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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | Advance in herpes simplex viruses for cancer therapy显示文摘Oncolytic virotherapy is an attractive approach that uses live viruses to selectively kill cancer cells. Oncolytic viruses can be genetically engineered to induce cell lyses through virus replication and cytotoxic protein expression. Herpes simplex virus (HSV) has become one of the most widely clinically used oncolytic agent. Various types of HSV have been studied in basic or clinical research. Combining oncolytic virotherapy with chemotherapy or radiotherapy generally produces synergic action with unclear molecular mechanisms. Arming HSV with therapeutic transgenes is a promising strategy and can be used to complement conventional therapies. As an efficient gene delivery system, HSV has been successfully used to deliver various immuno-modulatory molecules. Arming HSV with therapeutic genes merits further investigation for potential clinical application. | LIU ShangLong DAI MeiHua YOU Lei ZHAO YuPei | 2013 | Science China(Life Sciences)2013，56，4： | 4 |
| 3 | Human Identification Technique based on Iris Feature Watermarking显示文摘 | FAN Kefeng MO Wei WANG Meihua ZHAO Xinhua SHEN Ji | 2006 | Chinese Journal of Electronics2006，15，2： | 3 |
| 4 | Novel copyright protection scheme for digital content显示文摘A novel copyright protection scheme for digita l content is presented, which is a private watermarking scheme based on the waterm ark embedding in the DCT domain and watermark extraction using independent compo nent analysis (ICA). The system includes the key for watermark extraction and th e host image. The algorithm splits the original image into blocks and classifies these blocks based on visual masking, that is, noise visibility function (NVF). Watermark components with different strength are inserted into chosen direct cu rrent components of DCT coefficients according to the classifier. The watermark extraction is based on the characteristic of the statistic independence of the h ost image, watermark and key. Principle component analysis (PCA) whitening proce ss and FastICA techniques are introduced to ensure a blind watermark extraction without requiring the original image. Experimental results show the proposed tec hnique is robust under attacks such as image filtering and adding noise, croppin g and resizing. In addition, the proposed private watermarking system can be imp roved to the application of the DTV content protection system. | Fan Kefeng Wang Meihua Mo Wei Zhao Xinhua | 2006 | Journal of Systems Engineering and Electronics2006，17，2： | 3 |
| 5 | Identification of Risk Pathways and Functional Modules for Coronary Artery Disease Based on Genome-wide SNP Data显示文摘Coronary artery disease(CAD) is a complex human disease, involving multiple genes and their nonlinear interactions, which often act in a modular fashion. Genome-wide single nucleotide polymorphism(SNP) profiling provides an effective technique to unravel these underlying genetic interplays or their functional involvements for CAD. This study aimed to identify the susceptible pathways and modules for CAD based on SNP omics. First, the Wellcome Trust Case Control Consortium(WTCCC) SNP datasets of CAD and control samples were used to assess the jointeffect of multiple genetic variants at the pathway level, using logistic kernel machine regression model. Then, an expanded genetic network was constructed by integrating statistical gene–gene interactions involved in these susceptible pathways with their protein–protein interaction(PPI)knowledge. Finally, risk functional modules were identified by decomposition of the network. Of 276 KEGG pathways analyzed, 6 pathways were found to have a significant effect on CAD. Other than glycerolipid metabolism, glycosaminoglycan biosynthesis, and cardiac muscle contraction pathways, three pathways related to other diseases were also revealed, including Alzheimer's disease, non-alcoholic fatty liver disease, and Huntington's disease. A genetic epistatic network of 95 genes was further constructed using the abovementioned integrative approach. Of 10 functional modules derived from the network, 6 have been annotated to phospholipase C activity and cell adhesion molecule binding, which also have known functional involvement in Alzheimer's disease.These findings indicate an overlap of the underlying molecular mechanisms between CAD and Alzheimer's disease, thus providing new insights into the molecular basis for CAD and its molecular relationships with other diseases. | Xiang Zhao Yi-Zhao Luan Xiaoyu Zuo Ye-Da Chen Jiheng Qin Lv Jin Yiqing Tan Meihua Lin Naizun Zhang Yan Liang Shao-Qi Rao | 2016 | Genomics, Proteomics & Bioinformatics2016，14，6： | 3 |
| 6 | Metal Free Mono- and 2,3-Bis-sulfenylation of Indoles in Water with Sodium Sulfinates as a Sulfur Source显示文摘 | Changqing Liu Jian Fan Manyi Wu Jiahui Chen Yiming Zhao Meihua Xie | 2018 | Chinese Journal of Chemistry2018，36，9： | 2 |
| 7 | A non-local vectorial total variational model for multichannel SAR image speckle suppression显示文摘This paper aims at the multichannel synthetic aperture radar(SAR)image speckle reduction.This paper proposes a novel energy minimized regularization model for multichannel image denoising,which is an extension of the non-local total variational model for gray-scale image.It contains two terms,namely the vectorial data fidelity term and the non-local vectorial total variation term.The latter is constructed by high-dimensional non-local gradient that contains the structure information of the multichannel image.The existence and the uniqueness of the solution of the model are proved.A fixed point iterative algorithm is designed to acquire the solution of this model.The convergence property of this algorithm is proved as well.This model is applied to the multipolarimetric and multi-temporal RADARSAT-2 images despeckling.The result shows that this model performs better than the original vectorial total variational model on texture preserving. | Xi Rubing Wang Zhengming Xie Meihua Zhao Xia Wang Weiwei | 2015 | Chinese Journal of Aeronautics2015，28，3： | 1 |
| 8 | Microcalorimetric study of the effect of artesunate on the growth metabolism of mitochondria isolated from rat liver显示文摘 | Xuesong Shen Meihua Jin Chunxia Zhao Xinqiang Tan Hanfu Liu Xuelian Qin Zhuangpingi Qiu Yi Liu | 2013 | Journal of Thermal Analysis and Calorimetry2013，，3： | 1 |
| 9 | Stochas- tic resonance algorithm applied to quantitative analysis for weak liquid chromatographic signal of pyrene in water samples显示文摘 | Chen Changyun Ma Meihua Zhao Bo | 2011 | International Journal of Environ- ment Analytical Chemistry2011，1，91： | 1 |
| 10 | Study on structure and performance of polycarbonate ure- thane synthesized via different copolymerization methods显示文摘 | Guo Jintang Zhao Meihua Ti Yan | 2007 | J Mater Sci2007，42，： | 1 |
| 11 | Activating transcription factor 4 mediates a multidrug resistance phenotype of esophageal squamous cell carcinoma cells through transactivation of STAT3 expression显示文摘 | Hongwu Zhu Xiong Chen Bin Chen Bei Chen Jianyong Fan Weibing Song Ziying Xie Dan Jiang Qiuqiong Li Meihua Zhou Dayong Sun Yagang Zhao | 2014 | Cancer Letters2014，，1： | 1 |
| 12 | Ship anti-rolling technology is reviewed显示文摘 | Dong Meihua Ma Rujian Zhao Dong | 2008 | Journal of Jinan university(natural science edition)2008，，2： | 1 |
| 13 | Low-cost dyes based on methylthiophene for high-performance dye-sensitized solar cells显示文摘 | Zongfang Tian Meihua Huang Bin Zhao | 2010 | Dyes and Pigments2010，87，： | 1 |
| 14 | Sellar region lesions in imaging diagnosis and differential diagnosis of clinical 显示文摘 | Zhao Meihua Wang Xinyu Zhang Jiawen | 2012 | Rational use of drug journal2012，5，9： | 1 |
| 15 | Uniqueness theorems in the ambrosetti type semilinear wave equation 显示文摘 | Jin Zhengguo Pei Lianshu and Zhao Meihua | 2000 | Journal of Yanbian University2000，26，1： | 1 |
| 16 | Risk Factors for Gestational Diabetes Mellitus(GDM)in Subsequent Pregnancy Among Women Without GDM History in China:A Multicenter Retrospective Study显示文摘Objective:This study aimed to determine the likelihood of gestational diabetes mellitus(GDM)in subsequent pregnancy among women without GDM history and to identify risk factors for GDM in subsequent pregnancy.Methods:This retrospective cohort study involved participants who delivered twice in same hospital of 18 research centers when delivered the second baby from January 2018 to December 2018.Finally 6204 women were enrolled and 5180 women without GDM history were analyzed further.Women were categorized as non-GDM or GDM based on the blood glucose values of the subsequent pregnancy,and the characteristics and GDM risk of these groups were compared.A univariate analysis of potential risk factors was performed using the Chi-squared test and/ort-test for qualitative or quantitative variables,respectively.Associations withP values<0.1 were chosen to be included in the multivariate binary logistic regression model.Results:In primary analysis of 6204 women,the incidence of GDM in subsequent pregnancy is 48.9%(490/1002)in women with GDM history and 16.1%(835/5202)in women without GDM history.In a further analysis for 5180 women without GDM at index pregnancy,compared with the non-GDM group,the GDM group had a significantly higher age,prepregnancy body mass index,and blood glucose value at each oral glucose tolerance test(OGTT)timepoint(fasting,1 h and 2 h)during the index and subsequent pregnancies,as well as higher weight retention during the interval between the two pregnancies(P<0.001).Age above 35 years in subsequent pregnancy(odds ratio(OR)=1.540,95%confidence interval(CI)=1.257-1.886,P<0.001),macrosomia in index pregnancy(OR=1.749,95%CI=1.277-2.395,P=0.001),OGTT blood glucose values in index pregnancy(fasting,OR=2.487,95%CI=1.883-3.285,P<0.001;1 h,OR=1.142,95%CI=1.051-1.241,P=0.002;2 h,OR=1.290,95%CI=1.162-1.432,P<0.001)and weight retention(OR=1.052,95%CI=1.035-1.068,P<0.001)were independent risk factors for GDM in subsequent pregnancy.Conclusion:For women without GDM history,GDM risk factors including age,macrosomia history,OGTT value,and weight retention,these can be evaluated before a subsequent pregnancy.Early warning and interventions are needed for women at high risk. | Geng Song Yumei Wei Juan Juan Rina Su Jianying Yan Mei Xiao Xianlan Zhao Meihua Zhang Yuyan Ma Haiwei Liu Jingxia Sun Kejia Hu Huixia Yang | 2023 | Maternal-Fetal Medicine2023，5，1： | 1 |
| 17 | Prevalence and characteristics of macrosomia in the first and subsequent pregnancy: a multi-center retrospective study显示文摘To the Editor:Macrosomia is of growing prevalence and concern worldwide.In China,there has been a marked increase in the prevalence of macrosomia over the past few decades as a result of economic development and improvements in living standards. | Juan Juan Huixia Yang Yumei Wei Geng Song Rina Su Xu Chen Ruiqin Shan Jianying Yan Mei Xiao Ying Li Shihong Cui Xianlan Zhao Shangrong Fan Ling Feng Meihua Zhang Yuyan Ma Zishan You Haixia Mengn Haiwei Liu Jingxia Sun Yan Cai Kejia Hu | 2022 | Chinese Medical Journal2022，，12： | 1 |
| 18 | Attenuation of diabetic nephropathy by Chaihuang-Yishen granule through anti-inflammatory mechanism in streptozotocin-induced rat model of diabetics显示文摘 | Haojun Zhang Tingting Zhao Yuewen Gong Xi Dong Weiku Zhang Sifan Sun Hua Wang Yanting Gu Xiaoguang Lu Meihua Yan Ping Li | 2014 | Journal of Ethnopharmacology2014，，： | 1 |
| 19 | Pathway-based Analysis of the Hidden Genetic Heterogeneities in Cancers显示文摘Many cancers apparently showing similar phenotypes are actually distinct at the molecular level,leading to very different responses to the same treatment.It has been recently demonstrated that pathway-based approaches are robust and reliable for genetic analysis of cancers.Nevertheless,it remains unclear whether such function-based approaches are useful in deciphering molecular heterogeneities in cancers.Therefore,we aimed to test this possibility in the present study.First,we used a NCI60 dataset to validate the ability of pathways to correctly partition samples.Next,we applied the proposed method to identify the hidden subtypes in diffuse large B-cell lymphoma(DLBCL).Finally,the clinical significance of the identified subtypes was verified using survival analysis.For the NCI60 dataset,we achieved highly accurate partitions that best fit the clinical cancer phenotypes.Subsequently,for a DLBCL dataset,we identified three hidden subtypes that showed very different 10-year overall survival rates(90%,46% and 20%) and were highly significantly(P = 0.008) correlated with the clinical survival rate.This study demonstrated that the pathwaybased approach is promising for unveiling genetic heterogeneities in complex human diseases. | Xiaolei Zhao Shouqiang Zhong Xiaoyu Zuo Meihua Lin Jiheng Qin Yizhao Luan Naizun Zhang Yan Liang Shaoqi Rao | 2014 | Genomics, Proteomics & Bioinformatics2014，12，1： | 0 |
| 20 | Role of neutrophil extracellular traps in inflammatory evolution in severe acute pancreatitis显示文摘Severe acute pancreatitis(SAP)is a life-threatening acute abdominal disease with two peaks of death:the first in the early stage,characterized by systemic inflammatory response-associated organ failure;and the second in the late stage,characterized by infectious complications.Neutrophils are the main immune cells participating in the whole process of SAP.In addition to the traditional recognition of neutrophils as the origination of chemokine and cytokine cascades or phagocytosis and degranulation of pathogens,neutrophil extracellular traps(NETs)also play an important roles in inflammatory reactions.We reviewed the role of NETs in the occurrence and development of SAP and its fatal complications,including multiple organs injury,infected pancreatic necrosis,and thrombosis.This review provides novel insights into the involvement of NETs throughout the entire process of SAP,showing that targeting NETs might be a promising strategy in SAP treatment.However,precision therapeutic options targeting NETs in different situations require further investigation. | Hongxin Kang Yue Yang Lv Zhu Xianlin Zhao Juan Li Wenfu Tang Meihua Wan | 2022 | Chinese Medical Journal2022，135，23： | 0 |
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