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| 1 | A review on the eco-geography of soil fauna in China显示文摘这评论在过去的 30 年里在中国在土壤动物志 eco 地理总结主要研究调查结果。题目区域和主要结果是包括生物多样性和土壤动物志社区的 eco 地质的分发的 overviewed。在空间从的土壤动物志和动态范围的生态的分布的研究热带,对适度的区域副热带,并且在来自玷污环境的土壤动物志的森林,草地,沙漠,沼泽地,到城市的生态系统的农田,回答和指示的范畴。象火那样的集中的骚乱完成,放牧,耕作,土壤动物志上的授精包括敏感(例如线虫) 并且稀罕的组和社区索引。土壤动物志的功能包括环境建设,环境纯化,崽分解并且元素骑车被讨论。在在土壤生态系统的土壤动物志和另外的生物区系之间的相互作用并且连接在之间未葬、地下差异和在中国的土壤动物志社区上的全球变化的效果也被包括。最后,作者在土壤动物志指出了普通兴趣 eco 地理学习动物志 taxa,它包括分子生物学的申请进土壤;土壤动物志社区差异的功能和机制;在之间的相互作用未葬、地下生态系统;土壤动物志社区和功能上的骚乱,污染,生物侵略,和全球变化的效果。评论是为支持土壤动物志提供一个科学基础 eco 地理的在中国的研究。 | YIN Xiuqin SONG Bo DONG Weihua XIN Weidong WANG Yeqiao | 2010 | Journal of Geographical Sciences2010，20，3： | 93 |
| 2 | Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress显示文摘癌症房间以他们的能力著名给新陈代谢的小径换新电线在各种各样的压力条件下面支持幸存和增长。尽管在肝生产了,酉同类身体没在正常的成年的肝房间被消费。我们这里发现酉同类分解代谢或 ketolysis 在 hepatocellular 被重新激活在营养剥夺条件下面的癌(HCC ) 房间。机械学地, 3-oxoacid CoA-transferase 1 (OXCT1 ) ,其表情在正常的成年的肝纸巾被压制的限制率的 ketolytic 酶,被浆液重新导致被触发饥饿的 mTORC2-AKT-SP1 在 HCC 房间发信号。而且,我们观察到在 HCC 的那提高的 ketolysis 为 AMPK 激活的压抑是批评的并且保护 HCC 房间免受过多的 autophagy 的伤害,从而提高肿瘤生长。重要地,临床的 HCC 样品的分析表明那增加的 OXCT1 表情预言更高耐心的死亡。一起拿,我们这里揭开剥夺营养的 HCC 房间为精力由采用酉同类身体的新奇新陈代谢的改编供应和癌症前进。 | De Huang Tingting Li Lin Wang Long Zhang Ronghui Yan Kui Li Songge Xing Gongwei Wu Lan Hu Weidong Jia Sheng-Cai Lin Chi V Dang Libing Song Ping Gao Huafeng Zhang | 2016 | Cell Research2016，26，10： | 27 |
| 3 | SHRIMP zircon U-Pb dating from K-bentonite in the top of Ordovician of Wangjiawan Section,Yichang,Hubei,China显示文摘The Global boundary Stratotype Section and Point (GSSP) for the base of the Hirnantian Stage (the latest stage of the Ordovician System) is defined at a point 0.39m below the base of the Kuanyinchiao Bed in the Wangjiawan North Section, which is the upper most 'golden spike' of the Ordovician. However, this 'golden spike' is lack of reliable geochronology data. This article gives a sensitive high resolution ion microprobe (SHRIMPII) zircon U-Pb dating for a K-bentonite sample from the Kuany-inchiao Bed in the Wangjiawan North Section. The age of the K-bentonite sample is 443.2±1.6 Ma, that is to say, the isotopic age of the uppermost of Hirnantian Stage, the point of Ordovician-Silurian boundary, should be near to, but slightly younger than 443.2±1.6 Ma. This age is identical to the Ordovi-cian-Silurian boundary age 443.7±1.5 Ma as declared by International Commission on Stratigraphy (ICS). So, this research provides some good geochronlogical data for the Hirnantian Stage and the Ordovician-Silurian boundary as well as the global correlation. | HU YanHua ZHOU JiBin SONG Biao LI Wei SUN WeiDong | 2008 | Science China Earth Sciences2008，51，4： | 15 |
| 4 | Microstructure and Mechanical Properties of Al_2O_3/ZrO_2 Directionally Solidified Eutectic Ceramic Prepared by Laser 3D Printing显示文摘Directionally solidified eutectic ceramics such as(Al)_2O_3/ZrO_2 are promising structural materials for applications in harsh environment with an ultrahigh temperature. In this work, through adopting assistant heating laser 3D printing,(Al)_2O_3/ZrO_2eutectic samples were manufactured with suppressing the formation of cracks. The dependence of the average rod spacing(λav) on the scanning rate(V) follows a relation with λav V0.5= 1 μm1.5s–0.5. Typical eutectic microstructures, so-called complex regular, were analyzed with respect to its evolution with modulating the growth conditions. Formation mechanism of the solidification defect, shrinkage porosity, was discussed and the defect is found to be significantly suppressed by optimizing the solidification parameters. The maximum hardness and fracture toughness are measured to be 16.7 GPa and 4.5 MPa m1/2, respectively. The interplay between the propagation of cracks and the (Al)_2O_3/ZrO_2 interface is discussed. | Zhi Liu Kan Song Bo Gao Tian Tian Haiou Yang Xin Lin Weidong Huang | 2016 | Journal of Materials Science & Technology2016，32，4： | 12 |
| 5 | Carbon pools and fluxes in the China Seas and adjacent oceans显示文摘The China Seas include the South China Sea, East China Sea, Yellow Sea, and Bohai Sea. Located off the Northwestern Pacific margin, covering 4700000 km^2 from tropical to northern temperate zones, and including a variety of continental margins/basins and depths, the China Seas provide typical cases for carbon budget studies. The South China Sea being a deep basin and part of the Western Pacific Warm Pool is characterized by oceanic features; the East China Sea with a wide continental shelf, enormous terrestrial discharges and open margins to the West Pacific, is featured by strong cross-shelf materials transport; the Yellow Sea is featured by the confluence of cold and warm waters; and the Bohai Sea is a shallow semiclosed gulf with strong impacts of human activities. Three large rivers, the Yangtze River, Yellow River, and Pearl River, flow into the East China Sea, the Bohai Sea, and the South China Sea, respectively. The Kuroshio Current at the outer margin of the Chinese continental shelf is one of the two major western boundary currents of the world oceans and its strength and position directly affect the regional climate of China. These characteristics make the China Seas a typical case of marginal seas to study carbon storage and fluxes. This paper systematically analyzes the literature data on the carbon pools and fluxes of the Bohai Sea,Yellow Sea, East China Sea, and South China Sea, including different interfaces(land-sea, sea-air, sediment-water, and marginal sea-open ocean) and different ecosystems(mangroves, wetland, seagrass beds, macroalgae mariculture, coral reefs, euphotic zones, and water column). Among the four seas, the Bohai Sea and South China Sea are acting as CO_2 sources, releasing about0.22 and 13.86–33.60 Tg C yr^(-1) into the atmosphere, respectively, whereas the Yellow Sea and East China Sea are acting as carbon sinks, absorbing about 1.15 and 6.92–23.30 Tg C yr^(-1) of atmospheric CO_2, respectively. Overall, if only the CO_2 exchange at the sea-air interface is considered, the Chinese marginal seas appear to be a source of atmospheric CO_2, with a net release of 6.01–9.33 Tg C yr^(-1), mainly from the inputs of rivers and adjacent oceans. The riverine dissolved inorganic carbon (DIC) input into the Bohai Sea and Yellow Sea, East China Sea, and South China Sea are 5.04, 14.60, and 40.14 Tg C yr^(-1),respectively. The DIC input from adjacent oceans is as high as 144.81 Tg C yr^(-1), significantly exceeding the carbon released from the seas to the atmosphere. In terms of output, the depositional fluxes of organic carbon in the Bohai Sea, Yellow Sea, East China Sea, and South China Sea are 2.00, 3.60, 7.40, and 5.92 Tg C yr^(-1), respectively. The fluxes of organic carbon from the East China Sea and South China Sea to the adjacent oceans are 15.25–36.70 and 43.93 Tg C yr^(-1), respectively. The annual carbon storage of mangroves, wetlands, and seagrass in Chinese coastal waters is 0.36–1.75 Tg C yr^(-1), with a dissolved organic carbon(DOC) output from seagrass beds of up to 0.59 Tg C yr^(-1). Removable organic carbon flux by Chinese macroalgae mariculture account for 0.68 Tg C yr^(-1) and the associated POC depositional and DOC releasing fluxes are 0.14 and 0.82 Tg C yr^(-1), respectively. Thus, in total, the annual output of organic carbon, which is mainly DOC, in the China Seas is 81.72–104.56 Tg C yr^(-1). The DOC efflux from the East China Sea to the adjacent oceans is 15.00–35.00 Tg C yr^(-1). The DOC efflux from the South China Sea is 31.39 Tg C yr^(-1). Although the marginal China Seas seem to be a source of atmospheric CO_2 based on the CO_2 flux at the sea-air interface, the combined effects of the riverine input in the area, oceanic input, depositional export,and microbial carbon pump(DOC conversion and output) indicate that the China Seas represent an important carbon storage area. | Nianzhi JIAO Yantao LIANG Yongyu ZHANG Jihua LIU Yao ZHANG Rui ZHANG Meixun ZHAO Minhan DAI Weidong ZHAI Kunshan GAO Jinming SONG Dongliang YUAN Chao LI Guanghui LIN Xiaoping HUANG Hongqiang YAN Limin HU Zenghu ZHANG Long WANG Chunjie CAO Yawei LUO Tingwei LUO Nannan WANG Hongyue DANG Dongxiao WANG Si ZHANG | 2018 | Science China Earth Sciences2018，61，11： | 12 |
| 6 | The challenge of wide application of information and communication technologies to traditional location theory显示文摘信息和通讯技术(ICT ) 的宽申请被说服了对公司的空间转变批评。在沿着这根线的研究的最近的进展质问了传统的地点理论。然而,存在文学主要集中于 ICT 的影响在位置上的条件和工业空间分发上。在如此的变化后面的动力学被地理学者还没给了足够的注意。给这个背景,这份报纸在传统的地点理论和被新 ICT 启用的工业重定位的动力学上调查新 ICT 的影响,基于从 178 个公司的调查收集的数据。纸主张新 ICT 的申请是在信息时代的一个关键地点因素,并且时间费用对公司的空间组织正在变得批评特别地由于更短的产品生活和集体定制,在另外的动力学之中。 | SONG Zhouying | 2013 | Journal of Geographical Sciences2013，23，2： | 12 |
| 7 | Effective and persistent antitumor activity of HER2-directed CAR-T cells against gastric cancer cells in vitro and xenotransplanted tumors in vivo显示文摘 | Yanjing Song Chuan Tong Yao Wang Yunhe Gao Hanren Dai Yelei Guo Xudong Zhao Yi Wang Zizheng Wang Weidong Han Lin Chen | 2018 | Protein & Cell2018，9，10： | 11 |
| 8 | Mechanical properties and failure modes of stratified backfill under triaxial cyclic loading and unloading显示文摘Multiple filling of gobs will lead to a layered structure of the backfill.To explore the influence of layering structure on the mechanical properties and failure modes of backfill,different backfill specimens were prepared with a cement/sand ratio of 1:4,a slurry concentration of 75%,and backfilling times of 1,2,3 and 4,separately.Triaxial cyclic loading and unloading experiments were carried out.The results show that with an increase in backfilling time,the peak strength of backfill decreases as a polynomial function and the peak strain increases as an exponential function.The cyclic load enhances the linear characteristic of backfill deformation.The loading and unloading deformation moduli have a linear negative correlation with the backfilling time.The unloading deformation modulus is always slightly higher than the loading deformation modulus.The failure modes of stratified backfill are mainly characterized by conjugate shear failure at the upper layer and tensile failure across the layer plane,and there is usually no damage in the lower layer away from the loading area. | Wang Jie Song Weidong Cao Shuai Tan Yuye | 2019 | International Journal of Mining Science and Technology2019，29，5： | 11 |
| 9 | Numerical simulation of land subsidence and verification of its character for an iron mine using sublevel caving显示文摘Combined with a digital bored photography system and in-situ statistics concerning the joints and fissures of both ore-body and surrounding rock,a 2D discrete model was constructed using UDEC.The stress field and displacement field changes of different sublevel stoping systems were also studied.Changes in the overlying rock strata settlement pattern has been analyzed and validated by in-situ monitoring data.The results show that:in the caving process,there exists an obvious delay and jump for the overlying rock strata displacement over time,and a stable arch can be formed in the process of caving,which leads to hidden goafs.Disturbed by the mining activity,a stress increase occurred in both the hanging wall and the foot wall,demonstrating a hump-shaped distribution pattern.From the comparison between simulation results and in-situ monitoring results,land subsidence shows a slow-development,suddenfailure,slow-development cycle pattern,which leads eventually to a stable state.This pattern validates the existence of balanced arch and hidden goafs. | Cao Shuai Song Weidong Deng Dan Lei Yuankun Lan Jianqiang | 2016 | International Journal of Mining Science and Technology2016，26，2： | 9 |
| 10 | Spatial difference and mechanisms of influence of geo-economy in the border areas of China显示文摘Border areas are both important territorial security barriers and portals to the outside world. Considering the complicated geopolitical environment of China's inland borders, analysis of the current status and mechanisms of influence of geo-economy in border areas is of great significance. Namely, this analysis is important towards leveraging traditional advantages to accelerate China's development in border and minority areas. Based on a comprehensive analysis, our study constructed a framework to analyze the geo-economy in border areas, and also introduced three indexes: local economy, export-oriented economy and local development. In addition, our study systematically described geo-economic evolution in the border areas of China. We also analyzed the mechanism of geo-economic spatial differentiation in these border areas by using geographical detectors. Our results indicated that the level of geo-economic influence in border areas has grown steadily with significant spatial differentiation. The absolute geo-economic dominance of Northeast China gradually declines over time. Areas with geo-economic advantages are highly dispersed, showing a spatial polarization pattern with several polar nuclei including Mudanjiang city(Northeast China), Baotou city(Inner Mongolia), Bortala Mongol Autonomous Prefecture(Xinjiang), Dehong Dai and Jingpo Autonomous Prefecture and the city of Chongzuo(Yunnan-Guangxi area). Geo-economics in border area is mainly influenced by national policies, the development level of neighboring countries, as well as the desire of these countries to cooperate with China in bilateral trade. Favorable policies, traffic, cultural proximity and other factors also impact the geo-economics of border areas significantly. The Inner Mongolia and Tibet areas are mainly influenced by neighboring countries, while Northeast China and Xinjiang are mainly affected by Chinese policies; the Yunnan-Guangxi area is influenced by a combination of these factors. At the end of the study, we provide our recommendations for developing policies that further geo-economic advantages in complex geopolitical environments and in areas with varied development. | SONG Tao CHENG Yi LIU Weidong LIU Hui | 2017 | Journal of Geographical Sciences2017，27，12： | 9 |
| 11 | A study of the perforation of stiffened plates by rigid projectiles显示文摘In the present paper, a four-stage perforation model that accurately predicts the residual velocity is developed by adopting an energy method. The four stages are plug formation, dishing formation, petal formation and projectile exit. In addition, some important experimental results are presented and analyzed to validate the present perforation model. In the experiments, high speed camera system is used to record the perforation process. Observations on target damage and measurements of initial velocities and residual velocities with the aid of the system are presented. Numerical simulations are carried out for projectiles against single and layered plates adopted in the experiments. The perforation process is studied and the deformation and failure modes are obtained. The predictions of numerical simulations and analytical model are found in reasonably good agreement with those of experiments, and can be used to predict the ballistic limit and residual velocity of stiffened plates perforated by rigid projectiles. | Jianguo Ning Weidong Song Jing Wang | 2005 | Acta Mechanica Sinica2005，21，6： | 9 |
| 12 | Properties of hydrogen permeation barrier on the surface of zirconium hydride显示文摘A hydrogen permeation barrier was manufactured by the in situ reaction of zirconium hydride with oxygen. A reduction in the hydrogen permeation of the oxide films was detected by measuring the mass difference of the zirconium hydride samples after the dehydrogenation experiment. The reaction of zirconium hydride with oxygen occurs only under the condition that the temperature is higher than 673 K in the oxygen partial pressure of 0.1 MPa. The oxide film is composed of two layers, a permeable oxide layer and a dense oxide layer, and the main phase of the oxide film is ZrO2 with baddeleyite structure. The XPS analysis shows that O-H bonds exist in the oxide film, which are helpful for resisting hydrogen diffusion through the oxide film. | CHEN Weidong WANG Lijun HAN Lin CHEN Song | 2008 | Rare Metals2008，27，5： | 8 |
| 13 | Kilogram-scale synthesis of carbon quantum dots for hydrogen evolution, sensing and bioimaging显示文摘The development of large-scale synthetic methods for high quality carbon quantum dots(CQDs) is fundamental to their applications.However,the macroscopic preparation and scale up synthetic of CQDs is still in its infancy.Here,we report a facile,green,kilogram-scale synthesis of high quality fluorescent CQDs derived from poplar leaves via a one-step hydrothermal method.Notably,the throughput of CQDs can reach a level up to as high as 1.4975 kg in one pot.The structure and properties of the as-prepared CQDs were assessed through TEM,XRD,XPS and various spectroscopic methods.The obtained high quality CQD s with a photoluminescent quantum yield of 10.64% showed remarkable stability in aqueous media,rich functional groups,high photostability,consistent photoluminescence within biological pH range and low cytotoxicity.On account of these good properties,we demonstrated the multifunctional application to electrocatalytic water splitting,Fe^3+ sensing and bioimaging.It showed remarkable electrocatalytic activity,Fe^3+ sensitivity and good biocompatibility.This study provides a green,facile,inexpensive and large-scale method for producing high quality CQDs,which provides application value for large-scale production of CQDs. | Weidong Li Yuan Liu Boyang Wang Haoqiang Song Zhongyi Liu Siyu Lu Bai Yang | 2019 | Chinese Chemical Letters2019，30，12： | 7 |
| 14 | Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model显示文摘Background:Neuron-microglia communication plays a crucial role in the motor neurons(MNs)death in amyotrophic lateral sclerosis(ALS).Neurons can express chemokine(C-X3-C motif)ligand 1(CX3CL1),which mediates microglial activation via interacting with its sole receptor CX3CR1 in microglia.In the present study,we aimed to investigate the dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and MNs loss in SOD1G93A mouse model of ALS.Methods:qPCR,western blot and immunofluorescent staining were used to examine the mRNA and protein levels and localization of CX3CL1/CX3CR1 in the anterior horn region of spinal cord in both SOD1G93A mice and their agematched wild type(WT)littermates at 40,60,90 and 120 days of age.The M1/M2 microglial activation in the spinal cord tissues of SOD1G93A mice and WT mice were evaluated by immunofluorescent staining of M1/M2 markers and further confirmed by qPCR analysis of M1/M2-related cytokines.Results:The immunofluorescent staining revealed that CX3CL1 was predominately expressed in MNs,while CX3CR1 was highly expressed in microglia in the anterior horn region of spinal cord.Compared with age-matched WT mice,CX3CL1 mRNA level was elevated at 40 days but decreased at 90 and 120 days in the anterior horn region of spinal cords in ALS mice.Consistently,CX3CR1 mRNA level was increased at 90 and 120 days.Western blot assay further confirmed the dynamic changes of CX3CL1/CX3CR1 axis in ALS mice.Additionally,the levels of M1/M2 markers of microglia and their related cytokines in the anterior horn region of spinal cord in ALS mice were increased at 90 and 120 days.Moreover,while M1-related cytokines in ALS mice were persistently increased at 120 days,the upregulated M2-related cytokines started to decline at 120 days,suggesting an altered microglial activation.Conclusions:Our data revealed the dynamic changes of CX3CL1/CX3CR1 axis and an imbalanced M1/M2 microglial activation during ALS pathological progression.These findings may help identify potential molecular targets for ALS therapy. | Jingjing Zhang Yufei Liu Xinyao Liu Song Li Cheng Cheng Sheng Chen Weidong Le | 2018 | Translational Neurodegeneration2018，7，1： | 7 |
| 15 | 35 W continuous-wave Ho:YAG single-crystal fiber laser显示文摘We report on a high-power Ho:YAG single-crystal fiber(SCF)laser inband pumped by a high-brightness Tm-fiber laser at 1908 nm.The Ho:YAG SCF grown by the micro-pulling-down technique exhibits a propagation loss of 0.05±0.005 cm^-1 at 2.09μm.A continuous-wave output power of 35.2 W is achieved with a slope efficiency of 42.7%,which is to the best of our knowledge the highest power ever reported from an SCF-based laser in the 2µm spectral range. | Yongguang Zhao Li Wang Weidong Chen Jianlei Wang Qingsong Song Xiaodong Xu Ying Liu Deyuan Shen Jun Xu Xavier Mateos Pavel Loiko Zhengping Wang Xinguang Xu Uwe Griebner Valentin Petrov | 2020 | High Power Laser Science and Engineering2020，8，2： | 7 |
| 16 | Image formation of brain function in patients suffering from knee osteoarthritis treated with moxibustion显示文摘OBJECTIVES:Functional magnetic resonance imaging(fMRI) technology was used to study changes to the resting state blood flow in the brains of patients with knee osteoarthritis(KOA) before and after treatment with moxibustion at the acupoint of the left Dubi(ST 35) and to probe the cerebral mechanism underlying the effect of moxibustion.METHODS:The resting state brain function of 30 patients with left KOA was scanned with fMRI before and after treatment with moxibustion.The analytic methods of fractional amplitude of low frequency fluctuation(fALFF) and regional homogeneity(ReHo) were used to observe changes in resting state brain function.RESULTS:The fALFF values of the right cerebrum,extra-nucleus,left cerebellum,left cerebrum and white matter of patients after moxibustion treatment were higher than before treatment,and the fALFF values of the precentral gyrus,frontal lobe and occipital lobe were lower than before treatment(P<0.05,K≥85).The ReHo values of the thalamus,extra-nucleus and parietal lobe of patients were much higher than those before moxibustion treatment,and the ReHo values of the right cerebrum,left cerebrum and frontal lobe were lower than before treatment(P<0.05,K≥85).CONCLUSION:The influence of moxibustion on obvious changes in brain regions basically conforms to the way that pain and warmth is transmitted in the body,and the activation of sensitive systems in the body may be objective evidence of channel transmission.The regulation of brain function by moxibustion is not in a single brain region but rather in a network of many brain regions. | Hongwu Xie Fangming Xu Rixin Chen Tianyou Luo Mingren Chen Weidong Fang Fajin Lü Fei Wu Yune Song Jun Xiong | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 7 |
| 17 | sLe^(x) expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator显示文摘Objective: Mucin 1(MUC1/EMA) and sialyl Lewis X(sLe^(x)) indicate polarity reversal in invasive micropapillary carcinoma(IMPC). The purpose of this study was to evaluate the expression of MUC1/EMA and sLe^(x) and to assess their diagnostic and prognostic value in patients with IMPC.Methods: The expression of sLe^(x) and MUC1/EMA in 100 patients with IMPC and a control group of 89 patients with invasive ductal carcinoma not otherwise specified(IDC-NOS) were analyzed with IHC. Fresh tumor tissues were collected from patients with IMPC or IDC-NOS for primary culture and immunofluorescence analysis.Results: The rate of nodal metastasis was higher in patients with IMPC than those with IDC-NOS, and IMPC cells tended to express more sLe^(x) and MUC1/EMA in the cytomembranes(the stroma-facing surfaces of the micropapillary clusters) than IDC-NOS cells. In IMPC, high cytomembrane expression of sLe^(x), but not MUC1/EMA, indicated poor prognosis. In addition, among the 100 patients with IMPC, 10 patients had sLe^(x)+/EMA-expression patterns, and 8 patients had sLe^(x)-/EMA+ expression patterns. The primary IMPC cells were suspended, non-adherent tumor cell clusters, whereas the primary IDC cells were adherent tumor cells. Immunofluorescence analysis showed that MUC1/EMA and sLe^(x) were co-expressed on the cytomembranes in IMPC cell clusters and in the cytoplasm in IDC-NOS cells.Conclusions: sLe^(x) can be used as a prognostic indicator and can be combined with MUC1/EMA as a complementary diagnostic indicator to avoid missed IMPC diagnosis. | Yawen Song Hui Sun Kailiang Wu Jianke Lyu Jingyue Zhang Feng Gu Yongjie Ma Beibei Shen Chijuan Wang Xiaojiao Chen Jing Xu Weidong Li Fangfang Liu Li Fu | 2021 | Cancer Biology & Medicine2021，18，2： | 7 |
| 18 | Design of freeform geometries in a MEMS accelerometer with a mechanical motion preamplifier based on a genetic algorithm显示文摘This paper describes a novel,semiautomated design methodology based on a genetic algorithm(GA)using freeform geometries for microelectromechanical systems(MEMS)devices.The proposed method can design MEMS devices comprising freeform geometries and optimize such MEMS devices to provide high sensitivity,large bandwidth,and large fabrication tolerances.The proposed method does not require much computation time or memory.The use of freeform geometries allows more degrees of freedom in the design process,improving the diversity and performance of MEMS devices.A MEMS accelerometer comprising a mechanical motion amplifier is presented to demonstrate the effectiveness of the design approach.Experimental results show an improvement in the product of sensitivity and bandwidth by 100%and a sensitivity improvement by 141%compared to the case of a device designed with conventional orthogonal shapes.Furthermore,excellent immunities to fabrication tolerance and parameter mismatch are achieved. | Chen Wang Xiaoxiao Song Weidong Fang Fang Chen Ioannis Zeimpekis Yuan Wang Aojie Quan Jian Bai Huafeng Liu Gerold Schropfer Chris Welham Michael Kraft | 2020 | Microsystems & Nanoengineering2020，6，1： | 6 |
| 19 | Emerging predictors of the response to the blockade of immune checkpoints in cancer therapy显示文摘Checkpoint blockade-based immunotherapy offers new options and powerful weapons for the treatment of cancer,but its efficacy varies greatly among different types of cancer and across individual patients.Thus,the development of the right tools that can be used to identify patients who could benefit from this therapy is of utmost importance in order to maximize the therapeutic benefit,minimize risk of toxicities,and guide combination approaches.Multiple predictors have emerged that are based on checkpoint receptor ligand expression,tumor mutational burden,neoantigen and microsatellite instability,tumor-infiltrating immune cells,and peripheral blood biomarkers.In this review,we discuss the current state and progress of predictors as aids in checkpoint blockadebased immunotherapy in cancer. | Xiaolei Li Wenhui Song Changshun Shao Yufang Shi Weidong Han | 2019 | Cellular & Molecular Immunology2019，16，1： | 5 |
| 20 | Biomarker Discovery in Parkinson's Disease:Present Challenges and Future Opportunities显示文摘Parkinson's disease(PD)is the second most common neurodegenerative disorder affecting more than 1%of the older population.Histopathologically,PD is characterized by a severe loss of dopaminergic neurons in the substantia nigra and cytoplasmic inclusions composed of insoluble protein aggregates(Lewy bodies),which lead to a progressive movement disorder including the classic triad of tremor,bradykinesia,and rigidity. | Song Li Weidong Le | 2017 | Neuroscience Bulletin2017，33，5： | 5 |
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