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| 1 | Deep Learning in Medical Ultrasound Analysis: A Review显示文摘Ultrasound (US) has become one of the most commonly performed imaging modalities in clinical practice. It is a rapidly evolving technology with certain advantages and with unique challenges that include low imaging quality and high variability. From the perspective of image analysis, it is essential to develop advanced automatic US image analysis methods to assist in US diagnosis and/or to make such assessment more objective and accurate. Deep learning has recently emerged as the leading machine learning tool in various research fields, and especially in general imaging analysis and computer vision. Deep learning also shows huge potential for various automatic US image analysis tasks. This review first briefly introduces several popular deep learning architectures, and then summarizes and thoroughly discusses their applications in various specific tasks in US image analysis, such as classification, detection, and segmentation. Finally, the open challenges and potential trends of the future application of deep learning in medical US image analysis are discussed. | Shengfeng Liu Yi Wang Xin Yang Baiying Lei Li Liu Shawn Xiang Li Dong Ni Tianfu Wang | 2019 | Engineering2019，5，2： | 24 |
| 2 | The RppC-AvrRppC NLR-effector interaction mediates the resistance to southern corn rust in maize显示文摘Southern corn rust(SCR),caused by the fungal pathogen Puccinia polysora,is a major threat to maize pro-duction worldwide.Efficient breeding and deployment of resistant hybrids are key to achieving durable control of SCR.Here,we report the molecular cloning and characterization of RppC,which encodes an NLR-type immune receptor and is responsible for a major SCR resistance quantitative trait locus.Further-more,we identified the corresponding avirulence effector,AvrRppC,which is secreted by P.polysora and triggers RppC-mediated resistance.Allelic variation of AvrRppC directly determines the effectiveness of RppC-mediated resistance,indicating that monitoring of AvrRppC variants in the field can guide the rational deployment of RppC-containing hybrids in maize production.Currently,RppC is the most frequently deployed SCR resistance gene in China,and a better understanding of its mode of action is crit-ical for extending its durability. | Ce Deng April Leonard James Cahill Meng Lv Yurong Li Shawn Thatcher Xueying Li Xiaodi Zhao Wenjie Du Zheng Li Huimin Li Victor Llaca Kevin Fengler Lisa Marshall Charlotte Harris Girma Tabor Zhimin Li Zhiqiang Tian Qinghua Yang Yanhui Chen Jihua Tang Xintao Wang Junjie Hao Jianbing Yan Zhibing Lai Xiaohong Fei Weibin Song Jinsheng Lai Xuecai Zhang Guoping Shu Yibo Wang Yuxiao Chang Weiling Zhu Wei Xiong Juan Sun Bailin Li Junqiang Ding | 2022 | Molecular Plant2022，15，5： | 6 |
| 3 | Questions about NgAgo显示文摘 | Shawn Burgess Linzhao Cheng Feng Gu Zhiwei Huang Shuo Lin Jinsong Li Wei Li Wei Qin Yujie Sun Zhou Songyang Wensheng Wei Qiang Wu Haoyi Wang Xiaoqun Wang Jing-Wei Xiong Jianzhong Xi Hui Yang Bin Zhou Bo Zhang Junjiu Huang | 2016 | Protein & Cell2016，7，12： | 5 |
| 4 | 老年女性单周期中度有氧运动后睡眠质量提高:一项初步研究结果(英文)显示文摘背景:睡眠质量差会对健康产生不利影响。目前尚不明确运动能否提高睡眠质量,以及是否会受到运动强度的影响。方法:招募15名身体健康、体重未超标(BMI=24.4±2.1kg/m^2)、习惯久坐(每周运动不超过3次,每次时长<20分钟)的老年女性(年龄:66.1±3.9岁)自愿参加本研究。用梯度运动实验在装有代谢测量表的跑步机上测量耗氧量峰值(VO_(2peak))。经过为期7天的基线期,每位受试者都参与两个热量消耗相同的运动周期(期间间隔一周),但在每天上午9-11点时运动强度会有所不同(60%VO_(2peak)和45%VO_(2peak),顺序随机)。在每一个运动周期中都有2天利用ActiGraph腕动计评估受试者基线期和每次运动后两晚的睡眠质量。结果:中等强度(60%VO_(2peak))与轻度(45%VO_(2peak))运动的平均时长分别为54分钟和72分钟。与没有运动的基线期相比,中度运动的受试者入睡后清醒时间明显缩短(p=0.016),次数减少(p=0.046),总活动计数也降低(p=0.05)。结论:本研究表明单周期中度有氧运动能提高老年女性的睡眠质量。 | Xuewen Wang Shawn D.Youngstedt | 2014 | Journal of Sport and Health Science2014，3，4： | 3 |
| 5 | The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor显示文摘 | Anne E. Powell Yang Wang Yina Li Emily J. Poulin Anna L. Means Mary K. Washington James N. Higginbotham Alwin Juchheim Nripesh Prasad Shawn E. Levy Yan Guo Yu Shyr Bruce J. Aronow Kevin M. Haigis Jeffrey L. Franklin Robert J. Coffey | 2012 | Cell2012，，1： | 2 |
| 6 | Metabolic manifestations of insulin deficiency do not occur without glucagon action显示文摘 | Young Lee Eric D. Berglund May-yun Wang Xiaorong Fu Xinxin Yu Maureen J. Charron Shawn C. Burgess Roger H. Unger | 2012 | Proceedings of the National Academy of Sciences2012，，37： | 2 |
| 7 | Transdermal Delivery of Insulin Using Microneedles in Vivo显示文摘 | Wijaya Martanto Shawn P. Davis Nicholas R. Holiday Jenny Wang Harvinder S. Gill Mark R. Prausnitz | 2004 | Pharmaceutical Research2004，，6： | 2 |
| 8 | Transcriptome analysis of near-isogenic lines provides molecular insights into starch biosynthesis in maize kernel显示文摘Starch is the major component in maize kernels,providing a stable carbohydrate source for humans and livestock as well as raw material for the biofuel industry.Increasing maize kernel starch content will help meet industry demands and has the potential to increase overall yields.We developed a pair of maize near-isogenic lines(NILs) with different alleles for a starch quantitative trait locus on chromosome 3(q HS3), resulting in different kernel starch content. To investigate the candidate genes for q HS3 and elucidate their effects on starch metabolism, RNA-Seq was performed for the developing kernels of the NILs at 14 and 21 d after pollination(DAP). Analysis of genomic and transcriptomic data identified 76 genes with nonsynonymous single nucleotide polymorphisms and 384 differentially expressed genes(DEGs) in the in trogressed fragment, including a hexokinase gene, Zm HXK3 a, which catalyzes the conversion of glucose to glucose-6-phosphate and may play a key role instarch metabolism. The expression pattern of all DEGs in starch metabolism shows that altered expression of the candidate genes for q HS3 promoted starch synthesis,with positive consequences for kernel starch content. These results expand the current understanding of starch biosynthesis and accumulation in maize kernels and provide potential candidate genes to increase starch content. | Yingni Xiao Shawn Thatcher Min Wang Tingting Wang Mary Beatty Gina Zastrow-Hayes Lin Li Jiansheng Li Bailin Li Xiaohong Yang | 2016 | Journal of Integrative Plant Biology2016，58，8： | 2 |
| 9 | Spectroscopic investigation of the interactions between gold nanoparticles and bovine serum albumin显示文摘The interactions between bovine serum albumin(BSA) and gold nanoparticles(AuNPs) ,and the conformational changes of BSA induced by this interaction,were investigated by UV-visible absorption spectroscopy,fluorescence spectroscopy,and Fourier transform infrared in combination with attenuated total reflection spectroscopy(ATR-FTIR) .The critical adsorption density for preventing AuNP aggregation in 0.1 mol/L phosphate buffered saline(pH 7.2) was 23 BSA molecules per gold particle or 3.8×1012 BSA molecules/cm2.BSA bound to the AuNPs with high affinity(binding constant Ks=7.59×108 L/mol) ,and the intrin-sic fluorescence of BSA was quenched by the AuNPs in accordance with the static quenching mechanism.Both fluorescence spectroscopy and ATR-FTIR showed that AuNPs induced conformational changes in BSA,which resulted in it becoming less compact and increased the polarity of the microenvironment around the tryptophan residue Trp-212. | SHI XiuJuan LI Dan XIE Jing WANG Shawn WU ZhaoQiang CHEN Hong | 2012 | Chinese Science Bulletin2012，57，10： | 2 |
| 10 | Use of amino-terminal pro-B-type natriuretic peptide to guide outpatient therapy of patients with chronic left ventricular systolic dysfunction 显示文摘 | JAMES L JANUZZI JR MD SHAFIQ U REHMAN M D ASIM A MOHAMMED M D ANJU BHARDWAJ M D LINDA BARAJAS R N JUSTINE BARAJAS HAN-NA KIM M D MPH AARON L BAGGISH M D RORY B WEINER M D ANNABEL CHEN-TOURNOUX MD JANE E MARSHALL RDCS STEPHANIE A MOORE M D WILLIAM D CARLSON M D GREGORY D LEWIS M D JORDAN SHIN M D DOROTHY SULLIVAN ANP KIMBERLY PARKS D O THOMAS J WANG M D SHAWN A GREGORY M D SHANMUGAM UTHAMALINGAM M D MARC J SEMIGRAN M D | 2011 | J Am Coll Cardiol2011，58，18： | 1 |
| 11 | Synthesis, characterization, and use of asymmetric pyrenyl - gemini suffactants as emissive components in DNA- lipoplex systems 显示文摘 | Chuanzhong Wang Shawn D Wettig Marianna Foldvari Ronald E VerraU | 2007 | Langmuir2007，23，： | 1 |
| 12 | Transdermal Delivery of Insulin Using Microneedles in Vivo显示文摘 | Wijaya Martanto Shawn P. Davis Nicholas R. Holiday Jenny Wang Harvinder S. Gill Mark R. Prausnitz | 2004 | Pharmaceutical Research2004，，6： | 1 |
| 13 | Maize HapMap2 identifies extant variation from a genome in flux 显示文摘 | Jer-Ming Chia Chi Song Peter J Bradbury Denise Cos- tich Natalia de Leon John Doebley Robert J Elshire Brandon Gaut Laura Geller Jeffrey C Glaubitz Michael Gore Kate E Guill Jim Holland Matthew B Hufford Jinsheng Lai Meng Li Xin Liu Yanli Lu Richard Mc- Combie Rebecca Nelson Jesse Poland Boddupalli M Prasanna Tanja Pyhajarvi Tingzhao Rong Rajandeep S Sekhon Qi Sun Maud I Tenaillon Feng Tian Jun Wang Xun Xu Zhiwu Zhang Shawn M Kaeppler Jef- frey Ross-lbarra Michael D McMullen Edward S Buck- ler Gengyun Zhang Yunbi Xu Doreen Ware | 2012 | Nat Genet2012，，44： | 1 |
| 14 | Crystallographic comparison of the estrogen receptor's ligand binding domains显示文摘 | TANENBAUM D M WANG Yang SHAWN P | 1998 | Biochemistry1998，95，： | 1 |
| 15 | CD4(+)CD25(+) treg induction by an HSP60-derived peptide SJMHE1 from schistosoma japonicum is TLR2 dependent显示文摘Chronic schistosome infection results in the suppression of host immune responses, allowing long-term schistosome survival and restricting pathology.Current theories suggest that Treg play an important role in this regulation.However, the mechanism of Treg induction during schistosome infection is still unknown.The aim of this study was to determine the mechanism behind the induction of CD4(+)CD25(+) T cells by Schistosoma japonicum HSP60(SjHSP60)-derived peptide SJMHE1 as well as to elucidate the cellular and molecular basis for the induction of CD4(+)CD25(+) T cells during S.japonicum infection.Mice immunized with SJMHE1 or spleen and LN cells from naive mice pretreated.with SJMHE1 in vitro all displayed an increase in CD4(+)CD25(+) T-cell populations.Release of IL-10 and TGF-beta by SJMHE1 stimulation may contribute to suppression.Adoptively transferred SJMHE1induced CD4(+)CD25(+) T cells inhibited delayed-type hypersensitivity in BALB / c mice.Additionally, SJMHE1-treated APC were tolerogenic and induced CD4(+) cells to differentiate into suppressive CD4(+)CD25(+) Treg.Furthermore, our data support a role for TLR2 in SJMHE1-mediated CD4(+)CD25(+) Treg induction.These findings provide the basis for a more complete understanding of the S.japonicum-host interactions that contribute to host homeostatic mechanisms, preventing an excessive immune response. | Wang, Xuefeng Zhou, Sha Chi, Ying Wen, Xiaoyun Hoellwarth, Jason He, Lei Liu, Feng Wu, Calvin Dhesi, Shawn Zhao, Jiaqing Hu, Wei Su, Chuan | 2010 | 南京医科大学学报(自然科学版)2010，30，1： | 1 |
| 16 | Global transcriptional response of porcine mesenteric lymph nodes to Salmonella enterica serovar Typhimurium显示文摘 | Yanfang Wang Long Qu Jolita J. Uthe Shawn M.D. Bearson Daniel Kuhar Joan K. Lunney Oliver P. Couture Dan Nettleton Jack C.M. Dekkers Christopher K. Tuggle | 2007 | Genomics2007，，1： | 1 |
| 17 | Sensitivity a- nalysis for hydraulic models显示文摘 | Jim W Hall Shawn A Boyce Yueling Wang | 2009 | Journal of Hydraulic Engineer- ing2009，135，11： | 1 |
| 18 | More data on Major depression as an antecedent risk factor for first onset of chronic,back pain显示文摘 | Currie E Shawn R Wang JL | 2005 | Psychological Medicine2005，35，9： | 1 |
| 19 | Structural characterization of thick, high-quality epitaxial Ge on Si substrates grown by low-energy plasma-enhanced chemical vapor deposition显示文摘 | Shawn G. Thomas Sushil Bharatan Robert E. Jones Rainer Thoma Thomas Zirkle N. V. Edwards Ran Liu Xiang Dong Wang Qianghua Xie Carsten Rosenblad Juergen Ramm Giovanni Isella Hans Von K?nel | 2003 | Journal of Electronic Materials2003，，9： | 1 |
| 20 | Tissue engineering of biphasic cartilage constructs using various biodegradable scaffolds:an in vitro study显示文摘 | Wang Xuanhui Shawn P Grogan FR | 2004 | Biomaterials2004，25，17： | 1 |
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