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| 1 | The Chromosome-Level Genome Sequence of the Autotetraploid Alfalfa and Resequencing of Core Germplasms Provide Genomic Resources for Alfalfa Research显示文摘Alfalfa(Medicago sativa)is one of the most important forage crops in the world;however,its molecular genetics and breeding research are hindered due to the lack of a high-quality reference genome.Here,we report a de novo assembled 816-Mb high-quality,chromosome-level haploid genome sequence for‘Zhongmu No.1’alfalfa,a heterozygous autotetraploid.The contig N50 is 3.92 Mb,and 49165 genes are annotated in the genome.The alfalfa genome is estimated to have diverged from M.truncatula approximately 8 million years ago.Genomic population analysis of 162 alfalfa accessions revealed high genetic diversity,weak population structure,and extensive gene flow from wild to cultivated alfalfa.Genome-wide association studies identified many candidate genes associated with important agronomic traits.Furthermore,we showed that MsFTa2,a Flowering Locus T homolog,whose expression is upregulated in salt-resistant germplasms,may be associated with fall dormancy and salt resistance.Taken together,these genomic resources will facilitate alfalfa genetic research and agronomic improvement. | Chen Shen Huilong Du Zhuo Chen Hongwei Lu Fugui Zhu Hong Chen Xiangzhao Meng Qianwen Liu Peng Liu Lihua Zheng Xiuxiu Li Jiangli Dong Chengzhi Liang Tao Wang | 2020 | Molecular Plant2020，13，9： | 21 |
| 2 | A Review on Metal-and Metal Oxide-Based Nanozymes:Properties,Mechanisms,and Applications显示文摘Since the ferromagnetic(Fe_(3)O_(4))nanoparticles were firstly reported to exert enzyme-like activity in 2007,extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies.As promising alterna-tives for natural enzymes,nanozymes have broadened the way toward clinical medicine,food safety,environmental monitoring,and chemical production.The past decade has witnessed the rapid development of metal-and metal oxide-based nanozymes owing to their remarkable physicochemical proper-ties in parallel with low cost,high stability,and easy storage.It is widely known that the deep study of catalytic activities and mechanism sheds sig-nificant influence on the applications of nanozymes.This review digs into the characteristics and intrinsic properties of metal-and metal oxide-based nanozymes,especially emphasizing their catalytic mechanism and recent applications in biological analysis,relieving inflammation,antibacterial,and cancer therapy.We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials. | Qianwen Liu Amin Zhang Ruhao Wang Qian Zhang Daxiang Cui | 2021 | Nano-Micro Letters2021，13，10： | 15 |
| 3 | Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation显示文摘Heterochromatin Protein 1 (HP1) recognizes histone H3 lysine 9 methylation (H3K9me) through its conserved chromodomain and maintains heterochromatin from fission yeast to mammals. However, in Arabidopsis, Like Heterochromatin Protein 1 (LHP1) recognizes and colocalizes genome-wide with H3K27me3, and is the functional homolog of Polycomb protein. This raises the question whether genuine HP1 homologs exist in plants. Here, we report on the discovery of ADCP1, a plant-specific triple tandem Agenet protein, as a multivalent H3K9me reader in Arabidopsis, and establish that ADCP1 is essential for heterochromatin formation and transposon silencing through modulating H3K9 and DNA methylation levels. Structural studies revealed the molecular basis underlying H3K9me-specific recognition by tandem Agenet of ADCP1. Similar to human HP1α and fly HP1a, ADCP1 mediates heterochromatin phase separation. Our results demonstrate that despite its distinct domain compositions, ADCP1 convergently evolves as an HP1-equivalent protein in plants to regulate heterochromatin formation. | Shuai Zhao Lingling Cheng Yifei Gao Baichao Zhang Xiangdong Zheng Liang Wang Pilong Li Qianwen Sun Haitao Li | 2019 | Cell Research2019，29，1： | 10 |
| 4 | Impact of organic interlayer anions on the CO2 adsorption performance of Mg-Al layered double hydroxides derived mixed oxides显示文摘Herein we report a systematical investigation on the promoting effect of the carbon chain length of the intercalated carboxylic anions on the CO_2 capture performance of Mg-Al layer double hydroxides(LDHs).A series of organo-LDHs were successfully synthesized via co-precipitation and calcination-rehydration methods. All as-prepared samples were characterized by many techniques including XRD, ATR-FTIR, BET,and TGA. The XRD and ATR-FTIR studies indicated that organic anions were successfully intercalated into LDHs. The influence of some important parameters such as calcination temperature, adsorption temperature, and coating with(Li-Na-K)NO_3 molten salt was investigated. The results exhibited that when the number of carbon is greater than 10, the CO_2 capture capacity steadily increased with the increase in carbon number. After coating with 55 mol%(Li-Na-K)NO_3 molten salt, the CO_2 uptake of LDH-C16 sample with high Mg/Al ratios can be increased up to 3.25 mmol/g. The CO_2 adsorption/desorption cycling stability was also studied using temperature swing adsorption, which showed a stable CO_2 capture performance even after 22 cycles. Considering its high CO_2 capture capacity and good cycling stability, this novel CO_2 adsorbent is very promising in the sorption-enhanced water gas shift(SEWGS) processes. | Qingqing Qin Junya Wang Tuantuan Zhou Qianwen Zheng Liang Huang Yu Zhang Peng Lu Ahmad Umar Benoit Louis Qiang Wang | 2017 | Journal of Energy Chemistry2017，26，3： | 8 |
| 5 | Towards high-performance lithium metal anodes via the modification of solid electrolyte interphases显示文摘Li metal has been regarded as one of the most promising anodes for high-energy-density storage systems due to its high theoretical capacity and lowest electrochemical potential.Unfortunately,an unstable and non-uniform solid electrolyte interphase(SEI)deriving from the spontaneous reaction between Li metal anode and electrolyte causes uneven Li deposition,resulting in the growth of Li dendrites and low Coulombic efficiency,which have greatly hindered the practical application of Li metal batteries.Thus,the construction of a stable SEI is an effective approach to suppress the growth of Li dendrites and enhance the electrochemical performances of Li metal anode.In this review,we firstly introduce the formation process of inferior SEI of Li metal anode and the corresponding challenges caused by the unstable SEI.Next,recent progresses to modify SEI layer through the regulation of electrolyte compositions and exsitu protective coating are summarized.Finally,the remained issues,challenges,and perspectives are also proposed on the basis of current research status and progress. | Zhen Hou Jiaolong Zhang Wenhui Wang Qianwen Chen Baohua Li Chaolin Li | 2020 | Journal of Energy Chemistry2020，29，6： | 8 |
| 6 | Thermal reliability analysis and optimization of polymer insulating through-silicon-vias(TSVs) for 3D integration显示文摘Polymer insulating through-silicon-vias(TSVs)is an attractive approach for high-performance 3D integration systems.To further demonstrate the polymer insulating TSVs,this paper investigates the thermal stability by measuring the leakage current under bias-temperature condition,studies the thermal stress characteristics with Finite Element Analysis(FEA),and tries to improve the thermal mechanical reliability of high-density TSVs array by optimizing the geometry parameters of pitch,liner and redistribution layer(RDL).The electrical measurements show the polymer insulating TSVs can maintain good insulation capability(less than 2 10 11A)under challenging bias-temperature conditions of 20 V and 200 C,despite the leakage degradation observation.The FEA results show that the thermal stress is significantly reduced at the sidewall,but highly concentrates at the surface,which is the potential location of mechanical failure.And,the analysis results indicate that the polymer insulating TSVs(diameter of 10 m,depth of 50 m)array with a pitch of 20 m,liner thickness of 1 m and RDL radius of 9m has an optimized thermal-mechanical reliability for application. | ZHONG ShunAn WANG ShiWei CHEN QianWen DING YingTao | 2014 | Science China(Technological Sciences)2014，57，1： | 5 |
| 7 | Release characteristics of mercury in chemical looping combustion of bituminous coal显示文摘This study evaluated the release characteristics of mercury from bituminous coal in chemical looping combustion(CLC)using Australian iron ore as the oxygen carrier in a fixed bed reactor.The effects of several parameters,such as temperature in the fuel reactor(FR)and air reactor(AR),gasification medium in the FR,and reaction atmosphere in the AR,on mercury release characteristics,were investigated.The mercury speciation and release amount in the FR and AR under different conditions were further explored.The results indicate that most of the mercury in coal was released in the FR,while the rest of it was released in the AR.Hg0 was found to be the major species in the released mercury.The results also indicate that a higher temperature in the FR led to an increase in the total mercury release amount and a decrease in Hg0 proportion.However,a higher temperature in the AR resulted in a decrease in the total mercury release amount and Hg 0 proportion.The increase in the H2O/CO2 ratio of gasification mediums in the FR was beneficial for the increase in the total mercury release amount and Hg 0 proportion.A higher O2 concentration in reaction atmosphere in AR had a negligible effect on the total mercury release amount,but a positive effect on Hg0 oxidization. | Ling Ji Qianwen Wang Zhiyue Zhang Hao Wu Changsong Zhou Hongmin Yang | 2020 | Journal of Environmental Sciences2020，32，8： | 5 |
| 8 | Interfacial Engineering of NiFeP/NiFe-LDH Heterojunction for Efficient Overall Water Splitting显示文摘In consideration of application prospect of non-noble metallic materials catalysts,the study of exploring more highly effective electrocatalysts has been focused on by researchers.Herein,a novel strategy is employed to construct a heterojunction consisting of metal phosphide Ni_(x)Fe_(y)P and layered double hydroxide(LDH)with graphene oxide(GO)as conductive support.By adjusting the molar ratio of Ni to Fe,a series of heterojunctions with mixed valence state Fe^(δ+)/Fe^(3+)and Ni^(δ+)/Ni^(2+)(δis likely close to 0)redox couples are achieved and strong synergistic effects towards overall water splitting performance are found.The optimized catalyst with a Ni/Fe molar ratio of 0.72:0.33,namely Ni_(0.7)Fe_(0.3)P/LDH/GO,delivers ultra-low overpotentials for hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)of 79 and 198 mV at the current density of 10 mA·cm^(-2),respectively.Furthermore,for overall water-splitting practical application,it only requires 1.526 V at 10 mA·cm^(-2)with robust stability,which is superior to most reported electrocatalysts.Experimental results demonstrate the im-proved electronic conductivity,enlarged electrochemically active area and accelerated kinetics together account for the enhanced performance.This work supplies new prospects for the promotion and application of such heterojunction electrocatalysts in overall water splitting. | Xuanyu Long Jiazhi Meng Jiabao Gu Lanqing Ling Qianwen Li Nan Liu Kaiwen Wang Zequan Li | 2022 | Chinese Journal of Structural Chemistry2022，41，4： | 4 |
| 9 | Environmental control of mesozooplankton community structure in the Hangzhou Bay, China显示文摘A quarterly study of mesozooplankton community structure and environmental variables in the Hangzhou Bay was conducted to examine the response of mesozooplankton community to the variation of water mass and environmental condition. The southeast coast of China is a typical region under the intensive influence of Asia monsoon and freshwater discharge from rivers. The water mass and environmental condition of the Hangzhou Bay, which were influenced by the interaction of currents, freshwater discharge of the Qiantang River and Changjiang River Plume, showed significant seasonal variation. Our results showed that both biomass and abundance were significantly higher in summer((247.7±148.8) mg/m^3 and(350.9±215.6) ind./m^3, respectively)than those in other seasons. Four eco-geographical regions were divided based on the cluster analysis of zooplankton community of the Hangzhou Bay throughout the year, except for winter. Monsoon and the dissolved inorganic nitrogen(DIN) input from freshwater discharge of the Qiantang River and Changjiang River resulted in temporal and spatial variations of environmental gradient in the Hangzhou Bay, which significantly influenced the structure of mesozooplankton community. Redundancy analysis(RDA) indicated that the mesozooplankton community structure was strictly correlated with the DIN gradient, while salinity gradient showed a weak influence in the Hangzhou Bay. | SUN Dong LIU Zhensheng ZHANG Jing WANG Chunsheng SHAO Qianwen | 2016 | Acta Oceanologica Sinica2016，35，10： | 4 |
| 10 | Synthesis of layered double hydroxides/graphene oxide nanocomposite as a novel high-temperature CO_2 adsorbent显示文摘In this contribution, a novel high-temperature CO2 adsorbent consisting of Mg-Al layered double hydroxide(LDH) and graphene oxide(GO)nanosheets was prepared and evaluated. The nanocomposite-type adsorbent was synthesized based on the electrostatically driven self-assembly between positively charged Mg-Al LDH single sheet and negatively charged GO monolayer. The characteristics of this novel adsorbent were investigated using XRD, FE-SEM, HRTEM, FT-IR, BET and TGA. The results showed that both the CO2 adsorption capacity and the multicycle stability of LDH were increased with the addition of GO owing to the enhanced particle dispersion and stabilization. In particular, the absolute CO2 capture capacity of LDH was increased by more than twice by adding 6.54 wt% GO as support. GO appeared to be especially effective for supporting LDH sheets. Moreover, the CO2 capture capacity of the adsorbent could be further increased by doping with 15 wt%K2CO3. This work demonstrated a new approach for the preparation of LDH-based hybrid-type adsorbents for CO2 capture. | Junya Wang Xueyi Mei Liang Huang Qianwen Zheng Yaqian Qiao Ketao Zang Shengcheng Mao Ruoyan Yang Zhang Zhang Yanshan Gao Zhanhu Guo Zhanggen Huang Qiang Wang | 2015 | Journal of Energy Chemistry2015，24，2： | 4 |
| 11 | 中国淮安地区2009年至2011年恶性肿瘤的发病率及死亡率分析(英文)显示文摘Objective: The aim of the study was to investigate the cancer incidence and mortality in Huai'an area, China, from 2009 to 2011. Methods: The data about cancer incidence and mortality were provided by Huai'an Cancer Registry, China. In- cidence and mortality rates, and standardized rates were calculated by age, gender, areas (urban and rural areas of Huai'an) and cancer sites. Results: The crude incidence rate for all cancer sites was 205.60/10 5 and the standardized incidence rate was 166.22/10 5 . Both the crude and standardized rates were higher in urban area than in rural area for both sexes. The inci- dence rates increased in people aged 40 and over, and the peak ages of incidence were between 70-75 in both males and females. The crude mortality rate for all cancer sites was 153.88/10 5 and the standardized mortality rate was 122.14/10 5 . Both the crude and standardized rates were similar in urban and rural areas for both men and women. The mortality rates were at low level under the age 50 in both sexes, but increased after the age 50, reaching the peak at the ages of 80-85 in both males and females. The top 10 most common cancer sites in rank were esophagus, stomach, lung, liver, colon-rectum, breast, pancreas, cervix uteri, brain and central nervous system, and leukemia, accounting for 87.56% of all cancers. The top 10 most leading causes of cancer death in order were cancers of esophagus, lung, liver, stomach, colon-rectum, pancreas, brain and central nervous system, leukemia, breast and lymphoma, accounting for 90.53% of all cancer deaths. Conclusion: Cancer is one kind of major diseases threatening people's health in Huai'an area, China. Cancer prevention and control should be enhanced, especially for esophageal cancer. | Guangjin Yuan Qianwen Li Yunxiang Du Shunlin Shan Zhimin Wang Enchun Pan Yuan He Ting Wang | 2012 | The Chinese-German Journal of Clinical Oncology2012，11，9： | 3 |
| 12 | Placenta-derived IL-32β activates neutrophils to promote preeclampsia development显示文摘Immune activation at the maternal-fetal interface is a main pathogenic factor of preeclampsia(PE).Neutrophils(PMNs)are activated in PE patients,but the mechanism and consequences of PMN activation need to be further explored.Here,we demonstrated that interleukin-32(IL-32)expression was significantly upregulated in syncytiotrophoblasts(STBs)and that IL-32β was the major isoform with increased expression in the placenta of severe PE(sPE)patients.Furthermore,the level of IL-32 expression in the placenta was correlated with its level in the serum of sPE patients,indicating that IL-32 in the serum is derived mainly from the placenta.Then,in vitro experiments showed that IL-32β could highly activate PMNs and that these IL-32β-activated PMNs were better able to adhere to endothelial cells(HUVECs)and enhance the expression of vascular cell adhesion molecule-1(VCAM-1)and intercellular cell adhesion molecule-1(ICAM-1)in HUVECs,which could be reversed by preincubation with the NADPH oxidase inhibitor VAS 2870.In addition,we showed that IL-32β mainly activated PMNs by binding to proteinase 3.Finally,IL-32β administration induced a PE-like phenotype in a pregnant mouse model.This study provides evidence of the involvement of IL-32β in the pathogenesis of PE. | Dan Liu Qiang Li Hailin Ding Guangfeng Zhao Zhiyin Wang Chenrui Cao Yimin Dai Mingming Zheng Xiangyu Zhu Qianwen Wu Ya Wang Honglei Duan Huirong Tang Xianyan Lu Yayi Hou Yali Hu | 2021 | Cellular & Molecular Immunology2021，18，4： | 2 |
| 13 | The histone methyltransferase SUVR2 promotes DSB repair via chromatin remodeling and liquidliquid phase separation显示文摘Maintaining genomic integrity and stability is particularly important for stem cells,which are at the top of the cell lineage origin.Here,we discovered that the plant-specific histone methyltransferase SUVR2 maintains the genome integrity of the root tip stem cells through chromatin remodeling and liquid-liquid phase separation(LLPS)when facing DNA double-strand breaks(DSBs).The histone methyltransferase SUVR2(MtSUVR2)has histone methyltransferase activity and catalyzes the conversion of histone H3 lysine 9 monomethylation(H3K9me1)to H3K9me2/3 in vitro and in Medicago truncatula.Under DNA damage,the proportion of heterochromatin decreased and the level of DSB damage marker y-H2AX increased in suvr2 mutants,indicating that MtSUVR2 promotes the compaction of the chromatin structure through H3K9 methylation modification to protect DNA from damage.Interestingly,MtSUVR2 was induced by DSBs to phase separate and form droplets to localize at the damage sites,and this was confirmed by immunofluorescence and fluorescence recovery after photobleaching experiments.The IDR1 and lowcomplexity domain regions of MtSUVR2 determined its phase separation in the nucleus,whereas the IDR2 region determined the interaction with the homologous recombinase MtRAD51.Furthermore,we found that MtSUVR2 drove the phase separation of MtRAD51 to form'DNA repair bodies,'which could enhance the stability of MtRAD51 proteins to facilitate error-free homologous recombination repair of stem cells.Taken together,our study reveals that chromatin remodeling-associated proteins participate in DNA repair through LLPS. | Qianwen Liu Peng Liu Tuo Ji Lihua Zheng Chen Shen Shasha Ran Jinling Liu Yafei Zhao Yiding Niu Tao Wang Jiangli Dong | 2022 | Molecular Plant2022，15，7： | 1 |
| 14 | Investigation on mechanism of polymer filling in high-aspect-ratio trenches for through-silicon-via(TSV) application显示文摘Vacuum-assisted spin-coating is an effective polymer filling technology for sidewall insulating of through-silicon-via(TSV).This paper investigated the flow mechanism of the vacuum-assisted polymer filling process based on experiments and numerical simulation,and studied the effect of vacuum pressure,viscosity of polymer and aspect-ratio of trench on the filling performance.A 2D axisymmetric model,consisting of polymer partially filled into the trench and void at the bottom of trench,was developed for the computational fluid dynamics(CFD)simulation.The simulation results indicate that the vacuum-assisted polymer filling process goes through four stages,including bubble formation,bubble burst,air elimination and polymer re-filling.Moreover,the simulation results suggest that the pressure significantly affects the bubble formation and the polymer re-filling procedure,and the polymer viscosity and the trench aspect-ratio influence the duration of air elimination. | DING YingTao YAN YangYang CHEN QianWen WANG ShiWei CHEN Xiu CHEN YueYang | 2014 | Science China(Technological Sciences)2014，57，8： | 1 |
| 15 | Exploration and Application of Ubiquitous Mapping in Engineering Practice Courses in the Intelligence Age显示文摘In the current era of digital surveying and mapping to intelligent surveying and mapping,ubiquitous surveying and mapping has brought many opportunities and challenges to college engineering course teaching.With the development of ubiquitous surveying and mapping,college engineering practice courses urgently need to respond to ubiquitous surveying and mapping.The research aims to integrate the development of ubiquitous surveying and mapping into the teaching of engineering practice courses in colleges,including promoting Android,Brower/Server(B/S),and Client/Server(C/S)to build a platform for practice courses.This also incorporates real development cases in measurement data processing such as gravity field refinement.In this way,the teaching level of engineering practice courses in colleges can be improved,and new ideas can be put forward for cultivating surveying and mapping talents in the new era in colleges.Finally,it can also provide new ideas for the organization of surveying and mapping practice courses under the background of the pandemic. | Wei LI Xukang XIE Haowen YAN Van Der Meijde MARK Lulu LIU Qianwen WANG Pengcheng GAO Hongyuan YU | 2022 | Journal of Geodesy and Geoinformation Science2022，5，3： | 1 |
| 16 | Test Research of Seepage Monitoring Based on Distributed Optical Fiber显示文摘In this paper,a theoretical model of temperature and velocity of a fiber is derived.A test model simulating seepage indoor is designed.The optical fiber heating temperatures under different compaction degree and seepage velocities are measured through applying AC voltage on the optical fiber.The analyzing results show that the optical fiber heating temperature and seepage velocity are related in quadratic function.The quantitative relations of optical fiber temperature and seepage velocity under different soil types and compaction degree are fitted.Analysis on how the compaction degree influences the relation of optical fiber temperature and seepage velocity shows that with the increase of compaction degree,optical fiber heating temperature will gradually decline.The influence of soil type on fiber heating temperature is very complex.In practice,according to the characteristics of the soil,determining quantitative relationship and implementing quantitative monitoring of the seepage velocity are needed. | Zhao Xinming Gao Yifei Wang Qianwen Gao Junqi Zhou Yong Wu Gang Yao Jian | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，2： | 1 |
| 17 | Smart Attendance System Based on Frequency Distribution Algorithm with Passive RFID Tags显示文摘Staff attendance information has always been an important part of corporate management.However,some opportunistic employees may consign others to punch their time cards,which hampers the authenticity of attendance and effectiveness of record keeping.Hence,it is necessary to develop an innovative anti-cheating system for office attendance.Radio-Frequency IDentification(RFID)offers new solutions to solve such problems because of its strong anti-interference capability and non-intrusiveness.In this paper,we present a smart attendance system that extracts distinguishable phase characteristics of individuals to enable recognition of various targets.A frequency distribution histogram is extracted as a fingerprint for recognition and the K-means clustering method is utilized for more fine-grained recognition of targets with similar features.Compared with traditional attendance mechanisms,RFID-based attendance systems are based on living biological characteristics,which greatly reduces the possibility of false records.To evaluate the performance of our system,we conducted extensive experiments.The results of which demonstrate the efficiency and accuracy of our system with an average accuracy of 92%.Moreover,the system evaluation shows that our design is robust against differences in the clothing worn and time of day,which further verifies the successful performance of our system. | Qianwen Miao Fu Xiao Haiping Huang Lijuan Sun Ruchuan Wang | 2020 | Tsinghua Science and Technology2020，25，2： | 1 |
| 18 | Preparation and evaluation of aminopropyl-functionalized manganese-loaded SBA-15 for copper removal from aqueous solution显示文摘A novel material, aminopropyl-functionalized manganese-loaded SBA-15(NH2-Mn-SBA-15), was synthesized by bonding 3-aminopropyl trimethoxysilane(APTMS) onto manganeseloaded SBA-15(Mn-SBA-15) and used as a Cu2+adsorbent in aqueous solution. Fourier transform infrared spectroscopy(FT-IR), X-ray diffraction spectra(XRD), N2adsorption/desorption isotherms, high resolution field emission scanning electron microscopy(FESEM)and X-ray photoelectron spectroscopy(XPS) were used to characterize the NH2-Mn-SBA-15.The ordered mesoporous structure of SBA-15 was remained after modification. The manganese oxides were mainly loaded on the internal surface of the pore channels while the aminopropyl groups were mainly anchored on the external surface of SBA-15. The adsorption of Cu2+on NH2-Mn-SBA-15 was fitted well by the Langmuir equation and the maximum adsorption capacity of NH2-Mn-SBA-15 for Cu2+was over two times higher than that of Mn-SBA-15 under the same conditions. The Elovich equation gave a good fit for the adsorption process of Cu2+by NH2-Mn-SBA-15 and Mn-SBA-15. Both the loaded manganese oxides and the anchored aminopropyl groups were found to contribute to the uptake of Cu2+. The NH2-Mn-SBA-15 showed high selectivity for copper ions. Consecutive adsorption–desorption experiments showed that the NH2-Mn-SBA-15 could be regenerated by acid treatment without altering its properties. | Di Lei Qianwen Zheng Yili Wang Hongjie Wang | 2015 | Journal of Environmental Sciences2015，27，2： | 1 |
| 19 | DOCK2 regulates antifungal immunity by regulating RAC GTPase activity显示文摘Fungal infections cause~1.5 million deaths each year worldwide,and the mortality rate of disseminated candidiasis currently exceeds that of breast cancer and malaria.The major reasons for the high mortality of candidiasis are the limited number of antifungal drugs and the emergence of drug-resistant species.Therefore,a better understanding of antifungal host defense mechanisms is crucial for the development of effective preventive and therapeutic strategies.Here,we report that DOCK2(dedicator of cytokinesis 2)promotes indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.DOCK2-deficient macrophages exhibit decreased RAC GTPase(Rac family small GTPase)activation and ROS(reactive oxygen species)production,which in turn attenuates the killing of intracellular fungi and the activation of downstream signaling pathways.Mechanistically,after fungal stimulation,activated SYK(spleen-associated tyrosine kinase)phosphorylates DOCK2 at tyrosine 985 and 1405,which promotes the recruitment and activation of RAC GTPases and then increases ROS production and downstream signaling activation.Importantly,nanoparticle-mediated delivery of in vitro transcribed(IVT)Rac1 mRNA promotes the activity of Rac1 and helps to eliminate fungal infection in vivo.Taken together,this study not only identifies a critical role of DOCK2 in antifungal immunity via regulation of RAC GTPase activity but also provides proof of concept for the treatment of invasive fungal infections by using IVT mRNA. | Xiaojian Ma Xi Tan Bingbing Yu Wanwei Sun Heping Wang Huijun Hu Yanyun Du Ruirui He Ru Gao Qianwen Peng Zhihui Cui Ting Pan Xiong Feng Junhan Wang Chengqi Xu Bin Zhu Wei Liu Chenhui Wang | 2022 | Cellular & Molecular Immunology2022，19，5： | 1 |
| 20 | A likely autotetraploidization event shaped the Chinese mahogany(Toona sinensis)genome显示文摘Chinese mahogany(Toona sinensis) is of considerable medical and economic importance, and its genome has been deciphered. However, the process underlying its polyploidy is unclear, and the chromosomal evolutionary trajectory is poorly understood. Here, by reanalysing the T.sinensis genome, we found evidence of a tetraploidization event(T. sinensis special tetraploidization, TST) that occurred approximately 15-17 million years ago(MYA) after the core eudicot-common hexaploidization(ECH or gamma) event. We characterized the synonymous nucleotide substitution rates(Ks values) of collinear genes and found that T. sinensis genes affected by the TST evolve at a slower rate than Acer yangbiense genes. Furthermore, we identified homologous genes related to polyploidization and speciation and constructed multiple alignments with different reference genomes. Notably, the significant balance of gene retention and loss characterized in the two TST-derived subgenomes suggests an autopolyploid nature of the TST. Moreover, we deduced the chromosomal karyotypes of the two subgenomes and identified 7chromosomal fusions that have shaped the T. sinensis genome;more information is available on a newly constructed karyotype platform(http://gffzze84c5b42976d4cd7hucbf90v6vwb66fb0.ffgz.tsg.suse.edu.cn/Toona_sinensis/index.html). The T. sinensis genome preserves the ancestral chromosome structure of dicotyledons well and could serve as a good reference for understanding genomic changes in other Meliaceae and Sapindales plants. In addition, we verified that tandem duplication and the ECH have promoted the expansion of terpene synthase(TPS) genes;conversely, the TST seems to have inhibited expansion of these genes. This present effort has clarified the polyploidy events of the T. sinensis genome, filled gaps in the history of karyotype evolution, and laid a solid foundation for further genomic studies in the Meliaceae research community and beyond. | Jianyu Wang Ziyi Yang Tianyu Lei Yan Zhang Qimeng Xiao Zijian Yu Jiaqi Zhang Sangrong Sun Qiang Xu Shaoqi Shen Zimo Yan Mengnan Fang Yue Ding Zihan Liu Qianwen Zhu Ke Ren Yuxin Pan Haibin Liu Jinpeng Wang | 2023 | Horticultural Plant Journal2023，9，2： | 0 |
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