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| 1 | Gasdermin D is an executor of pyroptosis and required for interleukin-lp secretion显示文摘 | Wan-ting He Haoqiang Wan Lichen Hu Pengda Chen Xin Wang Zhe Huang Zhang-Hua Yang Chuan-Qi Zhong Jiahuai Han | 2015 | Cell Research2015，25，12： | 195 |
| 2 | Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis显示文摘Necroptosis 和 pyroptosis 是有血浆膜破裂的一个普通特征的规划房间死亡的二种形式。这里,我们与 necroptosis 比较学习了 pyroptosis 的形态学和机制。与 necroptosis 不同, pyroptosis 经历膜 blebbing 并且生产 apoptotic 在血浆膜以前的像身体的房间伸出(称为的 pyroptotic 身体) 破裂。在 necroptosis 的破裂是像爆炸的,而在 pyroptosis 它导致房间变平。necroptosis 的实行被混合的系 kinase 调停,这被知道像域(MLKL ) 在血浆膜的 oligomers,而 gasdermin-D (GSDMD ) 调停在它由 caspase-1 或 caspase-11 的劈开以后的 pyroptosis。我们显示出那 N 终端碎片 caspase 劈开产生的 GSDMD (GSDMD-N ) 也形成 oligomer 并且移居到血浆膜杀死房间。MLKL 和 GSDMD-N 是脂性的,两蛋白质的 N 终端序列为他们的 oligomerization 和血浆膜 translocation 是重要的。不同于在血浆膜上形成隧道的 MLKL,那导致渗透地胀大的选择离子的流入冲破的房间, GSDMD-N 形成非选择的毛孔并且不依靠增加的 osmolarity 破坏房间。我们的学习表明 GSDMD 的形成毛孔的活动和 MLKL 的形成隧道的活动在 pyroptosis 和 necroptosis 决定血浆膜破裂的不同方法。 | Xin Chen Wan-ting He Lichen Hu Jingxian Li Yuan Fang Xin Wang Xiaozheng Xu Zhuo Wang Kai Huang Jiahuai Han | 2016 | Cell Research2016，26，9： | 110 |
| 3 | Successive inverse and normal magnetocaloric effects in the Mn-vacancy compound Mn0.95Co0.75Cu0.25Ge显示文摘Ferromagnetic-structural transformation has been studied widely in MnCoGe-based materials. However, the magnetostructural transition(MST) from antiferromagnetic(AFM) orthorhombic phase to ferromagnetic(FM) hexagonal phase, which may lead to a large inverse magnetocaloric effect(MCE), has rarely been reported. Here, the introduction of Mn vacancy lowers the structural transition temperature while retains the AFM state in the orthorhombic phase, thus successfully realizing the AFM-FM MST in Mn0.95Co0.75Cu0.25Ge. Moreover, successive inverse and normal MCEs are observed around the first-order AFM-FM MST and the second-order FM-paramagnetic(PM) transition, respectively. A thermostat is proposed based on this special feature, which could release heat above the critical temperature while absorb heat below the critical temperature by simply applying the same magnetization/demagnetization cycles. This thermostat can be very useful in many applications where a constant temperature is required, such as cryostats and incubators. | FengXia Liu Hu Zhang He Zhou DaoYong Cong RongJin Huang LiChen Wang Yi Long | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，7： | 9 |
| 4 | A Pulse Immunization Model for Inhibiting Malware Propagation in Mobile Wireless Sensor Networks显示文摘Mobile wireless sensor networks(MWSNs)may be under attack due to their large-scale characteristics. One of the main threats is to inject malware into some nodes. To prevent malware from spreading in a largescale MWSN, an effective measure is to immunize susceptible nodes by disseminating and installing security patches. This work suggests a novel modeling framework and some mathematical models based on the pulse differential equation and the epidemic theory, in which the immunization operations are implemented on susceptible nodes in a pulse way. The maximum immunization period of time is derived to minimine the number of immunization operations while ensuring malware extinct over time in the MWSN. The theoretical results are confirmed by extensive simulations. | WANG Xiaoming HE Zaobo ZHANG Lichen | 2014 | Chinese Journal of Electronics2014，23，4： | 8 |
| 5 | Energy Efficient Forwarding Algorithm in Opportunistic Networks显示文摘In opportunistic networks, a successful message transmission between node pairs depends on the message size, the transmission speed and the connection duration time. This paper proposes a new message forwarding algorithm to improve the message delivery ratio and reduce the energy consumption. Previous encounter characteristics between nodes are used to estimate future connection duration time using a three point estimation method. Furthermore, the buffer utilization of nodes is used as a weight for the likelihoods to meet destinations according to the hop count of messages stored in the buffer.The simulation results show that the proposed forwarding algorithm achieves higher delivery ratio and less overhead ratio than the other four popular routing protocols.In addition, the proposed algorithm gains a better average residual energy performance among all the compared protocols. | ZHANG Feng | 2016 | Chinese Journal of Electronics2016，25，5： | 3 |
| 6 | Preparation of TiO2/MCM-41 by plasma enhanced chemical vapor deposition method and its photocatalytic activity显示文摘 | Shenghung WANG Kuohua WANG Jihmirn JEHNG Lichen LIU | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 3 |
| 7 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 8 | Reaction-Diffusion Equation Based Image Denoising Algorithm显示文摘 | ZHAO Xueqing WANG Xiaoming ZHANG Lichen | 2012 | Chinese Journal of Electronics2012，21，3： | 2 |
| 9 | Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC)显示文摘Co-delivery of anti-inflammatory siRNA and hydrophilic drug provides a promising approach for the treatment of ulcerative colitis (UC). However, lack of a suitable and efficient co-delivery carrier poses critical challenge against their utilization. We herein developed macrophage-targeting, reversibly crossli nked polymersomes (TKPR-RCP) based on the TKPR-modified, poly(ethyle ne glycol)-b-poly(trimethylene carbonate-codithiolane trimethylene carbonate)-b-polyethylenimine (PEG-P(TMC-DTC)-PEI) triblock copolymer, which could efficiently encapsulate TNF-α siRNA and dexamethasone sodium phosphate (DSP) in their hydrophilic core. The cationic PEI segments provided additional electrostatic interactions with cargo molecules to promote the encapsulatiion, and disulfide crosslinking of the polymersome membrane endowed the TKPR-RCP with high colloidal stability. Because the cationic PEI was embedded in the hydrophilic core, the polymersomes displayed neutral surface charge and thus possessed high serum stability. The TKPR-RCP co-encapsulating TNF-α siRNA and DSP could be efficiently internalized by macrophages (~98%) and undergo redox-responsive membrane de-crosslinking to accelerate cargo release in the cytoplasm, thus inducing efficient gene silencing and anti-inflammatory effect .Intravenous injectio n of the co-delivery TKPR-RCP mediated pote nt and cooperative anti-inflammatory effect in inflamed colons of UC mice, and significantly prevented animals from colonic injury. This study therefore provides a promising approach for the co-delivery of hydrophilic drug/siRNA toward the treatment of inflammatory bowel diseases. | Xin Xu Weijing Yang Qiujun Liang Yanan Shi Wenxin Zhang Xiao Wang Fenghua Meng Zhiyuan Zhong Lichen Yin | 2019 | Nano Research2019，12，3： | 2 |
| 10 | Serum Vitamin A Nutritional Status of Children and Adolescents Aged 6−17 Years—China,2016−2017显示文摘Summary What is already known on this topic?Vitamin A deficiency(VAD)in children is still a global public health problem,which needs continuous monitoring and timely intervention.What is added by this report?Using surveillance data from China Nutrition and Health Surveillance of Children and Lactating Mothers in 2016−2017,the prevalence of VAD and marginal deficiency was 0.96%and 14.71%,respectively. | Rui Wang Huidi Zhang Yi-chun Hu Jing Chen Zhenyu Yang Liyun Zhao Lichen Yang | 2021 | China CDC weekly2021，3，9： | 2 |
| 11 | A New Smart Material-Multilayer PTC Thermistor 显示文摘 | Wang Lichen Zhou Zhigang | 1995 | IEEE Trans-A1995，，18： | 1 |
| 12 | The impact of node velocity diversity on mobile opportunistic network performance显示文摘 | Lin Yaguang Wang Xiaoming Zhang Lichen | 2015 | Journal of Network and ComputerApplications2015，55，： | 1 |
| 13 | The impact of node velocity diversity on mobile opportunistic network performance显示文摘 | Lin Yaguang Wang Xiaoming Zhang Lichen | 2015 | Journal of Network and Computer Applications2015，55，： | 1 |
| 14 | Analysis of the degradation mechanism of methylene blue by atmospheric pressure dielectric barrier discharge plasma显示文摘 | Fangming Huang Lichen Honglin Wang Zongcheng Yan | | 0，，： | 1 |
| 15 | A fuzzy recommender systembased on the integration of subjective preferences and objec-tive information 显示文摘 | Cheng Lichen Wang Huaan | 2014 | Applied Soft Computing2014，，18： | 1 |
| 16 | Visible-light Photochromism of Phosphomolybdic Acid/ZnO Composite显示文摘 | SUN Wentian SI Yunheng JING Haitao DONG Zhaojun WANG Chunxu ZHANG Yupeng ZHAO Lichen FENG Wei YAN Yon | 2018 | Chemical Research in Chinese Universities2018，34，3： | 1 |
| 17 | Geological features and hydrocarbon accumulation in the Xinken oil field,Tarim Basin显示文摘Recently,a large-scale Ordovician oil and gas pool has been discovered in Xinken,north of the Tarim Basin,and it has strongly heterogeneous reservoirs and complicated fluid distribution.Through analyzing oil,gas and water samples collected from this area,in combination of field production and testing data,this study reveals that the Xinken oil pool contains dominantly normal oil characterized by low viscosity,low sulphur,and high wax.It has a low content of natural gas,which presents typical characteristics of wet gas and is oil-associated gas.Oil-gas correlation shows that the oil was from the Middle-Upper Ordovician source rocks and the charge and accumulation of oil and gas took place in the Late Hercynian Period.Controlled by paleogeomorphology,sedimentary facies,ancient karstification,faults,and other factors in the Caledonian Period,the Ordovician carbonate reservoirs are dominated by dissolved pores,cavities and fractures.The reservoir body of fractures and cavities is distributed in the shape of strip and laminate along faults and excellent reservoirs are mostly in the range of 70–100 m below the top of the Yijianfang Formation.As a whole,the Xinken oil pool is a fracture-cavity pool controlled by interbedded karst reservoirs and is a complex composed of stacked karst fractures and cavities of various sizes.It contains oil in large areas horizontally,which is quasi-laminated in distribution,and the accumulation of oil and gas is controlled by the distribution and development degree of the Ordovician carbonate reservoirs.The study shows that this area has abundant resources and a great exploration potential for oil and gas. | SONG Lichen ZHU Guangyou LIU Xingwang ZHU Yongfeng SU Jin WANG Kai | 2013 | Chinese Journal Of Geochemistry2013，32，4： | 1 |
| 18 | The Impact of Rural Mutual Health Care on Health Status:Evaluation of a Social Experiment in Rural China显示文摘 | Hong Wang Winnie Yip Lichen Zhang and William Hsiao | 2009 | Health Economics2009，，03： | 1 |
| 19 | GhTZF1 regulates drought stress responses and delays leaf senescence by inhibiting reactive oxygen species accumulation in transgenic Arabidopsis显示文摘 | Zhou Ting Yang Xiyan Wang Lichen | 2014 | Plant Molecular Biology2014，85，12： | 1 |
| 20 | Revision of P-wave Velocity and Thickness of Hydrate Layer in Shenhu Area, South China Sea显示文摘To revise P-wave velocity and thickness of the hydrate layer in the Shenhu area of the South China Sea, acoustic and resistivity logging curves are reanalyzed. The waterlogging phenomenon is found in the shallow sediments of five drilling wells, which causes P-wave velocity to approximate the propagation velocity of sea water(about 1500 m s-1). This also affects the identification of the hydrate layer and results in the underestimate of its thickness. In addition, because there could be about a 5 m thick velocity ramp above or below the hydrate layer as interpreted by acoustic and resistivity logging curves, the recalibrated thickness of this layer is less than the original estimated thickness. The recalibrated P-wave velocity of the hydrate layer is also higher than the original estimated velocity. For the drilling well with a relatively thin hydrate layer, the velocity ramp plays a more important role in identifying and determining the thickness of the layer. | GONG Jianming ZHANG Xunhua ZOU Changchun CHEN Qiang WANG Lichen YUAN Chunfang HU Gaowei JIANG Yubo | 2014 | Journal of Ocean University of China2014，13，5： | 1 |
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