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| 1 | Effects of biochar-based fertilizers on nutrient leaching in a tobacco-planting soil显示文摘Biochar is a soil amendment for increasing soil quality and decreasing nutrient leaching. However, there is little information on the impact of biochar-based fertilizer(BF) on soil nutrient leaching in agricultural soils. We conducted a soil column leaching experiment to study the effects of BF on the leaching of total nitrogen(TN), total phosphorus, and total potassium(TK) in tobacco soils. The distribution characteristics of NH_4^+-N, available P, and available K in soil profiles were analyzed after the application of BF. Biochar was prepared by pyrolysis of fluecured tobacco stems. It was applied at four levels, 0%, 3%,9%, and 15%(w/w), respectively, to the compound fertilizer. Compared with the control, the leaching loss of soil TN decreased by 8.36%, 6.72%, and 6.45%, and the loss of soil TK decreased by 9.18%, 9.31% and 11.82% in the 3%,9%, and 15% BF treatments, respectively. However, BF had no significant effect on the P leaching due to the low movement of P in the soil profile. In addition, the BF addition increased the immobilization of NH_4^+-N, available P, and available K in the soil profile. These results indicate that addition of BF to a tobacco-planting soil reduced nutrient leaching, and suggest that BF could be an effective method of applying biochar to agriculture fields. | Yunlong Li Jianzhong Cheng Xinqing Lee Yi Chen Weichang Gao Wenjie Pan Yuan Tang | 2019 | Acta Geochimica2019，38，1： | 13 |
| 2 | Visible Light Photocatalytic Properties of Metastable γ-Bi_2O_3 with Different Morphologies显示文摘The metastable γ-Bi_2O_3 photocatalysts with different morphologies were fabricated by means of a chemical precipitation method.The microstructure of as-prepared samples was characterized by X-ray diffraction,transmission electron microscopy and ultraviolet-visible diffusion reflectance spectroscopy.The photocatalytic performance of Bi_2O_3 powder was evaluated using rhodamine B as a model pollutant under visible light irradiation.The visible light photocatalytic activity of Bi_2O_3 with different morphologies is as follows,nanorod > nanorod/nanoflake > N doped TiO_2 > irregular particle > agglomerated particle.The γ-Bi_2O_3 shows the best photocatalytic performance and it can effectively degrade 97%RhB within 60 min. | Weichang Hao Yuan Gao Xi Jing Wen Zou Yan Chen Tianmin Wang | 2014 | Journal of Materials Science & Technology2014，30，2： | 4 |
| 3 | MicroRNA-142-3p is frequently upregulated in colorectal cancer and may be involved in the regulation of cell proliferation显示文摘MicroRNAs are small single-stranded RNA molecules consisting of approximately 22 nucleotides (nt), and have post-transcriptional regulatory functions. By gene chip screening, we previously showed that miR-142-3p was significantly upregulated in colorectal cancer tissue and was associated with clinicopathological features, compared with matched non-tumor tissue. In this study, we confirmed significant upregulation of miR-142-3p in 60 colorectal cancer samples and three colorectal cancer cell lines by quantitative real-time PCR (qRT-PCR). Using software and network resources, we predicted TCF7 as a target of miR-142-3p, which we confirmed with dual-luciferase assays. By RT-PCR and Western blot analysis, we found miR-142-3p negatively regulates TCF7 expression post-transcriptionally. CCK8 assays and growth curves indicated that overexpression of miR-142-3p in SW480 colorectal cancer cells potently inhibited cell proliferation in vitro. The expression of TCF7 mRNA and protein was upregulated in both colorectal cancer tissues and colorectal cancer cell lines, closely correlating with its function as an oncogene in promoting tumor cell proliferation and inhibiting apoptosis. With TCF7 as a direct target, our results suggested that miR-142-3p may be involved in the regulation of cell proliferation in colorectal cancer. | ZHOU JiaLiang JIANG Zhi WANG ZhengWu ZOU ShiTao ZHANG YunXia CAI Wei WANG MingZhi XU Min SHI DongTao CHEN WeiChang | 2013 | Chinese Science Bulletin2013，58，23： | 4 |
| 4 | Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress显示文摘Dear Editor,p53 acts as a transcription factor to modulate various types of cellular processes to suppress tumor development(Tackmann and Zhang,2017).The exquisite regulation of p53 functions is of vital importance for cell fate decisions.Although it is well accepted that p53-mediated cell-cycle arrest,senescence,and apoptosis serve as major tumor suppression mechanisms,recent studies suggest that other unconventional activities such as ferroptosis are also critically involved in its tumor suppressor function(Li et al.,2012).We and others found that p53 plays an important role in modulating ferroptotic responses through its metabolic targets(Jiang et al.,2015;Jennis et al.,2016;Wang et al.,2016).Ferroptosis is a regulated form of iron-dependent,non-apoptotic cell death characterized by excessive reactive oxygen species(ROS)generation and accumulation of lipid peroxidates(Stockwell et al.,2020).Lipid peroxides are normally eliminated by glutathione peroxidase 4(GPX4)and its co-factor glutathione(GSH),which convert lipid hydroperoxides to non-toxic lipid alcohols.Thus,ferroptosis can be artificially induced by pharmacological agents that disrupt this lipid repair system,allowing lethal accumulation of lipid peroxides.Such agents include direct GPX4 enzymatic inhibitors,as well as the small molecule erastin,which suppress glutathione synthesis and indirectly suppress GPX4 activation(Stockwell et al.,2020).Although activation of p53 expression is able to modulate ferroptosis induced by GPX4 inhibition in certain cell types(Jiang et al.,2015),p53-mediated ferroptotic responses are also observed upon ROS-induced stress,apparently through a GPX4-independent manner(Chu et al.,2019).Nevertheless,the molecular factors that modulate p53-dependent ferroptosis upon ROS stress need further elucidation.Sirt3 is a NAD-dependent deacetylase predominantly localized in mitochondria,which functions in multiple metabolic pathways,including electron transport chain,fatty acid oxidation,amino acid metabolism,redox balance,and the tricarboxylic acid(TCA)cycle(Van de Ven et al.,2017).Here,we identified Sirt3 as a novel repressor in p53-mediated ferroptosis induced by ROS stress. | Ying Jin Wei Gu Weichang Chen | 2021 | Journal of Molecular Cell Biology2021，13，2： | 3 |
| 5 | A high-Tc dc-SQUID-based single-channel MCG and its performance显示文摘A single-channel high-Tc dc-SQUID magnetometer and gradiometer have been developed to record the magnetic field component perpendicular to the human chest generated by heart-beat. Magnetocardiogram (MCG) measurements have been carried out inside a magnetically shielded room. By sequentially adjusting a non-magnetic patient table with 5 cm pitch in X and Y directions, the field signals on a rectangle grid 5×5 over the chest area were registered in real time trace point by point with a typical dwell time over 30 cardiocycles each. Utilizing standard electrocardiogram (ECG) recordings as timing reference measured simultaneously with the MCG signals, the MCG data were then averaged and combined to form magnetic field patterns every 10 ms or so. Both the current dipole, which is parallel to MCG measuring plane and produces the vertical magnetic field, and its depth were determined as a function of time in a standard way. We have compared the MCG of healthy hearts with that of a heart with right bundle | WANG Huiwu DING Hongsheng ZHANG Lihua HUANG Xuguang CHEN Weichang WANG Ziqiang FENG Ji LIU Yiping ZHAO Shiping REN Yufeng YU Hongwei XU Fengzhi WANG Xiaoyin CHEN Genghua YANG Qiansheng | 2002 | Chinese Science Bulletin2002，47，22： | 2 |
| 6 | Extraction, characterization of Astragalus polysaccharides and its immune modulating activities in rats with gastric cancer显示文摘 | LI Rui CHEN Weichang WANG Weipeng | 2009 | CarbohydratePolymers2009，78，4： | 1 |
| 7 | Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism显示文摘Primary biliary cholangitis(PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental mechanisms beyond common noncoding variants, we integrate whole exome sequencing with integrative network analysis to investigate genes harboring de novo mutations. Prominent convergence has been revealed on a network of disease-specific co-expression comprised of 55 genes associated with homeostasis and metabolism. The transcription factor gene MEF2 D and the DNA repair gene PARP2 are highlighted as hub genes and identified to be up-and down-regulated, respectively, in peripheral blood data set. Enrichment analysis demonstrates that altered expression of MEF2 D and PARP2 may trigger a series of molecular and cellular processes with pivotal roles in PBC pathophysiology. Our study identifies genes with de novo mutations in PBC and suggests that a subset of genes in homeostasis and metabolism tend to act in synergy through converging on co-expression network, providing novel insights into the etiology of PBC and expanding the pool of molecular candidates for discovering clinically actionable biomarkers. | Lu Wang Jinchen Li Chan Wang Ruqi Tang Jialong Liang Yuhua Gong Yaping Dai Ningling Ding Jian Wu Na Dai Lei Liu Yi Zhao Youlin Shao Weifeng Zhao Peng Jiang Xingjuan Shi Weichang Chen Ye Tian Xiangdong Liu Xiong Ma Zhongsheng Sun | 2022 | Journal of Genetics and Genomics2022，49，2： | 1 |
| 8 | Hunting Sodium Dendrites in NASICON-BasedSolid-State Electrolytes显示文摘NASICON-(Na superionic conductor-)based solid-state electrolytes(SSEs)are believed to be attracting candidates for solid-state sodium batteries due to their high ionic conductivity and prospectively reliable stability.However,the poor interface compatibility and the formation of Na dendrites inhibit their practical application.Herein,we directly observed the propagation of Na dendrites through NASICON-based Na3.1Zr2Si2.1P0.9O12 SSE for the first time.Moreover,a fluorinated amorphous carbon(FAC)interfacial layer on the ceramic surface was simply developed by in situ carbonization of PVDF to improve the compatibility between Na metal and SSEs.Surprisingly,Na dendrites were effectively suppressed due to the formation of NaF in the interface when molten Na metal contacts with the FAC layer.Benefiting from the optimized interface,both the Na||Na symmetric cells and Na3V2(PO4)3||Na solidstate sodium batteries deliver remarkably electrochemical stability.These results offer benign reference to the maturation of NASICON-based solid-state sodium batteries. | Qiangqiang Zhang Yaxiang Lu Weichang Guo Yuanjun Shao Lilu Liu Jiaze Lu Xiaohui Rong Xiaogang Han Hong Li Liquan Chen Yong-Sheng Hu | 2021 | Energy Material Advances2021，，1： | 1 |
| 9 | Cross- interactiom between Ni and Cu aross Sn layers with different thickness 显示文摘 | Chen Weichang Su Chunyang Tu Chunte | 2007 | Journal of Electronic Materials2007，36，： | 1 |
| 10 | Improvement of Agrobacterium-mediated transformation in Hi-II maize (Zea mays) using standard binary vectors显示文摘 | Juan M. Vega Weichang Yu Angela R. Kennon Xinlu Chen Zhanyuan J. Zhang | 2008 | Plant Cell Reports2008，，2： | 1 |
| 11 | Extraction,charaterization of astragalus polysaccharides and its immunemodulating activities in rats with gastric cancer显示文摘 | LI Rui CHEN Weichang WANG Weipeng | 2009 | CarbohydratePolymers2009，78，4： | 1 |
| 12 | Identifying the Criteria of Cadmium Pollution in Paddy Soils Based on a Field Survey显示文摘 | Weichang Ji Zhongqiu Chen Dan Li Wuzhong Ni | 2012 | Energy Procedia2012，，： | 1 |
| 13 | Extraction,characterization of Astragalus ploysaccharides ang its immunemodulating activities in rats with gastric cancer显示文摘 | LI RUI CHEN WEICHANG WANG WEIPENG | | 0，，04： | 1 |
| 14 | Extraction, characterization of Astragalus polysaccharides and its immune modulating activities in rats with gastric cancer显示文摘 | LI RUI CHEN WEICHANG WANG WEIPENCa | 2009 | Carbohydrate Polymers2009，78，4： | 1 |
| 15 | Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment显示文摘Enzyme-driven micro/nanomotors consuming in situ chemical fuels have attracted lots of attention for biomedical applications.However,motor systems composed by organism-derived organics that maximize the therapeutic efficacy of enzymatic products remain challenging.Herein,swimming proteomotors based on biocompatible urease and human serum albumin are constructed for enhanced antitumor therapy via active motion and ammonia amplification.By decomposing urea into carbon dioxide and ammonia,the designed proteomotors are endowed with self-propulsive capability,which leads to improved internalization and enhanced penetration in vitro.As a glutamine synthetase inhibitor,the loaded L-methionine sulfoximine further prevents the conversion of toxic ammonia into non-toxic glutamine in both tumor and stromal cells,resulting in local ammonia amplification.After intravesical instillation,the proteomotors achieve longer bladder retention and thus significantly inhibit the growth of orthotopic bladder tumor in vivo without adverse effects.We envision that the as-developed swimming proteomotors with amplification of the product toxicity may be a potential platform for active cancer treatment. | Hao Tian Juanfeng Ou Yong Wang Jia Sun Junbin Gao Yicheng Ye Ruotian Zhang Bin Chen Fei Wang Weichang Huang Huaan Li Lu Liu Chuxiao Shao Zhili Xu Fei Peng Yingfeng Tu | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 16 | 过氧化物酶体增殖物活化受体γ(PPAR γ)与肝癌瘤内微循环的关系(英文)显示文摘观察 peroxisome 的表示的协会的目的有微容器密度(MVD ) 和在肝细胞癌(HCC ) 的血管形成模仿(VM ) 的激活 proliferator 的受体 γ
(PPARγ) 并且探索他们的临床的意义。PPARγ 和 MVD 和 VM 的表情被 CD34 免疫测试的方法组织化学(IHC ) 染色并且在 HCC 纸巾和它的配对的非癌的纸巾的 34 种情况中的周期的 acid-Schiff (舞步) 反应。他们的生物行为被分析并且与 clinicopathological 特征联系了。结果 PPARγ 是过去表示的(24/34 ) 在 HCC 纸巾。它与肿瘤尺寸被联系(>
5 厘米, P = 0.027 ) ,破囊(P = 0.014 ) ,趋势到转移和复发(P = 0.001 ) 。MVD 更高(23/24 ) 在 HCC 纸巾比那在相应帕拉癌的纸巾(t = 18.925, P <
0.05 ) 。在 PPARγ 和高 MVD 的在表示上之间有重要积极关联(r = 0.519 ) 。Kaplan-Meier 分析显示 PPARγ 和 VM 和高 MVD 的那积极表情能被用于建立 HCC 病人的幸存率(P = 0.013, 0.036 和 0.022 分别地;木头等级测试) 。考克斯危险模型分析显示出那积极 PPARγ 表情,高 MVD 是为 HCC 的独立预示的因素。PPARγ 与发展相关的结论微在 HCC 循环。PPARγ 是为 HCC 评估的新奇预示的指示物。 | Xudong Wu Weichang Chen Suqing Zhang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，5： | 0 |
| 17 | Electrode structure enabling dendrite inhibition for high cycle stability quasi-solid-state lithium metal batteries显示文摘Lithium(Li)metal batteries(LMBs)are widely regarded as the ultimate choice for the next generation of high-energy–density batteries.However,the uncontrollable growth of Li dendrites formed by inhomogeneous deposition seriously hinders its commercialization.Although many studies have achieved significant results in inhibiting the formation of Li dendrites,it is still impossible to eradicate them completely.Therefore,regulating the deposition behavior,such as the growth direction of unevenly deposited Li,is preferable to unilaterally suppressing them in some cases.Here we report a structured anode that can confine the deposited Li within holes and tune it to become vertical-up/horizontal-centripetal mixed growth mode by optimizing the electric field/Li^(+)concentration gradient.The Li^(+) adsorbed by the poly(amic acid)(PAA)insulating layer coated on the anode surface can form the Li^(+)concentration gradient pointing to the center of the hole.Combined with the special electric field formed by the hole structure,it is favorable for the Li^(+)to move into the vertically arrayed holes and simultaneously deposit on the bottom and walls.Furthermore,both in-situ and ex-situ observations confirm that the growth mode is changed and the Li deposition morphology is denser,which can greatly delay capacity fading and prolong cycle life in both liquid and quasi-solid-state LMBs.All the results show that the novel anode provides a new perspective for deep research into solid-state LMBs. | Kaiming Wang Ao Yu Zhiyi Zhou Fei Shen Manni Li Liang Zhang Weichang Guo Yifei Chen Le Shi Xiaogang Han | 2023 | Journal of Energy Chemistry2023，，4： | 0 |
| 18 | Structural Variability and Rifting Process of the Segmented Cenozoic Pearl River Mouth Basin,Northern Continental Margin of the South China Sea显示文摘The Pearl River Mouth Basin(PRMB)is an important area for studying the evolution of continental marginal basins in the northern South China Sea(SCS),but the structural variability and spatiotemporal rifting process remains poorly understood.This study investigates the differential structural features of the eastern,middle and western PRMB,as well as the extensional deformation laws in operation during the rifting stage,according to an integrated analysis of geometric characteristics and kinematic parameters,i.e.,horizontal displacement and stretching factors of basin and crust.The PRMB underwent at least three phases of intense extension,which varied in time and space.(1)During the middle Eocene,most sags in the PRMB were intensely stretched and high-angle planar to listric boundary faults controlled the wedge-shaped stratigraphic geometry.(2)During the late Eocene-to-early Oligocene,the stratigraphic geometry of the sags was slightly wedge-shaped and continuously controlled by boundary faults,however,the extensional strength decreased relatively in the Northern depression zone,but increased in the Southern depression zone.(3)During the late Oligocene,the extension was extremely weak in the northeast PRMB,but relatively strong in the southwest PRMB,leading to tabular stratigraphic geometry in the northeast PRMB,but localized slightly wedge-shaped stratigraphic geometry in the southwest.The southwest PRMB still underwent relatively strong extension during the early Miocene.The southwest PRMB that was induced by a small-scale localized mantle convection system constantly rifted during the late Oligocene,controlled by the weak lithosphere,westward(southwestward)diachronous opening and southward jump of the ocean ridge.The applied quantitative parameters and spatiotemporal rifting process may be used as a reference with which to study the segmented continental margin rifts. | MA Bingshan QI Jiafu WU Guanghui REN Jianye YANG Linlong SUN Tong CHEN Shi CHEN Weichang GE Jiawang | 2022 | Acta Geologica Sinica(English Edition)2022，96，6： | 0 |
| 19 | Plant latent defense response to microbial non-pathogenic factors antagonizes compatibility显示文摘Unlike microbe-associated molecular patterns(MAMPs)that are readily targeted by host immunity,microbial non-pathogenic factors(NPFs)appear negligible as they do not elicit defense.Little is known about whether and how NPFs may be monitored by hosts to control compatibility.Herein,a forward genetic screening isolated an Arabidopsis mutant with a loss of plant-rhizobacteria mutualism,leading to the disclosure of a plant latent defense response(LDR)to NPFs.The activation of LDR in the mutant,named rol1 for regulator of LDR 1,is triggered by several non-pathogenic volatile organic compounds and antagonizes plant compatibility with the beneficial bacterium Bacillus amyloliquefaciens GB03.The activation of LDR in rol1 is mediated through the prokaryotic pathway of chloroplastic lipid biosynthesis.The rol1 root microbiome showed a reduced proportion of the Bacillaceae family.We propose that,parallel to the forefront immunity to MAMPs,LDR to certain NPFs provides a hidden layer of defense for controlling compatibility with commensal or beneficial microbes. | Yu Yang Shenglan Chen Xiaoxuan Wu Li Peng Juan I.Vílchez Richa Kaushal Xiaomin Liu Sunil K.Singh Danxia He Fengtong Yuan Suhui Lv Rafael J.L.Morcillo Wei Wang Weichang Huang Mingguang Lei Jian-Kang Zhu Paul W.Paré Huiming Zhang | 2022 | National Science Review2022，9，8： | 0 |
| 20 | Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure without appropriate treatment(Terziroli Beretta-Piccoli et al.,2019). | Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu | 2023 | Journal of Genetics and Genomics2023，50，10： | 0 |
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