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| 1 | Major advances in studies of the physical geography and living environment of China during the past 70 years and future prospects显示文摘The natural environment provides material essentials for human survival and development. The characteristics,processes, regional differentiation and forcing mechanisms of the elements of the natural environment(e.g. geomorphology,climate, hydrology, soil, etc.) are the main objects of research in physical geography. China has a complex natural environment and huge regional differentiation and therefore it provides outstanding reserach opportunities in physical geography. This review summarizes the most important developments and the main contributions of research in the physical geography and human living environment in China during the past 70 years. The major topics addressed are the uplift of the Tibetan Plateau and the evolution of its cryosphere, the development of fluvial systems, the acidification of the vast arid region of the Asian interior, variations in the monsoon and westerly climate systems on multiple timescales, the development of lakes and wetlands, the watershed system model, soil erosion, past human-environment interactions, biogeography, and physical geographic zonality. After briefly introducing international research developments, we review the history of research in physical geography in China, focusing on the major achievements and major academic debates, and finally we summarize the status of current research and the future prospects. We propose that in the context of the national demand for the construction of an ecological civilization, we should make full use of the research findings of physical geography, and determine the patterns and mechanisms of natural environmental processes in order to continue to promote the continued contribution of physical geography to national development strategies, and to further contribute to the theory of physical geography from a global perspective. | Fahu CHEN Bojie FU Jun XIA Duo WU Shaohong WU Yili ZHANG Hang SUN Yu LIU Xiaomin FANG Boqiang QIN Xin LI Tingjun ZHANG Baoyuan LIU Zhibao DONG Shugui HOU Lide TIAN Baiqing XU Guanghui DONG Jingyun ZHENG Wei YANG Xin WANG Zaijun LI Fei Wang Zhenbo HU Jie WANG Jianbao LIU Jianhui CHEN Wei HUANG Juzhi HOU Qiufang CAI Hao LONG Ming JIANG Yaxian HU Xiaoming FENG Xingguo MO Xiaoyan YANG Dongju ZHANG Xiuhong WANG Yunhe YIN Xiaochen LIU | 2019 | Science China Earth Sciences2019，62，11： | 11 |
| 2 | MicroRNA-324-3p Plays A Protective Role Against Coxsackievirus B3-Induced Viral Myocarditis显示文摘Viral myocarditis(VM) is an inflammatory disease of the myocardium associated with heart failure, which is caused by common viral infections. A majority of the infections are initiated by coxsackievirus B3(CVB3). Micro RNAs(mi RNAs)have a major role in various biological processes, including gene expression, cell growth, proliferation, and apoptosis, as well as viral infection and antiviral immune responses. Although, mi RNAs have been found to regulate viral infections,their role in CVB3 infection remains poorly understood. In the previous study, mi RNA microarray results showed that mi R-324-3 p expression levels were significantly increased when cells and mice were infected with CVB3. It was also found that miR-324-3p downregulated TRIM27 and decreased CVB3 replication in vitro and in vivo. In vitro, analysis of downstream signaling of TRIM27 revealed that, miR-324-3p inhibited CVB3 infection, and reduced cytopathic effect and viral plaque formation by reducing the expression of TRIM27. In vivo, miR-324-3p decreased the expression of TRIM27,reduced cardiac viral replication and load, thereby strongly attenuating cardiac injury and inflammation. Taken together,this study suggests that miR-324-3p targets TRIM27 to inhibit CVB3 replication and viral load, thereby reducing the cardiac injury associated with VM. | Tingjun Liu Jing Tong Chen Shao Junyan Qu Hua Wang Yi Shi Yajing Lin Yun Liu Shihe Shao Hongxing Shen | 2021 | Virologica Sinica2021，36，6： | 8 |
| 3 | Analyses on the air and snow temperatures near ground with observations of an AWS at Dome A,the summit of Antarctic Plateau显示文摘As the summit of the Antarctic Plateau, Dome A has been received international attentions.In this paper, observational data of an automatic weather station (AWS) at Dome A in 2005–2007 were used to analyze the seasonal variations of air temperatures near the ground and snow temperatures within a depth of 10 m. Analyses on the air temperatures show a typical feature of the coreless winter, and strong inversion maintains during the long winter. Accordingly the stratification near the ground is dominated by the near-neutral stable states. Seasonal fluctuations of the snow temperature decrease in amplitude and lag in phase with depth increasing, which leads to distinct seasonal temperature profiles within the depth of 10 m. Measurements show the mean annual air temperature near ground is about 5°C higher than the 10 m firn temperature due to the strong inversion near the ground. However, our estimation of the annual mean of air temperature at the ground based on the boundary layer theory is close to the mean 10 m firn temperature. The lowest air temperature (–82.7°C) currently measured at the Dome A is not the lowest one ever recorded in Antarctica, but the extremely low mean 10 m firn temperature (–58.2°C) indicates very low ground temperature. Given the prominent inversion near the ground, it is expected that Dome A might house the lowest ground temperature on the planet. | CHEN BaiLian ZHANG RenHe XIAO CunDe BIAN LinGen ZHANG TingJun | 2010 | Chinese Science Bulletin2010，55，14： | 6 |
| 4 | Effects of purified zearalenone on selected immunological and histopathologic measurements of spleen in post-weanling gilts显示文摘The present study was aimed at investigating the adverse effects of dietary zearalenone(ZEA) on the lymphocyte proliferation rate(LPR), interleukin-2(IL-2), mRNA expressions of pro-inflammatory cytokines, and histopathologic changes of spleen in post-weanling gilts. A total of 20 crossbred piglets(Yorkshire × Landrace × Duroc) with an initial BW of 10.36 ± 1.21 kg(21 d of age) were used in the study.Piglets were fed a basal diet with an addition of 0.1.1,2.0, or 3.2 mg/kg purified ZEA for 18 d ad libitum.The results showed that LPR and IL-2 production of spleen decreased linearly(P < 0.05) as dietary ZEA increased. Splenic mRNA expressions of interleukin-1β(IL-1β) and interleukin-6(IL-6) were linearly upregulated(P < 0.05) as dietary ZEA increased. On the contrary, linear down-regulation(P<0.05) of mRNA expression of interferon-γ(IFN-γ) was observed as dietary ZEA increased. Swelling splenocyte in1.1 mg/kg ZEA treatments, atrophy of white pulp and swelling of red pulp in 2.0 and 3.2 mg/kg ZEA treatments were observed. The cytoplasmic edema in 1.1 mg/kg ZEA treatments, significant chromatin deformation in 2.0 mg/kg ZEA treatment and phagocytosis in 3.2 mg/kg ZEA treatment were observed.Results suggested that dietary ZEA at 1.1 to 3.2 mg/kg can induce splenic damages and negatively affect immune function of spleen in post-weanling gilts. | Peng Chen Tingjun Liu Shuzhen Jiang Zaibin Yang Libo Huang Faxiao Liu | 2017 | Animal Nutrition2017，，3： | 5 |
| 5 | Establishment and Characterization of a New Cell Line from the Kidney of Spotted Halibut Verasper variegates显示文摘A cell line,SHK,was derived from the kidney of spotted halibut Verasper variegates.The cell line was subculturedmore than 40 passages in minimum essential medium(MEM)supplemented with fetal bovine serum(FBS)and 10 ng ml-1basic fi-broblast growth factor(bFGF).Cell morphology from primary culture and subculture was observed continuously by microscopy.TheSHK cell line consisted predominantly of fibroblast-like cells.The cell line was able to grow between 20℃and 30℃with the optimum growth at 24℃and with a reduced growth between 12℃and 20℃.The growth rate of the cells increased as the proportion ofFBS increased from 10%to 20%at 28℃with optimum growth at the concentration of 20%.The doubling time of the cells was de-termined to be 44.8 h.Chromosome analysis revealed that 52%of the SHK cells maintained a normal diploid chromosome number(2n=46).The cells were successfully transfected with green fluorescent protein(GFP)reporter plasmids and the expression of GFPgene in the cells indicated the possible utility of the cells in gene expression studies.The cells were infected by lymphosystis diseasevirus(LCDV)and found to be susceptible to the virus in cytopathic effect(CPE)observation.The infection was confirmed by PCRand electron microscopy experiments,which proved the existence of the viral particles in the cytoplasm of the virus-infected cells. | WANG Xianli CHEN Songlin SHA Zhenxia FAN Tingjun WANG Na | 2010 | Journal of Ocean University of China2010，9，2： | 4 |
| 6 | Soil-Transmitted Helminthiasis--China,2018显示文摘What is already known about this topic?Soil-transmitted helminthiasis(STH)is distributed widely in China and a large number of the population is afflicted.However,trends of STH infections are decreasing.What is added by this report?The most recent data indicates that the overall prevalence of STH was 1.29% in 2018 in China,which was based on the national sentinel surveillance and demonstrates a continuous decline pattern.What are the implications for public health practice?Considering the current prevalence in China and various endemic statuses in different regions,precision control measures should be implemented for the control and elimination of STH in China. | Huihui Zhu Jilei Huang Changhai Zhou Tingjun Zhu Menbao Qian Mizhen Zhang Yingdan Chen Shizhu Li | 2020 | China CDC weekly2020，2，3： | 2 |
| 7 | Dynamics,impacts,and future projections of Arctic rapid change显示文摘Observations show that Arctic sea ice has been dramatically declined,and the surface temperature in Arctic region is dramatically increasing since 1970s.By the end of 2020,the summer sea ice extent had been decreased by more than 50%comparing with the area in the late 1970s.The increasing rate of surface atmospheric and oceanic temperature was about 2-3 times faster than that of the global average(Meredith et al.,2019).Arctic is experiencing rapid change. | CHEN Xian-Yao ZHANG Tingjun | 2021 | Advances in Climate Change Research2021，12，4： | 1 |
| 8 | Stereospecificity of ginsenoside Rg3 in promotion of the immune response to ovalbumin in mice显示文摘 | Xiaojie Wei Jian Chen Fei Su Xiaoyan Su Tingjun Hu Songhua Hu | 2012 | International Immunology2012，，7： | 1 |
| 9 | Strontium doped electrospinning fiber membrane with antibacterial and osteogenic properties prepared by pulse electrochemical method显示文摘The osteogenic differentiation and new bone formation are commonly delayed by bacterial infection of orthopedic implants,which is urgent to be resolved quickly in the clinic.The current paper prepared a strontium-doped elec-trospinning fiber membrane with antibacterial and osteogenic properties by pulse electrochemical method.Poly-lactic acid/hydroxyapatite(PLLA/HA)composite fiber substrate was fabricated by electrospinning technology,and strontium doped SrHA/Cu/Polypyrrole(PPy)composite coating was constructed with pulse electrodeposi-tion method on its surface.The strontium doping technique,degradation of Sr^(2+)and Cu^(2+),cellular compatibility,and the antibacterial activity of the fiber membrane were examined.The results revealed that the deposition of phosphorus and calcium on composite fiber was the highest,indicating good biological activity.The release of Sr^(2+)and Cu^(2+)was stable and gradual due to the modulation of PPy.The composite fiber presented excellent antibacterial performance and the antibacterial rate was close to 100%against Staphylococcus aureus and Es-cherichia coli.Furthermore,it is conducive to the adhesion,spread,and proliferation of vascular endothelial cells and osteoblasts,namely outstanding osteogenesis and angiogenesis abilities.In conclusion,the multifunctional PLLA/HA@SrHA/Cu/PPy composite fiber membrane with good antibacterial and osteogenic activity by electro-spinning technology and pulsed electrochemical deposition method provides an effective strategy for the poor bone healing of infected bone defects. | Yonggang Liu Bolin Zhang Feifei Liu Yani Qiu Wenbo Mu Liang Chen Chuang Ma Tingjun Ye Yingbo Wang | 2022 | Engineered Regeneration2022，3，4： | 0 |
| 10 | Development of 57 Novel Polymorphic Microsatellite Markers in Half-Smooth Tongue Sole(Cynoglossus semilaevis)显示文摘Half-smooth tongue sole (Cynoglossus semilaevis) is a promising species for aquaculture in China.The wild population of C. semilaevis is under threat from environmental factors. Microsatellite markers are very suitable for assessing genetic diversity. Four microsatellite-enriched libraries of half smooth tongue sole (Cynoglossus semilaevis) were constructed,from which 57 polymorphic microsatellites were isolated and characterized.The polymorphism of these microsatellites was assessed by genotyping in 30 individual fish.The number of alleles ranged from 2 to 11, with an average of 4.614 alleles per locus.The values of observed and expected heterozygosities ranged from 0.1000 to 1.0000 and from 0.0966 to 0.8847 respectively. Polymorphism information content (PIC) ranged from 0.0905 to 0.862.These markers would be useful for population structure assessment,genetic linkage map construction and parentage analysis for this species. | MIAO Guidong XU Ying WANG Di CHEN Songlin FAN Tingjun TIAN Yongsheng | 2011 | Journal of Ocean University of China2011，10，3： | 0 |
| 11 | Structural insights into ligand recognition and activation of the melanocortin-4 receptor显示文摘Melanocortin-4 receptor(MC4R)plays a central role in the regulation of energy homeostasis.Its high sequence similarity to other MC receptor family members,low agonist selectivity and the lack of structural information concerning MC4R-specific activation have hampered the development of MC4R-seletive therapeutics to treat obesity.Here,we report four high-resolution structures of full-length MC4R in complex with the heterotrimeric Gs protein stimulated by the endogenous peptide ligand a-MSH,FDA-approved drugs afamelanotide(Scenesse™)and bremelanotide(Vyleesi™),and a selective small-molecule ligand THIQ,respectively.Together with pharmacological studies,our results reveal the conserved binding mode of peptidic agonists,the distinctive molecular details of small-molecule agonist recognition underlying receptor subtype selectivity,and a distinct activation mechanism for MC4R,thereby offering new insights into G protein coupling.Our work may facilitate the discovery of selective therapeutic agents targeting MC4R. | Huibing Zhang Li-Nan Chen Dehua Yang Chunyou Mao Qingya Shen Wenbo Feng Dan-Dan Shen Antao Dai Shanshan Xie Yan Zhou Jiao Qin Jin-Peng Sun Daniel H.Scharf Tingjun Hou Tianhua Zhou Ming-Wei Wang Yan Zhang | 2021 | Cell Research2021，31，11： | 0 |
| 12 | An optimization method of fidelity parameters of formation fluid sampling cylinder while drilling显示文摘A design idea of fidelity sampling cylinder while drilling based on surface nitrogen precharging and supplemented by downhole pressurization was proposed, and the working mode and optimization method of sampling parameters were discussed. The nitrogen chamber in the sampling cylinder functions as an energy storage air cushion, which can supplement the pressure loss caused by temperature change in the sampling process to some extent. The downhole pressurization is to press the sample into the sample chamber as soon as possible, and further increase the pressure of sample to make up for the pressure that the nitrogen chamber cannot provide. Through the analysis of working mode of the sampling fidelity cylinder, the non-ideal gas state equation was used to deduce and calculate the optimal values of fidelity parameters such as pre-charged nitrogen pressure, downhole pressurization amount and sampling volume according to whether the bubble point pressure of the sampling fluid was known and on-site emergency sampling situation. Besides, the influences of ground temperature on fidelity parameters were analyzed, and corresponding correction methods were put forward. The research shows that the fidelity sampling cylinder while drilling can effectively improve the fidelity of the sample. When the formation fluid sample reaches the surface, it can basically ensure that the sample does not change in physical phase state and keeps the same chemical components in the underground formation. | JIANG Chuanlong YAN Tingjun ZHANG Yang SUN Tengfei CHEN Zhongshuai SUN Haoyu | 2022 | Petroleum Exploration and Development2022，49，2： | 0 |
| 13 | Transcriptome of hepatopancreas in kuruma shrimp Marsupenaeus japonicus under low-salinity stress显示文摘The kuruma shrimp Marsupenaeus japonicus is one of the most commercially important shrimp species in the world.Low salinity would aff ect the penetration and immunity,and even led to its death of the shrimp.However,little is known about the molecular mechanism of the effect.Therefore,hepatopancreas of M.japonicus reared under low-salinity stress for 6,12,24,48,and 96 h was analyzed and the results were compared with that of the control group using transcriptomics.After removing reads containing adapters,88890960-1051300444 clean reads were generated from 10 libraries in the control group and experimental group.Compared with the control group,811,589,1095,745,and 875 diff erentially expressed genes were obtained in the five treatment groups.The N50 and N90 lengths of the transcripts were 1746 bp and 436 bp,respectively.The top 20 gene ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways associated with the diff erentially expressed genes were related mainly to osmotic regulation(ion exchange,lipid metabolism and carbohydrate metabolism),immune regulation(cellular and humoral immunity),chitin metabolism,and related functions.The diff erential expression patterns of nine randomly selected genes were confi rmed by quantitative real-time PCR.This is the fi rst report of osmotic regulation-related genes that are diff erentially expressed under low-salinity stress in the hepatopancreas of M.japonicus.Furthermore,we found that M.japonicus initiated its own immune regulation under low-salinity stress.These results will help elucidating the mechanism of osmotic regulation and immune responses in this shrimp species. | Tingjun CHEN Zhimin LI Jianyong LIU Caifeng LIANG Le YUAN | 2022 | Journal of Oceanology and Limnology2022，40，2： | 0 |
| 14 | Thermal Deformation Behavior and Processing Map of a Novel CrFeNiSi_(0.15)Medium Entropy Alloy显示文摘The thermal deformation behavior of a novel CrFeNiSi_(0.15)medium entropy alloy(MEA)was studied via isothermal compression experiments,with the processing parameter range of 900–1200℃and 0.001–1 s^(−1).According to experimental data,the modified constitutive equation had been obtained,which precisely predicted the flow behavior of CrFeNiSi_(0.15)MEA during thermal deformation.At the same time,the processing map was established on the basis of the dynamic material model(DMM)theory.According to the map,the optimal processing parameters were determined at 1130–1200℃/0.06–1 s−1,under which the power dissipation efficiency could reach above 34%.The peak efficiency was above 38%,which occurred at 1200℃/1 s^(−1).In such parameter,complete dynamic recrystallization(DRX)also occurred.The flow instability of CrFeNiSi_(0.15)MEA was estimated to occur at 900–985℃/0.12–1 s^(−1),which was shown as grain boundaries cracking.Furthermore,both the continuous DRX(CDRX)and discontinuous DRX(DDRX)occurred simultaneously during thermal deformation.Meanwhile,some twins were also newly formed during DRX process,most of which were primary twins.The occurrence of twinning was beneficial to promote the development of DRX behavior. | Hongbin Zhang Kang Chen Zhongwei Wang Haiping Zhou Chengcheng Shi Shengxue Qin Jie Liu Tingjun Lv Jian Xu | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，11： | 0 |
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