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| 1 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 2 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 3 | Long-term results of endovascular therapy for proximal subclavian arterial obstructive lesions显示文摘背景 Endovascular 治疗是为锁骨下的动脉的局部性的吸藏的一种处理选择。在与 59 个病人一起的长期的经验是在1998年6月和2008年9月之间的 presented.Methods 的这份报告,我们使用了 endovascular 治疗在 59 个病人对待 61 锁骨下的动脉的妨碍的损害( 46 男性和 13 女性,有一个平均数的 34-82 岁变老( 61.9 眠瑩?佃?????????????? | WANG Ke-qin WANG Zhong-gao YANG Bao-zhong YUAN Chao ZHANG Wang-de YUAN Biao XING Tong SONG Sheng-han LI Tan LIAO Chuan-jun ZHANG Yang | 2010 | Chinese Medical Journal2010，，1： | 21 |
| 4 | Clinical study of midazolam sequential with dexmedetomidine for agitated patients undergoing weaning to implement light sedation in intensive care unit显示文摘 | Xing Lu Jun Li Tong Li Jie Zhang Zhi-Bo Li Xin-Jing Gao Lei Xu | 2016 | Chinese Journal of Traumatology2016，19，2： | 20 |
| 5 | Leap Motion-based virtual reality training for improving motor functional recovery of upper limbs and neural reorganization in subacute stroke patients显示文摘Virtual reality is nowadays used to facilitate motor recovery in stroke patients. Most virtual reality studies have involved chronic stroke patients; however, brain plasticity remains good in acute and subacute patients. Most virtual reality systems are only applicable to the proximal upper limbs(arms) because of the limitations of their capture systems. Nevertheless, the functional recovery of an affected hand is most difficult in the case of hemiparesis rehabilitation after a stroke. The recently developed Leap Motion controller can track the fine movements of both hands and fingers. Therefore, the present study explored the effects of a Leap Motion-based virtual reality system on subacute stroke. Twenty-six subacute stroke patients were assigned to an experimental group that received virtual reality training along with conventional occupational rehabilitation, and a control group that only received conventional rehabilitation. The Wolf motor function test(WMFT) was used to assess the motor function of the affected upper limb; functional magnetic resonance imaging was used to measure the cortical activation. After four weeks of treatment, the motor functions of the affected upper limbs were significantly improved in all the patients, with the improvement in the experimental group being significantly better than in the control group. The action performance time in the WMFT significantly decreased in the experimental group. Furthermore, the activation intensity and the laterality index of the contralateral primary sensorimotor cortex increased in both the experimental and control groups. These results confirmed that Leap Motion-based virtual reality training was a promising and feasible supplementary rehabilitation intervention, could facilitate the recovery of motor functions in subacute stroke patients. The study has been registered in the Chinese Clinical Trial Registry(registration number: Chi CTR-OCH-12002238). | Zun-rong Wang Ping Wang Liang Xing Li-ping Mei Jun Zhao Tong Zhang | 2017 | Neural Regeneration Research2017，12，11： | 19 |
| 6 | Single whispering-gallery mode lasing in polymer bottle microresonators via spatial pump engineering显示文摘Single-mode lasing in whispering-gallery mode(WGM)microresonators is challenging to achieve.In bottle microresonators,the highly non-degenerated WGMs are spatially well-separated along the long-axis direction and provide mode-selection capability.In this work,by engineering the pump intensity to modify the spatial gain profiles of bottle microresonators,we demonstrate a simple and general approach to realizing single-mode WGM lasing in polymer bottle microresonators.The pump intensity is engineered into an interference distribution on the bottle microresonator surface.By tuning the spacing between axial positions of the interference pump patterns,the mode intensity profiles of single-bottle WGMs can be spatially overlapped with the interference stripes,intrinsically enabling single-mode lasing and selection.Attractive advantages of the system,including high sidemode suppression factors 420 dB,large spectral tunability 48 nm,low-lasing threshold and reversible control,are presented.Our demonstrated approach may have a variety of promising applications,ranging from tunable single-mode lasing and sensing to nonlinear optics. | Fuxing Gu Fuming Xie Xing Lin Shuangyi Linghu Wei Fang Heping Zeng Limin Tong Songlin Zhuang | 2017 | Light(Science & Applications)2017，6，1： | 17 |
| 7 | Relationship between Fas/ FasL expression and apoptosis of colon adenocarcinoma cell lines显示文摘INTRODUCTIONFas/ FasL system has been identified as a keymediator of apoptosis in tumor cells[1-4]. Theoccurrence and development of neoplasm are closelyrelated to apoptosis[5-7] Most chemotherapeuticdrugs kill cancer cells mainly by inducingapoptosis[8-14].' | Zhi Hai Peng Tong Hai Xing Guo Qiang Qiu Hua Mei Tang Shanghai No. 1 People’s Hospital, Shanghai 200080, China | 2001 | World Journal of Gastroenterology2001，7，1： | 15 |
| 8 | Object Detection Research of SAR Image Using Improved Faster Region-Based Convolutional Neural Network显示文摘Target detection technology of synthetic aperture radar(SAR)imageis widely used in the field of military reconnaissance and surveillance.The traditional SAR image target detection methods need to be provided a lot of empirical knowledge because the characteristics of SAR images in different configurations(attitude,pitch angle,imaging parameters,etc.)will change greatly,resulting in high generalization error.Currently,deep learning method has achieved great success in the field of image processing.Research shows that deep learning can achieve a more intrinsic description of the data,while the model has a stronger ability of modeling and generalization.In order to solve the problem of insufficient data in SAR data sets,an experimental system for acquiring SAR image data in real scenes was built.Then the transfer learning method and the improved convolution neural network algorithm(PCA+Faster R-CNN)are applied to improve the target detection precision.Finally,experimental results demonstrate the significant effectiveness of the proposed method. | Long SUN Tao WU Guangcai SUN Dazheng FENG Lieshu TONG Mengdao XING | 2020 | Journal of Geodesy and Geoinformation Science2020，3，3： | 13 |
| 9 | Relationship between lymph node sinuses with blood and lymphatic metastasis of gastric cancer显示文摘AIM: To elucidate the relationship between lymph nodesinuses with blood and lymphatic metastasis of gastric cancer.METHODS: Routine autopsy was carried out in the randomlyselected 102 patients (among them 100 patients died ofvarious diseases, and 2 patients died of non-diseasedreasons), their superficial lymph nodes locating in bilateralnecks (include supraclavicle), axilla, inguina, thorax, andabdomen were sampled. Haematoxylin-Eosin staining wasperformed on 10 % formalin-fixed and paraffin-embeddedlymph node tissue sections (Sum). The histological pattemsof the lymph sinuses containing blood were observed underlight microscope. The expression of CD31, a marker forendothelial cell, was detected both in blood and non-bloodcontaining lymph node sinuses with the method ofimmunohistochemistry.RESULTS: Among the 1322 lymph nodes sampled fromthe autopsies of 100 diseased cases, lymph node sinusescontaining blood were found in 809 lymph nodes sampledfrom 91 cases, but couldn't be seen in the lymph nodessampled from the non-diseased cases. According to histology,we divided the blood containing lymph node sinuses intofive categories: vascular-opening sinus, blood-deficient sinus,erythrophago-sinus, blood-abundant sinus, vascular-formative sinus. Immunohistochemical findings showed thatthe expression of CD31 was strongly positive in vascular-formative sinuses and some vascular-opening sinuses whileit was faint in blood-deficient sinuses, erythrophago-sinusesand some vascular-opening sinuses. It was almost negativein blood-abundant sinus and non-blood containing sinus.CONCLUSION: In the state of disease, the phenomenonof blood present in the lymph sinus is not uncommon. Bloodcould possibly enter into the lymph sinuses through thelymphaticovenous communications between the veins andthe sinuses in the node. Lymph circulation and the bloodcirculation could communicate with each other in the lymphnode sinuses. The skipping and distal lymphatic metastasisof gastric cancer may have some connection with the bloodcontaining lymph node sinuses. | Tong Yin Xiao-Long Ji Min-Shi Shen General Hospital of PLA,28 Fu Xing Road,Beijing 100853,China | 2003 | World Journal of Gastroenterology2003，9，1： | 12 |
| 10 | Efficacy and safety of the long-acting fusion inhibitor albuvirtide in antiretroviral-experienced adults with human immunodeficiency virus-1:interim analysis of the randomized,controlled,phase 3,non-inferiority TALENT study显示文摘Background:Albuvirtide is a once-weekly injectable human immunodeficiency virus(HIV)-1 fusion inhibitor.We present interim data for a phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral drugs.Methods:We carried out a 48-week,randomized,controlled,open-label non-inferiority trial at 12 sites in China.Adults on the World Health Organization(WHO)-recommended first-line treatment for>6 months with a plasma viral load>1000 copies/mL were enrolled and randomly assigned(1:1)to receive albuvirtide(once weekly)plus ritonavir-boosted lopinavir(ABT group)or the WHO-recommended second-line treatment(NRTI group).The primary endpoint was the proportion of patients with a plasma viral load below 50 copies/mL at 48 weeks.Non-inferiority was prespecified with a margin of 12%.Results:At the time of analysis,week 24 data were available for 83 and 92 patients,and week 48 data were available for 46 and 50 patients in the albuvirtide and NRTI groups,respectively.At 48 weeks,80.4%of patients in the ABT group and 66.0%of those in the NRTI group had HIV-1 RNA levels below 50 copies/mL,meeting the criteria for non-inferiority.For the per-protocol population,the superiority of albuvirtide over NRTI was demonstrated.The frequency of grade 3 to 4 adverse events was similar in the two groups;the most common adverse events were diarrhea,upper respiratory tract infections,and grade 3 to 4 increases in triglyceride concentration.Renal function was significantly more impaired at 12 weeks in the patients of the NRTI group who received tenofovir disoproxil fumarate than in those of the ABT group.Conclusions:The TALENT study is the first phase 3 trial of an injectable long-acting HIV drug.This interim analysis indicates that once-weekly albuvirtide in combination with ritonavir-boosted lopinavir is well tolerated and non-inferior to the WHO-recommended second-line regimen in patients with first-line treatment failure.Trial registration:ClinicalTrials.gov Identifier:NCT02369965;http://gffzz90ed6ce9d87f4798snbbwp0w5puvq6knb.ffgz.tsg.suse.edu.cn Clinical Trial Registry No.ChiCTR-TRC-14004276;http://gffzz62a03ee25e6f4a77hnbbwp0w5puvq6knb.ffgz.tsg.suse.edu.cn/enindex.aspx. | Bin Su Cheng Yao Qing-Xia Zhao Wei-Ping Cai Min Wang Hong-Zhou Lu Yuan-Yuan Chen Li Liu Hui Wang Yun He Yu-Huang Zheng Ling-Hua Li Jin-Feng Chen Jian-Hua Yu Biao Zhu Min Zhao Yong-Tao Sun Wen-Hui Lun Wei Xia Li-Jun Sun Li-Li Dai Tai-Yi Jiang Mei-Xia Wang Qing-Shan Zheng Hai-Yan Peng Yao Wang Rong-Jian Lu Jian-Hua Hu Hui Xing Yi-Ming Shao Dong Xie Tong Zhang Fu-Jie Zhang Hao Wu TALENT Study Team | 2020 | Chinese Medical Journal2020，，24： | 10 |
| 11 | Liraglutide alleviates cardiac fibrosis through inhibiting P4hα-1 expression in STZ-induced diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy is an important contributor to morbidity and mortality of diabetic patients by causing heart failure.Interstitial and perivascular fibrosis plays a crucial role in diabetic cardiomyopathy.However,there is a lack of effective specific treatments available for diabetic cardiomyopathy.In the present study,we aim to explore the effects of Liraglutide,a GLP-1 analogue,on diabetic cardiomyopathy in STZ-induced diabetic rats fed with high-fat diet.A total of 60 male Wistar rats were randomly assigned to three groups,i.e.normal group,model group,and Liraglutide group,with 20 rats in each group.Serum levels of TC,TG,LDL-C,NEFA,and hydroxyproline were measured using commercial kits.Cardiac function was evaluated by QRS waves,LVEDd,LVESd,and LVEF.Myocardial fibrosis was measured by immunohistochemistry.Our results demonstrated that chronic administration of Liraglutide decreased the level of blood glucose and significantly alleviated lipid metabolic disturbance compared with the model group.Furthermore,Liraglutide was found to improve the damaged cardiac function.In line with this,we also found that the alleviation of cardiac dysfunction was associated with the decreased fibrosis in diabetic myocardial tissues,which was reflected by the decreased expressions of P4hα-1,COL-1,COL-3,MMP-1,and MMP-9.Our results thus suggest that Liraglutide might have a myocardial protective effect by inhibiting P4hα-1-mediated myocardial fibrosis. | Tong Zhao Huiqiang Chen Fei Xu Juan Wang Yusheng Liu Xiaowei Xing Linlin Guo Mingxiang Zhang Qinghua Lu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 9 |
| 12 | Efficacy of a Chinese herbal formula on hepatitis B e antigenpositive chronic hepatitis B patients显示文摘BACKGROUND No guideline recommends antiviral therapy for hepatitis B e antigen(HBeAg)-positive chronic hepatitis B patients with persistently normal alanine aminotransferase levels and a high hepatitis B virus(HBV)DNA viral load.AIM To evaluate the feasibility and safety of a Chinese herbal formula as a therapeutic option for chronic HBV infection.METHODS In total,395 patients(30–65 years old)with confirmed HBeAg-positive chronic hepatitis B infection and persistently normal alanine aminotransferase were randomized to receive either Chinese herbal formula or placebo for 96 wk.Endpoints to evaluate therapeutic efficacy included:(1)HBV DNA levels decreased to less than 4 log10 IU/mL at weeks 48 and 96;and(2)HBeAg clearance and seroconversion rates at weeks 48 and 96.RESULTS HBV DNA levels≤4 log10 IU/mL were 10.05%at week 48 and 18.59%at week 96 in the treatment group.The HBeAg clearance and conversion rates were 8.54%and 8.04%at week 48 and 16.08%and 14.57%at week 96,respectively.However,HBV DNA levels≤4 log10 IU/mL were 2.55%and 2.55%at weeks 48 and 96,respectively,and the HBeAg clearance rates were 3.06%and 5.61%at weeks 48 and 96,respectively,in the control group.The quantitative hepatitis B surface antigen and HBeAg levels at baseline and changes during the treatment period as well as the alanine aminotransferase elevation at weeks 12 and 24 were strong predictors of HBeAg clearance.CONCLUSION High rates of HBV DNA reduction,HBeAg clearance and seroconversion could be achieved with Chinese herbal formula treatments,and the treatments were relatively safe for HBeAg-positive chronic hepatitis B-infected patients with persistently normal alanine aminotransferase.The ability of the compound to modulate host immune function probably contributed to this effect. | Yu-Feng Xing Chun-Shan Wei Tian-Ran Zhou Dan-Ping Huang Wei-Chao Zhong Bin Chen Hua Jin Xiao-Yu Hu Zhi-Yun Yang Qing He Kai-Ping Jiang Jun-Min Jiang Zhen-Bin Hu Xin Deng Fan Yang Feng-Yi Li Gang Zhao Li-Chun Wang Yu-Qiang Mi Zuo-Jiong Gong Peng Guo Jian-Hua Wu Wei-Qun Shi Hong-Zhi Yang Da-Qiao Zhou Guang-Dong Tong | 2020 | World Journal of Gastroenterology2020，26，30： | 7 |
| 13 | An improved genetic algorithm for searching for pollution sources显示文摘As an optimization method that has experienced rapid development over the past 20 years,the genetic algorithm has been successfully applied in many fields,but it requires repeated searches based on the characteristics of high-speed computer calculation and conditions of the known relationship between the objective function and independent variables.There are several hundred generations of evolvement,but the functional relationship is unknown in pollution source searches.Therefore,the genetic algorithm cannot be used directly.Certain improvements need to be made based on the actual situation,so that the genetic algorithm can adapt to the actual conditions of environmental problems,and can be used in environmental monitoring and environmental quality assessment.Therefore,a series of methods are proposed for the improvement of the genetic algorithm:(1) the initial generation of individual groups should be artificially set and move from lightly polluted areas to heavily polluted areas;(2) intervention measures should be introduced in the competition between individuals;(3) guide individuals should be added;and(4) specific improvement programs should be put forward.Finally,the scientific rigor and rationality of the improved genetic algorithm are proven through an example. | Quan-min BU Zhan-jun WANG Xing TONG | 2013 | Water Science and Engineering2013，6，4： | 7 |
| 14 | Convenient fabrication of BiOBr ultrathin nanosheets with rich oxygen vacancies for photocatalytic selective oxidation of secondary amines显示文摘Photocatalytic oxidation has been widely employed in organic synthesis,by virtue of the green,mild and simple reaction conditions as well as high selectivity.Introducing oxygen vacancies (OVs) with proper concentrations into the photocatalysts has been proven as an effective strategy to boost the catalytic performances.However,the currently used treatment method under high temperature at reducing atmosphere inevitably introduces a large number of OVs at the interior of the catalyst and serving as the recombination centers of carriers.To address this issue,here we develop a facile solvothermal process to prepare ultrathin BiOBr nanosheets with rich surface OVs.This method effectively decreases the bulk of the material and the ratio of interior OVs,rendering most of the OVs exposed on the surfaces which act as exposed catalytic sites and enhance the separation of carriers,therefore significantly elevates the photocatalytic performances.For the photo-oxidation reaction of secondary amines,under the conditions of visible light,ambient temperature and atmosphere,the BiOBr nanosheets featuring rich surface OVs deliver a doubled conversion compared to those with low OV concentrations,and a high selectivity of 99%,a high stability as the performance shows no reduction after 5 times of circular reaction. | Xuanjue Tong Xing Cao Tong Han Weng-Chon Cheong Rui Lin Zheng Chen Dingsheng Wang Chen Chen Qing Peng Yadong Li | 2019 | Nano Research2019，12，7： | 7 |
| 15 | Effects of Heart Rate Variability Biofeedback Therapy on Patients with Poststroke Depression: A Case Study显示文摘INTRODUCTION Poststroke depression (PSD) is one of the common complications of cerebrovascular diseases.Drug therapy and cognitive behavioral therapy are two commonly used methods in current clinical treatments of PSD.However,either method has its own drawbacks:The former has problems such as the slow onset of action and various side effects,and patients often have a poor response to the latter.[1] Recently,scientists have started using the heart rate variability (HRV) biofeedback approach to treating patients with depression and found significant clinical efficacy. | Xin Li Tong Zhang Lu-Ping Song Yong Zhang Gui-Gang Zhang Chun-Xiao Xing Hsinchun Chen | 2015 | Chinese Medical Journal2015，，18： | 6 |
| 16 | Oscillation of fourth-order delay dynamic equations显示文摘This paper is concerned with oscillatory behavior of a class of fourth-order delay dynamic equations on a time scale.In the general time scales case,four oscillation theorems are presented that can be used in cases where known results fail to apply.The results obtained can be applied to an equation which is referred to as Swift-Hohenberg delay equation on a time scale.These criteria improve a number of related contributions to the subject.Some illustrative examples are provided. | ZHANG Cheng Hui AGARWAL Ravi P. BOHNER Martin LI Tong Xing | 2015 | Science China Mathematics2015，58，1： | 5 |
| 17 | 土-膨润土隔离墙孔压静力触探非单调消散曲线研究(英文)显示文摘目的:土-膨润土隔离墙的水力特性可通过孔压静力触探试验进行评价。本文旨在研究土-膨润土隔离墙中孔压消散试验产生非单调孔压消散曲线的原因,并对现有计算固结系数与渗透系数的方法在土-膨润土隔离墙中的适用性进行分析。创新点:1.首次在土-膨润土隔离墙中测得非单调的孔压消散曲线;2.本文认为在土-膨润土隔离墙中测得非单调孔压消散曲线是由于探头贯入过程中在填料及其包裹的土块中产生的超孔压不一致引起的,并且由于填料的低渗透性,孔压上升的时间较长;3.比较不同方法的分析结果,并推荐结果与实测相近的计算方法作为工程应用。方法:1.通过室内一维固结试验和柔性壁渗透试验,分别获得墙体材料的固结系数和渗透系数;2.通过现场土-膨润土隔离墙的孔压静力触探试验与孔压消散试验,获得相应的力学参数与孔压消散曲线;3.分别采用不同方法对墙体材料的固结系数和渗透系数进行计算,并将计算结果与室内试验结果进行比较。结论:1.填料的非均质性导致探头贯入过程中产生的超孔压存在重分布,这使得土-膨润土隔离墙中产生了非单调孔压消散曲线,并且由于填料的低渗透性,测得孔压上升的时间较长;2.四种计算固结系数的方法中,有三种结果与室内一维固结试验结果相近,另一种结果则明显偏大;3.四种计算渗透系数的方法中,基于太沙基固结理论的关系式得到的结果与室内柔壁渗透试验结果相近,另两种经验公式得到的结果偏小,而基于探头贯入数据计算的渗透系数则偏大。 | Yu-chao LI Xing TONG Yun CHEN Han KE Yun-min CHEN Yi-duo WEN Qian PAN | 2018 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2018，19，4： | 5 |
| 18 | Current understanding of osteoarthritis pathogenesis and relevant new approaches显示文摘Osteoarthritis(OA)is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body.The molecular mechanisms of OA are currently unknown.OA is a heterogeneous disease that affects the entire joint,and multiple tissues are altered during OA development.To better understand the pathological mechanisms of OA,new approaches,methods,and techniques need to be used to understand OA pathogenesis.In this review,we first focus on the epigenetic regulation of OA,with a particular focus on DNA methylation,histone modification,and microRNA regulation,followed by a summary of several key mediators in OA-associated pain.We then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain,such as CRISPR,scRNA sequencing,and lineage tracing.Next,we discuss the timely updates concerning cell death regulation in OA pathology,including pyroptosis,ferroptosis,and autophagy,as well as their individual roles in OA and potential molecular targets in treating OA.Finally,our review highlights new directions on the role of the synovial lymphatic system in OA.An improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA. | Liping Tong Huan Yu Xingyun Huang Jie Shen Guozhi Xiao Lin Chen Huaiyu Wang Lianping Xing Di Chen | 2022 | Bone Research2022，10，4： | 4 |
| 19 | A novel mosquito-borne reassortant orbivirus isolated from Xishuangbanna,China显示文摘Dear Editor,The genus Orbivirus,within the family Reoviridae,includes 22 virus species(King et al.,2011).They are distributed globally,but are particularly prevalent in Europe,Asia,and Africa.In addition,they can be transmitted by ticks or other hematophagous insect vectors,including Culicoides,mosquitoes,and sandflies(Belaga- | Shaozhen Xing Xiaofang Guo Xianglilan Zhang Qiumin Zhao Lingli Li Shuqing Zuo Xiaoping An Guangqian Pei Qiang Sun Shi Cheng Yunfei Wang Hang Fan Zhiqiang Mi Yong Huang Zhiyi Zhang Hongning Zhou Jiusong Zhang Yigang Tong | 2017 | Virologica Sinica2017，32，2： | 4 |
| 20 | Superior performance and high service stability for Ge Te-based thermoelectric compounds显示文摘GeTe-based compounds have been intensively studied recently due to their superior thermoelectric performance,but their real applications are still limited so far due to the drastic volume variation that occurs during the rhombohedral–cubic phase transition,which may break the material or the material/electrode interface during service.Here,superior performance and high service stability for GeTe-based thermoelectric compounds are achieved by co-doping Mg and Sb into GeTe.The linear coefficient of thermal expansion before phase transition is greatly improved to match that after phase transition,yielding smooth volume variation around the phase transition temperature.Likewise,co-doping(Mg,Sb)in GeTe successfully tunes the carrier concentration to the optimal range and effectively suppresses the lattice thermal conductivity.A peak z T of 1.84 at 800 K and an average z T of 1.2 in 300–800 K have been achieved in Ge0.85Mg0.05Sb0.1Te.Finally,a Ni/Ti/Ge0.85Mg0.05Sb0.1Te thermoelectric uni-leg is fabricated and tested,showing quite good service stability even after 450 thermal cycles between 473 K and 800 K.This study will accelerate the application of GeTe-based compounds for power generation in the mid-temperature range. | Tong Xing Qingfeng Song Pengfei Qiu Qihao Zhang Xugui Xia Jincheng Liao Ruiheng Liu Hui Huang Jiong Yang Shengqiang Bai Dudi Ren Xun Shi Lidong Chen | 2019 | National Science Review2019，6，5： | 4 |
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