比为肿瘤免疫疗法的 IL-2 更有效的。由附近的房间的 IL-15 的 trans 演讲比它的可溶的 IL-15 为 NK 房间激活是更有效的。在这研究,熔化蛋白质 dsNKG2D-IL-15,由经由一个连接器联合到人的 IL-15 的人的 NKG2D 的二相同的细胞外的域组成了,在 Escherichia coli 被设计。DsNKG2D-IL-15 能高效地与二个 NKG2D 领域和 trans 礼品 IL-15 把人的肿瘤房间的链相关的蛋白质 A (云母) 绑在主要 histocompatibility 建筑群一级到 NK 或 CD8+ T 房间。我们移植了人的胃的癌症(SGC-7901 ) 房间进裸体老鼠和有进 C57BL/6 老鼠的云母(B16BL6 云母) 的宫外的表示的老鼠黑瘤房间。然后,我们学习了反肿瘤效果在二个 xenografted 肿瘤模特儿由 dsNKG2D-IL-15 调停了。人的 dsNKG2D-IL-15 在压制胃的癌症生长比 IL-15 展出了更高的效率。外长的人的 dsNKG2D-IL-15 集中地在老鼠肿瘤纸巾被散布基于在 vivo 实时成像。房间渗入了进跟随外部血 mononuclear 房间的注射进忍受人的胃的癌症的裸体老鼠的肿瘤纸巾的人的 CD56+ 的频率被人的 dsNKG2D-IL-15 治疗显著地增加。人的 dsNKG2D-IL-15 也由激活和招募的老鼠 NK 和 CD8+ T 房间推迟了移植黑瘤(B16BL6 云母) 的生长。在 C57BL/6 老鼠的人的 dsNKG2D-IL-15 的反黑瘤效果主要被减少由在里面老鼠 NK 房间的 vivo 弄空。这些数据热点为肿瘤的人的 dsNKG2D-IL-15 的潜在的使用治疗。 | Yan Chen Bei Chen Ti Yang Weiming Xiao Li Qian Yanbing Ding Mingchun Ji Xiaoqun Ge Weijuan Gong | 2017 | Cellular & Molecular Immunology2017，14，3： | 6 |
| 5 | A PILOT TRIAL FOR SEVERE ,REFRACTORY SYSTEMIC AUTOIMMUNE DISEASE WITH STEM CELL TRANSPLANTATION显示文摘Objective To evaluate the feasibility, efficacy, and safety of high dose immunosuppressive therapy (HDIT) and autolo- gous hemopoietic stem cell transplantation (HSCT) with CD34+ cell selection in patients with severe, refractory autoim- mune diseases. Methods Twenty-six patients with persistent systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), primary Sjgren’s syndrome (pSS), or systemic sclerosis (SSc) who had been treated unsuccessfully with conventional treatment were enrolled in the trial in Peking Union Medical College Hospital from September 1999 to June 2004. The patients received HDIT with 200 mg/kg cyclophosphamide followed by an infusion of autologous stem cells that were CD34 selected. Disease acti- vity, adverse effect, hemopoietic and immune reconstitution, and time to recurrence of disease were monitored. Results Overall treatment related mortality was 7.7% (2/26) with 1 patient died of cytomegalovirus infection and an- other of severe pneumonia. Relapse occurred in 3 SLE patients (17.6%) in 37, 26, and 19 months posttransplantation respectively, and 1 RA patient in 15 months posttransplantation. SLE Disease Activity Index (SLEDAI) scores of SLE survivors decreased significantly (P < 0.01). RA patients recorded a drop of Disease Activity Score 28 (DAS 28). The pSS patient remained symptoms free up to now, more than 50 months after the transplantation. Conclusion HSCT can be performed relative safely in patients with severe autoimmune disease. Short-term effect of HSCT is promising. However treatment related mortality and relapse were observed in a subset of patients. | Xiao-mei Leng Yan Zhao Dao-bing Zhou Huifen Situ Tai-sheng Li Ti Shen Yong-qiang Zhao Xiao-feng Zeng Feng-chun Zhang Yi Dong Fu-lin Tang | 2005 | Chinese Medical Sciences Journal2005，20，3： | 4 |
| 6 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 7 | Influence of Agricultural Activity on Nitrogen Budget in Chinese and Japanese Watersheds显示文摘To analyze the effect of agricultural activity on nitrogen(N) budget at the watershed scale,a comparative study was conducted at two Japanese watersheds,the Shibetsu River watershed(SRW) and Upper-Naka River watershed(UNRW),and one Chinese watershed,the Jurong Reservoir watershed(JRW).The total area and the proportion of agricultural area(in parentheses) of the watersheds were 685(51%),1 299(21%),and 46 km 2(55%) for SRW,UNRW,and JRW,respectively.The main agricultural land use in SRW was forage grassland,while paddy fields occupied the highest proportion of cropland in UNRW(11% of total area) and JRW(31% of total area).The farmland surplus N was 61,48,and 205 kg N ha 1 year 1 for SRW,UNRW,and JRW,respectively.The total input and output for the whole watershed were 89 and 76,83 and 61,and 353 and 176 kg N ha 1 year 1 for SRW,UNRW,and JRW,respectively.The proportion of discharged N to net anthropogenic N input was 31%,37%,and 1.7% for SRW,UNRW,and JRW,respectively.The two watersheds in Japan showed similar proportions of discharged N to those of previous reports,while the watershed in China(JRW) showed a totally different characteristic compared to previous studies.The high N input in JRW did not increase the amount of discharged N at the outlet of the watershed due to high proportions of paddy fields and water bodies,which was an underestimated N sink at the landscape scale. | S. D. KIMURA YAN Xiao-Yuan R. HATANO A. HAYAKAWA K. KOHYAMA TI Chao-Pu DENG Mei-Hua M. HOJITO S. ITAHASHI K. KURAMOCHI CAI Zu-Cong M. SAITO | 2012 | Pedosphere2012，22，2： | 4 |
| 8 | Ethnic Differences in Body Mass Index and Prevalence of Obesity in School Children of Urumqi City, Xinjiang, China显示文摘To investigate the prevalence of obesity and distribution of body mass index (BMI) in school children of four ethnic groups in Urumqi, Xinjiang, China, Methods A total of 55 508 school children of Han, Hui, Uygur and Kazak nationalities aged 8-18 years were selected by a cluster sampling from a districts of Urumqi City for anthropometric measurement and demographic survey. Prevalence of obesity and overweight and distribution of body mass index (BMI) by gender, age, and nationality were analyzed and compared. Cutoff points of BMI for defining obesity and overweight were based on the proposal set by the Working Group on Obesity in China (WGOC) to assess age-, gender- and nationality-specific prevalence of obesity and overweight. Results Prevalence of obesity was 5.34%, 6.78%, 3.39 %, and 1.22% for boys and 2.61%, 1.83%, 1.78%, and 1.40% for girls of Han, Hui, Uygur and Kazak nationalities, respectively. Prevalence of obesity tended to decrease with age overall, whereas that of overweight increased with age in Han children. Conclusions Prevalence of obesity in school children in Urumqi varies with their nationalities and is lower than that of an average national level and a level of western countries. Obesity is more prevalent in boys than in girls of Urmuqi overall, which is just the opposite in Kazak children. Han boys and Hui girls have the highest prevalence of obesity and Kazak boys and girls have the lowest ones. Prevalence of obesity decreases with age, but that of overweight shows a different trend. | WEI-LI YAN YU-JIAN ZHENG JUN WU SHU-FENG CHEN XIAO-KAI TI LING LI XIAO-RUI LIU | 2006 | Biomedical and Environmental Sciences2006，19，6： | 3 |
| 9 | Whole-body physiology-based pharmacokinetics of caspofungin for general patients, intensive care unit patients and hepatic insufficiency patients显示文摘Caspofungin 是抗真菌的代理人在病人为侵略 candidiasis 作为首要的治疗准许了与的 echinocandin 对到 azoles 的严重的病或最近的暴露中等。在这研究,我们开发了一个整个身体的基于生理学的 pharmacokinetics (WB-PBPK ) 模型预言 caspofungin 的 pharmacokinetics (PK ) ,并且与蒙特卡罗模拟(MCS ) 结合了在病人的不同类型优化 caspofungin 的临床的剂量政体。caspofungin 的一个 WB-PBPK 模型从一般病人,的 4 以前的试用与未加工的数据被造并且验证有孩子呸 B 的特别护理单位(ICU ) 病人,连续肾的代替治疗上的 ICU 病人,温和、中等的肝的 insuffciency (嗨) 病人。MCS 被用来在这些病人优化 caspofungin 的临床的剂量政体。90% 的价值被考虑是为完成最佳的实验治疗的最小的反应(CFR ) 的累积部分。WB-PBPK 模型的模仿的结果在对所有试用的观察价值的好同意。为有 caspofungin 70/50 mg 的将军和 ICU 病人, AUC 和 Cmax 随身体重量(BW ) 的增加被减少并且显示出大变化。MCS 证明所有一般病人不管 BW 完成了 CFR90% 。然而并非有更高的 BW (70 kg ) 的所有 ICU 病人能完成 CFR90% 。与在一般病人的标准剂量政体相比,在有孩子呸 B 的 ICU 病人的 caspofungin 70/35 mg 完成了显著地减少的 AUC 和 Cmax,但是获得了类似的 AUC 和 Cmax 在中等嗨有孩子呸 B 的病人。caspofungin 的 WB-PBPK 模型能正确地预言所有人口的 PK。有 MCS 的联合 WB-PBPK 模型能成功地在所有耐心的人口优化 caspofungin 的临床的剂量政体。 | Qian-ting YANG Ya-jing ZHAI Lu CHEN Tao ZHANG Yan YAN Ti MENG Lei-chao LIU Li-mei CHEN Xue WANG Ya- lin DONG | 2018 | Acta Pharmacologica Sinica2018，39，9： | 3 |
| 10 | A standardized injection technique and regimen ensures success and safety of N-butyl-2-cyanoacrylate injection for the treatment of gastric fundal varices (with videos)显示文摘 | Stefan Seewald Tiing Leong Ang Hiroo Imazu Mazen Naga Salem Omar Stefan Groth Uwe Seitz Yan Zhong Frank Thonke Nib Soehendra | 2008 | Gastrointestinal Endoscopy2008，，3： | 2 |
| 11 | Structure Optimization of Wheel Force Transducer Based on Natural Frequency and Comprehensive Sensitivity显示文摘The current research of wheel force transducer(WFT) mainly focuses on test signal processing and decoupling methods based on signal itself, while the WFT structure optimization research related to decreasing the mass and increase the natural frequency and comprehensive sensitivity is not enough. In order to improve the WFT test accuracy, a structure optimization method based on natural frequency and comprehensive sensitivity indicators is put forward. The WFT with 8-beam elastic body is used for the finite element modeling(FEM), in which the following variations are taken into consideration: the connection type of elastic body with modified rim, the number of connection holes, and the respects of strain beam including the shape, the cross sectional area and the length,etc.. The test results shows that the natural frequency of the connecting block type is increased by 65.5% compared with the connecting seat type of elastic body & modified rim, and the main channel sensitivity is improved as well.The results show that the connecting block type will achieve the best comprehensive performance when the number of connecting holes between the elastic body and the modified rim is 20. And the thinner and longer strain beam with smaller cross section area is preferable within the scope of elastic body mechanical strength. This research proposes a novel structure optimization method for WFT which contributes to improve the measurement performance of WFT. | Xiao-Long Zhang Ti Wu Yan Shao Jian Song | 2017 | Chinese Journal of Mechanical Engineering2017，30，4： | 2 |
| 12 | LONG‐TERM RESULTS AFTER ENDOSCOPIC DRAINAGE AND NECROSECTOMY OF SYMPTOMATIC PANCREATIC FLUID COLLECTIONS显示文摘 | STEFAN SEEWALD TIING LEONG ANG HUGO RICHTER KARL YU KIM TENG YAN ZHONG STEFAN GROTH SALEM OMAR NIB SOEHENDRA | 2011 | Digestive Endoscopy2011，，1： | 1 |
| 13 | Inducing immunogenic cell death in immuno-oncological therapies显示文摘Immunotherapy has revolutionized cancer treatment and substantially improved patient outcomes with respect to multiple types of tumors.However,most patients cannot benefit from such therapies,mainly due to the intrinsic low immunogenicity of cancer cells(CCs)that allows them to escape recognition by immune cells of the body.Immunogenic cell death(ICD),which is a form of regulated cell death,engages in a complex dialogue between dying CCs and immune cells in the tumor microenvironment(TME),ultimately evoking the damage-associated molecular pattern(DAMP)signals to activate tumor-specific immunity.The ICD inducers mediate the death of CCs and improve both antigenicity and adjuvanticity.At the same time,they reprogram TME with a“cold-warmhot”immune status,ultimately amplifying and sustaining dendritic cell-and T cell-dependent innate sensing as well as the antitumor immune responses.In this review,we discuss how to stimulate ICD based upon the biological properties of CCs that have evolved under diverse stress conditions.Additionally,we highlight how this dynamic interaction contributes to priming tumor immunogenicity,thereby boosting anticancer immune responses.We believe that a deep understanding of these ICD processes will provide a framework for evaluating its vital role in cancer immunotherapy. | Dongdong Ti Xin Yan Jianshu Wei Zhiqiang Wu Yao Wang Weidong Han | 2022 | Chinese Journal of Cancer Research2022，34，1： | 1 |
| 14 | A standardized injection technique and regimen ensures success and safety of N-butyl-2-cyanoacrylate injection for the treatment of gastric fundal varices (with videos)显示文摘 | Stefan Seewald Tiing Leong Ang Hiroo Imazu Mazen Naga Salem Omar Stefan Groth Uwe Seitz Yan Zhong Frank Thonke Nib Soehendra | 2008 | Gastrointestinal Endoscopy2008，，3： | 1 |
| 15 | Perioperative intraperitoneal chemotherapy for peritoneal surface malignancy显示文摘 | Yan TI) Stuart OA Yoo D | 2006 | J Transl Med2006，4，2： | 1 |
| 16 | Study on structure and performance of polycarbonate ure- thane synthesized via different copolymerization methods显示文摘 | Guo Jintang Zhao Meihua Ti Yan | 2007 | J Mater Sci2007，42，： | 1 |
| 17 | Homocysteine impaired endothelial function through compromised vascular endo thelial growth factor/Akt/endothelial nitric oxide syn thase signalling显示文摘 | Yan TT Ti Q Zhang XH | 2010 | Clin Exp Pharmacol Physiol2010，37，11： | 1 |
| 18 | United membrane biological reactor in the treatment of wastewater显示文摘The united membrane biological reactor(UMBR) was studied for the treatment of some simulate and municipal wastewater. The removal efficiency for COD and turbidity are greater than 80% and 99% respectively. Effluent COD is less than 100 mg/L while turbidity less than 5 The removal of LAS in bath wastewater is greater than 70%. In treatment of dinning hall wastewater, removal of fatty oil is greater than 90%, and its concentration in effluent is less than 5 mg/L. The match of biological reactor and the membrane separation component were calculated. The stable performance of wastewater treatment can be maintained by the optimization of operation conditions and the cleanout of membranes. | ZHOU Ji ti 1, YAN Bin 1* , DU Cui hong 1 , DONG Xiao li 1,2 (1 Environmental Engineering Institute, Dalian University of Technology, Dalian 116012, China. 2 Dalian Institute of Light Industry, Dalian 116034, China) | 2003 | Journal of Environmental Sciences2003，15，5： | 1 |
| 19 | Effects of cellular phone emissions on sperm motility in rats 显示文摘 | Yan JG Agres ti M Brace T | 2007 | Ferlil Steril2007，88，95： | 1 |
| 20 | Decreased Vδ2 γδ T Cells Associated With Liver Damage by Regulation of Th17 Response in Patients With Chronic Hepatitis B显示文摘 | Xiaoli Wu Ji-Yuan Zhang Ang Huang Yuan-Yuan Li Song Zhang Jun Wei Siyuan Xia Yajuan Wan Weiwei Chen Zheng Zhang Yangguang Li Ti Wen Yan Chen Yoshimasa Tanaka Youjia Cao Puyue Wang Liqing Zhao Zhenzhou Wu Fu-Sheng Wang Zhinan Yin | 2013 | Journal of Infectious Diseases2013，，8： | 1 |
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