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| 1 | Gasdermin D is an executor of pyroptosis and required for interleukin-lp secretion显示文摘 | Wan-ting He Haoqiang Wan Lichen Hu Pengda Chen Xin Wang Zhe Huang Zhang-Hua Yang Chuan-Qi Zhong Jiahuai Han | 2015 | Cell Research2015，25，12： | 195 |
| 2 | China Nutrition and Health Surveys(1982−2017)显示文摘The status of nutrition and health among residents is one of the important indicators reflecting the developing level in a country or a region.China’s government initiated the first China National Nutrition Survey in 1959.The Second National Nutrition Survey and the Third National Nutrition Survey were then conducted in 1982 and 1992,respectively(1-2).The China National Nutrition and Health Survey(2002)combined the nutrition and chronic diseases survey and became the fourth survey(3). | Dongmei Yu Liyun Zhao Jian Zhang Zhenyu Yang Lichen Yang Jian Huang Hongyun Fang Qiya Guo Xiaoli Xu Lahong Ju Gangqiang Ding | 2021 | China CDC weekly2021，3，9： | 6 |
| 3 | Experimental investigation on flow characteristics in circular tube inserted with rotor-assembled strand using PIV显示文摘Rotor-assembled strand works as a typical tube insert to achieve heat transfer augmentation and scale inhibition in a heat exchanger.In this work, the PIV experiment regarding the flow fields in a circular tube inserted with rotor-assembled strand was conducted and the flow characteristics on transverse section and longitudinal section were analyzed.The results showed that swirling flow was produced in the tube inserted with rotors and it was particularly strong within the swing diameter of the rotor on the section that contains the rotor;the average turbulence intensity and the radial velocity were improved notably; the velocity vectors on the longitudinal section remained along the direction of a straight line; both the swirling flow and average turbulence intensity were higher for the rotor with three blades than for the rotor with two blades except that the radial velocity was approximate, but they were all reduced by enlarging the lead of the rotor.Characterization of the flow patterns in a circular tube contributes to understanding the heat transfer efficiency and scale inhibition performance of the rotor-assembled strand and provides guidance for its application. | Lichen He Weimin Yang Changfeng Guan Hua Yan Lin Zheng Xiahua Zuo | 2019 | Chinese Journal of Chemical Engineering2019，27，1： | 3 |
| 4 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 5 | Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC)显示文摘Co-delivery of anti-inflammatory siRNA and hydrophilic drug provides a promising approach for the treatment of ulcerative colitis (UC). However, lack of a suitable and efficient co-delivery carrier poses critical challenge against their utilization. We herein developed macrophage-targeting, reversibly crossli nked polymersomes (TKPR-RCP) based on the TKPR-modified, poly(ethyle ne glycol)-b-poly(trimethylene carbonate-codithiolane trimethylene carbonate)-b-polyethylenimine (PEG-P(TMC-DTC)-PEI) triblock copolymer, which could efficiently encapsulate TNF-α siRNA and dexamethasone sodium phosphate (DSP) in their hydrophilic core. The cationic PEI segments provided additional electrostatic interactions with cargo molecules to promote the encapsulatiion, and disulfide crosslinking of the polymersome membrane endowed the TKPR-RCP with high colloidal stability. Because the cationic PEI was embedded in the hydrophilic core, the polymersomes displayed neutral surface charge and thus possessed high serum stability. The TKPR-RCP co-encapsulating TNF-α siRNA and DSP could be efficiently internalized by macrophages (~98%) and undergo redox-responsive membrane de-crosslinking to accelerate cargo release in the cytoplasm, thus inducing efficient gene silencing and anti-inflammatory effect .Intravenous injectio n of the co-delivery TKPR-RCP mediated pote nt and cooperative anti-inflammatory effect in inflamed colons of UC mice, and significantly prevented animals from colonic injury. This study therefore provides a promising approach for the co-delivery of hydrophilic drug/siRNA toward the treatment of inflammatory bowel diseases. | Xin Xu Weijing Yang Qiujun Liang Yanan Shi Wenxin Zhang Xiao Wang Fenghua Meng Zhiyuan Zhong Lichen Yin | 2019 | Nano Research2019，12，3： | 2 |
| 6 | Serum Vitamin A Nutritional Status of Children and Adolescents Aged 6−17 Years—China,2016−2017显示文摘Summary What is already known on this topic?Vitamin A deficiency(VAD)in children is still a global public health problem,which needs continuous monitoring and timely intervention.What is added by this report?Using surveillance data from China Nutrition and Health Surveillance of Children and Lactating Mothers in 2016−2017,the prevalence of VAD and marginal deficiency was 0.96%and 14.71%,respectively. | Rui Wang Huidi Zhang Yi-chun Hu Jing Chen Zhenyu Yang Liyun Zhao Lichen Yang | 2021 | China CDC weekly2021，3，9： | 2 |
| 7 | Synthesis of hypoallergenic derivatives of the major allergen Fag t 1 from tartary buckwheat via sequence restructuring显示文摘 | YANG Zhenhuang LI Yuying LIChen | 2012 | Food and Chemical Toxocology2012，50，8： | 1 |
| 8 | Nonlinear adaptive control for flexible-link manipulator显示文摘 | YANG Junghua LIAN Fengli FU Lichen | | 0，，01： | 1 |
| 9 | Study of Effi- ciency Simulation of Closed Pump Controlled Motor Hydraulic System显示文摘 | Liu Yong Gu Lichen Yang Bin | 2015 | Journal of Hefei University of Technology2015，38，7： | 1 |
| 10 | Emulsion stabilized by starch nanocrystals显示文摘 | LIChen SUN Peidong YANG Cheng | 2012 | Starch-Starke2012，64，6： | 1 |
| 11 | GhTZF1 regulates drought stress responses and delays leaf senescence by inhibiting reactive oxygen species accumulation in transgenic Arabidopsis显示文摘 | Zhou Ting Yang Xiyan Wang Lichen | 2014 | Plant Molecular Biology2014，85，12： | 1 |
| 12 | The electrochemical performance studies on novel LiFePO4 cathode materials for Li-ion batteries显示文摘 | SHI Z C LICHEN YANG Y | 2003 | Electrochem2003，9，1： | 1 |
| 13 | GhTZF1 regulates drought stress responses and delays leaf senescence by inhibiting reactive oxygen species accumulation in transgenic Arabidopsis显示文摘 | Zhou Ting Yang Xiyan Wang Lichen | 2014 | Plant Molecular Biology2014，85，12： | 1 |
| 14 | Interactions and gel strength of mixed myofibrillar with soy protein, 7S globulin and enzyme-hydrolyzed soy proteins显示文摘 | HUANG Xingjian LIChen YANG Fang | 2010 | European Food Research and Technology2010，231，： | 1 |
| 15 | Giant low-field magnetocaloric effect in ferromagnetically ordered Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds显示文摘Magnetocaloric material is the key working substance for magnetic refrigerant technology,for which the low-field and low-temperature magnetocaloric effect(MCE)performance is of great importance for practical applications at low temperatures.Here,a giant low-field magnetocaloric effect in ferromagnetically ordered Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds was reported,and the magnetic structure was characterized based on low-temperature neutron powder diffraction.With increasing Tm content from 0 to 1,the Curie temperature of Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds decreases from 16.0 K to 3.6 K.For Er_(0.7)Tm_(0.3)Al_(2) compound,it showed the largest low-field magnetic entropy change(–SM)with the peak value of 17.2 and 25.7 J/(kg K)for 0–1 T and 0–2 T,respectively.The(–SM)max up to 17.2 J/(kg K)of Er0.7Tm0.3Al2 compound for 0–1 T is the largest among the intermetallic magnetocaloric materials ever reported at temperatures below 20 K.The peak value of adiabatic temperature change(Tad)max was determined as 4.13 K and 6.87 K for 0–1 T and 0–2 T,respectively.The characteristic of second-order magnetic transitions was confirmed on basis of Arrott plots,the quantitative criterion of exponent n,rescaled universal curves,and the mean-field theory criterion.The outstanding low-field MCE performance with low working temperatures indicates that Er_(1-x)Tm_(x)Al_(2)(0≤x≤1)compounds are promising candidates for magnetic cooling materials at liquid hydrogen and liquid helium temperatures. | Shuxian Yang Xinqi Zheng Dingsong Wang Juping Xu Wen Yin Lei Xi Chaofan Liu Jun Liu Jiawang Xu Hu Zhang Zhiyi Xu Lichen Wang Yihong Yao Maosen Zhang Yichi Zhang Jianxin Shen Shouguo Wang Baogen Shen | 2023 | Journal of Materials Science & Technology2023，，15： | 0 |
| 16 | Volcanic Debris-avalanche Deposits of the Laoheishan Volcano and Huoshaoshan Volcano in Wudalianchi显示文摘Large amounts of volcanic debris-avalanche deposits, which take the shape of hummocks, are distributed around the peripheries of the Laoheishan volcano and Huoshaoshan volcano in Wudalianchi World Geopark. In earlier times, they were called 'satellite volcanoes', namely, freestanding volcanoes. This paper points out that these deposits actually came from the collapse of the cones of these two volcanoes. When the lava flow spilled out at the base of the slope of the cones, the slope broke up and collapsed under the action of gravity. Later, ravines were formed on the slope. Caved slope clastics, accompanying lava flow, accumulated at the rims of the volcano cones. Although some accumulations may form very large cones, they are not volcanoes, but deposits of volcanic debris avalanches. | Chen Hongzhou Yang Jinshan Li Tianxiang Wei Qinghai Zhang Lichen Guo Deming | 2009 | Earthquake Research in China2009，23，3： | 0 |
| 17 | Development and prospect of downhole monitoring and data transmission technology for separated zone water injection显示文摘This article outlines the development of downhole monitoring and data transmission technology for separated zone water injection in China.According to the development stages,the principles,operation processes,adaptability and application status of traditional downhole data acquisition method,cable communications and testing technology,cable-controlled downhole parameter real-time monitoring communication method and downhole wireless communication technology are introduced in detail.Problems and challenges of existing technologies in downhole monitoring and data transmission technology are pointed out.According to the production requirement,the future development direction of the downhole monitoring and data transmission technology for separated zone water injection is proposed.For the large number of wells adopting cable measuring and adjustment technology,the key is to realize the digitalization of downhole plug.For the key monitoring wells,cable-controlled communication technology needs to be improved,and downhole monitoring and data transmission technology based on composite coiled tubing needs to be developed to make the operation more convenient and reliable.For large-scale application in oil fields,downhole wireless communication technology should be developed to realize automation of measurement and adjustment.In line with ground mobile communication network,a digital communication network covering the control center,water distribution station and oil reservoir should be built quickly to provide technical support for the digitization of reservoir development. | LIU He ZHENG Lichen YU Jiaqing MING Eryang YANG Qinghai JIA Deli CAO Gang | 2023 | Petroleum Exploration and Development2023，50，1： | 0 |
| 18 | Engineering blood-brain barrier-permeable and tumor cell-ingestible pro-proteins for glioblastoma treatment显示文摘Intracellular protein therapeutics holds great potentials for the treatment of glioblastoma, which however, is greatly challenged by the unmet demands to concomitantly penetrate the blood-brain barrier(BBB) and glioblastoma cell membrane barrier with high efficiency and selectivity. Herein, a unique pro-protein platform was developed via facile green synthesis, which allowed efficient and selective delivery into glioblastoma cells in a carrier-free manner. Pro-proteins were engineered via reversible modification of native proteins in the aqueous buffer with 3,4-dihydroxy-phenylalanine, the substrate of L-type amino acid transporter(LAT1), bridged with a phenylboronic acid-containing linker. By harnessing the LAT1-mediated direct transport mechanism, the optimized pro-protein, named protein-M2-D, can efficiently penetrate BBB after i.v. injection, and subsequently enable selective and endocytosis-free delivery of various proteins including enzymes, toxins, and antibodies into glioblastoma cells, wherein intracellular H_(2)O_(2) triggered traceless restoration of the native protein structure. Systemic administration of saporin-M2-D provoked potent anti-tumor efficacy against orthotopic U87 glioblastoma in mice, without inducing systemic toxicity. Such a facile, versatile, and robust platform renders a promising paradigm for cytosolic protein delivery and glioblastoma treatment. | Xun Liu Wenting Si Ziyin Zhao Ningyu Liu Qiang Yang Renxiang Zhou Rongying Zhu Shanzhou Duan Yongbing Chen Lichen Yin | 2023 | Science China Chemistry2023，66，9： | 0 |
| 19 | Research Article Dynamically crosslinked nanocapsules for the efficient and serumresistant cytosolic protein delivery显示文摘Intracellular protein delivery is critical to the development of protein-based biopharmaceuticals and therapies.However,current delivery vectors often suffer from complicated syntheses,low generality among various proteins,and insufficient serum stability.Herein,we developed an enlightened cytosolic protein delivery strategy by dynamically crosslinking epigallocatechin gallate(EGCG),low-molecular-weight polyethylenimine(PEI 1.8k),and 2-acetylphenylboric acid(2-APBA)on the protein surface,hence forming the EPP-protein nanocapsules(NCs).EGCG enhanced protein encapsulation via hydrogen bonding,and reduced the positive charge density of PEI to endow the NCs with high serum tolerance,thereby enabling effective cellular internalization in serum.The formation of reversible imine and boronate ester among 2-APBA,EGCG,and PEI 1.8k allowed acid-triggered dissociation of EPP-protein NCs in the endolysosomes,which triggered efficient intracellular release of the native proteins.Such strategy therefore showed high efficiency and universality for diversities of proteins with different molecular weights and isoelectric points,including enzyme,toxin,antibody,and CRISPR(clustered regularly interspaced short palindromic repeats)-Cas9 ribonucleoprotein(RNP),outperforming the commercial protein transduction reagent PULSin and RNP transfection reagent lipofectamine CMAX.Moreover,intravenously(i.v.)injected EPP-saporin NCs efficiently delivered saporin into 4T1 tumor cells to provoke robust antitumor effect.This simple,versatile,and robust cytosolic protein delivery system holds translational potentials for the development of protein-based therapeutics. | Qiang Yang Ningyu Liu Ziyin Zhao Xun Liu Lichen Yin | 2024 | Nano Research2024，17，3： | 0 |
| 20 | MicroRNA-208a silencing against myocardial ischemia/reperfusion injury mediated by reversibly camouflaged biomimetic nanocomplexes显示文摘MicroRNA-208a(miR-208a)plays critical roles in the severe fibrosis and heart failure post myocardial ischemia/reperfusion(IR)injury.MiR-208a inhibitor(mI)with complementary RNA sequence can silence the expression of miR-208a,while it is challenging to achieve efficient and myocardium-targeted delivery.Herein,biomimetic nanocomplexes(NCs)reversibly coated with red blood cell membrane(RM)were developed for the myocardial delivery of mI.To construct the NCs,membrane-penetrating helical polypeptide(PG)was first adopted to condense mI and form the cationic inner core,which subsequently adsorbed catalase(CAT)via electrostatic interaction followed by surface coating with RM.The membrane-coated NCs enabled prolonged blood circulation after systemic administration,and could accumulate in the injured myocardium via passive targeting.In the oxidative microenvironment of injured myocardium,CAT decomposed H_(2)O_(2)to produce O_(2)bubbles,which drove the shedding of the outer RM to expose the positively charged inner core,thus facilitated effective internalization by cardiac cells.Based on the combined contribution of mI-mediated miR-208a silencing and CAT-mediated alleviation of oxidative stress,NCs effectively ameliorated the myocardial microenvironment,hence reducing the infarct size as well as fibrosis and promoting recovery of cardiac functions.This study provides an effective strategy for the cytosolic delivery of nucleic acid cargoes in the myocardium,and it renders an enlightened approach to resolve the blood circulation/cell internalization dilemma of cell membrane-coated delivery systems. | Jianhui Lu Jiaheng Zhang Wen Yan Chenglong Ge Yang Zhou Rongying Zhu Shanzhou Duan Lichen Yin Yongbing Chen | 2023 | Nano Research2023，16，8： | 0 |
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