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| 1 | An experimental study on stress-strain behavior and constitutive model of hardfill material显示文摘Hardfill is a new type of artificially cemented material for dam construction works,with a wide application prospect.Its mechanical behavior lies between concrete and rockfill materials.A series of large-scale triaxial tests are performed on hardfill specimens at different ages,and the stress-strain behavior of hardfill is further discussed.The strength and stress-strain relationship of hardfill materials show both frictional mechanism and cohesive mechanism.An age-related constitutive model of hardfill is developed,which is a parallel model consisting of two components,rockfill component and cementation component.Moreover,a comparison is made between the simulated and the experimental results,which shows that the parallel model can reflect the mechanical characteristics of both rockfill-like nonlinearity and concrete-like age relativity.In addition,a simplified method for the determination of parameters is proposed. | WU MengXi DU Bin YAO YuanCheng HE XianFeng | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 15 |
| 2 | Simulation procedure of unconfined seepage with an inner seepage face in a heterogeneous field显示文摘An inner seepage face phenomenon is given and a numerical simulation procedure has been developed.It may appear at the interface of two materials when an unconfined seepage flows from a porous media to a coarser porous media with a higher permeability.Inaccuracy and divergent problems may arise both in a saturated-only and in a variably saturated analysis while an inner seepage face is not simulated with a special procedure.The position of the seepage face is determined during the nonlinear iteration process and the flux of the inner seepage face nodes is transferred to the downstream side nodes.Validity and efficiency of the procedure are illustrated by the simulation of two dimensional steady state seepage examples of heterogeneous zoned dams which is usually used to validate algorithms.An analysis of a three-dimensional earth core rockfill dam is also presented here.The procedure can also be applied to general transient seepage problems. | WU MengXi YANG LianZhi YU Ting | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，6： | 7 |
| 3 | Rice productivity and profitability with slow-release urea containing organic-inorganic matrix materials显示文摘Applying slow-release fertilizers is possible means for reducing nitrogen(N) loss in rice production. Matrix-based fertilizers represent novel slow-release fertilizers. To date, there is little consensus about the effect of combined addition of organic and inorganic matrix materials on rice production. We developed a slow-release urea fertilizer with selected organic and inorganic matrix materials. The study aimed to: i) determine the effect of the slow-release urea on rice yield, profit, and agronomic efficiency and ii) elucidate its possible mechanisms. A two-year field experiment was conducted during 2015–2016. Besides,laboratory experiments were conducted to determine the potential N loss risk. Three treatments were set up: control without N application(CK), regular urea treatment(RU, 150 kg N ha^(-1)), and slow-release urea treatment(SU, 150 kg N ha^(-1)). The results showed that rice biomass and grain yield were significantly higher in SU than in RU(P < 0.05). The higher panicle density in SU was largely responsible for the greater grain yield. Net profit in SU was US$450 ha^(-1), higher than in RU. Agronomic efficiency was significantly greater in SU than in RU(P < 0.05). Rice height, root area, leaf chlorophyll, leaf nitrate reductase activity, and leaf glutamine synthetase activity were larger in SU than in RU. Less N loss and greater soil N availability were partly responsible for the improvements in rice growth traits and physiological parameters in SU. Overall, the slow-release urea is a promising fertilizer for rice production. | Yang YANG Binmei LIU Xiaoyu NI Liangzhi TAO Lixiang YU Ye YANG Mengxi FENG Wenjin ZHONG Yuejin WU | 2021 | Pedosphere2021，31，4： | 5 |
| 4 | Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes显示文摘Traumatic brain injury(TBI)is a global cause of morbidity and mortality.Initial management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a widely available,noninvasive diagnostic biomarker.In particular,a blood-based biomarker assay could provide a quick and minimally invasive process to stratify risk and guide early management strategies in patients with mild TBI(mTBI).Analysis of circulating exosomes allows the potential for rapid and specific identification of tissue injury.By applying acoustofluidic exosome separation—which uses a combination of microfluidics and acoustics to separate bioparticles based on differences in size and acoustic properties—we successfully isolated exosomes from plasma samples obtained from mice after TBI.Acoustofluidic isolation eliminated interference from other blood components,making it possible to detect exosomal biomarkers for TBI via flow cytometry.Flow cytometry analysis indicated that exosomal biomarkers for TBI increase in the first 24 h following head trauma,indicating the potential of using circulating exosomes for the rapid diagnosis of TBI.Elevated levels of TBI biomarkers were only detected in the samples separated via acoustofluidics;no changes were observed in the analysis of the raw plasma sample.This finding demonstrated the necessity of sample purification prior to exosomal biomarker analysis.Since acoustofluidic exosome separation can easily be integrated with downstream analysis methods,it shows great potential for improving early diagnosis and treatment decisions associated with TBI. | Zeyu Wang Haichen Wang Ryan Becker Joseph Rufo Shujie Yang Brian E.Mace Mengxi Wu Jun Zou Daniel T.Laskowitz Tony Jun Huang | 2021 | Microsystems & Nanoengineering2021，7，2： | 3 |
| 5 | Acoustofluidic separation of cells andparticles显示文摘Acoustofluidics,the integration of acoustics and microfluidics,is a rapidly growing research field that is addressing challenges in biology,medicine,chemistry,engineering,and physics.In particular,acoustofluidic separation of biological targets from complex fluids has proven to be a powerful tool due to the label-free,biocompatible,and contact-free nature of the technology.By carefully designing and tuning the applied acoustic field,cells and other bioparticles can be isolated with high yield,purity,and biocompatibility.Recent advances in acoustofluidics,such as the development of automated,point-of-care devices for isolating sub-micron bioparticles,address many of the limitations of conventional separation tools.More importantly,advances in the research lab are quickly being adopted to solve clinical problems.In this review article,we discuss working principles of acoustofluidic separation,compare different approaches of acoustofluidic separation,and provide a synopsis of how it is being applied in both traditional applications,such as blood component separation,cell washing,and fluorescence activated cell sorting,as well as emerging applications,including circulating tumor cell and exosome isolation. | Mengxi Wu Adem Ozcelik Joseph Rufo Zeyu Wang Rui Fang Tony Jun Huang | 2019 | Microsystems & Nanoengineering2019，5，1： | 2 |
| 6 | A finite-element algorithm for modeling variably saturated flows显示文摘 | Mengxi Wu | 2010 | Journal of Hydrology2010，，： | 1 |
| 7 | Ultra-tough artificial nacre based on conjugated cross-linked gra-phene oxide 显示文摘 | CHENG Qunfeng WU Mengxi LI Mingzhu | 2013 | Angewarldte Chemie2013，125，13： | 1 |
| 8 | Generating Basic Unit Movements with Conditional Generative Adversarial Networks显示文摘Arm motion control is fundamental for robot accomplishing complicated manipulation tasks.Different movements can be organized by configuring a series of motion units.Our work aims at equipping the robot with the ability to carry out Basic unit movements(BUMs),which are used to constitute various motion sequences so that the robot can drive its hand to a desired position.With the definition of BUMs,we explore a learning approach for the robot to develop such an ability by leveraging deep learning technique.In order to generate the BUM regarding to the current arm state,an internal inverse model is developed.We propose to use Conditional generative adversarial networks(CGANs)to establish the inverse model to generate the BUMs.The experimental results on a humanoid robot PKU-HR6.0Ⅱillustrate that CGANs could successfully generate multiple solutions given a BUM,and these BUMs can be used to constitute further reaching movement effectively. | LUO Dingsheng NIE Mengxi WU Xihong | 2019 | Chinese Journal of Electronics2019，28，6： | 1 |
| 9 | Orthogonally polarized RF optical single sideband generation with integrated ring resonators显示文摘We review recent work on narrowband orthogonally polarized optical RF single sideband generators as well as dualchannel equalization,both based on high-Q integrated ring resonators.The devices operate in the optical telecommunications C-band and enable RF operation over a range of either fixed or thermally tuneable frequencies.They operate via TE/TM mode birefringence in the resonator.We achieve a very large dynamic tuning range of over 55 dB for both the optical carrier-to-sideband ratio and the dual-channel RF equalization for both the fixed and tunable devices. | Mengxi Tan Xingyuan Xu Jiayang Wu Thach G.Nguyen Sai T.Chu Brent E.Little Arnan Mitchell Roberto Morandotti David J.Moss | 2021 | Journal of Semiconductors2021，42，4： | 1 |
| 10 | A finite-element algorithm for modeling variably saturated flows显示文摘 | WU Mengxi | 2010 | J Hydrology2010，394，34： | 1 |
| 11 | An isolation strategy to anchor atomic Ni or Co cocatalysts on TiO_(2)(A)for photocatalytic hydrogen production显示文摘TiO_(2) has been considered as an ideal photocatalyst for water splitting.However,narrow light absorbance,low charge separation efficiency,and rare surface active sites lead to the low photocatalytic efficiency of TiO_(2).Although extensive research attempted to improve the situation,there is still lack of method for constructing high active and noble-metal-free TiO_(2) photocatalyst for H_(2) evolution reactions(HER).In this work,we loaded single atomic(SA)Ni(or Co)on the surface of anatase TiO_(2)(TiO_(2)(A))nanosheets by an isolation strategy.Ethylene diamine tetraacetic acid and ethylene glycol(EDTA-EG)compounds were used to chelate metal ions in solution and form carbon quantum dots in the following thermal treatment to isolate the metal ions on surface of TiO_(2)(A).The prepared Ni SA/TiO_(2)(A)catalyst owned a“skin wrapped body”structure with in-situ formed twodimensional(2D)heterojunction facilitating the fast electron transfer.As a result,the Ni SA/TiO_(2)(A)catalyst showed a high H_(2) evolution rate of 2,900μmol·g−1·h−1.This work provides an isolation strategy for constructing promising single-atom metal catalyst for photocatalysis and beyond. | Shangchun Lv Mengxi Pei Yuxiang Liu Zhichun Si Xiaodong Wu Rui Ran Duan Weng Feiyu Kang | 2022 | Nano Research2022，15，7： | 0 |
| 12 | Latitudinal and Seasonal Variations in Tropical Cyclone-Induced Ocean Surface Cooling in the Tropical Western North Pacific显示文摘The passage of tropical cyclones induces ocean surface cooling through vertical mixing,upwelling,and surface heat loss.The dependence of tropical cyclone-induced ocean surface cooling on the intensity and translation speed of tropical cyclones has been documented in previous studies.The present study investigates the latitudinal and seasonal variations in tropical cyclone-induced ocean surface cooling in the tropical western North Pacific based on data for the 2001–2020 period.Our analysis focuses on the open ocean(0°–25°N,130°E–180°)to reduce the interference of coastal topography so that the obtained results better represent the influences of the intensity and translation speed of tropical cyclones.Our analysis confirms the dependence on the intensity and translation speed of tropical cyclone-induced cooling.The new findings are as follows.First,the time to reach the maximum cooling increases with the magnitude of the maximum cooling.Second,the magnitude of ocean surface cooling increases with latitude in the tropical region for tropical cyclones with different intensities and translation speeds.Third,the ocean surface cooling is larger in summer and autumn than in spring for tropical cyclones with different intensities and translation speeds.Fourth,the dependence of ocean surface cooling on the translation speed is more obvious at higher latitudes in the tropics and less apparent in spring.These new findings add to the existing knowledge of the impacts of tropical cyclone intensity and translation speed on ocean surface cooling. | Mengxi JIN Ziyuan ZHAO Renguang WU Peijun ZHU | 2023 | Journal of Meteorological Research2023，37，6： | 0 |
| 13 | Sealing functional ionic liquids in conjugated microporous polymer membrane by solvent-assisted micropore tightening显示文摘Porous organic polymers hold great promise for molecular sieving membrane separation.Although the inclusion of functional ionic liquid(IL)in the pores offers a facile way to manipulate their separation properties,the IL leaching during the separation process is difficult to avoid.Herein,we report a strategy to in-situ encapsulate ILs into the micropores of the conjugated microporous polymer membrane via a 6-min electropolymerization and further seal the aperture of the pores to prevent ILs leaching by solvent-assisted micropore tightening(SAMT).Upon screening the binding energy between different ILs and gas molecules,two ILs were selected to be incorporated into the membrane for CO_(2)/CH_(4) and O_(2)/N_(2) gas separations.The resultant separation performances surpass the 2008 Robeson upper bound.Notably,the ILs can be locked in the micropores by a facile high surface tension solvent treatment process to improve their separation stability,as evidenced by a 7-day continuous test.This simple and controllable process not only enables efficient and steady separation performance but also provides an effective strategy for confining and sealing functional guest molecules in the porous solids for various applications. | Mengxi Zhang Anke Yu Xiangyu Wu Pengpeng Shao Xin Huang Dou Ma Xianghao Han Jing Xie Xiao Feng Bo Wang | 2022 | Nano Research2022，15，3： | 0 |
| 14 | Perlecan/Hspg2 Deficiency Impairs Bone’s Calcium Signaling and Associated Transcriptome in Response to Mechanical Loading显示文摘Perlecan,a heparan sulfate proteoglycan,acts as a mechanical sensor for bone to detect external loading.Deficiency of perlecan increases the risk of osteoporosis in patients with Schwartz-Jampel Syndrome(SJS)and attenuates loading4nduced bone formation in perlecan deficient mice(Hypo).Considering that intracellular calcium[Ca2+]i is an ubiquitous messenger controlling numerous cellular processes including mechanotransduction,we hypothesized that perlecan deficiency impairs bone’s calcium signaling in response to loading.To test this,we performed real-time[Ca2+]i imaging on in situ osteocytes of adult murine tibiae under cyclic loading(8 N,Figure 1).Relative to wild type(WT),Hypo osteocytes showed decreases in the overall[Ca2+]i response rate(-58%),calcium peaks(-33%),cells with multiple peaks(-53%),peak magnitude(-6.8%),and recovery speed to baseline(-23%).RNA sequencing and pathway analysis of tibiae from mice subjected to one or seven days of unilateral loading demonstrated that perlecan deficiency significantly suppressed the calcium signaling,ECM-receptor interaction,and focal adhesion pathways following repetitive loading.Defects in the endoplasmic reticulum(ER)calcium cycling regulators such as Ryr1/ryanodine receptors and Atp2a1/Sercal calcium pumps were identified in Hypo bones.Taken together,impaired calcium signaling may contribute to bone’s reduced anabolic response to loading,underlying the osteoporosis risk for the SJS patients. | Shaopeng Pei Sucharitha Parthasarathy Ashutosh Parajuli Jerahme Martinez Mengxi Lv Sida Jiang Danielle Wu Shuo Wei XLucas Lu Mary CFarach-Carson Catherine BKirn-Safran Liyun Wang | 2019 | 医用生物力学2019，34，A01： | 0 |
| 15 | Optimization of in vitro Regeneration System of Benihoppe Strawberry (Fragaria × ananassa Duch.) with Orthogonal Experiment Design显示文摘[Objective] This study aimed to optimize the in vitro regeneration system of Benihoppe strawberry. [Method] Based on orthogonal experiment, the effects of different medium types, plant growth regulator types and concentrations on the regeneration of adventitious shoots of Benihoppe strawberry leaves were investigated. [Result] IBA is an important factor affecting the multiplication of adventitious shoots of Benihoppe strawberry leaves; the optimal induction medium is MS + 2.0 mg/L TDZ + 0.2 mg/L IBA, with an induction rate of 90.00%; the optimal differentiation medium is MS + 2.0 mg/L 6-BA + 0.2 mg/L IBA, with a differentiation rate of 8.1%; the optimal multiplication medium is MS + 1.0 mg/L 6-BA + 0.2 mg/L IBA, with an average multiplication rate of each adventitious shoot of 7.67; the optimal subculture medium is MS + 0.5 mg/L 6-BA + 0.1 mg/L 2, 4-D, with an average seeding height in each treatment of 5.98 cm; the optimal rooting medium is 1/2MS + 0.5 mg/L 6-BA + 0.1 mg/L 2, 4-D, with an average number of roots in each treatment of 4.5. [Conclusion] This study laid the foundation for further investigating the genetic transformation of strawberry and improving the quality of strawberry at the genetic level. | Xiangli SONG Zhihui WU Mengxi LU Bei GUO | 2012 | Agricultural Biotechnology2012，1，4： | 0 |
| 16 | Photonic radio frequency channelizers based on Kerr optical micro-combs显示文摘We review recent work on broadband RF channelizers based on integrated optical frequency Kerr micro-combs combined with passive micro-ring resonator filters,with microcombs having channel spacings of 200 and 49 GHz.This approach to realizing RF channelizers offers reduced complexity,size,and potential cost for a wide range of applications to microwave signal detection. | Mengxi Tan Xingyuan Xu Jiayang Wu Thach G.Nguyen Sai T.Chu Brent E.Little Roberto Morandotti Arnan Mitchell David J.Moss | 2021 | Journal of Semiconductors2021，42，4： | 0 |
| 17 | Combination of Solid-Phase Micro-Extraction and Direct Analysis in Real Time-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Sensitive and Rapid Analysis of 15 Phthalate Plasticizers in Beverages显示文摘A method for rapid identification and quantification of phthalate plasticizers in beverages was developed.A number of 15 phthalate plasticizers which covered all the phthalates concerned in the US Consumer Product Safety Improvement Act(CPSIA),European Union legislations and Chinese national standards(GB)were analyzed.By a combined solid-phase micro-extraction(SPME)and direct analysis in real time mass spectrometry(DART-MS)approach,phthalates at sub-ng•mL^(−1)levels can be qualitatively and quantitatively analyzed in a short time.The use of ultrahigh-resolving power and the accurate mass measurement capacity naturally provided by Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR-MS)minimizes the matrix interferences and thus enables the evaluation of phthalates in a complex matrix without extensive sample handlings or preparations.The limits of quantification(LOQs)were estimated to be at 0.3-5.0 ng•mL^(−1),lower than the Maximum Residue Limit(MRL)regulated by the European Union legislations(2007/19/EC)in foods,beverages,food packaging and toys(0.3-30 ng•mL^(−1)).This rapid and easy-to-use SPME-DART-FT-ICR-MS method provided a relatively high-throughput and powerful analytical approach for quick testing and screening phthalates in beverages and water samples to ensure food safety. | Mengxi Wu Haoyang Wang Guoqing Dong Brian D.Musselman Charles C.Liu Yinlong Guo | 2015 | Chinese Journal of Chemistry2015，33，2： | 0 |
| 18 | OGP: A Repository of Experimentally Characterized O-glycoproteins to Facilitate Studies on O-glycosylation显示文摘Numerous studies on cancers, biopharmaceuticals, and clinical trials have necessitated comprehensive and precise analysis of protein O-glycosylation. However, the lack of updated and convenient databases deters the storage of and reference to emerging O-glycoprotein data. To resolve this issue, an O-glycoprotein repository named OGP was established in this work.It was constructed with a collection of O-glycoprotein data from different sources. OGP contains 9354 O-glycosylation sites and 11,633 site-specific O-glycans mapping to 2133 O-glycoproteins, and it is the largest O-glycoprotein repository thus far.Based on the recorded O-glycosylation sites, an O-glycosylation site prediction tool was developed. Moreover, an OGP-based website is already available(http://gffzzefe90b8845f64b49hbpc6ofnp6ppn69uu.ffgz.tsg.suse.edu.cn/). The website comprises four specially designed and user-friendly modules:statistical analysis, database search, site prediction, and data submission. The first version of OGP repository and the website allow users to obtain various O-glycoprotein-related information, such as protein accession Nos., O-glycosylation sites,O-glycopeptide sequences, site-specific O-glycan structures, experimental methods, and potential O-glycosylation sites.O-glycosylation data mining can be performed efficiently on this website, which will greatly facilitate related studies. In addition, the database is accessible from OGP website(http://gffzzefe90b8845f64b49hbpc6ofnp6ppn69uu.ffgz.tsg.suse.edu.cn/download.php). | Jiangming Huang Mengxi Wu Yang Zhang Siyuan Kong Mingqi Liu Biyun Jiang Pengyuan Yang Weiqian Cao | 2021 | Genomics, Proteomics & Bioinformatics2021，19，4： | 0 |
| 19 | An alternative splicing variant of mineralocorticoid receptor discovered in preeclampsia tissues and its effect on endothelial dysfunction显示文摘The pathophysiology of preeclampsia(PE)remains unclear.PE spiral artery remodeling dysfunction and PE offspring cardiovascular future development has been a worldwide concern.We collected placental and umbilical artery samples from normotensive and PE pregnancies.Mineralocorticoid receptor(MR)and its alternative splicing variant(ASV)expression and their biological effects on PE were examined.An MR ASV was found to be highly expressed in all PE samples and slightly expressed in about half of the normotensive samples(umbilical artery,~57.58%;placenta,~36.84%).The MR ASV expression was positively associated with blood pressure in both groups.The MR ASV protein changed the aldosterone-induced expression pattern of MR target genes related to ion exchanges and cell signaling pathways.The MR ASV can also impair the proliferation,migration,and tube formation ability of endothelial cells.These findings indicate that MR ASV in PE placenta plays a pathogenic role in PE pathophysiology,especially in endothelial dysfunction,and the existence of the MR ASV in PE umbilical artery provides a new direction in the study of PE offspring with increased risk of cardiovascular diseases. | Mengxi Guo Chengliang Zhou Gufeng Xu Lin Tang Yechun Ruan Ying Yu Xianhua Lin Dandan Wu Hao Chen Priscilla Yu Luyang Jin Yinyu Wang Yimei Wu Kamran Ullah Tanzil Ur Rahman Xinmei Liu Jianzhong Sheng Hsiao-Chang Chan Hefeng Huang | 2020 | Science China(Life Sciences)2020，63，3： | 0 |
| 20 | COVID-19 Lexicon in English News Reports Based on the Theory of Semantic Field显示文摘Coronavirus disease,or simply COVID-19,has affected many regions worldwide.The pandemic has caused great losses from all walks of life.Millions of people have died from the virus.In order to facilitate people’s understanding of COVID-19,the present study adopts the theory of semantic field to analyze the COVID-19 lexicon that appeared in China Daily,an authoritative international daily newspaper issued by China.A total of 100 pieces of English news issued by China Daily have been randomly selected for this research.According to the theory of semantic field in structural linguistics,the meaning of a word cannot stand alone,but come into being with the meanings of its related words.Therefore,it is reasonable to try to understand COVID-19 as thoroughly as possible with relevant words,which form its semantic field. | Mengxi Wu | 2021 | Journal of Contemporary Educational Research2021，5，11： | 0 |
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