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| 1 | Effect of Jiaweiwumei decoction on regulatory T cells and interleukin-10 in a rat model of ulcerative colitis显示文摘OBJECTIVE:To investigate the effect of a decoction made from the Traditional Chinese Medicine Wumei pill,on regulatory T cells and interleukin-10(IL-10) in a rat model of ulcerative colitis induced by2,4,6-trinitrobenzene sulfonic acid(TNBS).METHODS:Rat ulcerative colitis was induced with TNBS.All modeled rats were randomly divided into six groups:normal control group;model group;sulfasalazine suppositories treatment group;and high,moderate,and low dosage of Jiaweiwumei decoction groups(12 rats each).Colon injury index was evaluated after 14 days.After peripheral blood lymphocyte separation,CD4 + T cells and CD4+/CD25+ T cell percentage was detected by flow cytometry.The content of IL-10 in serum and intestinal mucosa tissue was detected by sandwich enzyme-linked immunosorbent assay.RESULTS:Colon injury indices in the decoction groups were effectively reduced,compared with the model group(P < 0.05).Compared with that of the control group,the CD4+/CD25+ to CD4+ T lymphocyte ratio of the model group was significantly lower,while the decoction treatment improved the CD4 +/CD25 + to CD4 + T lymphocyte ratio(P <0.05).The serum and mucosal IL-10 content of the model group was significantly lower(P < 0.05) than that in the control group,while the decoction group had significantly higher serum and intestinal mucosal IL-10 content than that in the model group(P < 0.05).The regulatory T cell content was negatively correlated with the colonic injury index(r = 0.68,P < 0.05),and positively correlated with the content of serum IL-10(r = 0.87,P < 0.05) and intestinal mucosal IL-10(r= 0.79,P < 0.05).CONCLUSION:Jiaweiwumei decoction had significant effects on regulatory T cells and IL-10 in rats with TNBS-induced ulcerative colitis. | Tao Mei Wang Xuyan Wang Aiqin Gao Ninghan Pan Jie Liu Xiaoquan Wang Xiaoye | 2015 | Journal of Traditional Chinese Medicine2015，35，3： | 14 |
| 2 | Erosion effect on the productivity of black soil in Northeast China显示文摘Continuous soil erosion has caused serious land degradation in the black soil area of Northeast China. The primary objective of this study was to determine the effects of accelerated erosion on soil productivity, as measured by soybean (Glycine max L. Merr.) yields. Eight erosion levels, 0, 10, 20, 30, 40, 50, 60, and 70 cm, were simulated by imitating the integrated process of natural erosion and tillage activity. Each erosion level had two sub-treatments: conventional fertilization and no fertilization. Soil erosion was found to affect survival probability and to cause remarkable reductions in the Leaf Area Index (LAI), plant height, pod number, biomass, and yield. Soybean yield was exponentially decreased with the increase of soil erosion depth. Compared to erosion depth of 0 cm, erosion levels of 10, 20, 30, 40, 50, 60, and 70 cm experienced reductions in soybean yield by 28.8%, 37.8%, 43.5%, 52.6%, 53.1%, 52.9%, and 64.1% respectively when fertilized whereas the reductions at those levels were 32.6%, 42.2%, 53.0%, 54.0%, 65.8%, 69.7%, and 72.6%, respectively, when unfertilized. At the erosion depths of 10, 20, 30, 40, 50, 60, and 70 cm, the yield reductions per 10 cm of soil eroded when fertilized were 28.8%, 18.9%, 14.5%, 13.2%, 10.6%, 8.8%, and 9.2%, averaged 14.9%, but when unfertilized they were 32.6%, 21.1%, 17.7%, 13.5%, 13.2%, 11.6%, and 10.4%, averaged 17.1%. The results also showed that chemical fertili zers could enhance the yields of eroded soil, but could not recover the yields to the pre-erosion level. Additionally, the results indicated that the primary reason for the decrease in soybean yield with increasing erosion depth was the loss of soil organic matter, soil N and P. These results may aid in selecting effective soil erosion control strategy, forecasting land degradation, establishing soil erosion tolerance, and evaluating the economic cost of soil erosion in the black soil region in Northeast China. | WANG ZhiQiang LIU BaoYuan WANG XuYan GAO XiaoFei LIU Gang | 2009 | Science China Earth Sciences2009，52，7： | 9 |
| 3 | The zinc transporter Slc39a5 controls glucose sensing and insulin secretion in pancreatic β-cells via Sirt1- and Pgc-1α-mediated regulation of Glut2显示文摘Zinc levels are high in pancreatic β-cells, and zinc is involved in the synthesis, processing and secretion of insulin in these cells. However, precisely how cellular zinc homeostasis is regulated in pancreatic β-cells is poorly understood. By screening the expression of 14 Slc39a metal importer family member genes, we found that the zinc transporter Slc39a5 is significantly downregulated in pancreatic β-cells in diabetic db/db mice, obese ob/ob mice and high-fat diet-fed mice. Moreover,β-cell-specific Slc39a5 knockout mice have impaired insulin secretion. In addition, Slc39a5-deficient pancreatic islets have reduced glucose tolerance accompanied by reduced expression of Pgc-1α and its downstream target gene Glut2. The down-regulation of Glut2 in Slc39a5-deficient islets was rescued using agonists of Sirt1, Pgc-1α and Ppar-γ. At the mechanistic level, we found that Slc39a5-mediated zinc influx induces Glut2 expression via Sirt1-mediated Pgc-1α activation. These findings suggest that Slc39a5 may serve as a possible therapeutic target for diabetes-related conditions. | Xinhui Wang Hong Gao Wenhui Wu Enjun Xie Yingying Yu Xuyan He Jin Li Wanru Zheng Xudong Wang Xizhi Cao Zhuoxian Meng Ligong Chen Junxia Min Fudi Wang | 2019 | Protein & Cell2019，10，6： | 6 |
| 4 | Study on Dynamic Spectrum Management Model for Interactive Cognitive Radio显示文摘 | MA Zhonggui ZHOU Xianwei WANG Hongbo TU Xuyan | 2010 | Chinese Journal of Electronics2010，19，1： | 3 |
| 5 | A Real-time Compensation Strategy for Non-contact Gaze Tracking Under Natural Head Movement显示文摘 | HUANC Ying WANG Zhiliang TU Xuyan | 2010 | Chinese Journal of Electronics2010，19，3： | 2 |
| 6 | Molecular Characterisation of the Faecal Microbiota in Patients with Type II Diabetes显示文摘 | Xiaokang Wu Chaofeng Ma Lei Han Muhammad Nawaz Fei Gao Xuyan Zhang Pengbo Yu Chang’an Zhao Lianchuan Li Aiping Zhou Juan Wang John E. Moore B. Cherie Millar Jiru Xu | 2010 | Current Microbiology2010，，1： | 2 |
| 7 | E3 ligase FBXW7 aggravates TMPD-induced systemic lupus erythematosus by promoting cell apoptosis显示文摘Systemic lupus erythematosus(SLE)is a systemic autoimmune disease,and the pathogenesis of SLE has not been fully elucidated.The E3 ubiquitin ligase FBXW7 has been well characterized in cancer as a tumor suppressor that can promote the ubiquitination and subsequent degradation of various oncoproteins;however,the potential role of FBXW7 in autoimmune diseases is unclear.In the present study,we identified that FBXW7 is a crucial exacerbating factor for SLE development and progression in a mouse model induced by 2,6,10,14-tetramethylpentadecane(TMPD).Myeloid cell-specific FBXW7-deficient(Lysm+FBXW7f/f)C57BL/6 mice showed decreased immune complex accumulation,glomerulonephritis,glomerular mesangial cell proliferation,and basemembrane thickness in the kidney.Lysm+FBXW7f/f mice produced fewer anti-Sm/RNP and anti-ANA autoantibodies and showed a decreased MHC II expression in B cells.In Lysm+FBXW7f/f mice,we observed that cell apoptosis was reduced and that fewer CD11b+Ly6Chi inflammatory monocytes were recruited to the peritoneal cavity.Consistently,diffuse pulmonary hemorrhage(DPH)was also decreased in Lysm+FBXW7f/f mice.Mechanistically,we clarified that FBXW7 promoted TMPD-induced cell apoptosis by catalyzing MCL1 degradation through K48-linked ubiquitination.Our work revealed that FBXW7 expression in myeloid cells played a crucial role in TMPD-induced SLE progression in mice,which may provide novel ideas and theoretical support for understanding the pathogenesis of SLE. | Zhenlu Chong Chunjing Bao Jia He Tianxiao Chen Lijia Zhong Gaopeng Li Huanle Li Lutong Fang Yinjing Song Guoxiang Fu Xuyan Yang Lihua Lai Yang Liu Qingqing Wang | 2018 | Cellular & Molecular Immunology2018，15，12： | 2 |
| 8 | Methylation of 2-methylnaphthalene with methanol to 2,6-dimethylnaphtha- lene over ZSM-5 modified by Zr and Si 显示文摘 | Jin Lijun Hu Haoquan Wang Xuyan | 2006 | Ind Eng Chem Res2006，45，10： | 1 |
| 9 | Impact of Climate Change on Reference Crop Evapotranspiration in Chuxiong City, Yunnan Province显示文摘 | Wen Jun Wang Xinhua Guo Meihua XU Xuyan | 2012 | Procedia Earth and Planetary Science2012，，： | 1 |
| 10 | Xiaoaiping injection combined with cisplatin and gemcitabine for non-small cell lung cancer:a meta-analysis显示文摘目的:评价消癌平注射液辅助吉西他滨加顺铂(GP)化疗方案治疗晚期非小细胞肺癌(Nonsmall Cell Lung Cancer,NSCLC)的临床疗效。方法:计算机检索Cochrane Library,Pubmed,Embase,中国期刊全文数据库,中国生物医学文献数据库,中国科技期刊全文数据库和万方数据库中关于消癌平注射液辅助GP化疗方案治疗晚期非小细胞肺癌的随机对照试验(randomized controlled trial,RCT),检索时间限定为建库至2018年12月。Cochrane偏倚风险评估工具进行偏倚风险评估。Revman5.3.0进行数据分析。结果:最终纳入7个研究,共534例患者。Meta分析结果显示:与单纯GP化疗方案相比,消癌平注射液辅助GP化疗方案组的总有效率[OR=1.39,95%CI(0.97,1.98),P=0.07]和胃肠道反应发生率[OR=0.44,95%C I(0.16,1.23),P=0.12],差异无统计学意义;消癌平注射液辅助GP化疗方案组的血红蛋白的下降率[OR=0.49,95%CI(0.26,0.92),P=0.03]、白细胞的下降率[OR=0.40,95%CI(0.21,0.74),P=0.004]及血小板的下降率[OR=0.43,95%CI(0.22,0.87),P=0.02]均低于单纯GP化疗方案组,同时功能状态[OR=3.78,95%CI(2.24,6.38),P<0.0001]优于单纯GP化疗方案组。结论:消癌平注射液辅助GP化疗方案治疗晚期非小细胞肺癌有一定疗效,鉴于文献质量,仍需高质量随机对照试验的进行验证。 | Yue Ji Lin Wang Changying Chen Yihua Fan Xuyan Wang Hongtao Yang | 2019 | TMR Clinical Research2019，2，1： | 1 |
| 11 | Molecular cloning, expression and biochemical property analysis of AtKP1, a kinesin gene from Arabidopsis thaliana显示文摘Kinesins are common in a variety of eukaryotic cells with diverse functions. A cDNA encoding a member of the Kinesin-14B subfamily is obtained using 3′-RACE technology and named AtKP1 (for Arabidopsis kinesin protein 1). This cDNA has a maximum open reading frame of 3.3 kb encoding a polypeptide of 1087 aa. Protein domain analysis shows that AtKP1 contains the motor domain and the calponin homology domain in the central and amino-terminal regions, respectively. The carboxyl-terminal region with 202 aa residues is diverse from other known kinesins. Northern blot analysis shows that AtKP1 is widely expressed at a higher level in seedlings than in mature plants. 2808 bp of the AtKP1 promoter region is cloned and fused to GUS. GUS expression driven by the AtKP1 promoter region shows that AtKP1 is mainly expressed in vasculature of young organs and young leaf trichomes, indicating that AtKP1 may participate in the differentiation or development of Arabidopsis thaliana vascular bundles and trichomes. A truncated AtKP1 protein containing the putative motor domain is expressed in E. coli and affinity-purified. In vitro characterizations indicate that the polypeptide has nucleotide-dependent microtubule-binding ability and microtubule-stimulated ATPase activity. | LI XuYan WANG HaiQing XU Tao CAO QinHong REN DongTao LIU GuoQin | 2007 | Chinese Science Bulletin2007，52，10： | 1 |
| 12 | Changing Trends of Reference Crop Evapotranspiration and Impact Fac tors in Yunnan Mengzhi Plain in Recent 50 Years显示文摘 | WANG Xinhua GUO Meihua XU Xuyan | 2012 | Procedia Earth and Planetary Science2012，5，： | 1 |
| 13 | Tooth number abnormality:from bench to bedside显示文摘Tooth number abnormality is one of the most common dental developmental diseases,which includes both tooth agenesis and supernumerary teeth.Tooth development is regulated by numerous developmental signals,such as the well-known Wnt,BMP,FGF,Shh and Eda pathways,which mediate the ongoing complex interactions between epithelium and mesenchyme.Abnormal expression of these crutial signalling during this process may eventually lead to the development of anomalies in tooth number;however,the underlying mechanisms remain elusive.In this review,we summarized the major process of tooth development,the latest progress of mechanism studies and newly reported clinical investigations of tooth number abnormality.In addition,potential treatment approaches for tooth number abnormality based on developmental biology are also discussed.This review not only provides a reference for the diagnosis and treatment of tooth number abnormality in clinical practice but also facilitates the translation of basic research to the clinical application. | Han Zhang Xuyan Gong Xiaoqiao Xu Xiaogang Wang Yao Sun | 2023 | International Journal of Oral Science2023，15，1： | 1 |
| 14 | Service Oriented Dynamic Coordination Method Based on Role for Multi-level Hierarchical Information Systems显示文摘 | WANG Chengyao ZHENG Xuefeng TU Xuyan GAO Shaobo | 2013 | Chinese Journal of Electronics2013，22，2： | 1 |
| 15 | Methylation of 2-Methylnaphthalene with Methanol to 2, 6-Dimethylnaph- thalene over ZSM-5 Modified by Zr and Si 显示文摘 | Jin Lijun Hu Haoquan Wang Xuyan | 2006 | Ind Eng Chem Res2006，45，10： | 1 |
| 16 | Shuffled Mutation Glowworm Swarm Optimization and Its Application显示文摘If the glowworm individual has no memory during its movement,and the decision of next direction is limited to its current position.It is precisely these reasons mentioned above that make the basic Glowworm Swarm Optimization easy to trap into the local optimum.In order to solve the problem,this paper suggests a Shuffled mutation glowworm swarm optimization(SMGSO),which combines the thought of Shuffled Frog Leaping with Glowworm Swarm Optimization.Making use of a grouping idea of Shuffled Mutation,the glowworm swarm is divided into several subgroups.The location updating of each individual is not only influenced by the brightest node in neighbour scope,but also by the brightest one in their local subgroup,meanwhile the locations of those isolated nodes are updated by the difference mutation of the global optimum and local optimal.In group shuffling stage,an orthogonal strategy can guide the whole population to generate their offspring.The performance of this proposed approach is examined by well-known10 benchmark functions,and its obtained results are compared with what other variants hold.The experimental analysis show that the Shuffled mutation glowworm swarm optimization is effective and outperforms other variants in terms of solving multi-modal function optimization problems,and the proposed approach can improve the positioning accuracy of the centroid localization. | WANG Hongbo REN Xuena TU Xuyan | 2019 | Chinese Journal of Electronics2019，28，4： | 0 |
| 17 | Sulfur vacancies-doped Sb_(2)S_(3) nanorods as high-efficient electrocatalysts for dinitrogen fixation under ambient conditions显示文摘Tuning surface electron transfer process by sulfur(S)-vacancies engineering is an efficient strategy to develop high-efficient catalysts for electroreduction N_(2) reaction(NRR). Herein, the distinct Sb_(2)S_(3) nanorods with S-vacancies(Sv-Sb_(2)S_(3)) have been synthesized by a simple twostep method including hydrothermal and hydrogenation in H_(2)/Ar atmosphere, which shows improved performance for NRR with the NH_(3) yield rate of 10.85 μg h^(-1) mgcat^(-1) at-0.4 V vs. RHE, the faradaic efficiency(FE) of 3.75% at -0.3 V vs. RHE and excellent stability for 24 h, largely outperforming bulk Sb_(2)S_(3). X-ray photoelectron spectroscopy(XPS) and density function theory(DFT) calculations demonstrate that the abundant S-vacancies can create an electron-deficient environment and modulate the electron delocalization in Sv-Sb_(2)S_(3), which can not only facilitate the N_(2) molecule adsorption, but also activate the N≡N, resulting in the enhanced performance for NRR. | Xuyan Wang Jianwei Bai Yantao Wang Xiaoying Lu Zehua Zou Junfeng Huang Cailing Xu | 2022 | Green Energy & Environment2022，7，4： | 0 |
| 18 | 1α,25(OH)2D3对斑马鱼脂肪组织中脂肪酸氧化的促进显示文摘文章简介1α,25(OH)2D3被认为是哺乳类动物的矿物质代谢的重要调控激素,但其在动物脂肪组织代谢中的精确机制却不够清晰。肝细胞微小体中的细胞色素P450酶2R1(CYP2R1)是活化维生素D3的第一步,即25位的羟基化的羟基化酶,此功能在脊椎动物中是保守。 | Xuyan Peng Guohui Shang Wenqing Wang Xiaowen Chen Qiyong Lou Gang Zhai Dongliang Li Zhenyu Du Yali Ye Xia Jin Jiangyan He Yi Zhang 殷战 | 2018 | 科学新闻2018，0，4： | 0 |
| 19 | A Weighted Combination Forecasting Model for Power Load Based on Forecasting Model Selection and Fuzzy Scale Joint Evaluation显示文摘To solve the medium and long term power load forecasting problem,the combination forecasting method is further expanded and a weighted combination forecasting model for power load is put forward.This model is divided into two stages which are forecasting model selection and weighted combination forecasting.Based on Markov chain conversion and cloud model,the forecasting model selection is implanted and several outstanding models are selected for the combination forecasting.For the weighted combination forecasting,a fuzzy scale joint evaluation method is proposed to determine the weight of selected forecasting model.The percentage error and mean absolute percentage error of weighted combination forecasting result of the power consumption in a certain area of China are 0.7439%and 0.3198%,respectively,while the maximum values of these two indexes of single forecasting models are 5.2278%and 1.9497%.It shows that the forecasting indexes of proposed model are improved significantly compared with the single forecasting models. | Bingbing Chen Zhengyi Zhu Xuyan Wang Can Zhang | 2021 | Energy Engineering2021，118，5： | 0 |
| 20 | Fast ion diffusion alloy layer facilitating 3D mesh substrate for dendrite-free zinc-ion hybrid capacitors显示文摘Although aqueous zinc ion hybrid capacitors have advantageous integration of batteries and supercapacitors,they still suffer from the inherent problems of dendrite growth and interfacial side reactions on Zn anodes.Herein,a universal fast zinc-ion diffusion layer on a three-dimensional(3 D)mesh structure model is demonstrated to effectively improve Zn plating/stripping reversibility.The fast ion diffusion alloy layer accelerates the Zn^(2+)migration in an orderly manner to homogenize Zn^(2+)flux and overcomes the defects of the commercial mesh substrate,effectively avoiding dendrite growth and side reactions.Consequently,the proof-of-concept silver-zinc alloy modified stainless steel mesh delivers superb reversibility with the high coulombic efficiency over 99.4%at 4 mA cm^(-2)after 1600 cycles and excellent reliability of over 830 h at 1 mA cm^(-2),Its feasibility is also evidenced in commercial zinc ion hybrid capacitors with activated carbon as the cathode.This work enriches the fundamental comprehension of fast zinc-ion diffusion layer combined with a 3 D substrate on the Zn deposition and opens a universal approach to design advanced host for Zn electrodes in zinc ion hybrid capacitors. | Huaming Yu Quanyu Li Wen Liu Han Wang Xuyan Ni Qiwen Zhao Weifeng Wei Xiaobo Ji Yuejiao Chen Libao Chen | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
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