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| 1 | Foodborne Campylobacter: Infections, Metabolism, Pathogenesis and Reservoirs显示文摘 | Epps Sharon V R Harvey Roger B Hume Michael E Phillips Timothy D Anderson Robin C Nisbet David J | 2013 | International Journal of Environmental Research and Public Health2013，，12： | 1 |
| 2 | Neuromuscular Training Techniques to Target Deficits Before Return to Sport After Anterior Cruciate Ligament Reconstruction显示文摘 | Gregory D Myer Mark V Paterno Kevin R Ford Timothy E Hewett | 2008 | Journal of Strength and Conditioning Research2008，，3： | 1 |
| 3 | Biological sensing of small field differences by magnetically sensitive chemical reactions显示文摘 | James C W Timothy E V Dean A R | 2000 | Natrue2000，405，： | 1 |
| 4 | Southern Ocean iron enrichment experiment: Carbon cycling in high-and low-Si waters 显示文摘 | Coale K H Johnson K S Chavez F P Buesseler K O Barber R T Brzezinski M A Cochlan W P Millero F J Falkowski P G Bauer J E Wanninkhof R H Kudela R M Altabet M A Hales B E Takahashi T Landry M R Bidigare R R Wang Xiujun Chase Z Strutton P G Friederich G E Gorbunov M Y Lance V P Hilting A K Hiscock M R Demarest M Hiscock W T Sullivan K F Tanner S J Gordon R M Hunter C N Elrod V A Fitzwater S E Jones J L Tozzi S Koblizek M Roberts A E Herndon J Brewster J Ladizinsky N Smith G Cooper D Timothy D Brown S L Selph K E Sheridan C C Twining B S Johnson Z I | 2004 | Science2004，304，5669： | 1 |
| 5 | 显示文摘 | Timothy V Timothy E | 2001 | J Am Chem Soc2001，123，： | 1 |
| 6 | Atom transfer radical polymerization from nanoparticles:a tool for the preparation of well-defined hybrid nano structures and fo r understanding the chemistry of controlled/living radical polymerizations from surfaces显示文摘 | TIMOTHY V W TIMOTHY E P | 2001 | Journal of the American Chemical Society2001，123，31： | 1 |
| 7 | Dual Expression Lentiviral Vectors for Concurrent RNA Interference and Rescue显示文摘 | Narendra V Sankpal Timothy P Fleming William E Gillanders | | 0，，01： | 1 |
| 8 | Preparation of structurally welldefined polymer nanoparticle hybrids with controlled/living radical polymerizations显示文摘 | TIMOTHY V W TIMOTHY E P | 1999 | Journal of the American Chemical Society1999，121，： | 1 |
| 9 | Ca^sup 2+^/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart显示文摘 | Singh Madhu V Kapoun Ann Higgins Linda Kutschke William Thurman Joshua M Zhang Rong Singh Minati Yang Jinying Guan Xiaoqun Lowe John S Weiss Robert M Zimmermann Kathy Yull Fiona E Blackwell Timothy S Mohler Peter J Anderson Mark E | 2009 | Journal of Clinical Investigation2009，，4： | 1 |
| 10 | Electronic and defect structures of CuSCN 显示文摘 | John E J Tiffany C K Timothy C D Tamas V Mark E B Gregory J E | 2010 | Journal of Physical Chemistry C2010，114，： | 1 |
| 11 | Atom transfer radical polymerization from nanoparticles: A tool for the preparation of well-defined hybrid nanostructures and for understanding the chemistry of controlled/' Living' radical polymerizations from surfaces 显示文摘 | Timothy V Timothy E | 2001 | J Am Chem Soc2001，123，31： | 1 |
| 12 | Local scale analysis of carbon mitigation strategies: Tompkins County, New York, USA显示文摘 | TIMOTHY M V TIMOTHY J F RUTU E S | 2007 | Energy Policy2007，35，： | 1 |
| 13 | Potential of damage associated molecular patterns in synergising radiation and the immune response in oesophageal cancer显示文摘BACKGROUND There is an intimate crosstalk between cancer formation,dissemination,treatment response and the host immune system,with inducing tumour cell death the ultimate therapeutic goal for most anti-cancer treatments.However,inducing a purposeful synergistic response between conventional therapies and the immune system remains evasive.The release of damage associated molecular patterns(DAMPs)is indicative of immunogenic cell death and propagation of established immune responses.However,there is a gap in the literature regarding the importance of DAMP expression in oesophageal adenocarcinoma(OAC)or by immune cells themselves.AIM To investigate the effects of conventional therapies on DAMP expression and to determine whether OAC is an immunogenic cancer.METHODS We investigated the levels of immunogenic cell death-associated DAMPs,calreticulin(CRT)and HMGB1 using an OAC isogenic model of radioresistance.DAMP expression was also assessed directly using ex vivo cancer patient T cells(n=10)and within tumour biopsies(n=9)both pre and post-treatment with clinically relevant chemo(radio)therapeutics.RESULTS Hypoxia in combination with nutrient deprivation significantly reduces DAMP expression by OAC cells in vitro.Significantly increased frequencies of T cell DAMP expression in OAC patients were observed following chemo-(radio)therapy,which was significantly higher in tumour tissue compared with peripheral blood.Patients with high expression of HMGB1 had a significantly better tumour regression grade(TRG 1-2)compared to low expressors.CONCLUSION In conclusion,OAC expresses an immunogenic phenotype with two distinct subgroups of high and low DAMP expressors,which correlated with tumour regression grade and lymphatic invasion.It also identifies DAMPs namely CRT and HMGB1 as potential promising biomarkers in predicting good pathological responses to conventional chemo(radio)therapies currently used in the multimodal management of locally advanced disease. | Noel E Donlon Maria Davern Andrew Sheppard Fiona O'Connell Brendan Moran Timothy S Nugent Aisling Heeran James J Phelan Anshul Bhardwaj Christine Butler Narayanasamy Ravi Claire L Donohoe Niamh Lynam-Lennon Stephen Maher John V Reynolds Joanne Lysaght | 2023 | World Journal of Gastrointestinal Oncology2023，15，8： | 0 |
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