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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | Uplink Grant-Free Pattern Division Multiple Access (GF-PDMA) for 5G Radio Access显示文摘Massive machine type communication(m MTC) is one of the key application scenarios for the fifth generation mobile communication(5 G). Grant-free(GF) transmission can reduce the high signaling overhead in m MTC. Non-orthogonal multiple access(NMA) can support more users for m MTC than orthogonal frequency division multiple access(OFDMA). Applying GF transmission in NMA system becomes an active topic recently. The in-depth study on applying GF transmission in pattern division multiple access(PDMA), a competitive candidate scheme of NMA, is investigated in this paper. The definition, latency and allocation of resource and transmission mechanism for GF-PDMA are discussed in detail. The link-level and system-level evaluations are provided to verify the analysis. The analysis and simulation results demonstrate that the proposed GF-PDMA has lower latency than grant based PDMA(GB-PDMA), possesses strong scalability to confront collision and provides almost 2.15 times gain over GF-OFDMA in terms of supporting the number of active users in the system. | Wanwei Tang Shaoli Kang Bin Ren Xinwei Yue | 2018 | China Communications2018，15，4： | 10 |
| 3 | Edge biomarkers for classification and prediction of phenotypes显示文摘In general,a disease manifests not from malfunction of individual molecules but from failure of the relevant system or network,which can be considered as a set of interactions or edges among molecules.Thus,instead of individual molecules,networks or edges are stable forms to reliably characterize complex diseases.This paper reviews both traditional node biomarkers and edge biomarkers,which have been newly proposed.These biomarkers are classified in terms of their contained information.In particular,we show that edge and network biomarkers provide novel ways of stably and reliably diagnosing the disease state of a sample.First,we categorize the biomarkers based on the information used in the learning and prediction steps.We then briefly introduce conventional node biomarkers,or molecular biomarkers without network information,and their computational approaches.The main focus of this paper is edge and network biomarkers,which exploit network information to improve the accuracy of diagnosis and prognosis.Moreover,by extracting both network and dynamic information from the data,we can develop dynamical network and edge biomarkers.These biomarkers not only diagnose the immediate pre-disease state but also detect the critical molecules or networks by which the biological system progresses from the healthy to the disease state.The identified critical molecules can be used as drug targets,and the critical state indicates the critical point of disease control.The paper also discusses representative biomarker-based methods. | ZENG Tao ZHANG WanWei YU XiangTian LIU XiaoPing LI MeiYi LIU Rui CHEN LuoNan | 2014 | Science China(Life Sciences)2014，57，11： | 5 |
| 4 | Pattern Matrix Design of PDMA for 5G UL Applications显示文摘Pattern division multiple access(PDMA),which is a novel non-orthogonal multiple access(NOMA),has been proposed to address the challenges of massive connectivity and higher spectral efficiency for fifth generation(5G) mobile network.The performance of PDMA mainly depends on the design of PDMA pattern matrix.In this paper,pattern matrix design of PDMA for 5G uplink(UL) applications in massive machine type communication(mMTC) and enhanced mobile broadband(eMBB) deployment scenarios are studied.The design criteria and examples for application in UL mMTC and UL eMBB are investigated.The performance of the PDMA pattern matrix is analyzed with the discrete constellation constrained capacity(CC-Capacity),and verified by Monte Carlo simulation.The simulation results show that the preferred PDMA pattern matrix can achieve good performance with different overloading factors(OF). | Bin Ren Yingmin Wang Xiaoming Dai Kai Niu Wanwei Tang | 2016 | China Communications2016，13，S2： | 3 |
| 5 | Salivary microbiota may predict the presence of esophageal squamous cell carcinoma显示文摘The aim is to explore the predictive value of salivary bacteria for the presence of esophageal squamous cell carcinoma (ESCC). Saliva samples were obtained from 178 patients with ESCC and 101 healthy controls, and allocated to screening and verification cohorts, respectively. In the screening phase, after saliva DNA was extracted, 16S rRNA V4 regions of salivary bacteria were amplified by polymerase chain reaction (PCR) with high-throughput sequencing. Highly expressed target bacteria were screened by Operational Taxonomic Units clustering, species annotation and microbial diversity assessment. In the verification phase, the expression levels of target bacteria identified in the screening phase were verified by absolute quantitative PCR (Q-PCR). Receiver operating characteristic (ROC) curves were plotted to investigate the predictive value of target salivary bacteria. LEfSe analysis revealed higher proportions of Fusobacterium, Streptococcus and Porphyromonas, and Q-PCR assay showed significantly higher numbers of Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in patients with ESCC, when compared with healthy controls (all P < 0.05). The areas under the ROC curves for Streptococcus salivarius, Fusobacterium nucleatum, Porphyromonas gingivalis and the combination of the three bacteria for predicting patients with ESCC were 69%, 56.5%, 61.8% and 76.4%, respectively. The sensitivities corresponding to cutoff value were 69.3%, 22.7%, 35.2% and 86.4%, respectively, and the matched specificity were 78.4%, 96.1%, 90.2% and 58.8%, respectively. These highly expressed Streptococcus salivarius, Fusobacterium nucleatum and Porphyromonas gingivalis in the saliva, alone or in combination, indicate their predictive value for ESCC. | Junmin Wei Ruifeng Li Yanxian Lu Fan Meng Bohong Xian Xiaorong Lai Xiayi Lin Yu Deng Dongyang Yang Huabin Zhang Liangfang Li Xiaosong Ben Guibin Qiao Wanwei Liu Zijun Li | 2022 | Genes & Diseases2022，9，4： | 2 |
| 6 | CPT1C-mediated fatty acid oxidation facilitates colorectal cancer cell proliferation and metastasis显示文摘Fatty acid oxidation(FAO)has been proven to be an accomplice in tumor progression.Carnitine palmitoyltransferase 1C(CPT1C),a rate-limiting enzyme in FAO,mainly functions to catalyze fatty acid carnitinylation and guarantee subsequent entry into the mitochondria for FAO in colorectal cancer(CRC).Gene expression data and clinical information extracted from The Cancer Genome Atlas(TCGA)database show significantly higher expression of CPT1C in patients with metastatic CRC(P=0.005).Moreover,overexpression of CPT1C is correlated with worse relapse-free survival in CRC(HR 2.1,P=0.0006),while no statistical significance is indicated for CPT1A and CPT1B.Further experiments demonstrate that downregulation of CPT1C expression leads to a decrease in the FAO rate,suppression of cell proliferation,cell cycle arrest and repression of cell migration in CRC,whereas opposite results are obtained when CPT1C is overexpressed.Furthermore,an FAO inhibitor almost completely reverses the enhanced cell proliferation and migration induced by CPT1C overexpression.In addition,analysis of TCGA data illustrates a positive association between CPT1C expression and HIF1αlevel,suggesting that CPT1C is a transcriptional target of HIF1α.In conclusion,CPT1C overexpression indicates poor relapse-free survival of patients with CRC,and CPT1C is transcriptionally activated by HIF1α,thereby promoting the proliferation and migration of CRC cells. | Jing Li Wanwei Zheng Jie Wu Jun Zhang Bin Lv Wenshuai Li Jie Liu Xin Zhang Tiansheng Huang Zhongguang Luo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 1 |
| 7 | Towards Connecting Discrete Mathematics and Software Engineering显示文摘To enhance training in software development,we argue that students of software engineering should be exposed to software development activities early in the curriculum.This entails meeting the challenge of engaging students in software development before they take the software engineering course.In this paper,we propose a method to connect courses in the software engineering curriculum by setting comprehensive development projects to students in prerequisite courses for software development.Using the Discrete Mathematics(DM)course as an example,we describe the implementation of the proposed method and teaching practices using several practical and comprehensive projects derived from topics in discrete mathematics.Detailed descriptions of the sample projects,their application,and training results are given.Results and lessons learned from applying these practices show that it is a promising way to connect courses in the software engineering curriculum. | Tun Li Wanwei Liu Juan Chen Xiaoguang Mao Xinjun Mao | 2020 | Tsinghua Science and Technology2020，25，3： | 1 |
| 8 | Bile acids induced cell necropotosis显示文摘 | Wanwei L Menggang L Long C | 2014 | J Cytol Histol2014，54，： | 1 |
| 9 | Towards Sustainable Development Goals:Study on the Consequences of Food Insecurity Among Global Population—Worldwide,2022显示文摘Summary What is already known about this topic?The global population is predicted to reach 8 billion by the end of 2022,which can delay the progress and exacerbate the challenges of achieving the Sustainable Development Goals(SDGs),especially the goal of“Zero Hunger.”What is added by this report?During the next 15 years,it is predicted that the world’s population will increase from 8 billion to 9 billion people.Although food insecurity is anticipated to decrease over the next three decades for most of the world,food insecurity is anticipated to increase in Africa.Accelerating population growth is projected to lead to larger percentages of infants with low birth weight and of children under 5 years old with stunted growth.What are the implications for public health practice?Rapid population growth will make it more difficult to achieve the SDGs for ending hunger and ensuring good health and well-being.It is important to develop foresight and adopt proactive planning that is guided by careful demographic analysis. | Ping He Wanwei Dai Yanan Luo Ruoxi Ding Xiaoying Zheng | 2022 | China CDC weekly2022，4，27： | 1 |
| 10 | EffectofsolidloadingongelcastingofsilicaceramicsusingDMAA显示文摘 | WanWei YangJian ZengJinzhen etal | 2014 | CeramInt2014，40，17： | 1 |
| 11 | Identification and construction of a novel biomimetic delivery system of paclitaxel and its targeting therapy for cancer显示文摘Dear Editor,Paclitaxel(PTX)is among the frst-line therapeutic agents against diverse malignancies.However,problems still exist concerning its poor water-solubility,multidrug resistance,lack of specific targeting ability and severe toxic effects,and these issues are far from fully resolved despite the various PTX formulations available on.the market,e.g.the gold standard,PTX albumin nanoparticles Abraxane I and PTX liposomes Lipusu.Some studies that try to solve the multiple problems faced by chemotherapy drug delivery,however,fell into the prevailing trap of overcomplicated formulation design which sacrifices the druggability.To better reconcile this paradox,a novel glycosylated liposomal PTX was designed,inspired by the cytomembrane glycosyls with important roles in.maintaining both membrane structure and physiological functions,3 such as enhan-cing membrane stability,evading immunological clearance,and recognizing corresponding receptors.Ginsenosides,as natural amphiphilic molecules,are structurally similar to cholesterol,contain glycosyl moieties,and are easily obtainable. | Xue Wang Wanwei Zheng Qing Shen Yahua Wang Yujen Tseng Zhongguang Luo Xiaoyou Wang Lei Shi Chong Li Jie Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
| 12 | Application of Prochloraz-nano-titanium Dioxide Complex Fresh-keeping Agent in Refrigeration of Dioscorea alata Lirm. sp.显示文摘Prochloraz diluents( 450 ×,475 ×,500 ×) were added with different concentrations of nano-titanium dioxide( Ti O2)( 0. 8%,1. 0%) respectively to prepare complex fresh-keeping agents,which were applied in the refrigeration of Dioscorea alata Lirm. sp. With rot index,weight loss rate,browning degree( BD),total soluble solids( TSS) content,malondialdehyde( MDA) content,polyphenol oxidase( PPO) activity and peroxidase( POD) activity,DPPH· scavenging rate as evaluation indexes,the preservation effect of the prepared freshkeeping agents on D. alata during the cold storage period was analyzed. The results showed that prochloraz added with nano-titanium dioxide significantly prolonged the storage life,reduced the rot rate and weight loss rate,and slowed the loss of pulp of D. alata. The preservation effect of complex fresh-keeping agent of prochloraz diluent( 475 ×) and nano-titanium dioxide( 1. 0%) was better than that of other treatments. | Dongdi XIE Yanpei WEI Xiaoping WEI Wanwei WU | 2018 | Asian Agricultural Research2018，10，10： | 1 |
| 13 | In situ generation of palladium nanoparticles: ligand-free palladium catalyzed ultrafast Suzuki–Miyaura cross-coupling reaction in aqueous phase at room temperature显示文摘 | Zhengyin Du Wanwei Zhou Fen Wang Jin-Xian Wang | 2011 | Tetrahedron2011，，26： | 1 |
| 14 | In Situ Generation of PalladiumNanoparticles: Reusable, Ligand-Free Heck Reaction in PEG-400 Assistedby Focused Microwave Irradiation显示文摘 | Zhengyin Du Wanwei Zhou Lin Bai Fen Wang Jin-Xian Wang | 2011 | Synlett2011，，03： | 1 |
| 15 | FoxO1 inhibits sterol regulatory element-binding protein-lc (SREBP-lc) gane expression via transcription factors Spl and SREBP-lc 显示文摘 | Xiong D Wanwei Z Insug O S | 2012 | Journal of Biological Chemistry2012，287，20： | 1 |
| 16 | DOCK2 regulates antifungal immunity by regulating RAC GTPase activity显示文摘Fungal infections cause~1.5 million deaths each year worldwide,and the mortality rate of disseminated candidiasis currently exceeds that of breast cancer and malaria.The major reasons for the high mortality of candidiasis are the limited number of antifungal drugs and the emergence of drug-resistant species.Therefore,a better understanding of antifungal host defense mechanisms is crucial for the development of effective preventive and therapeutic strategies.Here,we report that DOCK2(dedicator of cytokinesis 2)promotes indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.DOCK2-deficient macrophages exhibit decreased RAC GTPase(Rac family small GTPase)activation and ROS(reactive oxygen species)production,which in turn attenuates the killing of intracellular fungi and the activation of downstream signaling pathways.Mechanistically,after fungal stimulation,activated SYK(spleen-associated tyrosine kinase)phosphorylates DOCK2 at tyrosine 985 and 1405,which promotes the recruitment and activation of RAC GTPases and then increases ROS production and downstream signaling activation.Importantly,nanoparticle-mediated delivery of in vitro transcribed(IVT)Rac1 mRNA promotes the activity of Rac1 and helps to eliminate fungal infection in vivo.Taken together,this study not only identifies a critical role of DOCK2 in antifungal immunity via regulation of RAC GTPase activity but also provides proof of concept for the treatment of invasive fungal infections by using IVT mRNA. | Xiaojian Ma Xi Tan Bingbing Yu Wanwei Sun Heping Wang Huijun Hu Yanyun Du Ruirui He Ru Gao Qianwen Peng Zhihui Cui Ting Pan Xiong Feng Junhan Wang Chengqi Xu Bin Zhu Wei Liu Chenhui Wang | 2022 | Cellular & Molecular Immunology2022，19，5： | 1 |
| 17 | Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘In the initial published version of this article, there was a mistake in the P value for the correlation between gene-expression changes and 5 hmC changes in tumors. The correct P value should be same as the P value shown in Fig. S6A: 9.8?×?10?6 (mistakenly shown as “9.8?×?106” in the main text). This correction does not affect the description of results or the conclusions of this study, since the range of P value is between 0 and 1. | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2019 | Cell Research2019，29，7： | 1 |
| 18 | An irrigation decision-making andappraisal model based on the weather data显示文摘 | Zhang Lizhen Huang Yushu Zhang Wanwei | 1997 | Irrigation and Drainage1997，16，4： | 1 |
| 19 | On the complexity of ω-pushdown automata显示文摘Finite automata over infinite words(called ω-automata) play an important role in the automatatheoretic approach to system verification. Different types of ω-automata differ in their succinctness and complexity of their emptiness problems, as a result, theory of ω-automata has received considerable research attention.Pushdown automata over infinite words(called ω-PDAs), a generalization of ω-automata, are a natural model of recursive programs. Our goal in this paper is to conduct a relatively complete investigation on the complexity of the emptiness problems for variants of ω-PDAs. For this purpose, we consider ω-PDAs of five standard acceptance types: B¨uchi, Parity, Rabin, Streett and Muller acceptances. Based on the transformation for ω-automata and the efficient algorithm proposed by Esparza et al. in CAV'00 for verifying the emptiness problem of ω-PDAs with B¨uchi acceptance, it is trivial to check the emptiness problem of other ω-PDAs. However, this naive approach is not optimal. In this paper, we propose novel algorithms for the emptiness problem of ω-PDAs based on the observations of the structure of accepting runs. Our algorithms outperform algorithms that go through B¨uchi PDAs. In particular, the space complexity of the algorithm for Streett acceptance that goes through B¨uchi acceptance is exponential, while ours is polynomial. The algorithm for Parity acceptance that goes through B¨uchi acceptance is in O(k3n2m) time and O(k2nm) space, while ours is in O(kn2m) time and O(nm) space, where n(resp. m and k) is the number of control states(resp. transitions and index). Finally,we show that our algorithms yield a better solution for the pushdown model checking problem against linear temporal logic with fairness. | Yusi LEI Fu SONG Wanwei LIU Min ZHANG | 2017 | Science China(Information Sciences)2017，60，11： | 0 |
| 20 | Probabilistic synthesis against GR(1) winning condition显示文摘Reactive synthesis is a technique for automatic generation of a reactive system from a high level specification.The system is reactive in the sense that it reacts to the inputs from the environment.The specification is in general given as a linear temporal logic(LTL)formula.The behaviour of the system interacting with the environment can be represented as a game in which the system plays against the environment.Thus,a problem of reactive synthesis is commonly treated as solving such a game with the specification as the winning condition.Reactive synthesis has been thoroughly investigated for more two decades.A well-known challenge is to deal with the complex uncertainty of the environment.We understand that a major issue is due to the lack of a sufficient treatment of probabilistic properties in the traditional models.For example,a two-player game defined by a standard Kriple structure does not consider probabilistic transitions in reaction to the uncertain physical environment;and a Markov Decision Process(MDP)in general does not explicitly separate the system from its environment and it does not describe the interaction between system and the environment.In this paper,we propose a new and more general model which combines the two-player game and the MDP.Furthermore,we study probabilistic reactive synthesis for the games of General Reactivity of Rank 1(i.e.,GR(1))defined in this model.More specifically,we present an algorithm,which for given model,a location and a GR(1)specification,determines the strategy for each player how to maximize/minimize the probabilities of the satisfaction of at location.We use an example to describe the model of probabilistic games and demonstrate our algorithm. | Wei ZHAO Rui LI Wanwei LIU Wei DONG Zhiming LIU | 2022 | Frontiers of Computer Science2022，16，2： | 0 |
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