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| 1 | Effects of Temperature and Pressure on Stress Corrosion Cracking Behavior of 310S Stainless Steel in Chloride Solution显示文摘310S is an austenitic stainless steel for high temperature applications, having strong resistance of oxidation, hydrogen embrittlement and corrosion. Stress corrosion cracking(SCC) is the main corrosion failure mode for 310 S stainless steel. Past researched about SCC of 310 S primarily focus on the corrosion mechanism and influence of temperature and corrosive media, but few studies concern the combined influence of temperature, pressure and chloride. For a better understanding of temperature and pressure's effects on SCC of 310 S stainless steel, prepared samples are investigated via slow strain rate tensile test(SSRT) in different temperature and pressure in NACE A solution. The result shows that the SCC sensibility indexes of 310 S stainless steel increase with the rise of temperature and reach maximum at 10 MPa and 160℃, increasing by 22.3% compared with that at 10 MPa and 80 ℃. Instead, the sensibility decreases with the pressure up. Besides, the fractures begin to transform from the ductile fracture to the brittle fracture with the increase of temperature. 310 S stainless steel has an obvious tendency of stress corrosion at 10 MPa and 160℃ and the fracture surface exists cleavage steps, river patterns and some local secondary cracks, having obvious brittle fracture characteristics. The SCC cracks initiate from inclusions and tiny pits in the matrix and propagate into the matrix along the cross section gradually until rupture. In particular, the oxygen and chloride play an important role on the SCC of 310 S stainless steel in NACE A solution. The chloride damages passivating film, causing pitting corrosion, concentrating in the cracks and accelerated SSC ultimately. The research reveals the combined influence of temperature, pressure and chloride on the SCC of 310 S, which can be a guide to the application of 310 S stainless steel in super-heater tube. | ZHONG Yunpan ZHOU Cheng CHEN Songying WANG Ruiyan | 2017 | Chinese Journal of Mechanical Engineering2017，30，1： | 9 |
| 2 | How do Chinese medicines that tonify the kidney inhibit dopaminergic neuron apoptosis?显示文摘Wistar rats were intragastrically perfused with Chinese medicines used for tonifying the kidney.These included 0.180 g/mL of Herba Epimedii(Epimedium), Semen Cuscutae(Dodder Seed), or Herba Cistanches(Desertliving Cistanche), 0.04 mg/mL monoamine oxidase-B inhibitor selegiline,or distilled water for 14 consecutive days to prepare drug-containing serum or blank serum.MES23.5 cells in the logarithmic phase were cultured in media supplemented with 15%drug-containing serum for 24 hours, followed by incubation in culture solution containing 100 μmol/L H2O2for 3 hours. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) and flow cytometry results showed that all drug-containing serums improved the survival rate of H2O2-injured MES23.5 cells, inhibited pro-apoptotic FasL and caspase-3 expression, promoted anti-apoptotic Bcl-2 expression. However, drug-containing serums had little influence on Fas expression in H2O2-injured MES23.5 cells. Enzyme-linked immunosorbent assay results showed that serum containing Herba Cistanches or Herba Epimedii increased the expression of nerve growth factor,brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in injured MES23.5cells; serum containing Semen Cuscutae only increased brain-derived neurotrophic factor expression; while expression of the above neurotrophic factors remained the same in cells treated with serum containing selegiline. These findings indicate that Chinese medicines used to tonify the kidney can protect nerve cells by regulating the expression of apoptosis-related factors and neurotrophic factors in MES23.5 cells. | Shaogang Lin Shuifen Ye Jinmu Huang Yun Tian Yihui Xu Mengqi Wu Jingxia Wang Songying Wu Jing Cai | 2013 | Neural Regeneration Research2013，8，30： | 9 |
| 3 | Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway显示文摘Whether and how garlic-derived S-allylmercaptocysteine(SAMC) inhibits hepatocellular carcinoma(HCC) is largely unknown. In the current study, the role of low-density lipoprotein receptor(LDLR)-related protein 6(LRP6) in HCC progression and the anti-HCC mechanism of SAMC was examined in clinical sample, cell model and xenograft/orthotopic mouse models. We demonstrated that SAMC inhibited cell proliferation and tumorigenesis, while induced apoptosis of human HCC cells without influencing normal hepatocytes. SAMC directly interacted with Wnt-pathway co-receptor LRP6 on the cell membrane. LRP6 was frequently over-expressed in the tumor tissue of human HCC patients(66.7% of 48 patients) and its overexpression only correlated with the over-expression of β-catenin, but not with age, gender, tumor size, stage and metastasis. Deficiency or over-expression of LRP6 in hepatoma cells could partly mimic or counteract the anti-tumor properties of SAMC, respectively. In vivo administration of SAMC significantly suppressed the growth of Huh-7 xenograft/orthotopic HCC tumor without causing undesirable side effects. In addition, stable down-regulation of LRP6 in Huh-7 facilitated the anti-HCC effects of SAMC. In conclusion, LRP6 can be a potential therapeutic target of HCC. SAMC is a promising specific anti-tumor agent for treating HCC subtypes with Wnt activation at the hepatoma cell surface. | Jia Xiao Feiyue Xing Yingxia Liu Yi Lv Xiaogang Wang Ming-Tat Ling Hao Gao Songying Ouyang Min Yang Jiang Zhu Yu Xia Kwok-Fai So George L.Tipoe | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 6 |
| 4 | Genetic divergence of weedy rice populations associated with their geographic location and coexisting conspecific crop: Implications on adaptive evolution of agricultural weeds显示文摘蔓延的米饭,栽培米饭的一样的生物种类,是大批出没于世界范围的稻田的一棵有害杂草。在中国决定蔓延的米饭的基因差异,结构,和关系,我们使用了插入 / 删除(InDel ) 分析蔓延的米饭人口从的分子的指纹对作为参考书种区域,使用的装饰用的梨树和 indica 米饭栽培变种的南部的米饭东北。InDel 指纹显示了相对高的全面基因差异(H 为从 14 张蔓延的米饭人口的 240 件样品的 e = 0.42) 。然而,许多更低的在内人口差异被检测,特别地为从东北、南部的中国的人口,与 H e 价值从 0.006 ~ 0.06 。江苏人口显示出高得多的在内人口基因差异(H e = 0.12-0.31) 比那些从另外的区域。分子的变化和 F st 显示出 ∼88% 在蔓延的米饭人口之中的基因变化。主要部件和结构分析显示了实质的 japonica-indica 蔓延的米饭人口的基因区别。从江苏省的蔓延的米饭甚至在人口以内正在经历 indica 装饰用的梨树区别,它由于由在这个区域的装饰用的梨树米饭变化的 indica 的代替是可能的。在结论,重要基因分叉在中国发生在蔓延的米饭人口之中,它与他们的地理地点和共存的米饭变化被联系。从栽培米饭的基因渗入在在人影响的 agro 生态系统塑造蔓延的米饭人口的基因差异和结构有一个关键角色。 | Zhuo-Jun songI Zhe Wang Yang Feng Nan Yao Ji Yang Bao-Rong Lu | 2015 | Journal of Systematics and Evolution2015，53，4： | 5 |
| 5 | Fault Detection in Coal Seam by the Channel Wave Method显示文摘 | Wei Wang Xing Gao Songying Li Yong Le Jiwen Teng Yuying Li | 2014 | 地球科学期刊(中英文版)2014，4，1： | 2 |
| 6 | An enrichment method to detect low concentration formaldehyde显示文摘 | Wang Jing Liu Li Cong Songying | 2008 | Sens Actuators B: Chem2008，134，2： | 1 |
| 7 | Study on Gd and Mg co-doped ceria electrolyte for intermediate temperature solid oxide fuel cells显示文摘 | Feng-Yun Wang Songying Chen Qin Wang Shuxin Yu Soofin Cheng | 2004 | Catalysis Today2004，，2： | 1 |
| 8 | microRNA-192, -194 and -215 are frequently downregulated in colorectal cancer 显示文摘 | Chiang Y SongY Wang Z | 2012 | Exp Ther Med2012，3，3： | 1 |
| 9 | Functional characterizations of chemosensory proteins of the alfalfa plant bug Adelphocorls lineolatus indicate their involvement in host recognition显示文摘 | Gu Shaohua Wang Songying Zhang Xueying | 2012 | PLoS One2012，7，42： | 1 |
| 10 | Functional characterizations of chemosensory proteins of the Alfalfa plant bug Adelphocoris lineolatus indicate their involvement in host recognition显示文摘 | Gu Shaohua Wang Songying Zhang Xueying | 2013 | PLoS One2013，7，42： | 1 |
| 11 | The First Discovery of Rhyolite Interlayer in the Mugagangri Group in the Bangonghu-Nujiang Suture Zone, Tibet and the U-Pb Dating显示文摘Objective The Mugagangri group(MP),named by Wen Shixuan(1979)in the southeast Mugegebori Mountain which is the main peak of Mugagangri,is a flysch formation with deep–semi-deep marine sedimentary features in the Bangonghu-Nujiang suture zone(BNSZ).The lithology is mainly composed of sandstones,graywackes,siltstones and silty mudstones with low-grade metamorphism.The previously defined Mugagangri group continues from east to west | LI Haifeng LIU Zhibo SONGY Yang LI Faqiao TENG Lei WANG Jiaxing WANG Chao | 2018 | Acta Geologica Sinica(English Edition)2018，92，1： | 1 |
| 12 | New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16显示文摘Interferon gamma-inducible protein 16(IFI16)senses DNA in the cytoplasm and the nucleus by using two tandem hematopoietic interferon-inducible nuclear(HIN)domains,HINa and HINb,through the cooperative assembly of IFI16 filaments on double-stranded DNA(dsDNA).The role of HINa in sensing DNA is not clearly understood.Here,we describe the crystal structure of the HINa domain in complex with DNA at 2.55A°resolution and provide the first insight into the mode of DNA binding by the HINa domain.The structure reveals the presence of two oligosaccharide/nucleotide-binding(OB)folds with a unique DNA-binding surface.HINa uses loop L45 of the canonical OB2 fold to bind to the DNA backbone.The dsDNA is recognized as two single strands of DNA.Interestingly,deletion of HINb compromises the ability of IFI16 to induce IFN-b,while HINa mutants impaired in DNAbinding enhance the production of IFN-b.These results shed light on the roles of IFI16 HIN domains in DNA recognition and innate immune responses. | Xiangmin Ni Heng Ru Feng Ma Lixia Zhao Neil Shaw Yingang Feng Wei Ding Weibin Gong Qiaofeng Wang Songying Ouyang Genhong Cheng Zhi-Jie Liu | 2016 | Journal of Molecular Cell Biology2016，8，1： | 1 |
| 13 | Gd3+ and Sm3+ co-doped ceria based electrolytes for intermediate temperature solid fuel cells显示文摘 | WANG FengYun CHEN Songying CHENG Soofin | 2004 | Electrochem Commun2004，6，： | 1 |
| 14 | Analysis on Tritium Controlling of the Dual-Cooled Lithium Lead Blanket for Fusion Power Reactor FDS-Ⅱ显示文摘 | SongY Huang Q Wang Y L | 2009 | Fusion Engineering and Design2009，84，： | 1 |
| 15 | A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein显示文摘The emerging SARS-CoV-2 variants,commonly with many mutations in S1 subunit of spike(S)protein are weakening the efficacy of the current vaccines and antibody therapeutics.This calls for the variant-proof SARS-CoV-2 vaccines targeting the more conserved regions in S protein.Here,we designed a recombinant subunit vaccine,HR121,targeting the conserved HR1 domain in S2 subunit of S protein.HR121 consisting of HR1–linker1–HR2–linker2–HR1,is conformationally and functionally analogous to the HR1 domain present in the fusion intermediate conformation of S2 subunit.Immunization with HR121 in rabbits and rhesus macaques elicited highly potent cross-neutralizing antibodies against SARS-CoV-2 and its variants,particularly Omicron sublineages.Vaccination with HR121 achieved near-full protections against prototype SARS-CoV-2 infection in hACE2 transgenic mice,Syrian golden hamsters and rhesus macaques,and effective protection against Omicron BA.2 infection in Syrian golden hamsters.This study demonstrates that HR121 is a promising candidate of variant-proof SARS-CoV-2 vaccine with a novel conserved target in the S2 subunit for application against current and future SARS-CoV-2 variants. | Wei Pang Ying Lu Yan-Bo Zhao Fan Shen Chang-Fa Fan Qian Wang Wen-Qiang He Xiao-Yan He Ze-Kai Li Tao-Tao Chen Cui-Xian Yang You-Zhi Li Si-Xuan Xiao Zu-Jiang Zhao Xu-Sheng Huang Rong-Hua Luo Liu-Meng Yang Mi Zhang Xing-Qi Dong Ming-Hua Li Xiao-Li Feng Qing-Cui Zhou Wang Qu Shibo Jiang Songying Ouyang Yong-Tang Zheng | 2022 | Cell Research2022，32，12： | 1 |
| 16 | Modeling the crystallization of magnesium ammonium phosphate for phosphorus recovery显示文摘 | Wang J S SongY H Yuan P | 2006 | Chemosphere2006，65，7： | 1 |
| 17 | Incidence of Eczema in Early Infancy and the Prenatal Risk Factors—Guangzhou,Guangdong,China,2018–2019显示文摘What is already known on this topic?Eczema is a common allergic disease in children,which seriously affects the quality of life of children and their families.What is added by this report?The results showed that the incidence of very-earlyonset eczema was 12.4%.Primiparity was associated with a higher risk of eczema[risk ratio(95%confidence interval):1.23(1.06–1.42)].What are the implications for public health practice?Very-early-onset eczema is common.Given its adverse impact on children’s health and life quality,this previously neglected public health issue needs to be prioritized.In addition,maternal parity could serve as an indicator in risk assessment and prediction for infant eczema. | Liting Deng Huihui Liu Dongmei Wei Jinhua Lu Chengrui Wang Songying Shen Jianrong He Xiu Qiu | 2021 | China CDC weekly2021，3，33： | 0 |
| 18 | Numerical Investigation of Lid-Driven Deep Cavity with Local Grid Refinement of MRT-LBM显示文摘In the case of lid-driven deep cavity flow, the effects of different resolutions of local grid refinement have been studied in the frame of multiple relaxation times (MRT) lattice Boltzmann method (LBM). In all the cases, the aspect ratio and Reynolds number are set as 1.5 and 3.200, respectively. First, the applied method is validated by comparing it with two reported works, with which agreements are reached. Then, six separate degrees of local grid refinement at the upper left corner, i.e. purely coarse grid, including 1/64, 1/32, 1/16, 1/8, 1/4 refinements of the lattice number in the width direction have been studied in detail. The results give the following indications:① The refinement degrees lower than 1/8 produce similar results;② For single corner refinement, 1/4 refinement is adequate for clearing the noises in the singularity zone to a large extent;③ New noise around the interface between coarse and fine zones are introduced by local grid refinement. Finally, refinement of entire subzone neighboring the lid is examined to avoid introducing new noises and it has been found effective. | Dongdong Wan Guichao Wang Songying Chen | 2019 | Journal of Beijing Institute of Technology2019，28，3： | 0 |
| 19 | Weak localization of bismuth cluster-decorated graphene and its spin-orbit interaction显示文摘弱本地化(WL ) 大小在一张双性人装饰簇的 graphene 表被执行。费用集中被使经常,并且传导力修正的振幅在双性人簇免职以后被压制。当门和温度被改变时,详细 WL 数据被获得。用 E。McCanns 公式,纺纱松驰时间被提取,它被发现与散布时间的橡皮增加。这被归因于 Elliott-Yafet 旋转松驰并且 Kane-Mele 类型纺纱轨道联合(SOC ) 。SOC 力量由于第一免职被提高到 2.64 兆电子伏。范围效果在第二免职以后根据测量被讨论。 | Jian-Lei Ge Tian-Ru Wu Ming Gao Zhan-Bin Bai Lu Cao Xue-Feng Wang Yu-Yuan Qin Feng-Qi Songi | 2017 | Frontiers of physics2017，12，4： | 0 |
| 20 | 细胞核内病毒RNA受体SAFA连接天然免疫和染色质重塑显示文摘文章简介天然免疫免疫从上世纪发现模式识别受体在现在一直学界研究的热点,而细胞核内的天然免疫识别和调节机制还不为人所知。本研究揭示了SAFA作为一个新型的细胞核内病毒双链RNA(dsRNA)监测器,连接染色质重塑和抗病毒天然免疫反应。该研究显示多种病毒感染宿主细胞后,在细胞核中产生dsRNA,被SAFA监测结合,引起SAFA发生寡聚化。 | Lili Cao Shengde Liu Yunfei Li Guang Yang Yujie Luo Siji Li Hongqiang Du Yingchi Zhao Dandan Wang Jingxuan Chen Zeming Zhang Mo Li Songying Ouyang Xiang Gao Yujie Sun Zekun Wang Long Yang Rongtuan Lin Penghua Wang 游富平 | 2020 | 科学新闻2020，，2： | 0 |
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