|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | SlMYB75,an MYB-type transcription factor,promotes anthocyanin accumulation and enhances volatile aroma production in tomato fruits显示文摘Genetic manipulation of genes to upregulate specific branches of metabolic pathways is a method that is commonly used to improve fruit quality.However,the use of a single gene to impact several metabolic pathways is difficult.Here,we show that overexpression of the single gene SlMYB75(SlMYB75-OE)is effective at improving multiple fruit quality traits.In these engineered fruits,the anthocyanin content reached 1.86mg g−1 fresh weight at the red-ripe stage,and these SlMYB75-OE tomatoes displayed a series of physiological changes,including delayed ripening and increased ethylene production.In addition to anthocyanin,the total contents of phenolics,flavonoids and soluble solids in SlMYB75-OE fruits were enhanced by 2.6,4,and 1.2 times,respectively,compared to those of wild-type(WT)fruits.Interestingly,a number of aroma volatiles,such as aldehyde,phenylpropanoid-derived and terpene volatiles,were significantly increased in SlMYB75-OE fruits,with some terpene volatiles showing more than 10 times higher levels than those in WT fruits.Consistent with the metabolic assessment,transcriptomic profiling indicated that the genes involved in the ethylene signaling,phenylpropanoid and isoprenoid pathways were greatly upregulated in SlMYB75-OE fruits.Yeast one-hybrid and transactivation assays revealed that SlMYB75 is able to directly bind to the MYBPLANT and MYBPZM cis-regulatory elements and to activate the promoters of the LOXC,AADC2 and TPS genes.The identification of SlMYB75 as a key regulator of fruit quality attributes through the transcriptional regulation of downstream genes involved in several metabolic pathways opens new avenues towards engineering fruits with a higher sensory and nutritional quality. | Wei Jian Haohao Cao Shu Yuan Yudong Liu Juanfang Lu Wang Lu Ning Li Jianhui Wang Jian Zou Ning Tang Chan Xu Yulin Cheng Yanqiang Gao Wanpeng Xi Mondher Bouzayen Zhengguo Li | 2019 | Horticulture Research2019，6，1： | 39 |
| 2 | An optimization method on runner blades in bulb turbine based on CFD analysis显示文摘In this paper an optimization method of the runner blades in a bulb turbine based on CFD analysis is proposed.In the method the main scales of the turbine including guide vane,runner and draft are maintained.Only the runner blades are modified based on the present method.In the optimization method the runner blade is expressed by spline surface with a gather of coordinate points.The B-spline curve is used to keep the modified blades smooth.In order to make the blade optimization simple and ef- ficient,one of the coordinates is fixed and only the angles of the points are changed according to different modification purposes.Three main optimization principles based on flow diagnosis are presented here.These three principles are all based on the CFD analysis of the internal flow in bulb turbine.For the purpose of method verification,the optimization method is used in a model bulb turbine.A three dimensional steady turbulent computation is carried out through the whole passage including the bulb body,guide vanes,runner and draft tube of the bulb turbine under seven different work conditions.An SST k-ωturbulence model is used during the CFD analysis and the performance of the turbine can be achieved.The runner blade is optimized according to the three optimization principles based on flow diagnosis.The CFD analysis is conducted again on the optimized turbine and another modification is needed if the new turbine can’t satisfy the required performance.Comparison of the computational results between the original turbine and an optimized one indicates that the optimization method is practical and does improve the performance of the bulb turbine. | YANG Wei WU YuLin LIU ShuHong | 2011 | Science China(Technological Sciences)2011，54，2： | 15 |
| 3 | Fatigue behavior of Ti-6Al-4V cellular structures fabricated by additive manufacturing technique显示文摘Porous titanium and its alloys have been considered as promising replacement for dense implants, as they possess low elastic modulus comparable to that of compact human bones and are capable of providing space for in-growth of bony tissues to achieve a better fixation. Recently, the additive manufacturing(AM) method has been successfully applied to the fabrication of Ti-6 Al-4 V cellular meshes and foams.Comparing to traditional fabrication methods, the AM method offers advantages of accurate control of complex cell shapes and internal pore architectures, thus attracting extensive attention. Considering the long-term safety in the human body, the metallic cellular structures should possess high fatigue strength.In this paper, the recent progress on the fatigue properties of Ti-6 Al-4 V cellular structures fabricated by the AM technique is reviewed. The various design factors including cell shapes, surface properties, post treatments and graded porosity distribution affecting the fatigue properties of additive manufactured Ti-6 Al-4 V cellular structures were introduced and future development trends were also discussed. | Dechun Ren Shujun Li Hao Wang Wentao Hou Yulin Hao Wei Jin Rui Yang R.Devesh K.Misra Lawrence E.Murr | 2019 | Journal of Materials Science & Technology2019，35，2： | 15 |
| 4 | Influence of Weave Structures on the Tribological Properties of Hybrid Kevlar/PTFE Fabric Composites显示文摘The existing research of the woven fabric self-lubricating liner mainly focus on the tribological performance improvements and the service life raised by changing different fiber type combinations, adding additive modification, and performing fiber surface modification. As fabric composites, the weave structures play an important role in the mechanical and tribological performances of the liners. However, hardly any literature is available on the friction and wear behavior of such composites with different weave structures. In this paper, three weave structures (plain, twill 1/3 and satin 8/5) of hybrid Kevlar/PTFE fabric composites are selected and pin-on-flat linear reciprocating wear studies are done on a CETR tester under different pressures and different frequencies. The relationship between the tensile strength and the wear performance are studied. The morphologies of the worn surfaces under the typical test conditions are analyzed by means of scanning electron microscopy (SEM). The analysis results show that at 10 MPa, satin 8/5 performs the best in friction-reduction and antiwear performance, and plain is the worst. At 30 MPa, however, the antiwear performance is reversed and satin 8/5 does not even complete the 2 h wear test at 16 Hz. There is no clear evidence proving that the tensile strength has an influence on the wear performance. So the different tribological performance of the three weave structures of fabric composites may be attributed to the different PTFE proportions in the fabric surface and the different wear mechanisms. The fabric composites are divided into three regions: the lubrication region, the reinforced region and the bonding region. The major mechanisms are fatigue wear and the shear effects of the friction force in the lubrication region. In the reinforced region fiber-matrix de-bonding and fiber breakage are involved. The proposed research proposes a regional wear model and further indicates the wear process and the wear mechanism of fabric composites. | GU Dapeng YANG Yulin QI Xiaowen DENG Wei SHI Lei | 2012 | Chinese Journal of Mechanical Engineering2012，25，5： | 12 |
| 5 | N and P resorption in a pioneer shrub(Artemisia halodendron) inhabiting severely desertified lands of Northern China显示文摘Nutrient resorption is an important conservation mechanism for plants to overcome nutrient limitation in the less fertile area of desertified land.In the semi-arid Horqin Sandy Land of Northern China,the shrub Artemisia halodendron usually colonizes into the bare ground of severely desertified land as a pioneer species.It is,therefore,expected that A.halodendron will be less dependent on current nutrient uptake through efficient and proficient resorption of nutrients.In this study,we found that averaged nitrogen(N)and phosphorus(P)concentrations in senesced leaves significantly varied from 12.3 and 1.2 mg/g in the shifting sand dune to 15.9 and 1.9 mg/g in the fixed sand dune,respectively,suggesting that foliar N and P resorption of A.halodendron were more proficient in the shifting sand dune.In particular,positive relationships between nutrient concentrations in senesced leaves and soil nutrient availability indicate that A.halodendron in infertile habitats is more likely to manage with a low level of nutrients in senesced leaves,giving this species an advantage in infertile soil.Moreover,foliar N-and P-resorption efficiencies and proficiencies showed limited inter-annual variability although annual precipitation varied greatly among 2007–2009.However,N and P resorption of A.halodendron were not more efficient and proficient than those previously reported for other shrubs,indicating that the pioneer shrub in sand dune environments does not rely more heavily than other plants on the process of resorption to conserve nutrients.Incomplete resorption of nutrients in A.halodendron suggests that senesced-leaf fall would return litter with high quality to the soil,and thereby would indirectly improve soil nutrient availability.The restoration of desertified land,therefore,may be accelerated after A.halodendron pioneers into shifting sand dunes. | YuLin LI Chen JING Wei MAO Duo CUI XinYuan WANG XueYong ZHAO | 2014 | Journal of Arid Land2014，6，2： | 11 |
| 6 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 7 | Impending HRT wave precursors to the Wenchuan M_s8.0 earthquake and methods of earthquake impending prediction by using HRT wave显示文摘We deployed four geo-electric monitoring stations in Sichuan and Yunnan provinces from 2004, using the new generation of equipment (PS-100) and technologies to capture the HRT wave earthquake precursor. Before the Wenchuan Ms8.0 earthquake, we recorded the HRT wave precursor at the only operating station in Hongge (HG, Δ=465 km) and found that significant impending signal had been recorded at the station in the early morning ( 0―5 am) of 12th of May, 2008. The precursor for this earthquake is consistent with precursors recorded for other strong earthquakes. The measured physical properties (geo-resistivity and telluric-current) show tidal wave period oscillations from several days to several months before the earthquakes and the amplitude of such HT oscillation increases significantly towards the occurrence of an earthquake. These HT and RT waves from the epicenter have a causal relationship with the earthquakes that happened several days later. The arrival time of two RT waves is proportional to the distance from the station to the epicenter. The estimated natural decay of the amplitude is correlated with the natural period (T0) of the earthquake fault, which is proportional to the fault length. From this relationship, we can predict the earthquake magnitude. For magnitude 6―9 earthquakes, the natural period is about 1―6 hours. Such oscillation comes from the epicenter area and they can propagate several thousand kilometers in the Earth's crust. Before a strong earthquake in the shallow crust, the conductive pore fluid will experience major changes before the fault rapture. Such fluid change will emit an oscillation in the pore fluid pressure. This is the mechanism for the HRT wave generation. Since the China Earthquake Administration funded the HRT wave short-term earth-quake prediction project in 2003, the first record of HRT precursor wave has been recorded from the 2004-12-26 Sumatra Mw9.0 earthquake with the largest epicentre distance Δ=2900 km. Thereafter, we have captured HRT waves from more than twenty strong earthquakes, which are well-matched and show repeatability, consistency and regularity. All our observation with the HRT waves demonstrate that HRT wave precursors to earthquakes indeed exist. Strong earthquakes can be predicted and short-term and impending earthquake prediction is achievable in the very near future. From all the observations, including the ones at HG station from Wenchuan Ms8.0 earthquake, we conclude that using HRT wave to predict earthquakes is feasible. | QIAN FuYe ZHAO BiRu QIAN Wei ZHAO Jian HE ShiGen ZHANG HongKui LI ShiYu LI ShaoKun YAN GuLiang WANG ChengMin SUN ZhenKai ZHANG DongNing LU Jun ZHANG Ping YANG GuoJun SUN JiaLin GUO ChunSheng TANG YuXiong XU JianMing XIA KunTao JU Hang YIN BangHong LI Ming YANG DongSheng QI WeiLuo HE TaiMing GUAN HuaPing ZHAO YuLin | 2009 | Science China Earth Sciences2009，52，10： | 8 |
| 8 | Overview of Biomass Conversion to Electricity and Hydrogen and Recent Developments in Low-Temperature Electrochemical Approaches显示文摘Biomass is plant or animal material that stores both chemical and solar energies,and that is widely used for heat production and various industrial processes.Biomass contains a large amount of the element hydrogen,so it is an excellent source for hydrogen production.Therefore,biomass is a sustainable source for electricity or hydrogen production.Although biomass power plants and reforming plants have been commercialized,it remains a difficult challenge to develop more effective and economic technologies to further improve the conversion efficiency and reduce the environmental impacts in the conversion process.The use of biomass-based flow fuel cell technology to directly convert biomass to electricity and the use of electrolysis technology to convert biomass into hydrogen at a low temperature are two new research areas that have recently attracted interest.This paper first briefly introduces traditional technologies related to the conversion of biomass to electricity and hydrogen,and then reviews the new developments in flow biomass fuel cells(FBFCs)and biomass electrolysis for hydrogen production(BEHP)in detail.Further challenges in these areas are discussed. | Wei Liu Congmin Liu Parikshit Gogoi Yulin Deng | 2020 | Engineering2020，6，12： | 7 |
| 9 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 10 | Heat treatment enhancing the compressive fatigue properties of open-cellular Ti-6Al-4V alloy prototypes fabricated by electron beam melting显示文摘In this work, we report the effect of annealing in α+β phase field on the fatigue properties of Ti-6 Al-4 V alloy meshes fabricated by electron beam melting. The results show that annealing at high temperature near the phase boundary enhances the ductility of the brittle mesh struts due to the formation of coarseα lamellas with a large thickness/length ratio. Accordingly, the fatigue endurance ratio of the studied meshes increases to up to ~0.6, which is much superior to that of the as-fabricated counterparts and comparable to those of dense materials. | Wei Yuan Wentao Hou Shujun Li Yulin Hao Rui Yang Lai-Chang Zhang Yue Zhu | 2018 | Journal of Materials Science & Technology2018，34，7： | 5 |
| 11 | Zanthoxylum-specific whole genome duplication and recent activity of transposable elements in the highly repetitive paleotetraploid Z.bungeanum genome显示文摘Zanthoxylum bungeanum is an important spice and medicinal plant that is unique for its accumulation of abundant secondary metabolites,which create a characteristic aroma and tingling sensation in the mouth.Owing to the high proportion of repetitive sequences,high heterozygosity,and increased chromosome number of Z.bungeanum,the assembly of its chromosomal pseudomolecules is extremely challenging.Here,we present a genome sequence for Z.bungeanum,with a dramatically expanded size of 4.23 Gb,assembled into 68 chromosomes.This genome is approximately tenfold larger than that of its close relative Citrus sinensis.After the divergence of Zanthoxylum and Citrus,the lineage-specific whole-genome duplication event q-WGD approximately 26.8 million years ago(MYA)and the recent transposable element(TE)burst~6.41 MYA account for the substantial genome expansion in Z.bungeanum.The independent Zanthoxylum-specific WGD event was followed by numerous fusion/fission events that shaped the genomic architecture.Integrative genomic and transcriptomic analyses suggested that prominent speciesspecific gene family expansions and changes in gene expression have shaped the biosynthesis of sanshools,terpenoids,and anthocyanins,which contribute to the special flavor and appearance of Z.bungeanum.In summary,the reference genome provides a valuable model for studying the impact of WGDs with recent TE activity on gene gain and loss and genome reconstruction and provides resources to accelerate Zanthoxylum improvement. | Shijing Feng Zhenshan Liu Jian Cheng Zihe Li Lu Tian Min Liu Tuxi Yang Yulin Liu Yonghong Liu He Dai Zujun Yang Qing Zhang Gang Wang Jisen Zhang Huifeng Jiang Anzhi Wei | 2021 | Horticulture Research2021，8，1： | 5 |
| 12 | Design and Application of Water, Fertilizer and Pesticide Integrated Automatic Control Device显示文摘Integration of water, fertilizer and pesticide is the final stage of agricultural development, which improves the utilization efficiency of water, fertilizer and pesticide. Starting from the design and realization of water, fertilizer and pesticide integrated automatic control device, the paper discusses selection and application of fertilizer pesticides, use procedure, water, fertilizer and pesticide saving effect and receptive crowd in the application process of modern planting industry, so as to provide the basis for promotion and popularization of water, fertilizer and pesticide integration. | Huang Wei Lu Meiling Liang Xin Zhu Yulin Wang Daobo | 2020 | Plant Diseases and Pests2020，11，1： | 4 |
| 13 | Allometric response of perennial Pennisetum centrasiaticum Tzvel to nutrient and water limitation in the Horqin Sand Land of China显示文摘Optimal partitioning theory(OPT)suggests that plants should allocate relatively more biomass to the organs that acquire the most limited resources.The assumption of this theory is that plants trade off the biomass allocation between leaves,stems and roots.However,variations in biomass allocation among plant parts can also occur as a plant grows in size.As an alternative approach,allometric biomass partitioning theory(APT)asserts that plants should trade off their biomass between roots,stems and leaves.This approach can minimize bias when comparing biomass allocation patterns by accounting for plant size in the analysis.We analyzed the biomass allocation strategy of perennial Pennisetum centrasiaticum Tzvel in the Horqin Sand Land of northern China by treating samples with different availabilities of soil nutrients and water,adding snow in winter and water in summer.We hypothesized that P.centrasiaticum alters its pattern of biomass allocation strategy in response to different levels of soil water content and soil nitrogen content.We used standardized major axis(SMA)to analyze the allometric relationship(slope)and intercept between biomass traits(root,stem,leaf and total biomass)of nitrogen/water treatments.Taking plant size into consideration,no allometric relationships between different organs were significantly affected by differing soil water and soil nitrogen levels,while the biomass allocation strategy of P.centrasiaticum was affected by soil water levels,but not by soil nitrogen levels.The plasticity of roots,leaves and root/shoot ratios was‘true’in response to fluctuations in soil water content,but the plasticity of stems was consistent for trade-offs between the effects of water and plant size.Plants allocated relatively more biomass to roots and less to leaves when snow was added in winter.A similar trend was observed when water was added in summer.The plasticity of roots,stems and leaves was a function of plant size,and remained unchanged in response to different soil nitrogen levels. | Wei MAO TongHui ZHANG YuLin LI XueYong ZHAO YingXin HUANG | 2012 | Journal of Arid Land2012，4，2： | 4 |
| 14 | Absorption and Transfer of Exogenous Selenium in Longan(Dimocarpus longan Lour.) and Its Effect显示文摘Different concentrations of sodium selenite and sodium selenate were applied to leaves and roots of longan( Dimocarpus longan Lour.) to study the absorption and transfer characteristics of exogenous selenium in longan,and the effects of nitrogen and phosphorus fertilizers on the absorption of selenium in longan were discussed. This study provides a theoretical basis and reference for the research and influence on the absorption and transfer mechanism of selenium in longan and the production of selenium-enriched longan. | Wei HUANG Zhaoliang LIU Yu ZHANG Yulin ZHU Daobo WANG | 2020 | Agricultural Biotechnology2020，9，3： | 3 |
| 15 | ZbAGL11, a class D MADS-box transcription factor of Zanthoxylum bungeanum, is involved in sporophytic apomixis显示文摘Apomixis is a reproductive model that bypasses sexual reproduction,so it does not require the combination of paternal and maternal gametes but instead results in the production of offspring directly from maternal tissues.This reproductive mode results in the same genetic material in the mother and the offspring and has signi fi cant applications in agricultural breeding.Molecular and cytological methods were used to identify the reproductive type of Zanthoxylum bungeanum(ZB).Fluorescence detection of the ampli fi ed products of 12 pairs of polymorphic SSR primers showed consistent fl uorescence signals for mother and offspring,indicating that no trait separation occurred during reproduction.In addition,the cytological observation results showed differentiation of ZB embryos(2n)from nucellar cells(2n)to form inde fi nite embryonic primordia and then form adventitious embryos(2n),indicating that the apomictic type of ZB is sporophytic apomixis.The MADS-box transcription factor ZbAGLll was highly expressed during the critical period of nucellar embryo development in ZB.Unpollinated ZbAGLll-OE Arabidopsis produced fertile offspring and exhibited an apomictic phenotype.The overexpression of ZbAGL11 increased the callus induction rate of ZB tissue.In addition,the results of the yeast two-hybrid experiment showed that ZbAGL11 could interact with the ZbCYP450 and ZbCAD11 proteins.Our results demonstrate that ZbAGL11 can cause developmental disorders of Arabidopsis fl ower organs and result in apomixis-like phenotypes. | Xitong Fei Qianqian Shi Yichen Qi Shujie Wang Yu Lei Haichao Hu Yulin Liu Tuxi Yang Anzhi Wei | 2021 | Horticulture Research2021，8，1： | 3 |
| 16 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 17 | Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization显示文摘Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment resistance.Therefore,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor immunotherapy.Herein,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in mice.As demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane permeabilization.Besides,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of TAMs.Our results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux inhibition.This study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment. | Siyue Zhang Fangyuan Xie Kaichun Li He Zhang You Yin Yuan Yu Guangzhao Lu Shihao Zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 18 | Development and Application of Special Fertilizer for Crops in Guangxi Region显示文摘Different crops need different kinds of nutrients. In this paper,formula of special fertilizer for common field crops in Guangxi is explored from the angle of grain crops,fruits,vegetables,sugar crops,oil crops,etc.,and corresponding production equipment and methods are provided,which could convenience for agricultural precision fertilization and theoretical basis and technical reference for cost saving and efficiency increasing of fertilizer. | Wei HUANG Meiling LU Xin LIANG Yulin ZHU Daobo WANG | 2020 | Meteorological and Environmental Research2020，11，2： | 2 |
| 19 | Exploring the role of psychological safety in promoting the intention to continue sha- ring knowledge in virtual communities 显示文摘 | Zhang Yixiang Fang Yulin Wei Kwokkee | 2010 | International Journal of Information Management2010，30，5： | 1 |
| 20 | A novel micro-fabricatedthruster for drug release in remote controlled capsule显示文摘 | Pi Xitian Lin Yulin Wei Kang | 2010 | Sensorsand Actuators A:Physical2010，159，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员