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| 1 | nterferon alpha (IFNα)-induced TRIM22 interrupts HCV 'eplication by ubiquitinating NS5A显示文摘 | Chen Yang Xinhao Zhao Dakang Sun Leilei Yang Chang Chong Yu Pan Xiumei Chi Yanhang Gao Moli Wang Xiaodong Shi Haibo Sun Juan Lv Yuanda Gao Jin Zhong Junqi Niu Bing Sun | 2016 | Cellular & Molecular Immunology2016，13，1： | 13 |
| 2 | Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication显示文摘Hepatitis B virus(HBV)can cause chronic hepatitis B,which may lead to cirrhosis and liver cancer.Type I interferon(IFN)is an approved drug for the treatment of chronic hepatitis B.However,the fundamental mechanisms of antiviral action by type I IFN and the downstream signaling pathway are unclear.TRIM25 is an IFN-stimulated gene(ISG)that has an important role in RIG-I ubiquitination and activation.Whether TRIM25 is induced in liver cells by type I IFN to mediate anti-HBV function remains unclear.Here we report that interleukin-27(IL-27)has a critical role in IFN-induced TRIM25 upregulation.TRIM25 induction requires both STAT1 and STAT3.In TRIM25 knockout HepG2 cells,type I IFN production was consistently attenuated and HBV replication was increased,whereas overexpression of TRIM25 in HepG2 cells resulted in elevated IFN production and reduced HBV replication.More interestingly,we found that TRIM25 expression was downregulated in HBV patients and the addition of serum samples from HBV patients could inhibit TRIM25 expression in HepG2 cells,suggesting that HBV might have involved a mechanism to inhibit antiviral ISG expression and induce IFN resistance.Collectively,our results demonstrate that type I IFN-induced TRIM25 is an important factor in inhibiting HBV replication,and the IFN-IL-27-TRIM25 axis may represent a new target for treating HBV infection. | Guangyun Tan Qingfei Xiao Hongxiao Song Feng Ma Fengchao Xu Di Peng Na Li Xiaosong Wang Junqi Niu Pujun Gao F Xiao-Feng Qin Genhong Cheng | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 3 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 4 | Biogenesis of Plant Prevacuolar Multivesicular Bodies显示文摘植物 prevacuolar 分隔空间(PVC ) ,或 multivesicular 身体(MVB ) ,是在调停起重要作用的单个膜界限细胞器蛋白质 trafficking 到在能分泌的小径的液泡。PVC/MVB 也在植物在 endocytic 小径用作迟了的内涵体。因为植物 PVC 超过 10 年以前作为 MVB 被识别,大进步在植物向 PVC/MVB 功能和生物的续生说的理解被取得了。在这评论,我们首先总结以前的研究进植物 PVCs/MVBs 的鉴定和描述,然后在位于 intraluminal 泡形成和植物 PVCs/MVBs 的成熟下面的机制上加亮最近的进展。另外,我们讨论看起来在植物在 autophagy 期间发生在 PVCs/MVBs 和 autophagosomes 之间的可能的串音。最后,我们在这块地里列出一些待研究的问题和现在的未来观点。 | Yong Cui Jinbo Shen Caiji Gao Xiaohong Zhuang Junqi Wang Liwen Jiang | 2016 | Molecular Plant2016，9，6： | 7 |
| 5 | Attribute-Based Encryption for Circuits on Lattices显示文摘In the previous construction of attributed-based encryption for circuits on lattices,the secret key size was exponential to the number of AND gates of the circuit.Therefore,it was suitable for the shallow circuits whose depth is bounded.For decreasing the key size of previous scheme,combining the techniques of Two-to-One Recoding(TOR),and sampling on lattices,we propose a new Key-Policy Attribute-Based Encryption(KP-ABE)scheme for circuits of any arbitrary polynomial on lattices,and prove that the scheme is secure against chosen plaintext attack in the selective model under the Learning With Errors(LWE)assumptions.In our scheme,the key size is proportional to the number of gates or wires in the circuits. | Jian Zhao Haiying Gao Junqi Zhang | 2014 | Tsinghua Science and Technology2014，19，5： | 4 |
| 6 | Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation显示文摘Although monkeys and pigs can be infected with SARS-Co V-2,they generally have a long growth cycle and a large size that is difficult to handle in large quantities.However,the readily available rats and mice are not susceptible to SARSCo V-2 because of differences in ACE2(angiotensin-converting enzyme 2),the receptor mediating cell entry of SARSCo V-2[1].Thus,the key to establishing a mouse model of COVID-19 is to make the mice express human ACE2 protein,and therefore become SARS-Co V-2 susceptible.Recently reported COVID-19 mouse models using a random insertion transgene approach[2,3]or adenoviral approach to express h ACE2[4],lack the tissue-specificity of h ACE2 expression and might not replicate COVID-19 precisely,limiting their applications in certain studies. | Feng-Liang Liu Kaixin Wu Jiaoyang Sun Zilei Duan Xiongzhi Quan Junqi Kuang Shilong Chu Wei Pang Han Gao Ling Xu Ying-Chang Li Hai-Lin Zhang Xue-Hui ang Rong-Hua Luo Xiao-Li Feng Hans RScholer Xinwen Chen Duanqing Pei Guangming Wu Yong-Tang Zheng Jiekai Chen | 2021 | National Science Review2021，8，2： | 3 |
| 7 | 96-Week Treatment of Tenofovir Amibufenamide and Tenofovir Disoproxil Fumarate in Chronic Hepatitis B Patients显示文摘Background and Aims:Tenofovir amibufenamide(TMF)is a novel phosphoramidated prodrug of tenofovir with nonin-ferior efficacy and better bone and renal safety to tenofovir disoproxil fumarate(TDF)in 48 weeks of treatment.Here,we update 96-week comparison results.Methods:Patients with chronic hepatitis B were assigned(2:1)to receive either 25 mg TMF or 300 mg TDF with matching placebo for 96 weeks.The virological suppression was defined as HBV DNA levels<20 IU/mL at week 96.Safety was evaluated thoroughly with focusing on bone,renal,and metabolic pa-rameters.Results:Virological suppression rates at week 96 were similar between TMF and TDF group in both HBeAg-positive and HBeAg-negative populations.Noninferior efficacy was maintained in the pooled population,while it was first achieved in patients with HBV DNA≥7 or 8 log10 IU/mL at baseline.Non-indexed estimated glomerular filtration rate for renal safety assessment was adopted,while a smaller decline of which was seen in the TMF group than in the TDF group(p=0.01).For bone mineral density,patients receiv-ing TMF displayed significantly lower reduction levels in the densities of spine,hip,and femur neck at week 96 than those receiving TDF.In addition,the lipid parameters were stable after week 48 in all groups while weight change still showed the opposite trend.Conclusions:TMF maintained similar efficacy at week 96 compared with TDF with continued superior bone and renal safety profiles(NCT03903796). | Zhihong Liu Qinglong Jin Yuexin Zhang Guozhong Gong Guicheng Wu Lvfeng Yao Xiaofeng Wen Zhiliang Gao Yan Huang Daokun Yang Enqiang Chen Qing Mao Shide Lin Jia Shang Huanyu Gong Lihua Zhong Huafa Yin Fengmei Wang Peng Hu Qiong Wu Chao Pan Wen Jia Chuan Li Chang’an Sun Junqi Niu Jinlin Hou TMF Study Group | 2023 | Journal of Clinical and Translational Hepatology2023，11，3： | 3 |
| 8 | MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3显示文摘Central precocious puberty(CPP)refers to a human syndrome of early puberty initiation with characteristic increase in hypothalamic production and release of gonadotropin-releasing hormone(GnRH).Previously,loss-of-function mutations in human MKRN3,encoding a putative E3 ubiquitin ligase,were found to contribute to about 30%of cases of familial CPP.MKRN3 was thereby suggested to serve as a‘brake’of mammalian puberty onset,but the underlying mechanisms remain as yet unknown.Here,we report that genetic ablation of Mkrn3 did accelerate mouse puberty onset with increased production of hypothalamic GnRH1.MKRN3 interacts with and ubiquitinates MBD3,which epigenetically silences GNRH1 through disrupting the MBD3 binding to the GNRH1 promoter and recruitment of DNA demethylase TET2.Our findings have thus delineated a molecular mechanism through which the MKRN3-MBD3 axis controls the epigenetic switch in the onset of mammalian puberty. | Chuanyin Li Wenli Lu Liguang Yang Zhengwei Li Xiaoyi Zhou Rong Guo Junqi Wang Zhebao Wu Zhiya Dong Guang Ning Yujiang Shi Yinmin Gu Peng Chen Zijian Hao Tianting Han Meiqiang Yang Wei Wang Xuehui Huang Yixue Li Shan Gao Ronggui Hu | 2020 | National Science Review2020，7，3： | 2 |
| 9 | Quality-Aware Massive Content Delivery in Digital Twin-Enabled Edge Networks显示文摘Massive content delivery will become one of the most prominent tasks of future B5G/6G communication.However,various multimedia applications possess huge differences in terms of object oriented(i.e.,machine or user)and corresponding quality evaluation metric,which will significantly impact the design of encoding or decoding within content delivery strategy.To get over this dilemma,we firstly integrate the digital twin into the edge networks to accurately and timely capture Quality-of-Decision(QoD)or Quality-of-Experience(QoE)for the guidance of content delivery.Then,in terms of machinecentric communication,a QoD-driven compression mechanism is designed for video analytics via temporally lightweight frame classification and spatially uneven quality assignment,which can achieve a balance among decision-making,delivered content,and encoding latency.Finally,in terms of user-centric communication,by fully leveraging haptic physical properties and semantic correlations of heterogeneous streams,we develop a QoE-driven video enhancement scheme to supply high data fidelity.Numerical results demonstrate the remarkable performance improvement of massive content delivery. | Yun Gao Junqi Liao Xin Wei Liang Zhou | 2023 | China Communications2023，20，2： | 1 |
| 10 | Monitoring of corrosion in reinforced concrete structure using Bragg grating sensing 显示文摘 | Gao Junqi Wu Jin Li Jun | 2011 | NDT E Int2011，，44： | 1 |
| 11 | Monitoring of corrosion in reinforced con- crete structure using Bragg grating sensing显示文摘 | GAO Junqi | 2011 | NDT~E Inter- national2011，44，： | 1 |
| 12 | Test Research of Seepage Monitoring Based on Distributed Optical Fiber显示文摘In this paper,a theoretical model of temperature and velocity of a fiber is derived.A test model simulating seepage indoor is designed.The optical fiber heating temperatures under different compaction degree and seepage velocities are measured through applying AC voltage on the optical fiber.The analyzing results show that the optical fiber heating temperature and seepage velocity are related in quadratic function.The quantitative relations of optical fiber temperature and seepage velocity under different soil types and compaction degree are fitted.Analysis on how the compaction degree influences the relation of optical fiber temperature and seepage velocity shows that with the increase of compaction degree,optical fiber heating temperature will gradually decline.The influence of soil type on fiber heating temperature is very complex.In practice,according to the characteristics of the soil,determining quantitative relationship and implementing quantitative monitoring of the seepage velocity are needed. | Zhao Xinming Gao Yifei Wang Qianwen Gao Junqi Zhou Yong Wu Gang Yao Jian | 2018 | Transactions of Nanjing University of Aeronautics and Astronautics2018，35，2： | 1 |
| 13 | Novel TiC/Ti Open Cellular Foams Prepared by a Modified Sponge-coating Method Using High Frequency Induction Heating Process显示文摘A new kind of open cellular foam material with three dimensionally interconnected TiC/Ti struts was prepared by a two-step sponge-coating and high frequency induction heating process.The microstructure,composition and compression strength of the prepared TiC/Ti foam materials were characterized.It was confirmed that the incorporation of Ti into TiC resulted in an inter-bonded Ti-TiC-Ti layered structure in the struts,which enhanced the plasticity of the composite foam materials. | Yong Gao Xingxiang Xu Zhenming Yang Junqi Zhang Chunhai Jiang Jinsong Zhang | 2013 | Journal of Materials Science & Technology2013，29，4： | 1 |
| 14 | MAVS-loaded unanchored Lys63-linked polyubiquitin chains activate the RIG-I-MAVS signaling cascade显示文摘The adaptor molecule MAVS forms prion-like aggregates to govern the RIG-I-like receptor(RLR)signaling cascade.Lys63(K63)-linked polyubiquitination is critical for MAVS aggregation,yet the underlying mechanism and the corresponding E3 ligases and deubiquitinating enzymes(DUBs)remain elusive.Here,we found that the K63-linked polyubiquitin chains loaded on MAVS can be directly recognized by RIG-I to initiate RIG-I-mediated MAVS aggregation with the prerequisite of the CARDRIG-I-CARDMAVS interaction.Interestingly,many K63-linked polyubiquitin chains attach to MAVS via an unanchored linkage.We identified Ube2N as a major ubiquitin-conjugating enzyme for MAVS and revealed that Ube2N cooperates with the E3 ligase Riplet and TRIM31 to promote the unanchored K63-linked polyubiquitination of MAVS.In addition,we identified USP10 as a direct DUB that removes unanchored K63-linked polyubiquitin chains from MAVS.Consistently,USP10 attenuates RIG-I-mediated MAVS aggregation and the production of type I interferon.Mice with a deficiency in USP10 show more potent resistance to RNA virus infection.Our work proposes a previously unknown mechanism for the activation of the RLR signaling cascade triggered by MAVS-attached unanchored K63-linked polyubiquitin chains and establishes the DUB USP10 and the E2:E3 pair Ube2N-Riplet/TRIM31 as a specific regulatory system for the unanchored K63-linked ubiquitination and aggregation of MAVS upon viral infection. | Feng Liu Wanxin Zhuang Bin Song Yuan Yang Junqi Liu Yi Zheng Bingyu Liu Jie Zheng Wei Zhao Chengjiang Gao | 2023 | Cellular & Molecular Immunology2023，20，10： | 0 |
| 15 | Intestinal microbiota links to allograft stability after lung transplantation: a prospective cohort study显示文摘Whether the alternated microbiota in the gut contribute to the risk of allograft rejection(AR)and pulmonary infection(Pl)in the setting of lung transplant recipients(LTRs)remains unexplored.A prospective multicenter cohort of LTRs was identified in the four lung transplant centers.Paired fecal and serum specimens were collected and divided into AR,Pl,and event-free(EF)groups according to the diagnosis at sampling.Fecal samples were determined by metagenomic sequencing. | Junqi Wu Chongwu Li Peigen Gao Chenhong Zhang Pei Zhang Lei Zhang Chenyang Dai unpeng Zhang Bowen Shi Mengyang Liu Junmeng Zheng Bo Pan Zhan Chen Chao Zhang Wanqing Liao Weihua Pan Wenjie Fang Chang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 16 | LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection显示文摘The activation of NLRC4 is a major host response against intracellular bacteria infection.However,NLRC4 activation after a host senses diverse stimuli is difficult to understand.Here,we found that the IncRNA LNCGM1082 plays a critical role in the activation of NLRC4.LNCGM1082 in macrophages affects the maturation of interleukin(IL)-1βand pyroptotic cell death only after exposure to an NLRC4 ligand.Similar to NLRC4-/-mice,LNCGM1082-/-mice were highly sensitive to Salmonella Typhimurium(S.T)infection.LNCGM1082 deficiency in mouse or human macrophages inhibited IL-1βmaturation and pyroptosis.Mechanistically,LNCGM1082 induced the binding of PKCS with NLRC4 in both mice and humans.In contrast,NLRC4 did not bind PKCo in LNCGM1082-/-macrophages.The activity of the IncRNA LNCGM1082 induced by S.T may be mediated through TLR5 in the macrophages of both mice and humans.In summary,our data indicate that TLR5-mediated LNCGM1082 activity can promote the binding of PKC with NLRC4 to activate NLRC4 and induce resistance to bacterial infection. | Yunhuan Gao Yazheng Yang Jianmei Wei Jianmei Yue Ya Wang Qianjing Zhang Mengli Jin Rong Wang Xiaorong Yang Junqi Zhang Xinqi Liu Lin Liu Yuan Zhang Rongcun Yang | 2023 | Cellular & Molecular Immunology2023，20，5： | 0 |
| 17 | Inhibition of the Neddylation Pathway Suppresses Enterovirus Replication显示文摘Dear Editor,Human enteroviruses(HEVs)comprise polioviruses,coxsackieviruses,echoviruses,rhinoviruses,and the enterovirus subgroups and belong to the genus Enterovirus in the family Picornaviridae(Baggen et al.2018).The HEV genome was thought to contain a single open reading frame(ORF)encoding one polyprotein,which was post-translationally processed into structural capsid proteins(VP1-4)and non-structural accessory proteins(2A,2B,2C,3A,3B,3C,3D)(Baggen et al.2018).Recently,we and others,have identified an additional upstream ORF(Guo et al.2019a;Lulla et al.2019)(ORF2/uORF). | Zhe Zhang Haoran Guo Jing Wang Yan Li Yanhang Gao Quan Liu Junqi Niu Wei Wei | 2021 | Virologica Sinica2021，36，6： | 0 |
| 18 | A case report of autochthonous Q fever with pneumonia and hepatitis in northeastern China显示文摘There are only a few case reports of Q fever caused by Coxiella burnetii in China,despite the nature as a ubiquitous zoonotic disease worldwide.In the northeast part of China,a 52-year-old male presented with fever,cough,shortness of breath,and sputum production,accompanied by headache,dizziness,chill,myalgia,and arthralgia.Chest computed tomography images showed pneumonia accompanied by bilateral scattered infiltrates and localized upper-lobe emphysema.The abnormal liver function was indicated by the increased levels of alanine aminotransferase and aspartate aminotransferase.Through high-throughput sequencing and molecular detection,Coxiella burnetii was positive in the patient's blood specimens.After treatment with moxifloxacin hydrochloride and vidarabine monophosphate for 12 days,the patient completely recovered.To our knowledge,this was the first reported case of Q fever with pneumonia and hepatitis in this country. | Yuan Gao Lihe Che Zedong Wang Junqi Niu Wei Wei Mingxin Song Quan Liu | 2021 | Biosafety and Health2021，3，3： | 0 |
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