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| 1 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 2 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 3 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 4 | Identification and Fine Mapping of a Gene Related to Pale Green Leaf Phenotype near the Centromere Region in Rice(Oryza sativa)显示文摘A thermo-insensitive pale green leaf mutant (pgl2) was isolated from T-DNA inserted transgenic lines of rice (Oryza sativa L. subsp. japonica cv. Nipponbare). Genetic analysis indicated that the phenotype was caused by a recessive mutation in a single nuclear-encoded gene. To map the PGL2 gene, an F2 population was constructed by crossing the mutant with Longtefu (Oryza sativa L. subsp. indica). The PGL2 locus was roughly linked to SSR marker RM331 on chromosome 8. To finely map the gene, 14 new InDel markers were developed around the marker, and PGL2 was further mapped to a 2.37 Mb centromeric region. Analysis on chlorophyll contents of leaves showed that there was no obvious difference between the mutant and the wild type in total chlorophyll (Chl) content, while the ratio of Chl a / Chl b in the mutant was only about 1, which was distinctly lower than that in the wild type, suggesting that the PGL2 gene was related to the conversion between Chl a and Chl b. Moreover, the method of primer design around the centromeric region was discussed, which would provide insight into fine mapping of the functional genes in plant centromeres. | ZHU Li LiuWenzhen WU Chao LUAN Wei jiang Fu Ya ping Hu Guo cheng SI Hua min SUN Zong xiu | 2007 | Rice science2007，14，3： | 11 |
| 5 | Triptolide, A Potential Autophagy Modulator显示文摘As a major active component extracted from traditional Chinese herb Tripterygium wilfordii Hook F, triptolide exhibits multiple pharmacological effects. Autophagy is an evolutionary conserved intracellular catabolic process involved in cytoplasmic materials degradation. Autophagic dysfunction contributes to the pathologies of many human diseases, which makes it a promising therapeutic target. Recent studies have shown that triptolide exerts neuroprotection, anti-tumor activities, organ toxicity, and podocyte protection by modulating autophagy. This article highlights the current information on triptolide-modulated autophagy, analyzes the possible pathways involved, and describes the crosstalk between autophagy and apoptosis modulated by triptolide, in hope of providing implications for the roles of autophagy in pharmacological effects of triptolide and expanding its novel usage as an autophagy modulator. | WEI Yan-ming WANG Yong-hui XUE Hui-qing LUAN Zhi-hua LIU Bi-wang REN Jin-hong | 2019 | Chinese Journal of Integrative Medicine2019，25，3： | 10 |
| 6 | Modeling of turbidity dynamics caused by wind-induced waves and current in the Taihu Lake显示文摘一个简单混浊模型与一个健全物理基础被开发基于在 situ 在泰胡·莱克,的短期的、强壮的导致风的沉积暂停的高周波的观察中国。确认结果证明模型能成功地模仿大风事件引起的混浊,尽管有为由骚乱的 cyanobacteria 的乘火车引起的混浊的高价值的相对差的模拟精确性。在里面 situ 观察和模型模拟结果显示风波浪在以内一狭窄光谱乐队,与光谱主要在反面上在 0.280.75 Hz 乐队以内散布的精力山峰频率站在一起。这些高周波、低精力的风波浪对过滤的深度敏感。然而,湖的平均深度仅仅是 1.9 m,并且弯屈波浪仍然在沉积水接口代表沉积暂停的主要力量。而且,湖水流具有到在平静波浪或涟漪并且在决心的背景混浊的维护的意义批评砍应力。由考虑水动力学和沉积的空间分发,模型能被用来为三维的数字模型象边界条件一样模仿全部湖的混浊。 | Ting-feng WU Bo-qiang QIN Guang-wei ZHU Meng-yuan ZHU Wei LI Cheng-mei LUAN | 2013 | International Journal of Sediment Research2013，28，2： | 9 |
| 7 | Aggregate-associated changes in nutrient properties,microbial community and functions in a greenhouse vegetable field based on an eight-year fertilization experiment of China显示文摘Soil aggregation,microbial community,and functions(i.e.,extracellular enzyme activities;EEAs)are critical factors affecting soil C dynamics and nutrient cycling.We assessed soil aggregate distribution,stability,nutrients,and microbial characteristics within>2,0.25-2,0.053-0.25,and<0.053 mm aggregates,based on an eight-year field experiment in a greenhouse vegetable field in China.The field experiment includes four treatments:100%N fertilizer(CF),50%substitution of N frtilizer with manure(M),straw(S),and manure plus straw(MS).The amounts of nutrient(N,P20,and K20)input were equal in each treatment.Results showed higher values of mean weight diameter in organic amended soils(M,MS,and S,2.43-2.97)vs.CF-amended soils(1.99).Relative to CF treatment,organic amendments had positive effects on nutrient(i.e.,available N,P,and soil organic C(SOC))conditions,microbial(e.g,bacterial and fungal)growth,and EEAs in the>0.053 mm aggregates,but not in the<0.053 mm aggregates.The 0.25-0.053 mm aggregates exhibited better nutrient conditions and hydrolytic activity,while the<0.053 mm aggregates had poor nutrient conditions and higher oxidative activity among aggregates,per SOC,available N,available P,and a series of enzyme activities.These results indicated that the 0.25-0.053 mm(<0.053 mm)aggregates provide suitable microhabitats for hydrolytic(oxidative)activity.Interestingly,we found that hydrolytic and oxidative activities were mainly impacted by fertilization(58.5%,P<0.01)and aggregate fractions(50.5%,P<0.01),respectively.The hydrolytic and oxidative activities were significantly(P<0.01)associated with nutrients(SOC and available N)and pH,electrical conductivity,respectively.Furthermore,SOC,available N,and available P closely(P<0.05)afected microbial communities within>0.25,0.25-0.053,and<0.053 mm aggregates,respectively.These findings provide several insights into microbial characteristics within aggregates under dfferent frilization modes in the greenhouse vegetable production system in China. | LUAN Hao-an GAO Wei TANG Ji-wei LI Ruo-nan LI Ming-yue ZHANG Huai-zhi CHEN Xin-ping Dainius MASILIUNAS HUANG Shao-wen | 2020 | Journal of Integrative Agriculture2020，19，10： | 7 |
| 8 | A programmable approach to revising knowledge bases显示文摘This paper presents a programmable approach to revising knowledge bases consisting of clauses. Some theorems and lemmas are shown in order to give procedures for generating maximally consistent subsets. Then a complete procedure and an incomplete procedure for generating the maximal consistent subsets are presented, and the correctness of the procedures is also shown. Furthermore, a way to implement knowledge base revision is presented, and a prototype system is introduced. Compared with related works, the main characteristic of our approach is that the approach can be implemented by a computer program. | LUAN Shangmin DAI Guozhong LI Wei | 2005 | Science in China(Series F)2005，48，6： | 6 |
| 9 | Biofilm-inspired adhesive and antibacterial hydrogel with tough tissue integration performance for sealing hemostasis and wound healing显示文摘Uncontrolled bleeding and infection can cause significant increases in mortalities.Hydrogel sealants have attracted extensive attention for their ability to control bleeding.However,because interfacial water is a formidable barrier to strong surface bonding,a challenge remains in finding a product that offers robust tissue adhesion combined with anti-infection properties.Inspired by the strong adhesive mechanism of biofilm and mussels,we report a novel dual bionic adhesive hydrogel(DBAH)based on chitosan grafted with methacrylate(CS-MA),dopamine(DA),and N-hydroxymethyl acrylamide(NMA)via a facile radical polymerization process.CS-MA and DA were simultaneously included in the adhesive polymer for imitating the two key adhesive components:polysaccharide intercellular adhesin(PIA)of staphylococci biofilm and 3,4-dihydroxy-L-phenylalanine(Dopa)of mussel foot protein,respectively.DBAH presented strong adhesion at 34 kPa even upon three cycles of full immersion in water and was able to withstand up to 168 mm Hg blood pressure,which is significantly higher than the 60–160 mm Hg measured in most clinical settings.Most importantly,these hydrogels presented outstanding hemostatic capability under wet and dynamic in vivo movements while displaying excellent antibacterial properties and biocompatibility.Therefore,DBAH represents a promising class of biomaterials for high-efficiency hemostasis and wound healing. | Wei Han Bo Zhou Kai Yang Xin Xiong Shifang Luan Yu Wang Zheng Xu Peng Lei Zhengshan Luo Jian Gao Yijing Zhan Guopu Chen Lei Liang Rui Wang Sha Li Hong Xu | 2020 | Bioactive Materials2020，5，4： | 6 |
| 10 | Effects of a decade of organic fertilizer substitution on vegetable yield and soil phosphorus pools, phosphatase activities, and the microbial community in a greenhouse vegetable production system显示文摘Partial substitution of chemical fertilizers by organic amendments is adopted widely for promoting the availability of soil phosphorus(P)in agricultural production.However,few studies have comprehensively evaluated the effects of longterm organic substitution on soil P availability and microbial activity in greenhouse vegetable fields.A 10-year(2009–2019)field experiment was carried out to investigate the impacts of organic fertilizer substitution on soil P pools,phosphatase activities and the microbial community,and identify factors that regulate these soil P transformation characteristics.Four treatments included 100%chemical N fertilizer(4 CN),50%substitution of chemical N by manure(2 CN+2 MN),straw(2 CN+2 SN),and combined manure with straw(2 CN+1 MN+1 SN).Compared with the 4 CN treatment,organic substitution treatments increased celery and tomato yields by 6.9-13.8%and 8.6-18.1%,respectively,with the highest yields being in the 2 CN+1 MN+1 SN treatment.After 10 years of fertilization,organic substitution treatments reduced total P and inorganic P accumulation,increased the concentrations of available P,organic P,and microbial biomass P,and promoted phosphatase activities(alkaline and acid phosphomonoesterase,phosphodiesterase,and phytase)and microbial growth in comparison with the 4 CN treatment.Further,organic substitution treatments significantly increased soil C/P,and the partial least squares path model(PLS-PM)revealed that the soil C/P ratio directly and significantly affected phosphatase activities and the microbial biomass and positively influenced soil P pools and vegetable yield.Partial least squares(PLS)regression demonstrated that arbuscular mycorrhizal fungi positively affected phosphatase activities.Our results suggest that organic fertilizer substitution can promote soil P transformation and availability.Combining manure with straw was more effective than applying these materials separately for developing sustainable P management practices. | ZHANG Yin-jie GAO Wei LUAN Hao-an TANG Ji-wei LI Ruo-nan LI Ming-yue ZHANG Huai-zhi HUANG Shao-wen | 2022 | Journal of Integrative Agriculture2022，21，7： | 5 |
| 11 | Back-n white neutron source at CSNS and its applications显示文摘Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March 2018.The Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the slices.In addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the world.Equipped with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional measurements.This article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn. | Jing-Yu Tang Qi An Jiang-Bo Bai Jie Bao Yu Bao Ping Cao Hao-Lei Chen Qi-Ping Chen Yong-Hao Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li Xiao Li Yang Li Jie Liu Rong Liu Shu-Bin Liu Xing-Yan Liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun Yang Yi-Wei Yang Han Yi Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 | 2021 | Nuclear Science and Techniques2021，32，1： | 4 |
| 12 | Investigation on Precooling Effects of 4 K Stirling-Type Pulse Tube Cryocoolers显示文摘Stirling-type pulse tube cryocoolers(SPTCs)working at liquid-helium temperatures are appealing in space applications because of their promising advantages such as high reliability,compactness,etc.Worldwide efforts have been put in to develop SPTCs operating at liquid-helium temperatures especially with helium-4 as the working fluid.Staged structure is essential to reach such low temperatures.Generally,both the regenerator of the last section and the pulse tube together with the phase shifter are precooled by its upper stage or by external cold source to a low temperature of around 20 K.However,the precooling effects on the regenerator and the pulse tube are synthetic in previous studies,and their independent effects have not been studied clearly.In this manuscript,the precooling effects on the regenerator and on the pulse tube together with the phase shifter are tested independently on a unique-designed precooled SPTC.The tested precooling temperature is between 13.3 K and 22 K,and the no-load refrigeration temperature gets down to 3.6 K.Further analyses and numerical calculations have been carried out.It is found that the influence on the regenerator is remarkable,which is different from previous conclusions.It is also found that the precooling effects on the pulse tube are relatively weak because of the large pressure-induced enthalpy flow of a real gas working at the temperatures near to the critical point.Furthermore,the phase shifting capacity is analyzed with two cases and with both helium-4 and helium-3 as working fluids,and it keeps quite constant after optimizing the frequency and the precooling temperature for each case.The investigation on these independent effects will provide valid reference on the precooling mechanism study of SPTCs working down to liquid-helium temperatures. | CAO Qiang LI Zimu LUAN Mingkai SUN Zheng TANG Xiao LI Peng JIANG Zhenhua WEI Li | 2019 | Journal of Thermal Science2019，28，4： | 4 |
| 13 | Ablation characteristics of mosaic structure ZrC-SiC coatings on low-density, porous C/C composites显示文摘Mosaic structure ZrC-SiC coatings were fabricated on low-density, porous C/C composites via thermal evaporation and an in-situ method. ZrC was packed in a typical lamellar mode, and the mosaic structure was formed by the deposition of Zr and Si atoms on the shallow surface of the porous C/C composites.Ablation analysis showed that the defects in the coatings originate from the boundary between the ZrC and holes created by the consumption of SiC at 2500℃. After ablation for 200 s at 3000℃, a dense ZrO2 layer formed on the coating surface, and the defects were sealed owing to the continuous supply of ablative components. The mass and line ablation rates of the Zr C-SiC coatings were-0.46 ± 0.15 mg cm^-2·s^-1 and-1.00± 0.04 μm s^-1, respectively. | Yonglong Xu Wei Sun Xiang Xiong Fuqun Liu Xingang Luan | 2019 | Journal of Materials Science & Technology2019，35，12： | 4 |
| 14 | Laminar Distribution of Neurochemically-Identified Interneurons and Cellular Co-expression of Molecular Markers in Epileptic Human Cortex显示文摘Inhibitory GABAergic interneurons are fundamental elements of cortical circuits and play critical roles in shaping network activity. Dysfunction of interneurons can lead to various brain disorders, including epilepsy,schizophrenia, and anxiety. Based on the electrophysiological properties, cell morphology, and molecular identity,interneurons could be classified into various subgroups. In this study, we investigated the density and laminar distribution of different interneuron types and the coexpression of molecular markers in epileptic human cortex.We found that parvalbumin(PV) and somatostatin(SST)neurons were distributed in all cortical layers except layer I, while tyrosine hydroxylase(TH) and neuropeptide Y(NPY) were abundant in the deep layers and white matter.Cholecystokinin(CCK) neurons showed a high density in layers IV and VI. Neurons with these markers constituted*7.2%(PV), 2.6%(SST), 0.5%(TH), 0.5%(NPY), and4.4%(CCK) of the gray-matter neuron population. Doubleand triple-labeling revealed that NPY neurons were also SST-immunoreactive(97.7%), and TH neurons were more likely to express SST(34.2%) than PV(14.6%). A subpopulation of CCK neurons(28.0%) also expressed PV, but none contained SST. Together, these results revealed the density and distribution patterns of different interneuron populations and the overlap between molecular markers in epileptic human cortex. | Qiyu Zhu Wei Ke Quansheng He Xiongfei Wang Rui Zheng Tianfu Li Guoming Luan Yue-Sheng Long Wei-Ping Lia Yousheng Shu | 2018 | Neuroscience Bulletin2018，34，6： | 3 |
| 15 | Microstructure and corrosion behavior of Zr–1.0Cr–0.4Fe–xMo alloys显示文摘Possibility of using Mo as an alloying element in Zr-based alloys was attractive in terms of microstructure refinement and mechanical properties strengthening. In this research, Zr–1.0Cr–0.4Fe–xMo(0, 0.2, 0.4, and 0.6) alloys with different Mo contents were prepared by vacuum arcmelting method, the microstructure and the corrosion resistance of these alloys were investigated. Addition of Mo has a refinement effect on the microstructure; with the increase of Mo content, the a-laths in the as-cast samples and the grain size in the annealed samples decrease. Zr–1.0Cr–0.4Fe–xMo alloys have large numbers of fine second-phase particles(SPPs) in the matrix, the area fraction of the SPPs is more than 10 %. With the increase of Mo content, the population density of the SPPs increases significantly, while the average diameter of the SPPs decreases. Mo addition also affects the texture; the intensity of basal pole texture aligning normal direction decreases with the increase of Mo content in the alloys.Compared with Zr-4 and Zr–1Nb, Zr–1.0Cr–0.4Fe–xMo alloys have excellent corrosion resistance in 500 °C/10.3 MPa steam. The corrosion rates of Mo-containing alloys are higher than that of Mo-free alloy, which is mainly attributed to the solute Mo atoms in the Zr matrix.Change of the SPPs features due to the increase of Mo content alleviates the degradation of corrosion resistance in some degree, but it is not the dominant factor. | Tian-Guo Wei Lu Zhang Zhi Miao Hong Liu Bai-Feng Luan Wen Wang Chong-Sheng Long | 2015 | Rare Metals2015，34，2： | 3 |
| 16 | Dopamine Agonists Exert Nurrl-inducing Effect in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease显示文摘 | Li-Min Zhang Cong-Cong Sun Ming-Shu Mo Luan Cen Lei Wei Fei-Fei Luo Yi Li Guo-Fei Li Si-Yun Zhang Li Yi Wei Huang Zhuo-Lin Liu Wei-Dong Leg Ping-Yi Xu | 2015 | Chinese Medical Journal2015，，13： | 3 |
| 17 | Stimuli-responsive nanocarriers for bacterial biofilm treatment显示文摘Bacterial biofilm infections have been threatening the human’s life and health globally for a long time because they typically cause chronic and persistent infections.Traditional antibiotic therapies can hardly eradicate biofilms in many cases,as biofilms always form a robust fortress for pathogens inside,inhibiting the penetration of drugs.To address the issues,many novel drug carriers emerged as promising strategies for biofilm treatment.Among them,stimuli-responsive nanocarriers have attracted much attentions for their intriguing physicochemical properties,such as tunable size,shape and surface chemistry,especially smart drug release characteristic.Based on the microenvironmental difference between biofilm infection sites and normal tissue,many stimuli,such as bacterial products accumulating in biofilms(enzymes,glutathione,etc.),lower pH and higher H_(2)O_(2)levels,have been employed and proved in favor of“on-demand”drug release for biofilm elimination.Additionally,external stimuli including light,heat,microwave and magnetic fields are also able to control the drug releasing behavior artificially.In this review,we summarized recent advances in stimuli-responsive nanocarriers for combating biofilm infections,and mainly,focusing on the different stimuli that trigger the drug release. | Meng Ding Wei Zhao Ling-Jie Song Shi-Fang Luan | 2022 | Rare Metals2022，41，2： | 3 |
| 18 | Optomechanically-induced-transparency cooling of massive mechanical resonators to the quantum ground state显示文摘Ground state cooling of massive mechanical objects remains a difficult task restricted by the unresolved mechanical sidebands. We propose an optomechanically-induced-transparency cooling scheme to achieve ground state cooling of mechanical motion without the resolved sideband condition in a pure optomechanical system with two mechanical modes coupled to the same optical cavity mode. We show that ground state cooling is achievable for sideband resolution ωm/κ as low as~0.003. This provides a new route for quantum manipulation of massive macroscopic devices and high-precision measurements. | LIU Yong-Chun XIAO Yun-Feng LUAN Xing-Sheng WONG Chee Wei | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，5： | 3 |
| 19 | The biomarkers of immune dysregulation and inflammation response in Parkinson disease显示文摘Parkinson’s disease(PD)is referring to the multi-systemicα-synucleinopathy with Lewy bodies deposited in midbrain.In ageing,the environmental and genetic factors work together and overactive major histocompatibility complex pathway to regulate immune reactions in central nerve system which resulting in neural degeneration,especially in dopaminergic neurons.As a series of biomarkers,the human leukocyte antigen genes with its related proteomics play cortical roles on the antigen presentation of major histocompatibility complex molecules to stimulate the differentiation of T lymphocytes and i-proteasome activities under their immune response to the PD-related environmental alteration and genetic variation.Furthermore,dopaminergic drugs change the biological characteristic of T lymphatic cells,affect theα-synuclein presentation pathway,and inhibit T lymphatic cells to release cytotoxicity in PD development.Taking together,the serum inflammatory factors and blood T cells are involved in the immune dysregulation of PD and inspected as the potential clinic biomarkers for PD prediction. | Li Chen Mingshu Mo Guangning Li Luan Cen Lei Wei Yousheng Xiao Xiang Chen Shaomin Li Xinling Yang Shaogang Qu Pingyi Xu | 2016 | Translational Neurodegeneration2016，5，1： | 3 |
| 20 | Association Analysis of Proteasome Subunits and Transporter Associated with Antigen Processing on Chinese Patients with Parkinson's Disease显示文摘 | Ming-Shu Mo Wei Huang Cong-Cong Sun Li-Min Zhang Luan Cen You-Sheng Xiao Guo-Fei Li Xin-Ling Yang Shao-Gang Qu Ping-Yi Xu | 2016 | Chinese Medical Journal2016，，9： | 3 |
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