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| 1 | Anisotropic coding metamaterials and their powerful manipulation of differently polarized terahertz waves显示文摘Metamaterials based on effective media can be used to produce a number of unusual physical properties(for example,negative refraction and invisibility cloaking)because they can be tailored with effective medium parameters that do not occur in nature.Recently,the use of coding metamaterials has been suggested for the control of electromagnetic waves through the design of coding sequences using digital elements‘0’and‘1,'which possess opposite phase responses.Here we propose the concept of an anisotropic coding metamaterial in which the coding behaviors in different directions are dependent on the polarization status of the electromagnetic waves.We experimentally demonstrate an ultrathin and flexible polarization-controlled anisotropic coding metasurface that functions in the terahertz regime using specially designed coding elements.By encoding the elements with elaborately designed coding sequences(both 1-bit and 2-bit sequences),the x-and y-polarized waves can be anomalously reflected or independently diffused in three dimensions.The simulated far-field scattering patterns and near-field distributions are presented to illustrate the dual-functional performance of the encoded metasurface,and the results are consistent with the measured results.We further demonstrate the ability of the anisotropic coding metasurfaces to generate a beam splitter and realize simultaneous anomalous reflections and polarization conversions,thus providing powerful control of differently polarized electromagnetic waves.The proposed method enables versatile beam behaviors under orthogonal polarizations using a single metasurface and has the potential for use in the development of interesting terahertz devices. | Shuo Liu Tie Jun Cui Quan Xu Di Bao Liangliang Du Xiang Wan Wen Xuan Tang Chunmei Ouyang Xiao Yang Zhou Hao Yuan Hui Feng Ma Wei Xiang Jiang Jiaguang Han Weili Zhang Qiang Cheng | 2016 | Light(Science & Applications)2016，5，1： | 36 |
| 2 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 3 | Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro显示文摘 | Jia-lin DUAN Jing-wen WANG Yue GUAN Ying YIN Guo WEI Jia CUI Dan ZHOU Yan-rong ZHU Wei QUAN Miao-miao XI Ai-dong WEN | 2013 | Acta Pharmacologica Sinica2013，34，4： | 27 |
| 4 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 5 | Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro显示文摘OBJECTIVE: To determine the cardioprotective effect of magnesium lithospermate B (MLB) on myocardial ischemia/reperfusion (MI/R) injury and to investigate the antioxidant potential in vivo and in vitro. METHODS: MI/R injury was induced by the occlusion of left anterior descending coronary artery for 30 min followed by reperfusion for 3 h in rats. After reperfusion, hearts were harvested to assess infarct size, histopathological damages, the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA). Blood samples were col- lected to determine serum levels of creatine kinase-MB (CK-MB), cardiac troponin (cTnI) and lactate dehydrogenase (LDH). Furthermore, simulatedischemia/reperfusion (SI/R) injury in vitro was established by oxygen and glucose deprivation (OGD) for 2 h followed by 24-hour recovery period in cardiomyocytes. The activity of LDH in the cultured supernatant and the levels of intracellular reactive oxygen species (ROS), SOD and MDA in cardiomyocytes were also measured. Finally, cardiomyocytes apoptosis was determined with flow cytometry. RESULTS: MLB significantly limited infarct size, ameliorated histopathological damages and prevented leakage of CK-MB, cTnI and LDH. Additionally, SOD, CAT, GPx and GSH activities were notably increased by MLB, along with the MDA content decreased as compared with the model group in rats. In vitro study, MLB also decreased LDH activity in the cultured supernatant, increased SOD activity in cardiomyocytes, reduced intracellular ROS and MDA levels, and significantly suppressed cardiomyocytes apoptosis. CONCLUSION: MLB possessed remarkably cardioprotective effects on MI/R injury in vivo and in vitro. The protection of MLB may contribute to its antioxidant properties. | Wei Quan Ying Yin Miaomiao Xi Dan Zhou Yanrong Zhu Yue Guan Chao Guo Yanhua Wang Jialin Duan Aidong Wen | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 21 |
| 6 | Nickel-exposed Workers in China: A Cohort Study显示文摘There are more than 50 000 workers in Jinchuan Group Co,Ltd(JNMC).Since all staff in JNMC are eligible for a medical examination every two years,only 23 484 nickel-exposed subjects who participated in medical examination were included in this study.Their data,collected from June 22,2011 to September 28,2012,in a | BAI Ya Na YAGN Ai Min PU Hong Quan HE Jie CHENG Ning ZHENG Tong Zhang DAI Min ZHANG Ya Wei BASSING Bryan WANG Qiu Ying | 2014 | Biomedical and Environmental Sciences2014，27，3： | 20 |
| 7 | Joint Radar and Communication: A Survey显示文摘Joint radar and communication(JRC)technology has become important for civil and military applications for decades.This paper introduces the concepts,characteristics and advantages of JRC technology,presenting the typical applications that have benefited from JRC technology currently and in the future.This paper explores the state-of-the-art of JRC in the levels of coexistence,cooperation,co-design and collaboration.Compared to previous surveys,this paper reviews the entire trends that drive the development of radar sensing and wireless communication using JRC.Specifically,we explore an open research issue on radar and communication operating with mutual benefits based on collaboration,which represents the fourth stage of JRC evolution.This paper provides useful perspectives for future researches of JRC technology. | Zhiyong Feng Zixi Fang Zhiqing Wei Xu Chen Zhi Quan Danna Ji | 2020 | China Communications2020，17，1： | 19 |
| 8 | Chemokine SR-PSOX/CXCL16 expression in peripheral blood of patients with acute coronary syndrome显示文摘背景:绑 phosphatidylserine 和氧化 lipoprotein/CXC chemokine ligand 的清道工人受体(SR-PSOX/CXCL16 ) 16 通过肿瘤坏死因素(TNF ) 支持泡沫房间形成 -alpha 调停了机制。因为 chemokine CXCL16 能在动脉粥样硬化患者损害和 induce 平滑肌房间(SMC ) 增长被表示,我们想在病人的外部血的单核白血球 SR-PSOX/CXCL16 察觉将为动脉粥样硬化的早诊断和预后是重要的(作为) 。方法:在这注册了学习是有急性冠的症候群(交流) 的 40 个病人,包括有尖锐心肌的梗塞(AMI ) 的 20 个病人和有不稳定的心绞痛(UAP ) 的 20 个病人,并且 20 正常控制。在外部血的单核白血球被孤立,并且 CXCL16/SR-PSOX mRNA 的表示的变化用反向的抄写聚合酶链反应(RT-PCR ) 被比较,与象内部控制的贝它肌动朊。我们在 ACS 亚群比较了 CXCL16/SR-PSOX 的表示,用对分析蛋白质表示层次西方污点。组织节由象正常控制一样与易传染的心内膜炎,肝肝硬化,和肺癌症从病人拿的活体检视标本制造了。并且 CXCL16/SR-PSOX 的表示与一台共焦的显微镜被分析。结果:在外部血的单核白血球的 CXCL16/SR-PSOX mRNA 和蛋白质的表示比在正常控制在交流病人是显著地更高的(P <
0.05 ) ;然而,在在 UAP 组和 AMI 组之间的 CXCL16/SR-PSOX 表示没有有效差量(P >
0.05 ) 。Immunofluorescence 证明有在正常脉管的 endothelial 的 SR-PSOX 的低表示并且在感染的容器的每层提高了表示,当从 endothelial 传播到包围感染变得更坏的纸巾时。共焦的显微镜学证明 SR-PSOX 的表示在肝肝硬化在渗入的淋巴细胞被提高,并且表示铺平,这对在门 hepatis 和叶的发炎的度相称。结论:在外部血的单核白血球的 CXCL16/SR-PSOX 的表达式比在控制在交流病人是显著地更高的。CXCL16/SR-PSOX-mediated 发炎可以贡献交流的致病,并且 CXCL16 可以在致病和发展起一个重要作用是在人。 | YANG Hui-ling XU Yang-yan DU Li-fen LIU Chang-hui ZHAO Qiang WEI Wu-jie YOU Yong QUAN Zhi-hua | 2008 | Chinese Medical Journal2008，，2： | 17 |
| 9 | Characteristics of pulsed plasma synthetic jet and its control effect on supersonic flow显示文摘The plasma synthetic jet is a novel flow control approach which is currently being studied. In this paper its characteristic and control effect on supersonic flow is investigated both experimentally and numerically. In the experiment, the formation of plasma synthetic jet and its propagation velocity in quiescent air are recorded and calculated with time resolved schlieren method. The jet velocity is up to 100 m/s and no remarkable difference has been found after changing discharge parameters. When applied in Mach 2 supersonic flow, an obvious shockwave can be observed. In the modeling of electrical heating, the arc domain is not defined as an initial condition with fixed temperature or pressure, but a source term with time-varying input power density, which is expected to better describe the influence of heating process. Velocity variation with different heating efficiencies is presented and discussed and a peak velocity of 850 m/s is achieved in still air with heating power density of 5.0 · 1012W/m3. For more details on the interaction between plasma synthetic jet and supersonic flow, the plasma synthetic jet induced shockwave and the disturbances in the boundary layer are numerically researched. All the results have demonstrated the control authority of plasma synthetic jet onto supersonic flow. | Jin Di Cui Wei Li Yinghong Li Fanyu Jia Min Sun Quan Zhang Bailing | 2015 | Chinese Journal of Aeronautics2015，28，1： | 16 |
| 10 | Surgical approaches for stage Ⅰ and Ⅱ thymoma-associated myasthenia gravis:feasibility of complete video-assisted thoracoscopic surgery (VATS) thymectomy in comparison with trans-sternal resection显示文摘Complete resection could be achieved in virtually all myasthenic patients with Masaoka stage Ⅰ and Ⅱ thymoma using the trans-sternal technique.Whether this is appropriate for minimally invasive approach is not yet clear.We evaluated the feasibility of complete video-assisted thoracoscopic surgery (VATS) thymectomy for the treatment of Masaoka stage Ⅰ and Ⅱ thymoma-associated myasthenia gravis,compared to conventional trans-sternal thymectomy.We summarized 33 patients with Masaoka stage Ⅰ and Ⅱ thymoma-associated myasthenia gravis between April 2006 and September 2011.Of these,15 patients underwent right-sided complete VATS (the VATS group) by using adjuvant pneuomomediastinum,comparing with 18 patients using the trans-sternal approach (the T3b group).No intraoperative death was found and no VATS case required conversion to median sternotomy.Significant differences between the two groups regarding duration of surgery and volume of intraoperative blood loss (P=0.001 and P < 0.001,respectively) were observed.Postoperative morbidities were 26.7% and 33.3% for the VATS and T3b groups,respectively.All 33 patients were followed up for 12 to 61 months in the study.The cumulative probabilities of reaching complete stable remission and effective rate were 26.7% (4/15) and 93.3% (14/15) in the VATS group,which had a significantly higher complete stable remission and effective rate than those in the T3b group (P=0.026 and P=0.000,respectively).We conclude that VATS thymectomy utilizing adjuvant pneuomomediastinum for the treatment of stage Ⅰ and Ⅱ thymoma-associated myasthenia gravis is technically feasible but deserves further investigation in a large series with long-term follow-up. | Zhicheng He Quan Zhu Wei Wen Liang Chen Hai Xu Hai Li | 2013 | The Journal of Biomedical Research2013，27，1： | 15 |
| 11 | Phosphorus Status and Risk of Phosphate Leaching Loss From Vegetable Soils of Different Planting Years in Suburbs of Changsha, China显示文摘The aim of the study was to develop an index to assess the environmental risk of P loss potential in vegetable soils with chronic difference of plantation in the suburbs of Changsha, Hunan Province, China. Chemical methodology was used to study soil phosphorus status and the relationships between available P in soil and potential soil leaching P. The results showed that there was a significant linear relationship between Olsen P and CaCl2-P or P concentration in soil solution. Olsen P increased sharply when either CaCl2-P or P concentration in soil solution reached a certain level. It was confirmed that 80 mg kg-1 of Olsen P was the critical value of soil P leaching in the vegetable soils. P leaching probability over the critical was assessed by GIS and indicator Kriging and four secondary risks of phosphorus leaching loss were defined. In the area with vegetable cropping for over 30 yr (Chenjiadu) and 10-15 planting years (Huangxingzhen), the indices of phosphorus leaching loss risk were 3 and 2.93, respectively. These two areas belonged to strong secondary of risk of phosphate leaching loss. In the new vegetable planting field less than 2 yr (Ningxiang), the index was 0.06, which had almost no risk of phosphorus leaching. In vegetable soils in the suburban region of Changsha, the phosphorus leaching peotential is high and the phosphorus leaching loss is related to chronic length of vegetable cropping. | QIN Hong-ling QUAN Zhi LIU Xin-liang LI Ming-de ZONG Yong WU Jin-shui WEI Wen-xue | 2010 | Agricultural Sciences in China2010，9，11： | 15 |
| 12 | Large-scale analysis of small RNAs derived from traditional Chinese herbs in human tissues显示文摘Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development. | Fengming Huang Jianchao Du Zhu Liang Zhichao Xu Jiantao Xu Yan Zhao Yexuan Lin Song Mei Quan He Jindong Zhu Qiang Liu Yanxu Zhang Yuhao Qin Wei Sun Jingyuan Song Shilin Chen Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 14 |
| 13 | Layer-by-layer deposition of bioactive layers on magnesium alloy stent materials to improve corrosion resistance and biocompatibility显示文摘Magnesium alloy is considered as one of the ideal cardiovascular stent materials owing to its good mechanical properties and biodegradability.However,the in vivo rapid degradation rate and the insufficient biocompatibility restrict its clinical applications.In this study,the magnesium alloy(AZ31B)was modified by combining the surface chemical treatment and in-situ self-assembly of 16-phosphonyl-hexadecanoic acid,followed by the immobilization of chitosan-functionalized graphene oxide(GOCS).Heparin(Hep)and GOCS were alternatively immobilized on the GOCS-modified surface through layer by layer(LBL)to construct the GOCS/Hep bioactive multilayer coating,and the corrosion resistance and biocompatibility were extensively explored.The results showed that the GOCS/Hep bioactive multilayer coating can endow magnesium alloys with an excellent in vitro corrosion resistance.The GOCS/Hep multilayer coating can significantly reduce the hemolysis rate and the platelet adhesion and activation,resulting in an excellent blood compatibility.In addition,the multilayer coating can not only enhance the adhesion and proliferation of the endothelial cells,but also promote the vascular endothelial growth factor(VEGF)and nitric oxide(NO)expression of the attached endothelial cells on the surfaces.Therefore,the method of the present study can be used to simultaneously control the corrosion resistance and improve the biocompatibility of the magnesium alloys,which is expected to promote the application of magnesium alloys in biomaterials or medical devices,especially cardiovascular stent. | Fan Gao Youdong Hu Guicai Li Sen Liu Li Quan Zhongmei Yang Yanchun Wei Changjiang Pan | 2020 | Bioactive Materials2020，5，3： | 12 |
| 14 | Stress-mediated p38 activation promotes somatic cell reprogramming显示文摘环境调停压力的改编在生活的进化起必要作用。细胞的改编机制通常包含染色质结构,抄写, mRNA 稳定性和翻译的规定,它最后在基因表示导致有效变化。全球 epigenetic 变化也涉及体的细胞的 reprogramming 进导致的 pluripotent 由定义因素的茎(iPS ) 细胞。这里,我们报导象 hyperosmosis 那样的那个环境压力不仅便于四调停因素的 reprogramming,而且提高二或一导致因素的 iPS 房间代。导致 Hyperosmosis 的 p38 激活在这个过程起一个关键作用。组成的活跃 p38 模仿 hyperosmosis 的积极效果,当主导的否定 p38 和 p38 禁止者堵住 hyperosmosis 的效果时。进一步的学习显示调停压力的 p38 激活可以由减少全球 DNA methylation 水平并且提高 pluripotency 基因的表示支持 reprogramming。我们的结果表明象 hyperosmosis 一样的简单环境应力怎么帮助经由细胞内部的发信号和 epigenetic 调整改变房间的命运。 | Xinxiu Xu Quan Wang Yuan Long Ru Zhang Xiaoyuan Wei Mingzhe Xing Haifeng Gu Xin Xie | 2013 | Cell Research2013，23，1： | 12 |
| 15 | Efficacy analysis of flexible neuroendoscopy combined with dry-field techniques in the treatment of chronic subdural hematoma显示文摘Chronic subdural hematoma (CSDH) is a common and frequently occurring disease in neurosurgery, whose incidence accounts for around 10% of all intracranial hematomas. There have been many theories about the mechanism of CSDH, including acute subdural hematoma, slow hemorrhage after bridge vein injury, and traumatic subdural effusion evolution With improvements in medical imaging technology and related basic research, the perception of CSDH as an inflammatory vascular proliferative disease has gradually reached consensus In addition to head trauma, brain atrophy leading to expanded subdural space is the premise and primary reason for the occurrence of CSDH in the older adult population. | Feng Guan Wei-Cheng Peng Hui Huang Bin Dai Guang-Tong Zhu Zhi-Yong Xiao Bei-Bei Mao Zhen-Yang Lin Quan Zhou Ya-Ping Wei Zhi-Qiang Hu | 2019 | Chinese Medical Journal2019，，11： | 12 |
| 16 | Quantitative T2 mapping evaluation for articular cartilage lesions in a rabbit model of anterior cruciate ligament transection osteoarthritis显示文摘印射的背景量的 T2 是为病理学的软骨性质的评估的一个广泛地使用的方法,并且在兔子的骨关节炎的组织学的评价系统被出版了学习的 recently.The 目的是调查为前面的十字形的系带横断( ACLT )的一个兔子模型的关节的软骨损害印射评估的量的 T2 的有效性 osteoarthritis.Methods 二十只新西兰怀特( NZW )兔子被划分成 ACLT 外科的 | WEI Zheng-mao DU Xiang-ke HUO Tian-long LI Xu-bin QUAN Guang-nan LI Tian-ran CHENG Jin ZHANG Wei-tao | 2012 | Chinese Medical Journal2012，，5： | 11 |
| 17 | Effect of High Suspension and Low Incision Surgery Based on Traditional Ligation of Chinese Medicine in Treatment of Mixed Haemorrhoids:A Multi-centre,Randomized,Single-Blind,Non-inferiority Clinical Trial显示文摘Objective:To observe the clinical effect of high suspension and low incision(HSLI)surgery on mixed haemorrhoids,compared with Milligan-Morgan haemorrhoidectomy.Methods:A multi-centre,randomized,singleblind,non-inferiority clinical trial was performed.Participants with mixed haemorrhoids from Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing Rectum Hospital,Air Force Medical Center of People's Liberation Army of China,and Puyang Hospital of Traditional Chinese Medicine were enrolled from September 2016 to March 2018.By using a blocked randomization scheme,participants were assigned to two groups.The experimental group was treated with HSLI,while the control group was treated with Milligan-Morgan haemorrhoidectomy.The primary outcome was the clinical effect evaluated at 12 weeks after operation.The secondary outcomes included the number of haemorrhoids treated during the operation,pain scores,use of analgesics,postoperative oedema,wound healing,incidence of anal stenosis,anorectal manometry after operation,as well as surgical duration,length of stay and total hospitalization expenses.A safety evaluation was also conducted.Results:In total,246 eligible participants were enrolled,with 123 cases in each group.There was no significant difference in the clinical effect between the two groups(100.00% vs.99.19%,P>0.05).Compared with the control group,the number of external haemorrhoids treated during the operation and the pain scores after operation were significantly reduced in the experimental group(P<0.05 or P<0.01);the patient number with wound healing at 2 weeks after operation and the functional length of anal canal at 12 weeks after operation were significantly increased in the experimental group(P<0.05).There was no significant difference in the incidence of anal stenosis,the numbers of patients using analgesics and patients with postoperative oedema between the two groups after operation(P>0.05).The surgical duration and length of stay in the experimental group were significantly longer than those in the control group,and the total hospitalization expense was significantly higher than that in the control group(all P<0.05).No adverse events were reported in either group during the whole trial or follow-up period.Conclusion:HSLI had the advantages of preserving the skin of anal canal completely,alleviating postsurgical pain and promoting rapid recovery after operation.(Registration No.Chi CTR1900022883). | JIA Xiao-qiang CAO Wei-wei QUAN Long-fang ZHAO Wei-bing CHENG Fang JIA Shan FENG Liu-quan WEI Xu-feng XIE Zhen-nian WANG Dong XU Chun-yan CUI Chun-hui CAI Xing-juan HE Lan-ye WANG Zhan-jun TIAN Ying SHI Shu-min SUN Si-miao SU Liang ZHAI Meng-fan | 2021 | Chinese Journal of Integrative Medicine2021，27，9： | 11 |
| 18 | A 12-year cohort study on the efficacy of plasmaderived hepatitis B vaccine in rural newborns显示文摘AIM To understand the anti-HBs persistenceand the long-term preventive efficacy in ruralnewborns after vaccination with plasma-derivedhepatitis B vaccine.METHODS In the time of expanded program onimmunization(EPI),the newborns werevaccinated with 10μg×3 doses of hepatitis Bvaccine and 762 newborns who were HBsAgnegative after primary immunization wereselected for cohort observation from 1986 to1998.Their serum samples were detectedqualitatively and quantitatively for hepatitis Binfecting markers,including HBsAg,anti-HBsand anti-HBc by SPRIA Kits.The annual HBsAgpositive conversion rate was counted by life-table method.RESULTS①The anti-HBs positive rate was94.44% for the babies born to HBsAg negativemothers and 84.21% for those born to HBsAgpositive mothers in the 1st year afterimmunization,and dropped to 51.31% and52.50% in the 12th year respectively.GMT valuewas dropped from 31.62 to 3.13 and 23.99 to 3.65in the 2nd to the 12th year respectively.Therewas a marked drop in GMT at the 3rd to the 5thyear,and in anti-HBs positive rate at the 9th tothe 10th year.②In the period of 12 yearsobservation,the person-year HBsAg positive conversion rates were 0.12%(5/4150.0)innewborns born to HBsAg negative mothers and0.20%(1/508.0)in those born to HBsAgpositive mothers,and none of the HBsAgpositive converted children became HBsAgchronic carriers.Compared with the baselinebefore immunization,the protective rates were97.19% and 95.32% respectively.CONCLUSION The protective efficacy ofplasma-derived hepatitis B vaccine persisted atleast 12 years,and a booster dose seems notnecessary within at least 12 years after theprimary three-doses immunization to newbornsborn to HBsAg negative mothers. | Hong Bin Liu Zong Da Meng Jing Chen Ma Chang Quan Han Ying Lin Zhang Zhan Chun Xing Yu Wei Zhang Yu Zhong Liu Hui Lin Cao | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 19 | Signaling pathways and targeted therapy for myocardial infarction显示文摘Although the treatment of myocardial infarction(MI)has improved considerably,it is still a worldwide disease with high morbidity and high mortality.Whilst there is still a long way to go for discovering ideal treatments,therapeutic strategies committed to cardioprotection and cardiac repair following cardiac ischemia are emerging.Evidence of pathological characteristics in MI illustrates cell signaling pathways that participate in the survival,proliferation,apoptosis,autophagy of cardiomyocytes,endothelial cells,fibroblasts,monocytes,and stem cells.These signaling pathways include the key players in inflammation response,e.g.,NLRP3/caspase-1 and TLR4/MyD88/NF-κB;the crucial mediators in oxidative stress and apoptosis,for instance,Notch,Hippo/YAP,RhoA/ROCK,Nrf2/HO-1,and Sonic hedgehog;the controller of myocardial fibrosis such as TGF-β/SMADs and Wnt/β-catenin;and the main regulator of angiogenesis,PI3K/Akt,MAPK,JAK/STAT,Sonic hedgehog,etc.Since signaling pathways play an important role in administering the process of MI,aiming at targeting these aberrant signaling pathways and improving the pathological manifestations in MI is indispensable and promising.Hence,drug therapy,gene therapy,protein therapy,cell therapy,and exosome therapy have been emerging and are known as novel therapies.In this review,we summarize the therapeutic strategies for MI by regulating these associated pathways,which contribute to inhibiting cardiomyocytes death,attenuating inflammation,enhancing angiogenesis,etc.so as to repair and re-functionalize damaged hearts. | Qing Zhang Lu Wang Shiqi Wang Hongxin Cheng Lin Xu Gaiqin Pei Yang Wang Chenying Fu Yangfu Jiang Chengqi He Quan Wei | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 11 |
| 20 | MicroRNA-185-5p mediates regulation of SREBP2 expression by hepatitis C virus core protein显示文摘AIM: To investigate the molecular mechanism for regulation of cholesterol metabolism by hepatitis C virus(HCV) core protein in Hep G2 cells.METHODS: HCV genotype 1b core protein was cloned and expressed in Hep G2 cells. The cholesterol content was determined after transfection. The expression of sterol regulatory element binding protein 2(SREBP2) and the rate-limiting enzyme in cholesterol synthesis(HMGCR) was measured by quantitative real-time PCR and immunoblotting after transfection. The effects of core protein on the SREBP2 promoter and 3'-untranslated region were analyzed by luciferase assay. We used different target predictive algorithms, micro RNA(mi RNA) mimics/inhibitors, and site-directed mutation to identify a putative target of a particular mi RNA.RESULTS: HCV core protein expression in Hep G2 cells increased the total intracellular cholesterol level(4.05 ± 0.17 vs 6.47 ± 0.68, P = 0.001), and this increase corresponded to an increase in SREBP2 and HMGCR m RNA levels(P = 0.009 and 0.037, respectively) and protein expression. The molecular mechanism studyrevealed that the HCV core protein increased the expression of SREBP2 by enhancing its promoter activity(P = 0.004). In addition, mi R-185-5p expression was tightly regulated by the HCV core protein(P = 0.041). Moreover, overexpression of mi R-185-5p repressed the SREBP2 m RNA level(P = 0.022) and protein expression. In contrast, inhibition of mi R-185-5p caused upregulation of SREBP2 protein expression. mi R-185-5p was involved in the regulation of SREBP2 expression by HCV core protein. CONCLUSION: HCV core protein disturbs the cholesterol homeostasis in Hep G2 cells via the SREBP2 pathway; mi R-185-5p is involved in the regulation of SREBP2 by the core protein. | Min Li Qi Wang Shun-Ai Liu Jin-Qian Zhang Wei Ju Min Quan Sheng-Hu Feng Jin-Ling Dong Ping Gao Jun Cheng | 2015 | World Journal of Gastroenterology2015，21，15： | 10 |
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