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| 1 | Single Zircon LA-ICP-MS U-Pb Dating of the Guandimiao and Wawutang Granitic Plutons in Hunan,South China and Its Petrogenetic Significance显示文摘The Guandimao and Wawutang plutons are located at the center of Hunan, South China. The former is mainly composed of biotite monzonitic granites/granodiorites and two-mica monzonitic granites, but the latter only consists of biotite monzonitic granites. The zircon ages of 203.0±1.6 Ma (biotite monzonitic granites) and 208.0±3.2 Ma (two-mica monzonitic granites) for the Guandimao pluton and 204±3 Ma for the Wawutang pluton obtained with the LA-ICP-MS U-Pb dating indicate that they were formed during the late Indosinian. In consideration of other geochronological data from Indosinian rocks of South China and adjacent regions, it is inferred that the two plutons were derived from crustal materials by decompressional melting in a post-collisional tectonic setting during spontaneous thinning of the thickened curst. Moreover, the inherited zircon age of 1273±57 Ma from the Wawutang pluton indicates that the source of the two plutons is related to the early Proterozoic crustal basement. | CHEN Weifeng CHEN Peirong ZHOU Xinmin HUANG Hongye DING Xing SUN Tao | 2007 | Acta Geologica Sinica(English Edition)2007，81，1： | 5 |
| 2 | Clinical relevance of angiographic coronary collaterals during primary coronary intervention for acute ST-elevation myocardial infarction显示文摘 | Shen Ying Wu Feng Pan Chunzang Zhu Tianqi Zhang Qi Zhang Ruiyan Ding Fenghua Lu Lin Hu Jian Yang Zhenkun Shen Weifeng Wu Zonggui | 2014 | Chinese Medical Journal2014，，1： | 2 |
| 3 | An On-chip Interconnection QoS Verification Platform of Processor of Large Data for Architectural Modeling Analysis显示文摘This paper presents introduction for a QoS verification of on-chip interconnection based on the new progress of the industry, which combined with an AMD processor chip design for big data. Some verification experience in architectural modeling and simulation of on-chip interconnection is also introduced in this paper. | Li Qinghua Qin Jilong Ding Xu Wang Endong Gong Weifeng | 2015 | 国际计算机前沿大会会议论文集2015，，1： | 1 |
| 4 | Synergistic antitumor efficacy by combining adriamycin with recombinanthuman endostatin in an osteosarcoma model显示文摘 | Hairong Xu Xiaohui Niu Qing Zhang Lin Hao Yi Ding Weifeng Liu Lu Yao | 2011 | Oncology Letters2011，，5： | 1 |
| 5 | MiR-196a2 rs11614913 T<ce:hsp sp='0.25'/>><ce:hsp sp='0.25'/>C polymorphism and risk of esophageal cancer in a Chinese population<!-- miRNA polymorphism and esophageal cancer risk -->显示文摘 | Jishu Wei Liang Zheng Shenghua Liu Jun Yin Liming Wang Xu Wang Yijun Shi Aizhong Shao Weifeng Tang Guowen Ding Chao Liu Suocheng Chen Haiyong Gu | 2013 | Human Immunology2013，，： | 1 |
| 6 | Based on rough set and fuzzy clustering of MRI brain segmentation显示文摘 | Yang Zhang Shufan Ye Weifeng Ding | 2017 | International Journal of Biomathematics2017，10，2： | 1 |
| 7 | Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism显示文摘Primary biliary cholangitis(PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental mechanisms beyond common noncoding variants, we integrate whole exome sequencing with integrative network analysis to investigate genes harboring de novo mutations. Prominent convergence has been revealed on a network of disease-specific co-expression comprised of 55 genes associated with homeostasis and metabolism. The transcription factor gene MEF2 D and the DNA repair gene PARP2 are highlighted as hub genes and identified to be up-and down-regulated, respectively, in peripheral blood data set. Enrichment analysis demonstrates that altered expression of MEF2 D and PARP2 may trigger a series of molecular and cellular processes with pivotal roles in PBC pathophysiology. Our study identifies genes with de novo mutations in PBC and suggests that a subset of genes in homeostasis and metabolism tend to act in synergy through converging on co-expression network, providing novel insights into the etiology of PBC and expanding the pool of molecular candidates for discovering clinically actionable biomarkers. | Lu Wang Jinchen Li Chan Wang Ruqi Tang Jialong Liang Yuhua Gong Yaping Dai Ningling Ding Jian Wu Na Dai Lei Liu Yi Zhao Youlin Shao Weifeng Zhao Peng Jiang Xingjuan Shi Weichang Chen Ye Tian Xiangdong Liu Xiong Ma Zhongsheng Sun | 2022 | Journal of Genetics and Genomics2022，49，2： | 1 |
| 8 | Progress in Antarctic marine geophysical research by the Chinese Polar Program显示文摘Marine geophysical survey by the Chinese National Antarctic Research Expedition(CHINARE) began with the first science expedition in 1984/1985, although only four cruises were performed in the vicinity of the Antarctic Peninsula between then and 1991/1992. After a 20 year hiatus, Antarctic marine geophysical research was relaunched by the Chinese Polar Environmental Comprehensive Investigation and Assessment Programs(known simply as the Chinese Polar Program) in 2011/2012. Integrated geophysical surveys have been carried out annually since, in Prydz Bay and the Ross Sea. During the last 5 years, we have acquired about 5500 km of bathymetric, gravimetric, and magnetic lines; more than 1800 km of seismic reflection lines; and data from several heat flow and Ocean Bottom Seismometer(OBS) stations. This work has deepened understandings of geophysical features and their implications for geological tectonics and glacial history in Antarctica and its surrounding seas. Compiled Antarctic Bouguer and Airy isostatic gravity anomalies show different features of tectonics between the East Antarctic stability and West Antarctic activity. Calculated magnetic anomalies, heat flow anomalies and lithospheric anisotropy offshore of Prydz Bay may imply high heat capacity of mantle shielded by the continental shelf lithosphere, but high heat dissipation of mantle due to the Cretaceous breakup of Gondwana along the continent and ocean transition(COT), where large sediment ridges would be brought about by the Oligocene ice sheet retreat and would enlarge free-air gravity anomalies. In the western Ross Sea, CHINARE seismic profiles indicate northern termination of the Terror Rift and deposition time of the grounding zone wedge in the northern JOIDES Basin. | GAO Jinyao SHEN Zhongyan YANG Chunguo WANG Wei JI Fei WU Zhaocai NIU Xiongwei DING Weifeng LI Dongxu ZHANG Qiao | 2017 | Advances in Polar Science2017，28，4： | 1 |
| 9 | Seroprevalence of influenza viruses in Shandong,Northern China during the COVID-19 pandemic显示文摘Nonpharmaceutical interventions(NPIs)have been commonly deployed to prevent and control the spread of the coronavirus disease 2019(COVID-19),resulting in a worldwide decline in influenza prevalence.However,the influenza risk in China warrants cautious assessment.We conducted a cross-sectional,seroepidemiological study in Shandong Province,Northern China in mid-2021.Hemagglutination inhibition was performed to test antibodies against four influenza vaccine strains.A combination of descriptive and meta-analyses was adopted to compare the seroprevalence of influenza antibodies before and during the COVID-19 pandemic.The overall seroprevalence values against A/H1N1pdm09,A/H3N2,B/Victoria,and B/Yamagata were 17.8%(95%CI 16.2%–19.5%),23.5%(95%CI 21.7%–25.4%),7.6%(95%CI 6.6%–8.7%),and 15.0(95%CI 13.5%–16.5%),respectively,in the study period.The overall vaccination rate was extremely low(2.6%).Our results revealed that antibody titers in vaccinated participants were significantly higher than those in unvaccinated individuals(P<0.001).Notably,the meta-analysis showed that antibodies against A/H1N1pdm09 and A/H3N2 were significantly low in adults after the COVID-19 pandemic(P<0.01).Increasing vaccination rates and maintaining NPIs are recommended to prevent an elevated influenza risk in China. | Chuansong Quan Zhenjie Zhang Guoyong Ding Fengwei Sun Hengxia Zhao Qinghua Liu Chuanmin Ma Jing Wang Liang Wang Wenbo Zhao Jinjie He Yu Wang Qian He Michael J.Carr Dayan Wang Qiang Xiao Weifeng Shi | 2022 | Frontiers of Medicine2022，16，6： | 1 |
| 10 | Motion and removal behavior of inclusions in electrode tip during magnetically controlled electroslag remelting:X-ray microtomography characterization and modeling verification显示文摘Detailed three-dimensional(3 D)microtomography characterizations of inclusions in electrode matrix,mushy zone(MZ)and liquid melt film(LMF)were performed to elucidate the motion and removal behavior of inclusions in electrode tip during magnetically controlled electroslag remelting(MC-ESR)process.A transient 2 D numerical model was also built to verify the experimental results and proposed mechanisms.The number and size of inclusions exhibited an obvious increasing trend from edge to mid region in LMF,while remained almost the same in electrode matrix and MZ.The inclusions in LMF migrated from edge to mid region of LMF,accompanied with removal process.In addition,the kinetic conditions for inclusion migrating to LMF/slag interface(LSI)were enhanced during MC-ESR process,thereby improving the inclusion removal efficiency in LMF.This work highlights the 3 D characterization and motion/removal mechanisms of inclusions in electrode tip,as well as sheds new light on preparing high purity materials. | Yifeng Guo Zhibin Xia Qiang Li Mingyue Sun Weifeng Liu Shaogang Wang Zhe Shen Tianxiang Zheng Biao Ding Yunbo Zhong | 2022 | Journal of Materials Science & Technology2022，，1： | 1 |
| 11 | Intensification of β-poly( l -malic acid) production by Aureobasidium pullulans ipe-1 in the late exponential growth phase显示文摘 | Weifeng Cao Jianquan Luo Juan Zhao Changsheng Qiao Luhui Ding Benkun Qi Yi Su Yinhua Wan | 2012 | Journal of Industrial Microbiology & Biotechnology2012，，7： | 1 |
| 12 | Sfmbt2 10th intron-hosted miR-466(a/e)-3p are important epigenetic regulators of Nfat5 signaling, osmoregulation and urine concentration in mice显示文摘 | Yu Luo Ying Liu Meng Liu Jie Wei Yunyun Zhang Jinpao Hou Weifeng Huang Tao Wang Xun Li Ying He Feng Ding Li Yuan Jianchun Cai Feng Zheng James Y. Yang | 2014 | BBA - Gene Regulatory Mechanisms2014，，2： | 1 |
| 13 | Comparing the accuracy of Demirjian and Nolla methods and establishing a new method for dental age estimation in northeastern Chinese children显示文摘Dental age estimation plays an important role in the field of clinic medicine and forensic medicine.The Demirjian and Nolla methods are common scoring methods for dental age estimation but there was no research about the comparison of accuracy of these two methods in northeastern Chinese children.Hence,in this study,we compared the accuracy of these two methods to explore more suitable method for our studied population.We collected 535 orthopantomograms from northern Chinese children aged from 6 to 15 years and divided them into training dataset and testing dataset according to the ratio of 7:3.The dental age of training dataset were estimated using Demirjian and Nolla methods,respectively.The results suggested that the mean differences of these two methods were 0.24 and−0.40 years,and mean absolute difference were 0.65 and 0.59 years.Then to further improve the accuracy of dental age assessment,the new improved formulas and dental age conversion tables were established after analyzing the relationship between the sum scores based on Nolla method and chronology age in training dataset.According to the new method used in testing dataset,the minimum value of mean difference(0.00)and mean absolute difference(0.49)were obtained,which are largely smaller than that of Demirjian and Nolla methods.The new developed method and dental age conversion scales may be more suitable dental age estimation method for northeastern Chinese children. | Dan Wen Zhiyu Ding Zhikai Tian Wenshuang Wu Weifeng Qu Wei He Chudong Wang Jienan Li Lagabaiyila Zha Ying Liu | 2022 | Forensic Sciences Research2022，7，4： | 0 |
| 14 | Study on the influence of fracture lengths and fracture angles on residual oil distribution based on the slab model显示文摘After fracturing in the pilot area,channeling occurs at a low fracture angle(15).Based on the resistance-water saturation relationship,three-dimensional physical simulation methods are used in the laboratory to study the effect of different fracture angles and lengths on the residual oil distribution during the displacement process.Meanwhile,recovery percent,displacement efficiency and expanding sweep co-efficient to the improvement of recovery percent are also discussed.The results show that the fracture angle and length are closely related to the oil saturation distribution in these models.As the fracture angle increases,the sweep coefficient decreases(0.2412→0.1463),and the recovery percent also in-creases(46.16→56.88%),but the extent of increase has been reduced(7.96→2.96%).The extension of the fracture length is more prone to have a cross-flow phenomenon;the sweep coefficient is reduced(0.2412→0.1463).Compared to the model with 1/2 oil-water well spacing,the recovery percent is decreased by 14.29%.In different fracture models,the increasable sweep coefficient has a greater impact on oil recovery than the increasable displacement efficiency(71.30→28.70%). | Guihui Lian Zhenhua Ding Liang Chen Xiaoguang Wang Jiru Yang Jigang Zhang Ming Gao Weifeng Lv Zhenpeng Leng | 2022 | Petroleum Research2022，7，4： | 0 |
| 15 | Electrolyte induced synergistic construction of cathode electrolyte interphase and capture of reactive free radicals for safer high energy density lithium-ion battery显示文摘As the energy density of battery increases rapidly,lithium-ion batteries(LIBs)are facing serious safety issue with thermal runaway,which largely limits the large-scale applications of high-energy-density LIBs.It is generally agreed that the chemical crosstalk between the cathode and anode leads to thermal runaway of LIBs.Herein,a multifunctional high safety electrolyte is designed with synergistic construction of cathode electrolyte interphase and capture of reactive free radicals to limit the intrinsic pathway of thermal runaway.The cathode electrolyte interphase not only resists the gas attack from the anode but suppresses the parasitic side reactions induced by electrolyte.And the function of free radical capture has the ability of reducing heat release from thermal runaway of battery.The dual strategy improves the intrinsic safety of battery prominently that the triggering temperature of thermal runaway is increased by 24.4℃and the maximum temperature is reduced by 177.7℃.Simultaneously,the thermal runaway propagation in module can be self-quenched.Moreover,the electrolyte design balances the trade-off of electrochemical and safety performance of high-energy batteries.The capacity retention of LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)|graphite pouch cell has been significantly increased from 53.85%to 97.05%with higher coulombic efficiency of 99.94%at operating voltage extended up to 4.5 V for 200 cycles.Therefore,this work suggests a feasible strategy to mitigate the safety risk of high-energy-density LIBs without sacrificing electrochemical performances. | Mengfei Ding Xuning Feng Yong Peng Jing Jing Tong Bowen Hou Yalan Xing Weifeng Zhang Li Wang Yu Wu Jiabin Lv Chunyan Luo Dejun Xiong Shichao Zhang Minggao Ouyang | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 16 | Improved Model of Radial Vibration in Switched Reluctance Motor Including Magnetic Saturation显示文摘This paper proposes an improved method for the prediction of radial vibration in switched reluctance motor(SRM)considering magnetic saturation.In this paper,the basic modeling principle is briefly introduced,it is based on the derivation that the peak acceleration is dependent on the product of phase current and current gradient idi/dt.However,the derivation may cause errors due to saturation effect.Thus in this paper,the discrete sample data are firstly acquired based on DC pulse measurement method,by which electromagnetic,torque and peak acceleration characteristics can all be acquired.Then the entire peak acceleration characteristics are obtained by improved Least Square Support Vector Machine(LSSVM).Based on the obtained static peak acceleration characteristics,the time-varied radial vibration model is established based on superposition of natural oscillations of dominant vibration modes.Finally,a simulation model is built up using MATLAB/Simulink.The good agreement between simulation and experiment shows that the proposed method for modeling is feasible and accurate,even under saturation.In addition,since LSSVM does not need any prior knowledge,it is much easier for modeling compared with other existing literatures. | Xiaoqiang Guo Rui Zhong Mingshu Zhang Desheng Ding Weifeng Sun | 2018 | CES Transactions on Electrical Machines and Systems2018，2，4： | 0 |
| 17 | Comprehensive analysis of complement-associated molecular features in hepatocellular carcinoma显示文摘The complement cascade plays a“complementing”role in human immunity.However,the potential roles of complement system in impacting molecular and clinical features of hepatocellular carcinoma(HCC)remain unclear.In this study,eleven public datasets are analyzed to compare the complement status between normal and cancerous samples based on 18 classical complement-associated genes.The complement scores are constructed to quantify complement signatures of individual tumors.HCC patients in the The Cancer Genome Atlas(TCGA)cohort are focused to perform systematical analyses between complement status and immune infiltration,miRNA expression,DNA methylation,clinicopathological features,and drug response.The results show that the complement scores in normal tissues are dramatically higher than those of tumor tissues.Tumor samples in the TCGA cohort are classified into complement score-low and score-high groups.Pathway analysis reveals that tumor-promoting pathways are typically inhibited in complement score-high group.This study also shows that tumor-killing immune cells,such as CD8^(+)T cells and natural killer cells are abundant and tumor-suppressing miRNAs are upregulated in complement score-high samples.In addition,we identify that complement scores are negatively correlated with certain clinical features,including pathological grade,clinical-stage,and portal vein invasion.Moreover,various molecular features together with complement scores are found to be correlated with response to anti-cancer drugs.This study provides a comprehensive and multidimensional analysis conducive to understanding the role of complement in cancer. | Run Huang Guiqi Zhu Xiutao Fu Weiren Liu Chenyang Tao Jun Gao Weifeng Qu Yuan Fang Xifei Jiang Zhenbin Ding Jian Zhou Yinghong Shi Jia Fan Zheng Tang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 0 |
| 18 | Highly π-extended copolymer as additive-free hole- transport material for perovskite solar cells显示文摘Organolead 卤化物 perovskite 太阳能电池完成了 22.1% 的证明力量变换效率(PCE ) 并且因此在下一代的光电的设备的最有希望的候选人之中。迄今为止,大多数高效率的 perovskite 太阳能电池采用了基于 arylamine 的洞运输材料(HTM ) ,它是昂贵的并且有低活动性。复杂的做过程和在这些 HTM 使用的潜在地稳定性不利的掺杂物在为 perovskite 太阳能电池(PSC ) 的商品化的主要瓶颈之中。此处,我们在场有直到 8.2 厘米 2 楨楢整 ? 潮漠癢潩獵挠慨杮?? 灭牯慴瑮祬 ? 桴 ? 潣癮 牥楳湯漠 ? 的洞活动性的基于 polythiophene 的共聚物(PDVT-10 )? 偎眠獡猠杩楮楦慣瑮祬攠桮湡散 ? 湵敤 ? 楬桧 ? 物慲楤瑡潩 ? 牰癯摩摥戠 ????? 敘氠浡 ? 琨敨瘠獩扩敬氠杩?映潲 ? 畣潴晦栠癡? 煥慵 ? 畦据楴湯 ? 戠瑵甠瑬慲楶汯瑥氠杩?搠摩渠瑯瀠潲潭整琠敨挠湯敶獲潩 ? 吠敨挠湯敶獲潩 ? 楴敭眠獡爠摥 ' 讚充?财‰潴㈠ ? 猠眠瑩 ? 楬桧 ? 物慲楤瑡潩 ? ㄨ‵? 慩? 删癥獩摥 ? 楤楴湯㈠ ? 8 玔? 玔?? | Jie Liu Qianqing Ge Weifeng Zhang Jingyuan Ma Jie Ding Gui Yu Jinsong Hu | 2018 | Nano Research2018，11，1： | 0 |
| 19 | Improving antibody affinity through in vitro mutagenesis in complementarity determining regions显示文摘High-affinity antibodies are widely used in diagnostics and for the treatment of human diseases.However,most antibodies are isolated from semi-synthetic libraries by phage display and do not possess in vivo affinity maturation,which is triggered by antigen immunization.It is therefore necessary to engineer the affinity of these antibodies by way of in vitro assaying.In this study,we optimized the affinity of two human monoclonal antibodies which were isolated by phage display in a previous related study.For the 42A1 antibody,which targets the liver cancer antigen glypican-3,the variant T57H in the second complementarity-determining region of the heavy chain(CDR-H2)exhibited a 2.6-fold improvement in affinity,as well as enhanced cell-binding activity.For the I4A3 antibody to severe acute respiratory syndrome coronavirus 2,beneficial single mutations in CDR-H2 and CDR-H3 were randomly combined to select the best synergistic mutations.Among these,the mutation S53P-S98T improved binding affinity(about 3.7 fold)and the neutralizing activity(about 12 fold)compared to the parent antibody.Taken together,single mutations of key residues in antibody CDRs were enough to increase binding affinity with improved antibody functions.The mutagenic combination of key residues in different CDRs creates additive enhancements.Therefore,this study provides a safe and effective in vitro strategy for optimizing antibody affinity. | Wei Ye Xiaoyu Liu Ruiting He Liming Gou Ming Lu Gang Yang Jiaqi Wen Xufei Wang Fang Liu Sujuan Ma Weifeng Qian Shaochang Jia Tong Ding Luan Sun Wei Gao | 2022 | The Journal of Biomedical Research2022，36，3： | 0 |
| 20 | Refocusing of the optical branched flow on a rough curved surface显示文摘The phenomenon of branched flow has attracted researchers since its inception,with recent observations of the light branching on soap bubbles.However,previous studies have primarily focused on the flat spacetime,overlooking the effect of surface curvature on branched flows.In this paper,we explore the branched flow phenomenon of light on a rough curved surface called constant Gaussian curvature surfaces(CGCSs).Compared with flat space,a CGCS demonstrates that the first branching point advances due to the focusing effect of the positive curvature of the surface.Furthermore,unlike on flat space,optical branches on curved surfaces do not consistently become chaotic during its transmission in a random potential field.On the contrary,the“entropy”decreases at specific positions,which reveals a sink flow phenomenon following the generation of branched flows.This result highlights the time inversion characteristics of CGCSs.Lastly,we demonstrated that the anomalous entropy reduction is related to the transverse and longitudinal coherence transformations of light.We suppose these efforts would fuel further investigation of the thermodynamic evolution and spatiotemporal inversion of random caustics,as well as their future application in the information transmission of random potentials in curved spacetime. | WEIFENG DING ZHAOYING WANG CHAOKAI YANG | 2023 | Photonics Research2023，11，12： | 0 |
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