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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the efficacy and safety of Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease(HFMD). METHODS: A stratified-block randomized, double-blind, parallel-controlled, and multicenter clinical trial was conducted with 360 patients in five hospitals across China: Quanzhou Children's Hospital, Shijiazhuang No. 5 Hospital, Shanghai Public Health Centre, Hunan Provincial Children's Hospital, and Kaifeng Children's Hospital. Patients were randomized into three groups with 120 in each. Group A was treated with Western Medicine, group B with Reduning injection, a Chinese herbal medicine, and group C with both Reduning injection and Western Medicine. Results were compared for treatment efficacy and safety on HFMD. The clinical outcomes were observed as follows: fever and onset time of antifebrile effect(time to bring the body temperature down ≥0.5℃ after medication); cumulative time for fever recovery(body temperature recovering to normal and lasting more than 24 h without medication); cumulative time for rash disappearance(without new rashes or ulcers appearing and the original ones fading away); and cumulative time for mouth ulcer disappearance. RESULTS: For the onset time of the antifebrile effect, there was no statistical difference between groups A and B(P>0.05) and groups B and C(P> 0.05). However, there was a statistical difference between groups A and C(P<0.05), and the effect in group C was the best. For the cumulative time for rash disappearance, there was no statistical difference between groups A and B(P>0.05). There were statistical differences between groups A and C, and groups B and C(P<0.05), and the effect in group C was the best. For the cumulative time for mouth ulcers disappearance, there were no statistical differences among the three groups(P>0.05). CONCLUSION: Reduning injection with Western Medicine for symptomatic treatment is most effective for mild HFMD. No adverse reactions were observed. | Guoliang Zhang Jie Zhao Liyun He Shiyan Yan Ziqiang Zhuo Haojie Zheng Yongping Mu Shuangjie Li Xi Zhang Jihan Huang Xiuhui Li Jianping Liu Hehe Wan Chaoyu Wei Wei Xiao | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 7 |
| 3 | Efficacy and Safety of Yanggan Jian in Hepatitis B Virusrelated Decompensated Cirrhosis:A Randomized,Doubleblind,Controlled Trial显示文摘Background and Aims:The aim was to evaluate the efficacy and safety of Yanggan Jian(YGJ)in HBV-infected patients with decompensated cirrhosis.Methods:This randomized,double-blind controlled trial enrolled 160 patients with HBV-related decompensated cirrhosis who were already receiving or about to start antiviral therapy.Patients were randomly assigned to receive YGJ or placebo for 24 weeks,and were followed-up to 36 weeks.The primary outcome was the proportion of patients with a≥2 point reduction in Child-Turcotte-Pugh(CTP)score from baseline at week 24.Secondary outcomes were CTP class and score,serum liver function indices,mortality,incidence of hepatocellular carcinoma and variceal bleeding.Results:The proportion of patients with a CTP score reduction≥2 was significantly greater in the YGJ than in the placebo group(p=0.009);the percentage of patients with CTP class C was significantly less than that in the placebo group(p<0.05),and the YGJ group had a significantly greater mean change from baseline in CTP score at week 24(p=0.034).The improvement in measured values and change from baseline of prothrombin time,serum albumin,platelets,cholinesterase,international normalized ratio,and activated partial thromboplastin time were significantly better with YGJ than with placebo.Between-group differences in cumulative rates of variceal bleeding,hepatocellular carcinoma,death,or the frequency of any adverse event(AE),AEs related to treatment,or discontinuation because of AEs were not significant.Conclusions:YGJ significantly improved CTP scores and hepatic synthetic and reserve function in patients with HBV-related decompensated cirrhosis,and was safe and well tolerated. | Long Chen Chaoqun Zhao Weili Yao Wei Liu Hua Zhang Yongping Mu Hong Cai Dongying Xue Chengbao Wang Wan’e Wang Yuehong Lin Jiamei Chen Ping Liu | 2023 | Journal of Clinical and Translational Hepatology2023，11，1： | 3 |
| 4 | H7N9 virus infection triggers lethal cytokine storm by activating gasdermin E-mediated pyroptosis of lung alveolar epithelial cells显示文摘The H7N9 influenza virus emerged in China in 2013,causing more than 1560 human infections,39% of which were fatal.A ‘cytokine storm’ in the lungs of H7N9 patients has been linked to a poor prognosis and death;however,the underlying mechanism that triggers the cytokine storm is unknown.Here,we found that efficient replication of the H7N9 virus in mouse lungs activates gasdermin E(GSDME)-mediated pyroptosis in alveolar epithelial cells,and that the released cytosolic contents then trigger a cytokine storm.Knockout of Gsdme switched the manner of death of A549 and human primary alveolar epithelial cells from pyroptosis to apoptosis upon H7N9 virus infection,and Gsdme knockout mice survived H7N9 virus lethal infection.Our findings reveal that GSDME activation is a key and unique mechanism for the pulmonary cytokine storm and lethal outcome of H7N9 virus infection and thus opens a new door for the development of antivirals against the H7N9 virus. | Xiaopeng Wan Jiqing Li Yupeng Wang Xiaofei Yu Xijun He Jianzhong Shi Guohua Deng Xianying Zeng Guobin Tian Yanbing Li Yongping Jiang Yuntao Guan Chengjun Li Feng Shao Hualan Chen | 2022 | National Science Review2022，9，1： | 3 |
| 5 | Effective properties of coated fibrous piezoelectric composites with spring-type interfaces under anti-plane mechanical and in-plane electrical loads显示文摘In this paper, we investigate the effective properties of three-phase(matrix/coating/fiber) cylindrical piezoelectric composites with imperfect interfaces under anti-plane mechanical and in-plane electrical loads. By using the electromechanically coupling spring-type interface model and the generalized self-consistent method(GSM), we analytically derived the effective electroelastic moduli. The present solutions include as special cases the three-phase cylindrical piezoelectric composites with perfect interfaces as well as the two-phase(matrix/fiber) case with imperfect or perfect interfaces. Selected calculations are graphically shown to demonstrate dependence of the effective moduli on the interfacial properties. The particular size-dependent characteristic due to the interfacial imperfection is also discussed. | Yin Shi YongPing Wan Zheng Zhong | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，10： | 2 |
| 6 | Triangulation of red sprites observed above a mesoscale convective system in North China显示文摘The triangulation of red sprites was obtained, based on concurrent observations over a mesoscale convective system(MCS) in North China from two stations separated by about 450 km. In addition, broadband sferics from the sprite-producing lightning were measured at five ground stations, making it possible to locate and identify the individual causative lightning discharges for different elements in this dancing sprite event. The results of our analyses indicate that the sprites were produced above the trailing stratiform region of the MCS, and their parent strokes were located mainly in the peripheral area of the stratiform. The lateral offset between sprites and causative strokes ranges from a few km to more than 50 km. In a particularly bright sprite, with a distinct halo feature and streamers descending down to an altitude of approximately 48 km, the sprite current signal identified in the electric sferic, measured at a range of about 1,110 km, peaked at approximately 1 ms after the return stroke. | YongPing Wang GaoPeng Lu Ming Ma HongBo Zhang YanFeng Fan GuoJin Liu ZheRun Wan Yu Wang Kang-Ming Peng ChangZhi Peng FeiFan Liu BaoYou Zhu BinBin Ni XuDong Gu Long Chen Juan Yi RuoXian Zhou | 2019 | Earth and Planetary Physics2019，3，2： | 2 |
| 7 | Review and Analysis of Key Techniques in Marine Sediment Sampling显示文摘Deep-sea sediment is extremely important in marine scientific research,such as that concerning marine geology and microbial communities.The research findings are closely related to the in-situ information of the sediment.One prerequisite for investigations of deep-sea sediment is providing sampling techniques capable of preventing distortion during recovery.As the fruit of such sampling techniques,samplers designed for obtaining sediment have become indispensable equipment,owing to their low cost,light weight,compactness,easy operation,and high adaptability to sea conditions.This paper introduces the research and application of typical deep-sea sediment samplers.Then,a representative sampler recently developed in China is analyzed.On this basis,a review and analysis is conducted regarding the key techniques of various deep-sea sediment samplers,including sealing,pressure and temperature retaining,low-disturbance sampling,and no-pressure drop transfer.Then,the shortcomings in the key techniques for deep-sea sediment sampling are identified.Finally,prospects for the future development of key techniques for deep-sea sediment sampling are proposed,from the perspectives of structural diversification,functional integration,intelligent operation,and high-fidelity samples.This paper summarizes the existing samplers in the context of the key techniques mentioned above,and can provide reference for the optimized design of samplers and development of key sampling techniques. | Shudong He Youduo Peng Yongping Jin Buyan Wan Guangping Liu | 2020 | Chinese Journal of Mechanical Engineering2020，33，5： | 2 |
| 8 | Design and Experimental Study of Pressure Compensation System for Full-Ocean-Depth Gas-Tight Sediment Sampler显示文摘Aiming at the requirement of the full-ocean-depth(operating water depth 11000 m)manned submersible to carry out the gas-tight sampling operation of the abyss seabed sediment,a kind of full-ocean-depth carrier submersible mechanical hand-held,full-ocean-depth gas-tight sediment sampler(GTSS)with the function of pressure-retaining and coring is designed.Firstly,the volume change model of pressure compensator is established,and it is pointed out that the volume of pressure compensator is about 16.14%equal to the volume of gas-tight sediment sampler(GTSS).Secondly,the pressure compensator is analyzed and calculated,and the relationship between the precharge pressure of the pressure compensator,the nominal volume of the pressure compensator and the pressure holding effect of the gas-tight sediment sampler(GTSS)is studied.The results show that with the increase of gas precharge pressure in the pressure compensator,the final pressure of the sampler also increases.Under the same precharge pressure condition,the larger the nominal volume of the pressure compensator,the greater the final pressure of the sampler.Finally,the air tightness test method is designed by using the developed gas tightness sampler of the full-ocean-depth product,and the change of the final pressure in the gas tight sampler under different precharge pressure is observed.The test results are consistent with the simulation results,indicating the correctness of the pressure compensation system(PCS)model. | Guangping Liu Yongping Jin Youduo Peng Buyan Wan | 2022 | Chinese Journal of Mechanical Engineering2022，35，2： | 1 |
| 9 | The unlined relationship between stress and strain of magnetostrictive materials显示文摘 | WAN Yongping FANG Daining HUANG Kezhi | 2001 | Acta Mechanica Sinica2001，，： | 1 |
| 10 | A Two-dimensional Analysis of Surface Acoustic Waves In Finite Solids with the Consideration of Electrodes 显示文摘 | Wang Ji Lin Jingbo Wan Yongping | 2005 | Intl J Applied Electromagnetics and Mechanics2005，，22： | 1 |
| 11 | The Analysis for the Efficiency Properties of the Fuel Cell Engine显示文摘 | Hou Yongping Zhuang Mingxi Wan Gang | 2007 | Renew Energy2007，32，7： | 1 |
| 12 | A Transient Semi-Empirical Voltage Model of a Fuel Cell Stack显示文摘 | Yongping Hou Mingxi Zhuang Gang Wan | 2007 | International Journal of Hydrogen Energy2007，32，： | 1 |
| 13 | 2017年中国出现的H7N9高致病性病毒的快速进化显示文摘文章简介为了防控H7N9病毒,中国2017年9月开始对鸡进行了H5/H7二价禽流感灭活疫苗。为了解H7N9病毒在中国家禽中的分布情况,研究团队进行了系统的禽流感病毒监测。2017年2月至2017年5月之间在379个活禽市场和665个家禽养殖场共采集30201份样品(其中活禽市场采集12504份. | Jianzhong Shi Guohua Deng Shujie Ma Xianying Zeng Xin Yin Mei Li Bo Zhang Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Liling Liu Pucheng Chen Yongping Jiang Yuntao Guan Jinxiong Liu Wenli Gu Shuyu Han Yangming Song Libin Liang Zhiyuan Qu Yujie Hou Xiurong Wang Hongmei Bao Guobin Tian Yanbing Li Li Jiang Chengjun Li 陈化兰 | 2019 | 科学新闻2019，0，2： | 1 |
| 14 | THE EFFECTIVE ELECTROMECHANICAL PROPERTIES OF CELLULAR PIEZOELECTRET FILM:FINITE ELEMENT MODELING显示文摘Cellular space-charge polymer film,also called cellular piezoelectret,has very large piezoelectric effect due to their unique microvoid structure.In this article,the cellular piezoelectret film is considered to be a periodic composite material with closed-cell microvoids aligned periodically.Three dimensional finite element modeling is carried out to obtain the effective elastic modulus and piezoelectric coefficients.Sensitivity analysis was presented by modeling the effective electromechanical properties with different individual variable,including material constants and void shape parameters.By assuming a relation between void shape and void volume fraction,the finite element model can simulate quite well the inflation experiments of the voided charged Polypropylene film published in literature.Finally,the finite element model is used to explore the voided charge polymer film with non-uniform distribution of the trapped charges on the internal surface of voids.It was found that the resultant overall piezoelectric coefficients will be more significant if charges are closely gathered in the central area,and sparse in the around area of the internal surface of voids. | Yongping Wan Liangliang Fan Zheng Zhong | 2013 | Acta Mechanica Solida Sinica2013，26，1： | 1 |
| 15 | Multilayered piezomagnetic/piezoelectric composite with periodic interface cracks under magnetic or electric field显示文摘 | Yongping Wan Yanpeng Yue Zheng Zhong | 2012 | Engineering Fracture Mechanics2012，，： | 1 |
| 16 | Non-linear constitutive relations for magnetostrictive materials显示文摘 | Wan Yongping Fang Daining Hwang K C | 2003 | International Journal Non linear Mechanics2003，38，7： | 1 |
| 17 | Variational bounds of the effective moduli of piezoelectric composites显示文摘The classical Hashin-Shtrikman variational principle was re-generalized to the heterogeneous piezoelectric materials.The auxiliary problem is very much simplified by selecting the reference medium as a linearly isotropic elastic medium.The electromechanical fields in the inhomogeneous piezoelectrics are simulated by introducing into the homogeneous reference medium certain eigenstresses and eigen electric fields.A closed-form solution can be obtained for the disturbance fields,which is convenient for the manipulation of the energy functional.As an application,a two-phase piezoelectric composite with nonpiezoelectric matrix is considered.Expressions of upper and lower bounds for the overall electromechanical moduli of the composite can be developed.These bounds are shown better than the Voigt-Reuss type ones. | WAN YongPing XIE LongTao ZHONG Zheng | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，11： | 0 |
| 18 | Theoretical study on dynamic effective electroelastic properties of random piezoelectric composites with aligned inhomogeneities显示文摘The closed-form solutions of the dynamic problem of heterogeneous piezoelectric materials are formulated by introducing polarizations into a reference medium and using the generalized reciprocity theorem.These solutions can be reduced to the ones of an elastodynamic problem.Based on the effective medium method,these closedform solutions can be used to establish the self-consistent equations about the frequencydependent effective parameters,which can be numerically solved by iteration.Theoretical predictions are compared with the experimental results,and good agreement can be found.Furthermore,the analyses on the effects of microstructure and wavelength on the effective properties,resonance frequencies,and attenuation are also presented,which may provide some guidance for the microstructure design and analysis of piezoelectric composites. | Yanpeng YUE Yongping WAN | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，4： | 0 |
| 19 | Simulated and Experimental Study of Seabed Sediments Sampling Parameters Based on the VOF Method显示文摘Sediments in the seabed hold vital clues to the study of marine geology,microbial communities and history of ocean life,and the remote operated vehicle(ROV)mounted tubular sampling is an important way to obtain sediments.However,sampling in the seabed is a particularly difficult and complicated task due to the difficulty accessing deep water layers.The sampling is affected by the sampler’s structural parameters,operation parameters and the interaction between the sampling tube and sediments,which usually results in low volume and coring rate of sediments obtained.This paper simulated the soft viscous seabed sediments as non-Newtonian Herschel-Bulkley viscoplastic fluids and established a numerical model for the tubular sampling based on the volume of fluid(VOF)method.The influence rules of the sampling tube diameter,drainage area rate,penetration velocity,and sediments dynamic viscosity on coring rate and volume were studied.The results showed that coring volume was negatively correlated with all the parameters except the sampling tube diameter.Furthermore,coring rate decreased with increases in penetration velocity,drainage area rate,and sediments dynamic viscosity.The coring rate first increased and then decreased with increasing of the sampling tube diameter,and the peak value was also influenced by penetration velocity.Then,based on the numerical simulation results,an experimental sampling platform was set up and real-world sampling experiments were conducted.The simulation results tallied with the experimental results,with a maximum absolute error of only 4.6%,which verified that the numerical simulation model accurately reflected real-world sampling.The findings in this paper can provide a theoretical basis for facilitating the optimal design of the geometric structure of the seabed sediments samplers and the parameters in the sampling process. | Shudong He Youduo Peng Yongping Jin Jian Yan Buyan Wan | 2022 | Chinese Journal of Mechanical Engineering2022，35，2： | 0 |
| 20 | Comparison of Hematoxylin-eosin Staining and Methyl Violet Staining for Displaying Ghost Cells显示文摘Purpose:.To compare the merits and limitations of hematoxylin-eosin(HE) and methyl violet staining for displaying ghost cells from vitreous or aqueous humor.Methods:.A specimen containing ghost cells was adjusted to five different concentrations:(12×104,.10×104,.8×104, 6×104and 4×104cells / ml) and subjected to smearing and methyl violet and HE staining..The staining results were observed by light microscopy.Results: The ghost cells were readily observed at a cell density of > 8×104cells / ml with methyl violet staining,.but only a few cells were occasionally seen at lower cell densities..In contrast,.ghost cells were seen at all cell densities with HE staining.Conclusion: Methyl violet staining is more rapid and simpler for the identification of ghost cells, but its staining color more readily fades, the slides cannot be stored, and it is only effective at a cell density of > 8 ×104cells / ml. In contrast,.HE staining is more time-consuming but it can display cell morphology and distinguish cell components more explicitly and slides can be permanently stored. HE staining has advantages over methyl violet staining in detecting the ghost cells when the concentration is < 8×104cells / ml. | Wenxin Zhang Yongping Li Jianxian Lin Shangtao Wan Huanhuan Gao Lanzhi Zhang Jianliang Zheng Ping Zhang | 2013 | Eye Science2013，28，3： | 0 |
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