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| 1 | SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2显示文摘 | Huize Pan Di Guan Xiaomeng Liu Jingyi Li Lixia Wang Jun Wu Junzhi Zhou Weizhou Zhang Ruotong Ren Weiqi Zhang Ying Li Jiping Yang Ying Hao Tingting Yuan Guohong Yuan Hu Wang Zhenyu Ju Zhiyong Mao Jian Li Jing Qu FuchouTang Guang-Hui Liu | 2016 | Cell Research2016，26，2： | 32 |
| 2 | Effect of compound Kushen injection on T-cell subgroups and natural killer cells in patients with locally advanced non-small-cell lung cancer treated with concomitant radiochemotherapy显示文摘OBJECTIVE: To observe effect of compound Kushen injection on T-cell subgroups and NK cells in patients with locally advanced non-small-cell lung cancer(NSCLC) treated with concomitant radiochemotherapy.METHODS: We randomly divided 60 patients with locally advanced NSCLC who were treated at our hospital between May 2011 and May 2013 into a treatment group and a control group by drawing.The treatment group(n = 30) received concomitant radiochemotherapy plus compound Keshen injection, and the control group(n = 30) received only radiochemotherapy.RESULTS: After treatment, levels of CD3+, CD4+,CD4 +/CD8 + and CD16 +/CD56 + cells had significantly increased, and CD8 + cells had significantly decreased, in the treatment group compared with both their pretreatment levels and with levels in the control group. In the control group, post-treatment levels of CD3 +, CD4 +, CD4 +/CD8 + and CD16+/CD56+ cells were not significantly changed from pretreatment levels. The two groups did not significantly differ in their rates of toxicity reactions(P > 0.05).CONCLUSION: Compound Kushen injections can increase immunologic function in patients with locally advanced non-small cell lung cancer who receive concomitant radiochemotherapy. | Zhao Zhongquan Liao Hehe Ju Ying | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 29 |
| 3 | Blockade of Tim-3 Pathway Ameliorates Interferon-γ Production from Hepatic CD8^+ T Cells in a Mouse Model of Hepatitis B Virus Infection显示文摘T cell immunoglobulin-and mucin-domain-containing molecule-3(Tim-3) has been reported to participate in the pathogenesis of inflammatory diseases. However,whether Tim-3 is involved in hepatitis B virus(HBV) infection remains unknown. Here,we studied the expression and function of Tim-3 in a hydrodynamics-based mouse model of HBV infection. A significant increase of Tim-3 expression on hepatic T lymphocytes,especially on CD8+ T cells,was demonstrated in HBV model mice from day 7 to day 18. After Tim-3 knockdown by specific shRNAs,significantly increased IFN-γ production from hepatic CD8+ T cells in HBV model mice was observed. Very interestingly,we found Tim-3 expression on CD8+ T cells was higher in HBV model mice with higher serum anti-HBs production. Moreover,Tim-3 knockdown influenced anti-HBs production in vivo. Collectively,our data suggested that Tim-3 might act as a potent regulator of antiviral T-cell responses in HBV infection. | Ying Ju Nan Hou Xiaoning Zhang Di Zhao Ying Liu Jinjin Wang Fang Luan Wei Shi Faliang Zhu Wensheng Sun Lining Zhang Chengjiang Gao Lifen Gao Xiaohong Liang Chunhong Ma | 2009 | Cellular & Molecular Immunology2009，6，1： | 19 |
| 4 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 5 | Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis显示文摘The role of Fas/Fas ligand (FasL) in mediating alveolar macrophage (AM)-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied.It showed that the serum levels of IL-1β,TNF-α,IL-8,MIP-1α,MCP-1,and TGF-β1were higher in silicosis patients than in controls,and increased with the progression of silicosis except TGF-β1 and IL-8.TGF-β1,IL-8,MCP-1,MIP-1αwere efficiently down-regulated by anti-FasL antibody or caspase-8 inhibitor,indicating that Fas/FasL signaling promotes the | YAO San Qiao HE Qin Cheng YUAN Ju Xiang CHEN Jie CHEN Gang LU Yao BAI Yu Ping ZHANG Chun Min YUAN Yang XU Ying Jun | 2013 | Biomedical and Environmental Sciences2013，26，11： | 13 |
| 6 | Paleoclimate Modeling in China: A Review显示文摘This paper provides a review of paleoclimate modeling activities in China. Rather than attempt to cover all topics, we have chosen a few climatic intervals and events judged to be particularly informative to the international community. In historical climate simulations, changes in solar radiation and volcanic activity explain most parts of reconstructions over the last millennium prior to the industrial era, while atmospheric greenhouse gas concentrations play the most important role in the20 th century warming over China. There is a considerable model–data mismatch in the annual and boreal winter temperature change over China during the mid-Holocene [6000 years before present(ka BP)], while coupled models with an interactive ocean generally perform better than atmospheric models. For the Last Glacial Maximum(21 ka BP), climate models successfully reproduce the surface cooling trend over China but fail to reproduce its magnitude, with a better performance for coupled models. At that time, reconstructed vegetation and western Pacific sea surface temperatures could have significantly affected the East Asian climate, and environmental conditions on the Qinghai–Tibetan Plateau were most likely very different to the present day. During the late Marine Isotope Stage 3(30–40 ka BP), orbital forcing and Northern Hemisphere glaciation, as well as vegetation change in China, were likely responsible for East Asian climate change. On the tectonic scale,the Qinghai–Tibetan Plateau uplift, the Tethys Sea retreat, and the South China Sea expansion played important roles in the formation of the East Asian monsoon-dominant environment pattern during the late Cenozoic. | JIANG Dabang YU Ge ZHAO Ping CHEN Xing LIU Jian LIU Xiaodong WANG Shaowu ZHANG Zhongshi YU Yongqiang LI Yuefeng JIN Liya XU Ying JU Lixia ZHOU Tianjun YAN Xiaodong | 2015 | Advances in Atmospheric Sciences2015，32，2： | 12 |
| 7 | Proliferation and phenotypic changes of stromal cells in response to varying estrogen/androgen levels in castrated rats显示文摘人的良性的 prostatic 增生可能从雌激素 / 雄激素(E/T ) 产生,这被知道不平衡。我们学习了阉割的老鼠前列腺的反应到传播 E/T 的不同比率。阉割的男 Wistar 老鼠随机在不同比率与 E/T 被注射 4 个星期。染色的 prostatic 索引, hematoxylin 和曙红给不同 prostatic 增生回答看的 E/T (1:100 ) 组的前列腺,和光滑的肌肉肌动朊(SMA ) 的量的 immunohistochemical 分析。在这个组,为 Vimentin 积极的房间,非肌肉肌浆球蛋白重链(NMMHC ) 和原子抗原(PCNA ) 在基质和上皮增加了的增殖的房间。而且, mRNA 光滑的肌肉肌浆球蛋白铺平重链(SMMHC ) 和增加的 NMMHC。在 1:100 的比率的 E/T 能因此导致 stromal 在阉割的老鼠的前列腺的增生的反应。观察的主要变化是光滑的肌肉房间的增加,而一些上皮的变化也在老鼠前列腺被看见。 | Ying Zhou Xiang-Qian Xiao Lin-Feng Chen Rui Yang Jian-Dang Shi Xiao-Ling Du Helmut Klocker Irwin Park Chung Lee Ju Zhang | 2009 | Asian Journal of Andrology2009，11，4： | 10 |
| 8 | Adult endothelial progenitor cells from human peripheral blood maintain monocyte/macrophage function throughout in vitro culture显示文摘密度坡度 centrifugation 从外部血孤立的 Mononuclear 房间(MNC ) 是人的 fibronectin 涂的文化盘子上的 plated 并且在 EGM-2 有教养中等。依附塑造锭子的房间,由一些调查者作为 endothelial 祖先房间(EPC ) 报导了,从支持者回合房间伸长了,但是没从以前想了的房间的一个小数字增殖。主要 EPC 的生长曲线证明房间几乎没有很少 proliferative 能力。当他们能也表示 CD14 时,流动 cytometry 分析证明房间能表示一些 endothelial 系标记,它在整个文化被认为单核白血球 / 巨噬细胞系的一个标记。在 endothelial 函数试金,房间比在反向的抄写聚合酶的成熟 endothelial 房间锁住反应并且没显示一个能力在 vitro 在 angiogenesis 试金开发像试管的结构表明了 eNOS 的表示的底层。在这研究,我们由低密度的脂蛋白(Dil-Ac-LDL ) 和印度墨水举起测试的联合标记 Dil 的乙酰 ated 识别了 EPC 的单音的似细胞的功能。所有房间是双的为在天的 Dil-Ac-LDL 和印度墨水举起积极 4 文化, 14 和 28,它意味着 EPC 在整个文化维持了单音的似细胞的功能。因此,尽管从外部 MNC 的成年 EPC 有一些 endothelial 系性质,他们维持典型 monocytic 功能并且几乎没有很少 proliferative 能力。 | Shi Ju Zhang Hao Zhang Ying Jie Wei Wen Jun Su Zhong Kai Liao Mai Hou Jian Ye Zhou Sheng Shou Hu | 2006 | Cell Research2006，16，6： | 9 |
| 9 | Evaluation of Vaporized Hydrogen Peroxide Fumigation as a Method for the Bio-decontamination of the High Efficiency Particulate Air Filter Unit显示文摘Objective To evaluate the performance of vaporized hydrogen peroxide (VHP) for the bio-decontamination of the high efficiency particulate air (HEPA) filter unit. Methods Self-made or commercially available bioindicators were placed at designated locations in the HEPA filter unit under VHP fumigation. The spores on coupons were then extracted by 0.5 h submergence in eluent followed by 200-time violent knocks. Results Due to the presence of HEPA filter in the box, spore recovery from coupons placed at the bottom of the filter downstream was significantly higher than that from coupons placed at the other locations. The gap of decontamination efficiency between the top and the bottom of the filter downstream became narrower with the exposure time extended. The decontamination efficiency of the bottom of the filter downstream only improved gently with the injection rate of H2O2 increased and the decontamination efficiency decreased instead when the injection rate exceeded 2.5 g/min. The commercially available bioindicators were competent to indicate the disinfection efficiency of VHP for the HEPA filter unit. Conclusion The HEPA filter unit is more difficult than common enclosure to decontaminate using VHP fumigation. Complete decontamination can be achieved by extending fumigation time. VHP fumigation can be applied for in-situ biodecontamination of the HEPA filter unit as an alternative method to formaldehyde fumigation. | JIA Hai Quan LI Yan Ju SUN Bei ZHAO Si Qing YI Ying ZHAO Ming ZHANG Zong Xing PAN Xin QI Jian Cheng | 2013 | Biomedical and Environmental Sciences2013，26，2： | 8 |
| 10 | Hsa-miR-1246, hsa-miR-320a and hsa-miR-196b-5p inhibitors can reduce the cytotoxicity of Ebola virus glycoprotein in vitro显示文摘Ebola virus(EBOV)causes a highly lethal hemorrhagic fever syndrome in humans and has been associated with mortality rates of up to 91%in Zaire,the most lethal strain.Though the viral envelope glycoprotein(GP)mediates widespread inflammation and cellular damage,these changes have mainly focused on alterations at the protein level,the role of microRNAs(miRNAs)in the molecular pathogenesis underlying this lethal disease is not fully understood.Here,we report that the miRNAs hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p were induced in human umbilical vein endothelial cells(HUVECs)following expression of EBOV GP.Among the proteins encoded by predicted targets of these miRNAs,the adhesion-related molecules tissue factor pathway inhibitor(TFPI),dystroglycan1(DAG1)and the caspase 8 and FADD-like apoptosis regulator(CFLAR)were significantly downregulated in EBOV GP-expressing HUVECs.Moreover,inhibition of hsa-miR-1246,hsa-miR-320a and hsa-miR-196b-5p,or overexpression of TFPI,DAG1 and CFLAR rescued the cell viability that was induced by EBOV GP.Our results provide a novel molecular basis for EBOV pathogenesis and may contribute to the development of strategies to protect against future EBOV pandemics. | SHENG MiaoMiao ZHONG Ying CHEN Yang DU JianChao JU XiangWu ZHAO Chen ZHANG GuiGen ZHANG LiFang LIU KangTai YANG Ning XIE Peng LI DangSheng ZHANG Michael Q. JIANG ChengYu | 2014 | Science China(Life Sciences)2014，57，10： | 7 |
| 11 | A new anthraquinone glycoside from seeds of Cassia obtusifolia显示文摘新 anthraquinone glycoside 1,与已知的 anthraquinone glycoside aurantio-obtusin-6-O- 尾 - d-glucopyranoside 一起 2,从肉桂 obtusifolia 的种子被孤立。根据光谱、化学证据, 1 的结构作为 1-demethylaurantio-obtusin-2-O- 尾 - d-glucopyranoside 被建立。而且, 2 的 13C NMR 基于二维的 NMR 第一次完全并且正确地被分配。 | Li Ying Tang Zhu Ju Wang Mei Hong Fu Yan He Hong Wei Wu Lu Qi Huang | 2008 | Chinese Chemical Letters2008，19，9： | 7 |
| 12 | Molecular and functional characterization of sulfiredoxin homologs from higher plants显示文摘由在氧化 peroxiredoxin 减少 cysteine-sulfinic 酸, sulfiredoxin (Srx ) 在酵母和人的房间在氧化压力抵抗起一个重要作用。这里,我们从更高的植物报导 Srx 相当或相同的事物的第一分子、功能的描述。生物信息的分析揭示了把序列编码为两张单音的简易窄床和 dicot 植物种类的潜在的 Srx 的存在。通常认为的植物 Srx 蛋白质从酵母和人展出了重要身份到他们的 orthologs,并且为催化作用包含了保存签名顺序和残余必需品。然而,植物 Srxs 不同于酵母和人的 orthologs,都被预言在他们的主要结构拥有叶绿体运输肽。从 Arabidopsis 和米饭的 Srx 蛋白质(指定了为 AtSrx 和 OsSrx,分别地) 在 SRX1 删除酵母房间的 Srx 的补充功能的缺乏。AtSrx 的 GFP 熔化蛋白质在 Arabidopsis 叶肉原物被指向到叶绿体。AtSrx 抄写在植物、繁殖的机关发生了,并且最高的抄本水平在叶子被检测。在氧化应力下面, AtSrx 抄本水平实质地被增加,哪个有在维持被发现必要的 2-Cys peroxiredoxins 的提高的抄写的 paralleled 叶绿体氧化还原作用平衡。除了氧化应力, osmotic/water 赤字或冷处理也提起了 AtSrx 抄本水平。与上面的调查结果一致, AtSrx 的猛烈异种是显著地,产生氧化的更多比野类型 Arabidopsis 强调植物。总起来说,这个工作的结果在是必要的让工厂应付氧化应力的更高的工厂显示功能的 Srx 相当或相同的事物的存在。 | Xian Peng Liu Xue Ying Liu Juan Zhang Zong Liang Xia Xin Liu Huan Ju Qin Dao Wen Wang | 2006 | Cell Research2006，16，3： | 7 |
| 13 | Eosinophil-derived CCL-6 impairs hematopoietic stem cell homeostasis显示文摘嗜曙红血球(曙光女神) 长在层次造血的系统被看作了结束阶段受动器房间。证据的众多的线建议了那个曙光女神是关于各种各样的煽动性或有免疫力的反应的开始,繁殖和规定的多功能的白血球,特别在过敏疾病。最近的研究证明了那个曙光女神也为骨头髓血浆房间的维护和 B 房间的区别被要求。然而,曙光女神是否贡献造血的干细胞(HSC ) 的规定,仍然保持不清楚动态平衡。这里,我们证明曙光女神由在野类型的老鼠损害 HSC 静止和体质能力破坏 HSC 动态平衡后面的 ovalbumin (卵) 挑战并且甚至由引起骨头髓 HSC 在 Cd3-Il-5 转基因的老鼠的失败和疲劳。HSC 的损害维护和功能与导致曙光女神的氧化还原作用不平衡(增加的氧化 phosphorylation 和减少的抗氧化剂层次) 被联系。用集体 spectrometry,更重要地,我们决定 CCL-6 在嗜曙红血球过多下面在高水平被表示。我们证明 CCL-6 为损害 HSC 动态平衡导出曙光女神、负责。有趣地,有特定的抵销抗体的 CCL-6 的阻塞,当在质问卵的老鼠加重嗜曙红血球过多航线发炎时,恢复了 HSC 的体质能力。因此,我们的学习在 HSC 动态平衡揭示 Eos/CCL-6 的意外功能。 | Chao Zhang, Fei Li, Xufei Du, Man Luo, Wen Hua, Wen Li, Zhihua Chen, Songmin Ying, Huahao Shen Weiwei Yi, Hu Wang, Zhenyu Ju Hu Wang, Zhenyu Ju Ping Wu, Chao Peng, Catherine CL Wong James J Lee Songmin Ying Songmin Ying Huahao Shen | 2018 | Cell Research2018，28，3： | 6 |
| 14 | The Medium Energy X-ray telescope (ME) onboard the Insight-HXMT astronomy satellite显示文摘The Medium Energy X-ray telescope(ME) is one of the three main telescopes on board the Insight hard X-ray modulation telescope(Insight-HXMT) astronomy satellite. ME contains 1728 pixels of Si-PIN detectors sensitive in 5-30 ke V with a total geometrical area of 952 cm^2. The application specific integrated circuit(ASIC) chip, VA32TA6, is used to achieve low power consumption and low readout noise. The collimators define three kinds of field of views(FOVs) for the telescope, 1°×4°, 4°×4°,and blocked ones. Combination of such FOVs can be used to estimate the in-orbit X-ray and particle background components.The energy resolution of ME is ~3 ke V at 17.8 ke V(FWHM) and the time resolution is 255 μs. In this paper, we introduce the design and performance of ME. | XueLei Cao WeiChun Jiang Bin Meng WanChang Zhang Tao Luo Sheng Yang ChunLei Zhang YuDong Gu Liang Sun XiaoJing Liu JiaWei Yang Xian Li Ying Tan ShaoZhen Liu YuanYuan Du FangJun Lu YuPeng Xu Ju Guan ShuangNan Zhang HuanYu Wang TiPei Li ChengMo Zhang XiangYang Wen JinLu Qu LiMing Song XiaoBo Li MingYu Ge YuPeng Zhou ShaoLin Xiong Shu Zhang YongJie Zhang ZeHao Cheng Fei Zhang MaoShun Li XiaoHua Liang Min Gao EnBo Yang XiaoHang Liu HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 5 |
| 15 | m6A promotes R-loop formation to facilitate transcription termination显示文摘R-loops are three-stranded nucleic acid structures consisting of a DNA:RNA heteroduplex and a displaced single DNA strand.They constitute a prevalent genomic feature with important functions in all kingdoms of eukaryotes.1,2,3 For example,R-loops have been found over unmethylated CpG island promoters,G-rich terminators,and many other regulatory chromosomal loci.2,3 Moreover,they are essential for diverse cellular processes,such as immunoglobulin class switching,mitotic chromosome segregation,4 DNA replication and repair,genome stability regulation,5 as well as in multiple steps during transcription.6,7 R-loops can be formed both in cis and in trans;cis R-loops are formed between a nascent RNA and its DNA template following transcribing RNA polymerases and exert co-transcriptional regulatory effects.3,8 Therefore,it is important to control their formation and resolution,and many external factors have already been identified for this process.7 However,it is still unknown whether the intrinsic properties of the RNA itself,such as various modifications,can modulate the formation of DNA:RNA hybrids. | Xin Yang Qian-Lan Liu Wei Xu Yi-Chang Zhang Ying Yang Lin-Fang Ju Jing Chen Yu-Sheng Chen Kuan Li Jie Ren Qianwen Sun Yun-Gui Yang | 2019 | Cell Research2019，29，12： | 5 |
| 16 | Two new glycosides from the genus of Cassia显示文摘二新 glycosides 被孤立并且描绘由光谱从肉桂 obtusifolia 的种子和肉桂 angustifolia 的叶子的分析。结构作为 1-hydroxyl-2-acetyl-3,8-dimethoxynaphthalene-6-O- β -d-apiofuranosyl- 被阐明(1 → 2 )- β -d-glucopyranoside 和 2-acetyl-3-methyl-8-methoxyl-1,4-naphthoquinone-6-O- β - d-glucopyranoside。 | Zhu Ju Wang Qiu Ping Wu Li Ying Tang Mei Hong Fu Yan He Qian Feng Gong Lu Qi Huang | 2007 | Chinese Chemical Letters2007，18，10： | 4 |
| 17 | Crystal structure of β-cyclodextrin-4-chlorobenzoic acid complex:Unusual C-Cl…π interaction between 4-chlorobenzoic acids in β-cyclodextrin dimer显示文摘The inclusion complex ofβ-cyclodextrin(β-CD) with 4-chlorobenzoic acid was synthesized and its crystal structure was determined by single crystal X-ray diffraction under cryogenic condition.The complex contains twoβ-CDs,two 4-chlorobenzoic acids and twenty-nine water molecules in the asymmetric unit,and can be formulated as 2(C_(42)H_(70)O_(35))·2(C_7H_5O_2Cl)·29(H_2O).In the crystal lattice,twoβ-CDs form a face-to-face dimer jointed together through hydrogen bonding between the secondary hydroxyl groups ofβ-CDs.Two 4-chlorobenzoic acid molecules which contact by C-Cl…πinteractions are included in theβ-CD dimer cavity.Theβ-CD dimers are arranged in brickwork-like pattern along the crystallographic a-axis.The effect of guest molecule length on the inclusion geometry was discussed by comparative study of someβ-CD complexes containing similar guests. | En Ju Wang Guang Ying Chen | 2011 | Chinese Chemical Letters2011，22，7： | 4 |
| 18 | Antagonism of estrogen-mediated cell proliferation by raloxifene in prevention of ageing-related prostatic hyperplasia显示文摘雌激素在良性的 prostatic 增生(BPH ) 的开始和发展有重要角色。雌激素受体的管理者(嗯) 织物特定、房间特定。我们评估了雌激素对手的效果, raloxifene (Ral ) ,在由在二不同前列腺的增长上调查它的效果的 BPH 的预防和治疗上,房间排队:一根 stromal 房间线, WPMY-1,和良性的 prostatic 增生上皮的房间线, BPH-1。我们另外在雌激素和雄激素在一个老鼠模型导致的 prostatic 增生上评估了它的效果。prostatic 增生的预防上的 Ral 的效果被 haematoxylin 并且曙红为原子抗原和伪 - 弄平的增殖的房间染色和量的 immunohistochemistry (IHC ) 分析肌肉肌动朊。在 vitro 并且在 vivo, tamoxifen (Tam ) ,另一反雌激素药,和 finasteride (鳍) ,为 BPH 的临床的处理的药,用作功效控制。在里面 vitro 数据证明既不 Ral 也不 Tam 独自既不影响了 WPMY-1 的增长, BPH-1,而是两个在支持二个房间的增长反对了 oestradiol 的效果。从老鼠前列腺染色的 IHC 的结果显示了那,类似于 Tam 和鳍, Ral 在 vivo 禁止了 stromal 房间的增长。与 Tam 相对照,有趣地, Ral 和鳍禁止了上皮的房间的增长。Furthemore, Ral 治疗强烈很减少了 prostatic acini 的数字和光滑的肌肉房间的包围的层比鳍(P < 0.05 ) 。我们的数据第一次证明 Ral 可以在对的老鼠前列腺的反应有一个角色选择嗯调节的人。 | Rui Yang Yu-Xia Ma Lin-Feng Chen Ying Zhou Zhan-Po Yang Yan Zhu Xiao-Ling Du Jian-Dang Shi Hong-Shun Ma Ju Zhang | 2010 | Asian Journal of Andrology2010，12，5： | 4 |
| 19 | Computer Predictions and Experimental Verification of Residual Stresses and Distortion in Carburizing-Quenching of Steel显示文摘In this paper, the carburizing-quenching process of carbon steel is analyzed with computer simulation which is based on the metallo-thermo-mechanical theory and finite element analysis coupled temperature, phase transformation and stress/strain fields. The residual stresses and distortion of a steel cylinder during carburizing quenching process were predicted and compared with experimental data. From the prediction results, improvement of hardness and strength of the cylinder component in carburizing-quenching process was verified. | Dong- Ying Ju, Michiharu Narazaki , Hirofumi Kamisugi , Haruyoshi Hirano 1 . Department of Mechanical Engineering, Saitama Institute of Technology, Saitama, Japan 2 . Department of Mechanical Systems Engineering, Utsunomiya University, Utsunomiya, Japan 3 | 2000 | Journal of Shanghai Jiaotong university(Science)2000，5，1： | 4 |
| 20 | Substantial transition to clean household energy mix in rural China显示文摘The household energy mix has significant impacts on human health and climate,as it contributes greatly to many health-and climate-relevant air pollutants.Compared to the well-established urban energy statistical system,the rural household energy statistical system is incomplete and is often associated with high biases.Via a nationwide investigation,this study revealed high contributions to energy supply from coal and biomass fuels in the rural household energy sector,while electricity comprised∼20%.Stacking(the use of multiple sources of energy)is significant,and the average number of energy types was 2.8 per household.Compared to 2012,the consumption of biomass and coals in 2017 decreased by 45%and 12%,respectively,while the gas consumption amount increased by 204%.Increased gas and decreased coal consumptions were mainly in cooking,while decreased biomass was in both cooking(41%)and heating(59%).The time-sharing fraction of electricity and gases(E&G)for daily cooking grew,reaching 69%in 2017,but for space heating,traditional solid fuels were still dominant,with the national average shared fraction of E&G being only 20%.The non-uniform spatial distribution and the non-linear increase in the fraction of E&G indicated challenges to achieving universal access to modern cooking energy by 2030,particularly in less-developed rural and mountainous areas.In some non-typical heating zones,the increased share of E&G for heating was significant and largely driven by income growth,but in typical heating zones,the time-sharing fraction was<5%and was not significantly increased,except in areas with policy intervention.The intervention policy not only led to dramatic increases in the clean energy fraction for heating but also accelerated the clean cooking transition.Higher income,higher education,younger age,less energy/stove stacking and smaller family size positively impacted the clean energy transition. | Guofeng Shen Rui Xiong Yanlin Tian Zhihan Luo Bahabaike Jiangtulu Wenjun Meng Wei Du Jing Meng Yuanchen Chen Bing Xue Bin Wang Yonghong Duan Jia Duo Fenggui Fan Lei Huang Tianzhen Ju Fenggui Liu Shunxin Li Xianli Liu Yungui Li Mu Wang Ying Nan Bo Pan Yanfang Pan Lizhi Wang Eddy Zeng Chao Zhan Yilin Chen Huizhong Shen Hefa Cheng Shu Tao | 2022 | National Science Review2022，9，7： | 4 |
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