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| 1 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 2 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 3 | Safety and efficacy of ciprofol vs.propofol for sedation in intensive care unit patients with mechanical ventilation:a multi-center,open label,randomized,phase 2 trial显示文摘Background:Ciprofol(HSK3486;Haisco Pharmaceutical Group Co.,Ltd.,Chengdu,China),developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applicated as continuous intravenous infusion for 12 h maintenance sedation in a previous phase 1 trial.The phase 2 trial was designed to investigate the safety,efficacy,and pharmacokinetic characteristics of ciprofol for sedation of patients undergoing mechanical ventilation.Methods:In this multicenter,open label,randomized,propofol positive-controlled,phase 2 trial,39 Chinese intensive care unit patients receiving mechanical ventilation were enrolled and randomly assigned to a ciprofol or propofol group in a 2:1 ratio.The ciprofol infusion was started with a loading infusion of 0.1-0.2 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 0.30 mg·kg^(-1)·h^(-1),which could be adjusted to an infusion rate of 0.06 to 0.80 mg·kg^(-1)·h^(-1),whereas for propofol the loading infusion dose was 0.5-1.0 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 1.50 mg·kg^(-1)·h^(-1),which could be adjusted to 0.30-4.00 mg·kg^(-1)·h^(-1)to achieve-2 to+1 Richmond Agitation-Sedation Scale sedation within 6-24 h of drug administration.Results:Of the 39 enrolled patients,36 completed the trial.The median(min,max)of the average time to sedation compliance values for ciprofol and propofol were 60.0(52.6,60.0)min and 60.0(55.2,60.0)min,with median difference of 0.00(95%confidence interval:0.00,0.00).In total,29(74.4%)patients comprising 18(69.2%)in the ciprofol and 11(84.6%)in the propofol group experienced 86 treatment emergent adverse events(TEAEs),the majority being of severity grade 1 or 2.Drug-and sedation-related TEAEs were hypotension(7.7%vs.23.1%,P=0.310)and sinus bradycardia(3.8%vs.7.7%,P=1.000)in the ciprofol and propofol groups,respectively.The plasma concentration-time curves for ciprofol and propofol were similar.Conclusions:ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting.Trial registration:ClinicalTrials.gov,NCT04147416. | Yongjun Liu Xiangyou Yu Duming Zhu Jun Zeng Qinhan Lin Bin Zang Chuanxi Chen Ning Liu Xiao Liu Wei Gao Xiangdong Guan | 2022 | Chinese Medical Journal2022，，9： | 19 |
| 4 | ALDH2 protects against stroke by clearing 4-HNE显示文摘(ALDH2 ) 醛脱氢酶 2 是使象 4-hydroxy-2-nonenal (4-HNE ) 那样的乙醇和有毒的醛产生代射变化的 mitochondrial 酶。用不偏的 proteomic 搜索,我们作为与自发地高血压的老鼠(SHR ) 相比在击容易的自发地高血压的老鼠(SHR-SP ) 识别了 ALDH2 缺乏。我们作为 overexpression 在 neuronal 损害结束了 ALDH2 缺乏的原因的角色或 ALDH2 的激活由清除 4-HNE 在授与 neuroprotection 在 vitro 研究。进一步, ALDH2 击倒的老鼠揭示了 PKCε 的 neuroprotective 效果的缺席;。被知道对击施加保护的中等乙醇管理被显示提高 4-HNE 的 detoxification,并且免于 ischemic 通过 PKCε 的服的损害; -ALDH2 小径。在 SHR-SP,浆液 4-HNE 水平固执地与 lifespan 相反地被提高并且相关。在在人的击的 4-HNE 的角色被它的血浆层次的坚持的举起也在击以后建议至少 6 个月。最后,我们观察到发展了的跟随 8 年的 1 242 个题目中的 21 个比没得中风的那些摸有的更高起始的血浆 4-HNE 层次。这些调查结果建议 ALDH2 小径的激活可以在击容易的题目的鉴定用作一个有用索引,并且 ALDH2 小径可以是在击的治疗学的干预的一个潜在的目标。 | Jin-Min Guo Ai-Jun Liu Pu Zang Wen-Zhe Dong Li Ying Wei W ang Pu Xu Xu-Rui Song Jun Cai She-Qing Zhang Jun-Li Duan Jawahar L Mehta Ding-Feng Su | 2013 | Cell Research2013，23，7： | 19 |
| 5 | Using interacting multiple model particle filter to track airborne targets hidden in blind Doppler显示文摘In airborne tracking,the blind Doppler makes the target undetectable,resulting in tracking difficulties. In this paper,we studied most possible blind-Doppler cases and summed them up into two types:targets' intentional tangential flying to radar and unintentional flying with large tangential speed. We proposed an interacting multiple model(IMM) particle filter which combines a constant velocity model and an acceleration model to handle maneuvering motions. We compared the IMM particle filter with a previous particle filter solution. Simulation results showed that the IMM particle filter outperforms the method in previous works in terms of tracking accuracy and continuity. | DU Shi-chuan SHI Zhi-guo ZANG Wei CHEN Kang-sheng | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，8： | 16 |
| 6 | Effect of anaphylatoxin C3a, C5a on the tubular epithelial-myofibroblast transdifferentiation in vitro显示文摘背景 Tubulointerstitial 肾的纤维变性是进步的肾疾病的普通结束点,并且管状的 epithelial-myofibroblast transdifferentiation ( TEMT )在 tubulointerstitial 的进步起一个关键作用肾的 fibrosis.Anaphylatoxin C3a 和 C5a 在肾的疾病并且作为这研究的潜在的新治疗学的 targets.The 目的作为新奇 profibrotic 因素被识别是调查是否 C3a , C5a 能由转变生长 factor-31 ( TGF-1 ) /connective 织物生长因素调整 TEMT 控制组, 10 ng/ml TGF-31 组, 50 nmol/L C5a 组,加 2.5 mol/L C5aRA 的 50 nmol/L C5a group.TGF-1 受体对手( TGF-1 RA ) 10 g/ml 被用来调查 导致C3a 、 导致C5a 的 TEMT.Electron 的机制显微镜学被用来观察染色的词法 changes.Immunocytochemistry ,即时 PCR 并且西方的弄污被用来检测光滑的肌肉肌动朊的表情( -SMA),E-cadherin,Col-I,C3a 受体( C3aR ), C5aR , CTGF 和与 C3a 和 C5a fo 有教养的 TGF-1.Results HK-2 | LIU Fang GOU Rong HUANG Jun FU Ping CHEN Feng FAN Wen-xing HUANG You-qun ZANG Li WU Min QIU Hong-yu WEI Da-peng | 2011 | Chinese Medical Journal2011，，23： | 15 |
| 7 | RESTplus: an improved toolkit for resting-state functional magnetic resonance imaging data processing显示文摘Resting-state functional magnetic resonance imaging (RS-fMRI)[1,2] provides relatively high spatial and temporal resolution for mapping spontaneous brain activity non-invasively. It has been widely used in cognitive neuroscience and clinical studies. A number of comprehensive software packages have been developed for RS-fMRI data analysis, among which a MATLAB package named REST (RESing-state fMRI data analysis Toolkit, released in October 2008 at http://gffzz99d25abdda23474bh060xq5ncc9b96qoo.ffgz.tsg.suse.edu.cn)[3] is the earliest one dedicated to RS-fMRI analysis. REST focuses on RS-fMRI postprocessing metrics. | Xi-Ze Jia Jue Wang Hai-Yang Sun Han Zhang Wei Liao Ze Wang Chao-Gan Yan Xiao-Wei Song Yu-Feng Zang | 2019 | Science Bulletin2019，64，14： | 14 |
| 8 | Activation of Mitochondrial orf355 Gene Expression by a Nuclear-Encoded DREB Transcription Factor Causes Cytoplasmic Male Sterility in Maize显示文摘Coordination between mitochondria and the nucleus is crucial for fertility determination in plants with cytoplasmic male sterility(CMS).Using yeast one-hybrid screening,we identified a transcription factor,ZmDREB1.7,that is highly expressed in sterile microspores at the large vacuole stage and activates the expression of mitochondria-encoded CMS gene orf355.Δpro,a weak allele of ZmDREB1.7 with the loss of a key unfolded protein response(UPR)motif in the promoter,partially restores male fertility of CMS-S maize.ZmDREB1.7 expression increases rapidly in response to antimycin A treatment,but this response is attenuated in theΔpro allele.Furthermore,we found that expression of orf355 in mitochondria activates mitochondrial retrograde signaling,which in turn induces ZmDREB1.7 expression.Taken together,these findings demonstrate that positive-feedback transcriptional regulation between a nuclear regulator and a mitochondrial CMS gene determines male sterility in maize,providing new insights into nucleus-mitochondria communication in plants. | Senlin Xiao Jie Zang Yuanrong Pei Jie Liu Juan Liu Wei Song Zi Shi Aiguo Su Jiuran Zhao Huabang Chen | 2020 | Molecular Plant2020，13，9： | 10 |
| 9 | Novel method for the determination of five carbamate pesticides in water samples by dispersive liquid-liquid microextraction combined with high performance liquid chromatography显示文摘A novel method for the determination of five carbamate pesticides(metolcarb,carbofuran,carbaryl,isoprocard and diethofencard)in water samples was developed by dispersive liquid-liquid microextraction(DLLME)coupled with high performance liquid chromatography-diode array detector(HPLC-DAD).Some experimental parameters that influence the extraction efficiency were studied and optimized to obtain the best extraction results.Under the optimum conditions for the method,the calibration curve was linear in the concentration range from 5 to 1000 ng mL^(-1)for all the five carbamate pesticides, with the correlation coefficients(r^2)varying from 0.9984 to 0.9994.Good enrichment factors were achieved ranging from 80 to 177- fold,depending on the compound.The limits of detection(LODs)(S/N=3)were ranged from 0.1 to 0.5 ng mL^(-1).The method has been successfully applied to the analysis of the pesticide residues in environmental water samples. | Zhi Mei Liu Xiao Huan Zang Wei Hua Liu Chun Wang Zhi Wang | 2009 | Chinese Chemical Letters2009，20，2： | 10 |
| 10 | Three-dimensional porous graphene sponges assembled with the combination of surfactant and freeze-drying显示文摘与表面活化剂和 freeze-drying 的联合,我们开发了二种 graphene 多孔的结构。在一方面,把肥皂水泡的泡沫用作模板,有富有的层次毛孔的三维的多孔的 graphene 海绵被综合了。材料的毛孔包含长度规模的三个层次,包括毫米,测微计和纳米。结构能被改变结冰媒介调节,调整激动人心的率或增加功能的添加剂。由 graphene 氧化物 / 表面活化剂暂停的直接 freeze-drying,在另一方面,有方向性地排列的毛孔的一个多孔的框架被准备。表面活化剂给 graphene 氧化物表的更好的分散,导致一个高特定的表面区域。两个获得的材料展出优秀吸收能力和好压缩性能,提供大量可能的应用程序,例如吸收剂,存储媒介,和搬运人。 | Rujing Zhang Yachang Cao Peixu Li Xiaobei Zang Pengzhan Sun Kunlin wang Minlin Zhong Jinquan Wei Dehai Wu Feiyu Kang Hongwei Zhu | 2014 | Nano Research2014，7，10： | 10 |
| 11 | Initial experience of single-incision plus one port left-side approach totally laparoscopic distal gastrectomy with uncut Roux-en-Y reconstruction显示文摘BACKGROUND Single incision plus one port left-side approach(SILS+1/L)totally laparoscopic distal gastrectomy(TLDG)is an emerging technique for the treatment of gastric cancer.Reduced port laparoscopic gastrectomy has a number of potential advantages for patients compared with conventional laparoscopic gastrectomy:relieving postoperative pain,shortening hospital stay and offering a better cosmetic outcome.Nevertheless,there are no previous reports on the use of SILS+1/L TLDG with uncut Roux-en-Y(uncut R-Y)reconstruction.AIM To investigate the initial feasibility of SILS+1/L TLDG with uncut Roux-en-Y digestive tract reconstruction(uncut R-Y reconstruction)to treat distal gastric cancer.METHODS A total of 21 patients who underwent SILS+1/L TLDG with uncut R-Y reconstruction for gastric cancer were enrolled.All patients were treated at The Second Hospital of Shandong University.Reconstructions were performed intracorporeally with 60 mm endoscopic linear stapler and 45 mm no-knife stapler.The clinicopathological characteristics,surgical details,postoperative short-term outcomes,postoperative follow-up upper gastrointestinal radiography findings and endoscopy results were analyzed retrospectively.RESULTS All SILS+1/L operations were performed by SILS+1/L TLDG successfully.The patient population included 13 men and 8 women with a mean age of 48.2 years(ranged from 40 years to 70 years)and median body mass index of 22.8 kg/m^2.There were no conversions to open laparotomy,and no other port was placed.The mean operation time was 146 min(ranged 130-180 min),and the estimated mean blood loss was 54 mL(ranged 20-110 mL).The mean duration to flatus and discharge was 2.3(ranged 1-3.5)and 7.3(ranged 6-9)d,respectively.The mean number of retrieved lymph nodes was 42(ranged 30-47).Two patients experienced mild postoperative complications,including surgical site infection(wound at the navel incision)and mild postoperative pancreatic fistula(grade A).Follow-up upper gastrointestinal radiography and endoscopy were carried out at 3 mo postoperatively.No patients experienced moderate or severe food stasis,alkaline gastritis or bile reflux during the follow-up period.No recanalization of the biliopancreatic limb was found.CONCLUSION SILS+1/L TLDG with uncut R-Y reconstruction could be safely performed as a reduced port surgery. | Wei Zhou Chang-Zheng Dong Yi-Feng Zang Ying Xue Xing-Guo Zhou Yu Wang Yin-Lu Ding | 2020 | World Journal of Gastroenterology2020，26，31： | 7 |
| 12 | Numerical Simulation for Crevice Corrosion of 304 Stainless Steel in Sodium Chloride Solution显示文摘The authors presented a mechanistic model describing the chemical reactions within a corroded thin, nar-row crevice. In the mathematical model, a two-dimensional steady-state was used to predict the crevice pH profile by taking into account dissolved oxygen and hydrogen ions within the crevice. It consists of six parallel electrochemical reactions: multi anodic reactions(Fe, Cr, Ni dissolution reactions) and three cathodic reactions(the oxygen reduction, the hydrogen reaction and water dissociation). Current density distribution and oxygen concentration distribution were determined to be corresponding to the evolution of potential distribution within the crevice. The contribution of each metal reaction to the overall corrosion process was in proportion to the mole fraction, and the simulation pro-vided a good agreement with published experimental results for the crevice corrosion of stainless steel in sodium chloride solution. | WANG Wei SUN Hu-yuan SUN Li-juan SONG Zu-wei ZANG Bei-ni | 2010 | Chemical Research in Chinese Universities2010，26，5： | 6 |
| 13 | Chance-constrained Coordinated Optimization for Urban Electricity and Heat Networks显示文摘Urban electricity and heat networks(UEHN)consist of the coupling and interactions between electric power systems and district heating systems,in which the geographical and functional features of integrated energy systems are demonstrated.UEHN have been expected to provide an effective way to accommodate the intermittent and unpredictable renewable energy sources,in which the application of stochastic optimization approaches to UEHN analysis is highly desired.In this paper,we propose a chance-constrained coordinated optimization approach for UEHN considering the uncertainties in electricity loads,heat loads,and photovoltaic outputs,as well as the correlations between these uncertain sources.A solution strategy,which combines the Latin Hypercube Sampling Monte Carlo Simulation(LHSMCS)approach and a heuristic algorithm,is specifically designed to deal with the proposed chance-constrained coordinated optimization.Finally,test results on an UEHN comprised of a modified IEEE 33-bus system and a 32-node district heating system at Barry Island have verified the feasibility and effectiveness of the proposed framework. | Zhinong Wei Juan Sun Zhoujun Ma Guoqiang Sun Haixiang Zang Sheng Chen Side Zhang Kwok W.Cheung | 2018 | CSEE Journal of Power and Energy Systems2018，4，4： | 6 |
| 14 | Active optical clock based on four-level quantum system显示文摘Active optical clock,a new conception of atomic clock,has been proposed recently.In this work,we propose a scheme of active optical clock based on four-level quantum system.The final accuracy and stability of two-level quantum system are limited by second-order Doppler shift of thermal atomic beam.To three-level quantum system,they are mainly limited by light shift of pumping laser field.These limitations can be avoided effectively by applying the scheme proposed here.Rubidium atom four-level quantum system,as a typical example,is discussed.The population inversion between 6S 1/2 and 5P 3/2 states can be built up at a time scale of 10-6 s.With the mechanism of active optical clock,in which the cavity mode linewidth is much wider than that of the laser gain profile,it can output a laser with quantum-limited linewidth narrower than 1 Hz in theory.An experimental configuration is designed to realize this active optical clock. | ZHANG TongGang WANG YanFei ZANG XiaoRun ZHUANG Wei CHEN JingBiao | 2013 | Chinese Science Bulletin2013，58，18： | 6 |
| 15 | Quantitatively determine the dominant driving factors of the spatial–temporal changes of vegetation NPP in the Hengduan Mountain area during 2000-2015显示文摘The Hengduan mountain area,located in the upper reaches of the Yangtze River of China,is an important ecological barrier that significantly impacts the climate and ecological environment of the surrounding region and western China as a whole.This paper introduces the gravity center model used to analyze the spatial-temporal variation patterns of vegetation Net Primary Productivity(NPP)from 2000 to 2015,which were determined by the use of MOD17 A3 NPP products.Additionally,the dominant driving factors of the spatial–temporal changes of vegetation NPP of the Hengduan Mountain area were quantitatively determined with a geographical detector over 2000-2015.The results revealed that:(1)From 2000 to 2015,there was an increasing trend of vegetation NPP in the Hengduan mountain area.Throughout the whole study region,the vegetation NPP with a mean value of 611.37 gC·m^(-2)·a^(-1) indicated a decreasing trend from southeast to northwest in terms of spatial distribution.(2)The gravity centers of vegetation NPP in 2000-2015 were mainly concentrated in Zhongdian County.During the study period,the gravity center of vegetation NPP moved northward,which indicated that the increment and increasing rate of vegetation NPP in the northern parts were greater than that of the southern areas.(3)The vegetation NPP showed a moderately positive correlation with temperature,accumulated temperature(>10℃),and sunshine,while there was an overall negative relationship between NPP and precipitation.(4)The dominant factors and interactive dominant factors changed in different subregions over different segments of the study period.The dominant factors of most sub-regions in Hengduan mountain were natural factors,and the climate change factors played an increasingly greater role over the 16 years of the study period. | CHEN Shu-ting GUO Bing ZHANG Rui ZANG Wen-qian WEI Cui-xia WU Hong-wei YANG Xiao ZHEN Xiao-yan LI Xing ZHANG Da-fu HAN Bao-min ZHANG Hai-ling | 2021 | Journal of Mountain Science2021，18，2： | 5 |
| 16 | Does Postoperative Rehabilitation for Radical Cystectomy Call for Enhanced Recovery after Surgery?A Systematic Review and Metaanalysis显示文摘The aim of this review was to systematically compare the outcomes of enhanced recovery after surgery(ERAS)with standard care(SC)after radical cystectomy.We performed a systematic search of PubMed,Ovid?Web of Science,and the Cochrane Library to identify studies published until September 2017 which involved a comparison of ERAS and SC.A meta-analysis was performed to assess the outcomes of ERAS versus SC.Sixteen studies including 8 prospective and 8 retrospective trials met the eligibility criteria.A total of 2100 participants were assigned to ERAS(1258 cases)or SC(842 cases).The time to first flatus passage[WMD=-0.95 days,95%Cl(-1.50,-0.41),P=0.0006],time until return to a regular diet[WMD=-2.15 days,95%Cl(-2.86,—1.45),P<0.00001]and the length of hospital stay[WMD=-3.75 days,95%Cl(-5.13,-2.36),P<0.00001]were significantly shorter,and the incidence of postoperative complications[OR=0.60,95%Cl(0.44,0.83),P=0.002],especially postoperative paralytic ileus[OR=0.43,95%Cl(0.30,0.62),P<0.00001]and cardiovascular complications[OR=0.28,95%Cl(0.09,0.90),P=0.03]was significantly lower in the ERAS group than those in the SC group.This meta-analysis demonstrated that ERAS was associated with a shorter time to first flatus passage,return of bowel fimction,and the length of hospital stay than SC in patients undergoing radical cystectomy,as well as a lower rate of postoperative complications,especially paralytic ileus and cardiovascular complications. | Jun XIAO Meng WANG Wei HE Jing WANG Fan YANG Xue-you MA Yu ZANG Chun-guang YANG Gan YU Zhi-hua Wang Zhang-qun YE | 2019 | Current Medical Science2019，39，1： | 5 |
| 17 | Development and experiment of rice hill-drop drilling machine for dry land based on proportional speed regulation显示文摘Rice precision hill-drop drilling technique in dry land uses fixed hill spacing to achieve orderly planting of crops and to attain good ventilating and day-lighting effects in rice fields.The technique is also beneficial in improving root growth and root structure and in increasing lodging resistance.The high-yield record of Xinjiang Production and Construction Corp’s first division for three consecutive years shows that rice precision hill-drop drilling technique in dry land is one of the important directions to developed rice cultivating mechanization technology.To further improve the quality of rice precision hill-drop drilling machine for dry land,a single profiling,electro-hydraulic proportional real-time adjustment of system was developed according to the agronomic requirements.This machine can simultaneously finish various kinds of seedbed leveling,furrowing and seeding operations,as well as soil covering and pressing.Electro-hydraulic proportional speed regulation makes an AMESim simulation test and analyzes the stability and error of hydraulic adjusting planting distance.Bench testing was carried out on the metering device by simultaneously employing high speed photography technology and analyzing the relationship of the high speed of hill distance and seed charge height.Finally,machine trial was completed.The two-year field experiments of Xinjiang Production and Construction Corp showed that when the machine operation speed is 2.8-3.2 km/h,the sowing depth percent of pass is 75%or higher,the qualified rate of row spacing is 80%or more,the pass rate of row spacing is 90%or higher,and the quantity per hill is 75%or higher.This machine met the various indicators of hill sowing quality requirements. | Fu Wei Zhang Zhiyuan Zang Ying Luo Xiwen Zeng Shan Wang Zaiman | 2017 | International Journal of Agricultural and Biological Engineering2017，10，4： | 5 |
| 18 | Metabolic characteristics and nutrient utilization in high-feedefficiency pigs selected using different feed conversion ratio models显示文摘An understanding of the nutrient utilization characteristics of pigs with different feed efficiencies(FEs) will help us to develop new strategies to reduce the costs of pig production.In this study,we selected pigs with a range of FEs according to two feed conversion ratio models: the feed intake(FI) model,where pigs had the same average daily gains(ADGs) but different FIs,and the ADG model,where pigs had the same FIs but different ADGs.High-FE pigs had a higher abundance of short chain fatty acid(SCFA)-producing bacteria(Lachnospiraceae,Clostridiaceae1,and Coriobacteriaceae) in their caecum in the FI model,and low-FE pigs had a higher abundance of two families(BacteroidalesS247group and Peptococcaceae) and two genera(Anaerotruncus and CandidatusSoleaferrea) in both models.By contrast,high-FE pigs had more goblet cells and higher m RNA expression of insulin-like growth factor 1(IGF-1) in the FI model,and higher mRNA expression of occludin but lower expressions of adenosine monophosphate-activated protein kinase(AMPK)-α2 and peroxisome proliferator-activated receptor gamma coactivator 1 alpha(PGC1α) in the ADG model.These findings suggest that the presence of SCFA-producing bacteria in the caecum and increased muscular growth may contribute to the high FE of low-FI pigs,while improved intestinal functions and decreased mitochondrial activity in the skeletal muscle are related to the high FE of high-ADG pigs. | Beibei He Tiantian Li Wei Wang Hang Gao Yu Bai Shuai Zhang Jianjun Zang Defa Li Junjun Wang | 2019 | Science China(Life Sciences)2019，62，7： | 5 |
| 19 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 20 | Prenatal Genotyping of Four Common Oculocutaneous Albinism Genes in 51 Chinese Families显示文摘Oculocutaneous albinism(OCA)is an autosomal recessive disorder characterized by hypopigmentation in eyes,hair and skin,accompanied with vision loss.Currently,six genes have been identified as causative genes for non-syndromic OCA(OCA-1w4,6,7),and ten genes for syndromic OCA(HPS-1e9,CHS-1).Genetic counseling of 51 Chinese OCA families(39 OCA-1 with mutations in the TYR gene,6 OCA-2 with mutations in the OCA2 gene,4 OCA-4 with mutations in the SLC45A2 gene,1 HPS-1(Hermanskye Pudlak syndrome-1)with mutation in the HPS1 gene,and 1 mixed OCA-1 and OCA-4)led us to perform the prenatal genetic testing of OCA using amniotic fluid cells through the implementation of our optimized strategy.In our cohort,eleven previously unidentified alleles(PUAs)(5 in TYR,2 in OCA2,and 4 in SLC45A2)were found.Three missense PUAs(p.C112R,p.H363R and p.G379V of TYR)and one in-frame deletional PUA(p.S222del of SLC24A5)led to fetuses with OCA when co-inherited with other disease causative alleles.Three PUAs(p.P152H and p.W272X of TYR,p.A486T of SLC24A5)identified in the OCA probands did not co-transmit with known pathological alleles and thus gave rise to unaffected fetuses.Four PUAs(p.Q83X and p.A658T of TYR,p.G161R and p.G366R of SLC24A5)did not transmit to the unaffected fetuses.In addition,the in vitro transfection assays showed that the p.S192Y variant of TYR produced less pigment compared to the wild-type allele.A fetus with a digenic carrier of OCA-1 and OCA-4 was unaffected.In combination with functional assays,the family inheritance pattern is useful for the evaluation of pathogenicity of PUAs and genetic counseling of OCA. | Ai-Hua Wei Dong-Jie Zang Zhao Zhang Xiu-Min Yang Wei Li | 2015 | Journal of Genetics and Genomics2015，42，6： | 5 |
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