|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 2 | Species-specific detection and quantification of scyphomedusae in Jiaozhou Bay,China,using a quantitative real-time PCR assay显示文摘Over the past decades,jellyfish occurred increasingly and abundantly in coastal areas worldwide.Usually,biomass of jellyfish,especially when they bloom,can be determined by visual counting.However,tiny individuals of jellyfish(e.g.,planulae,polyps,and ephyrae)are difficult to detect in the field.In this study,species-specific quantitative real-time PCR assays(qPCR)(SYBR Green I)targeting the mitochondrial 16S rDNA(mt-16S rDNA)of jellyfish were developed and were used to estimate the distribution and seasonal fluctuations of four jellyfish species(Nemopilema nomurai,Cyanea nozakii,Rhopilema esculentum,and Aurelia coerulea)in Jiaozhou Bay(JZB),China in 2013.The mt-16S rDNA of A.coerulea and N.nomurai was detected in most of the survey months and it peaked in July(1.03×10^(4) copies/L)and September(1.08×10^(6) copies/L),respectively.The mt-16S rDNA of C.nozakii occurred from August to October only with monthly mean values of 7.18-46.17 copies/L and was mainly located from the middle part to the outer part of the bay.The mt-16S rDNA of R.esculentum was the least abundant among the four species and was detected in only one sample(B2 station in March),with a value of 88.49 copies/L.The Spearman correlation test revealed that phytoplankton biomass was significantly and positively correlated with the mt-16S rDNA abundance of A.coerulea(R=0.37,P<0.01)and negatively with the mt-16S rDNA of N.nomurai(R=-0.36,P<0.01).The qPCR assay will enable the identification and quantification of jellyfish species in their whole life history and can be used as an approach in combination of the traditional jellyfish survey. | Jianyan WANG Tiezhu MI Zhigang YU Guoshan WANG Qinsheng WEI Jing YANG Yu ZHEN | 2021 | Journal of Oceanology and Limnology2021，39，4： | 3 |
| 3 | Brief Introduction about the SVOM Mission显示文摘SVOM is a mission dedicated for studying γ-Ray Bursts, and will also be a powerful target-ofopportunity observatory for the whole astronomy community. The mission has been approved jointly by both Chinese and French space agencies. It is planned to be in the orbit in 2021 with an altitude ≤600 km and an inclination ≤30°. | WEI Jianyan | 2018 | 空间科学学报2018，38，5： | 1 |
| 4 | A quasar possibly ejected from NGC4579显示文摘With the 2.16 m telescope at Beijing Astronomical Observatory, it is identified that a compact X-ray source detected by ROSAT located in the vicinity of 5’ .9 from the LINER galaxy NGC4579 is a quasar with a redshift z = 0.106. A further analysis indicates that this quasar is possibly ejected from NGC4579. | ZHU Xingfen CHU Yaoquan WEI Jianyan ZHANG Haotong HU Jingyao | 2000 | Chinese Science Bulletin2000，45，10： | 0 |
| 5 | Progress on SVOM Satellite Development显示文摘SVOM(Space-based multiband astronomical Variable Objects Monitor)is a Chinese-French space mission dedicated to studying Gamma-Ray Bursts.The satellite has four instruments to detect and localize the prompt GRB emission and measure the evolution of the afterglow in the visible band and in X-rays,and a VHF communication system enabling the fast transmission of SVOM alerts to the ground.The ground segment includes an array of wide-angle cameras and two follow-up telescopes.It was planned to be in orbit in 2021,and now has to be delayed about six months because of COVID-19 epidemic. | WEI Jianyan | 2020 | 空间科学学报2020，40，5： | 0 |
| 6 | Detecting the intrinsic Baldwin Effect of the optical FeII complex in Luminous Seyfert 1 Galaxy Fairall 9显示文摘We analyze the optical spectra of Fairall 9,a luminous Seyfert 1 galaxy.They are obtained from the AGN Watch program that has monitored this object for 9 months.The flux and variation of the optical FeII complex is measured using multi-component profile modeling with FeⅡ templates.A convincing intrinsic Baldwin Effect(BEff) of optical FeⅡ emission blends in Fairall 9 is discovered for the first time.The variation of FeⅡ/Hβ(RFe) in Fairall 9 is obtained.We also detect a marginal anti-correla tion between RFe and the continuum flux in its spectra.This anti-correlation and the relatively broad profile of Hβ in this galaxy support the dichotomy reported by Wang et al.(2005). | HAN XuHui WANG Jing WEI JianYan YANG DaWei HOU JinLiang | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，2： | 0 |
| 7 | LUT:A Lunar-based Ultraviolet Telescope显示文摘The Lunar-based Ultraviolet Telescope (LUT) is a funded lunar-based ultraviolet telescope dedicated to continuously monitoring variable stars for as long as dozens of days and performing low Galactic latitude sky surveys. The slow and smooth spin of the Moon makes its step by step pointing strategy possible. A flat mirror mounted on a gimbal mount is configured to enlarge the sky coverage of the LUT. A Ritchey-Chrétien telescope with a Nasmyth focus configuration is adopted to reduce the total length of the system. A UV enhanced back illuminated AIMO CCD 47-20 chip together with the low noise electric design will minimize the instrumental influence on the system. The preliminary proposal for astrometric calibration and photometric calibration are also presented. | CAO Li RUAN Ping CAI HongBo DENG JinSong HU JingYao JIANG XiaoJun LIU ZhaoHui QIU YuLei WANG Jing WANG Shen YANG JianFeng ZHAO Fei WEI JianYan | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员