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| 1 | COVID-19 Super Spreading Event Amongst Elderly Individuals—Jilin Province,China,January 2021显示文摘Summary What is already known on this topic?Clusters of COVID-19 cases often happened in small settings(e.g.,families,offices,school,or workplaces)that facilitate person-to-person virus transmission,especially from a common exposure.What is added by this report?On January 10 and 11,2021,an individual gave three product promotional lectures in Tonghua City. | Laishun Yao Mingyu Luo Tiewu Jia Xingang Zhang Zhulin Hou Feng Gao Xin Wang Xiaogang Wu Weihua Cheng Guoqian Li Jing Lu Bing Zhao Tao Li Enfu Chen Dapeng Yin Biao Huang | 2021 | China CDC weekly2021，3，10： | 13 |
| 2 | Experimental comparison between aircraft fuel tank inerting processes using NEA and MIG显示文摘Fuel tank inerting technologies are able to reduce the fire risk by injection of inert gas into the ullage or fuel, the former called ullage washing and the latter fuel scrubbing. The Green On-Board Inert Gas Generation System(GOBIGGS) is a novel technology based on flameless catalytic combustion, and owning to its simple structure and high inerting efficiency, it has received a lot of attentions. The inert gas in the GOBIGGS is mainly comprised of CO_2, N_2, and O_2(hereinafter, Mixed Inert Gas(MIG)), while that in the On-Board Inert Gas Generation System(OBIGGS), which is one of the most widely used fuel tank inerting technologies, is NitrogenEnriched Air(NEA). The solubility of CO_2 is nearly 20 times higher than that of N_2 in jet fuels,so the inerting capability and performance are definitely disparate if the inert gas is selected as NEA or MIG. An inerting test bench was constructed to compare the inerting capabilities between NEA and MIG. Experimental results reveal that, if ullage washing is adopted, the variations of oxygen concentrations on the ullage and in the fuel are nearly identical no matter the inert gas is NEA or MIG. However, the ullage and dissolved oxygen concentrations of MIG scrubbing are always higher than those of NEA scrubbing. | Lei SHAO Weihua LIU Chaoyue LI Shiyu FENG Chenchen WANG Jun PAN | 2018 | Chinese Journal of Aeronautics2018，31，7： | 11 |
| 3 | Measurement of mass diffusion coefficients of O_2 in aviation fuel through digital holographic interferometry显示文摘The experimental apparatus to measure the mass diffusion coefficients of O2 in aviation fuel was constructed based on the digital holographic interferometry method. The theory of mass diffusion coefficient and interference image processing were introduced in detail. The accuracy of the experiment was verified by measuring the mass diffusion coefficient of 0.33 mol/L KCl in aqueous solution at 298.15 K. The mass diffusion coefficients of O_2 in RP3 and RP5 aviation fuels were measured at temperature from 278.15 K to 333.15 K, and the Arrhenius equation was employed to fit the experimental data. In terms of the Stokes-Einstein equation, the viscosities of these two aviation fuels were tested to estimate the correlation among mass diffusion coefficient, viscosity and temperature. A uniform polynomial calculation correlation was proposed to predict the mass diffusion coefficients of O_2 in both RP3 and RP5 aviation fuels, and its accuracy is considerably higher than that of the Stokes-Einstein equation. | Chaoyue LI Weihua LIU Xiaotian PENG Lei SHAO Shiyu FENG | 2019 | Chinese Journal of Aeronautics2019，32，5： | 7 |
| 4 | A Sequential Converted Measurement Kalman Filter with Doppler Measurements in ECEF Coordinate System显示文摘When there is the correlation between Doppler and slant range, previous literatures have presented some sequential filter algorithms. However, they are only applied to simplified fixed radar' s local coordinate system. As a result, a Sequential converted measurement Kalman filter(SCMKF) with Doppler measurements based on the Earth centered earth fixed(ECEF) coordinate system applicable to a moving airborne platform which has time varying attitude is proposed. Firstly, the correlated Doppler and range are decorrelated using the Cholesky factorization, then the converted position measurements are obtained by a series of coordinate transformation with unchanged range component and other observations, such as azimuth and elevation angles; the corresponding error covariances are derived which are used to the Converted measurement Kalman filter(CMKF).Finally the sequential filter is implemented for changed pseudo-Doppler measurements. The proposed method is validated through Monte Carlo test compared with the performance of CMKF with just converted position measurements and traditional SCMKF with Doppler which ignores the correlation between Doppler and range noises,and the conclusion is obtained that utilizing Doppler information correctly can improve tracking performance, nevertheless, the improvement gain of filter accuracy is limited,which can provide some references for engineering application. | WU Weihua JIANG Jing FENG Xun QIN Xing | 2016 | Chinese Journal of Electronics2016，25，1： | 6 |
| 5 | Enabling an intrinsically safe and high-energy-density 4.5 V-class Li-ion battery with nonflammable electrolyte显示文摘Developing nonflammable electrolyte with a wide electrochemical window has become an urgent demand for high-energy-density and high-safe lithium-ion batteries(LIBs).Herein,a fluorinated nonflammable phosphate electrolyte is developed to construct a safe 4.5 V-class LIB(Si-SiC-C/0.35Li2MnO3-0.65LiNi0.5Mn0.5O2).The proposed fluorinated phosphate electrolyte,0.8 M LiPF6/tris(2,2,2-trifluoroethyl)phosphate(TFEP)+5 vol%fluoroethylene carbonate(FEC)+5 vol%vinylene carbonate(VC),is not only completely nonflammable but also exhibits excellent oxidative/reductive stability on 0.35Li2MnO30.65LiNi0.5Mn0.5O2 cathode and Si-SiC-C anode.The in situ differential electrochemical mass spectrometry and X-ray photoelectron spectroscopy proved that TFEP-based electrolyte does not decompose into gases but forms a high-quality electrode-electrolyte interface on cathode surface at high working potential.The 4.5 V-class LIBs using 0.8 M LiPF6 TFEP-based nonflammable electrolyte shed some light on potential application for high-safe and low-cost larger-scale energy storage. | Ziqi Zeng Xingwei Liu Xiaoyu Jiang Zhenjie Liu Zhangquan Peng Xiangming Feng Weihua Chen Dingguo Xia Xinping Ai Hanxi Yang Yuliang Cao | 2020 | InfoMat2020，2，5： | 6 |
| 6 | Effect of a modified Banxia Xiexin decoction plus chemotherapy on stage Ⅲ colon cancer显示文摘OBJECTIVE: To investigate the effect of a modified Banxia Xiexin decoction(MBXD) plus chemotherapy on postoperative adverse reaction in patients with stage Ⅲ colon cancer in patients whose symptoms were identified as cold-heat complicated pattern in terms of the theory of Traditional Chinese Medicine(TCM).METHODS: A prospective non-randomized control study of patients with stage Ⅲ colon cancer in Beijing Shijitan Hospital and Guang'anmen Hospital between January 2012 and December 2013. A total of 80 patients were divided into experimental group(MBXD + chemotherapy) and control group(chemotherapy). The adverse reactions, life quality and disease-free survival(DFS) were compared between the two groups.RESULTS: The cold-heat complex pattern was released in 94.3% of patients in experimental group whereas 62.2% in control group(P < 0.05). Life quality was improved in 24 vs 14 cases, stabilized in 9 vs14 cases whereas decreased in 2 vs 15 cases in experimental group and control group, respectively(P < 0.05). The average DFS was 22.371 months in experimental group, while 13.932 months in control group(P < 0.05).CONCLUSION: MBXD combined with chemotherapy may significantly relieve clinical symptoms, reduce chemotherapy associated adverse effects, improve life quality, and prolong DFS of patients with stage Ⅲ colon cancer(cold-heat complicated pattern). | Li Kai Liu Rui Xu Guangzhong Zhang Weihua Liu Chen Zhu Bin Hua Baojin Feng Xingzhong | 2019 | Journal of Traditional Chinese Medicine2019，39，2： | 6 |
| 7 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 8 | Immobilizing VN ultrafine nanocrystals on N-doped carbon nanosheets enable multiple effects for high-rate lithium-sulfur batteries显示文摘The exploitation of new sulfiphilic and catalytic materials is considered as the promising strategy to overcome severe shuttle effect and sluggish kinetics conversion of lithium polysulfides within lithium-sulfur batteries.Herein,we design and fabricate monodisperse VN ultrafine nanocrystals immobilized on nitrogen-doped carbon hybrid nanosheets(VN@NCSs)via an one-step in-situ selftemplate and self-reduction strategy,which simultaneously promotes the interaction with polysulfides and the kinetics of the sulfur conversion reactions demonstrated by experimental and theoretical results.By virtue of the multifunctional structural features of VN@NCSs,the cell with ultrathin VN@NCSs(only 5 pm thickness)modified separator indicates improved electrochemical performances with long cycling stability over 1,000 cycles at 2 C with only 0.041%capacity decay per cycle and excellent rate capability(787.6 mAh g^(-1) at 10 C).Importantly,it delivers an areal reversible capacity of 3.71 mAh cm^(-2) accompanied by robust cycling life. | Ning Song Baojuan Xi Peng Wang Xiaojian Ma Weihua Chen Jinkui Feng Shenglin Xiong | 2022 | Nano Research2022，15，2： | 4 |
| 9 | Preparation of an anti-diethylstilbestrol monoclonal antibody and development of an indirect competitive ELISA to detect diethylstilbestrol in biological samples显示文摘Based on the preparation of an anti-diethylstilbestrol(DES) monoclonal antibody,a simple and convenient indirect competitive enzyme-linked immunosorbent assay(ELISA) method for DES detection has been developed.The monoclonal antibody demonstrated high sensitivity to DES with an IC50 value of 275 pg mL-1 and detection limit(LOD) of 90 pg mL-1.The specificity of the assay was studied by measuring cross-reactivity of the antibody with structurally related compounds of ethinyl estradiol(<7%),estrone(<0.1%),estriol(<0.1%),and diethylstilbestrol benzoate(<0.1%).Chicken,fish,shrimp,urine and bile spiked with different concentration of DES were detected by the developed method,and the recovery rates were greater than 79.5%.Intra-and inter-assay variations were about 6%.This method exhibited high stability with a coefficient of variation less than 10% in buffer and in real samples.The LODs in fish/shrimp,liver,feed and urine spiked with DES were 600,600,4800 and 600 pg mL-1,respectively.These results confirmed that the antibody to DES was successfully produced and could be used to establish ELISA methods for DES detection in food producing animals. | LI WeiHua MENG Meng HE FangYang WAN YuPing XUE HuYin LIU Wei YIN WeiWei XU Jing FENG CaiWei WANG ShanLiang LU Xiao LIU JinTing XI RiMo | 2011 | Chinese Science Bulletin2011，56，8： | 4 |
| 10 | Synthesis of carbon nanotubes-supported porous silicon microparticles in low-temperature molten salt for highperformance Li-ion battery anodes显示文摘Silicon-based materials has attracted attention as a promising candidate for lithium-ion batteries(LIBs)with high energy density.However,severe volume variation,pulverization,and poor conductivity hindered the development of Si based materials.In this study,porous Si microparticles supported by carbon nanotubes(p-Si/CNT)are fabricated through simple molten salt assisted dealloying process at low temperature followed by acid treatment.The ZnCl2 molten salt not only provides the liquid environment to enhance the reaction,but also participates the dealloying process and works as template for porous structure when removes by acid treatment.Additionally,distribution of defect sites in CNTs also increases after molten salt process.Density function theory(DFT)calculations further prove the defects could improve the adsorption of Li+.The participation of CNTs can also contribute to the reaction kinetics and retain the integrity of the electrode.As expected,the p-Si/CNT anode manifests enhanced lithium-storage performance in terms of superior cycling stability and good rate capability.The p-Si/CNT//LiCoO_(2) full cell assembly further demonstrates its potential as a prospective anode for high-performance LIBs. | Qianliang Zhang Baojuan Xi Weihua Chen Jinkui Feng Yitai Qian Shenglin Xiong | 2022 | Nano Research2022，15，7： | 4 |
| 11 | Competition for electrons between reductive dechlorination and denitrification显示文摘 | Lifeng Cao Weihua Sun Yuting Zhang Shimin Feng Jinyun Dong Yongming Zhang Bruce E. Rittmann | 2017 | Frontiers of Environmental Science & Engineering2017，11，6： | 3 |
| 12 | Hetero-nanostructure of silver nanoparticles on MO_x(M=Mo,Ti and Si) and their applications显示文摘This paper reviews the recent research progress in the hetero-nanostructure of silver nanoparticles on MOx (M=Mo, Ti and Si). It describes the general synthesis of hetero-nanostructure of silver nanoparticles on MOx, and then outlines the interesting catalytic and sensing properties found in these hetero-nanostructures of silver nanoparticles on MOx. | DONG WenJun ZHAO HaiXin LI ChaoRong MEI Jie CHEN BeYong TANG WeiHua SHI Zhan FENG ShouHua | 2011 | Science China Chemistry2011，54，6： | 3 |
| 13 | Facile synthesis of hierarchical Na2Fe(SO4)2@rGO/C as high-voltage cathode for energy density-enhanced sodium-ion batteries显示文摘Fe-based sulfates are ideal cathode candidates for sodium-ion batteries(SIBs) owing to their high operating voltage and low cost but suffer from the nature of poor power performance. Herein, a hierarchical porous Na2Fe(SO4)2@reduced graphene oxide/carbon dot(Na2Fe(SO4)2@rGO/C) with low carbon content(4.12 wt%) was synthesized via a facile homogeneous strategy benefiting for engineering application,which delivers excellent sodium storage performance(high voltage plateau of 3.75 V, 85 m Ah g-1 and330 Wh kg-1 at 0.05 C;5805 W kg-1 at 10 C) and high Na+diffusion coefficient(1.19 × 10-12 cm2 s-1).Moreover, the midpoint voltage of assembled full cell could reach 3.0 V. The electron transfer and reaction kinetics are effectively boosted since the nanoscale Na2Fe(SO4)2 is supported by a robust crosslinked carbon matrix with rGO sheets and carbon dots. The slight rGO sheets sufficiently enhance the electron transfer like a current collecter and restrain the aggregation, as well as ensure smooth ion channels. Meanwhile, the carbon dots in the whole space connect with Na2Fe(SO4)2 and help rGO to promote the conductivity of the electrode. Ex-situ X-ray powder diffraction and X-ray photoelectron spectrometry analysis confirm the high reversibility of this sodiation/desodiation process. | Ge Yao Xixue Zhang Yongliang Yan Jiyu Zhang Keming Song Juan Shi Liwei Mi Jinyun Zheng Xiangming Feng Weihua Chen | 2020 | Journal of Energy Chemistry2020，29，11： | 3 |
| 14 | Oxygen concentration variation in ullage influenced by dissolved oxygen evolution显示文摘To determine the oxygen concentration variation in ullage that results from dissolved oxygen evolution in an inert aircraft fuel tank,the CFD method with a mass transfer source is applied in the present study.An experimental system is also designed to evaluate the accuracy of the CFD simulations.The dissolved oxygen evolution is simulated under different conditions of fuel load and initial oxygen concentration in ullage of an inert fuel tank with stimulations of heating and pressure decrease.The increase in the oxygen concentration in ullage ranges from 0.82%to 5.92%upon stimulation of heating and from 0.735%to 12.36%upon stimulation of a pressure decrease for an inert ullage in the simulations.The heating accelerates the release of the dissolved oxygen from the fuel by increasing the mass transfer rate in the mass transfer source and decreasing the pressure,thereby accelerating the dissolved oxygen evolution by increasing the concentration difference between the gas and the fuel.The time constant that represents the oxygen evolution rate is independent of the initial oxygen concentration in ullage of an inert tank but depends closely on the fuel load,temperature and pressure.The time constant can be fitted using a polynomial equation relating the fuel load to temperature in the heating stimulation with an accuracy of 4.77%.Upon stimulation of a pressure decrease,the time constant can be expressed in terms of the fuel load and the pressure,with an accuracy of 5.02%. | Shiyu FENG Chaoyue LI Xiaotian PENG Tao WEN Yan YAN Rongjie JIANG Weihua LIU | 2020 | Chinese Journal of Aeronautics2020，33，7： | 3 |
| 15 | Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation显示文摘Accumulating evidence suggests that a reduction in the number of Foxp3^(+) regulatory T cells(Tregs)contributes to the pathogenesis of acute graft-versus-host disease(aGVHD),which is a major adverse complication that can occur after allogeneic hematopoietic stem cell transplantation(allo-HSCT).However,the precise features and mechanism underlying the defects in Tregs remain largely unknown.In this study,we demonstrated that Tregs were more dramatically decreased in bone marrow compared with those in peripheral blood from aGVHD patients and that bone marrow Treg defects were negatively associated with hematopoietic reconstitution.Tregs from aGVHD patients exhibited multiple defects,including the instability of Foxp3 expression,especially in response to IL-12,impaired suppressor function,decreased migratory capacity,and increased apoptosis.Transcriptional profiling revealed the downregulation of Lkb1,a previously identified critical regulator of murine Treg identity and metabolism,and murine Lkb1-regulated genes in Tregs from aGVHD patients.Foxp3 expression in human Tregs could be decreased and increased by the knockdown and overexpression of the Lkb1 gene,respectively.Furthermore,a loss-of-function assay in an aGVHD murine model confirmed that Lkb1 deficiency could impair Tregs and aggravate disease severity.These findings reveal that Lkb1 downregulation contributes to multiple defects in Tregs in human aGVHD and highlight the Lkb1-related pathways that could serve as therapeutic targets that may potentially be manipulated to mitigate aGVHD. | Xiuhua Su Qianqian Wang Wei Guo Xiaolei Pei Qing Niu Maolan Liu Yuanyuan Liu Song Chen Sizhou Feng Yi He Donglin Yang Rongli Zhang Qiaoling Ma Weihua Zhai Aiming Pang Jialin Wei Yong Huang Yuechen Luo Mingzhe Han Xiaoming Feng Erlie Jiang | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 16 | Significance of E-cadherin, β-catenin, and vimentin expression as postoperative prognosis indicators in cervical squamous cell carcinoma显示文摘 | Yong Cheng Ying Zhou Wenjing Jiang Xia Yang Jing Zhu Dingqing Feng Ying Wei Min Li Fengqiu Yao Weiping Hu Weihua Xiao Bin Ling | 2012 | Human Pathology2012，，8： | 3 |
| 17 | Carbon coated ultrasmall anatase TiO_2 nanocrystal anchored on N,S-RGO as high-performance anode for sodium ion batteries显示文摘Anatase TiO_2 has been investigated as one of the most promising anode materials for sodium ion batteries(SIBs)with low cost and high theoretical capacity.Herein,a composite material of TiO_2 /N,S-RGO@C with carbon coated ultrasmall anatase TiO_2 anchored on nitrogen and sulfur co-doped RGO matrix was successfully prepared by a rational designed process.The composite structure exhibited ultrasmall crystal size,rich porous structure,homogeneous heteroatoms doping and thin carbon coating,which synergistically resulted in elevated electron and ion transfer.The anode exhibited high rate capacities with good reversibility under high rate cycling.The carbon coating was investigated to be effective to prevent active material falling and lead to long term cycling performance with a high capacity retention of 181 m Ah g^(à1)after 2000cycles at 2 C.Kinetic studies were carried out and the results revealed that the superior performance of the composite material were derived from the decreased charge transfer resistance and elevated ion diffusion.Results suggested that the TiO_2 /N,S-RGO@C composite is a promising anode material for sodium ion batteries. | Lingfei Zhao Tong Tang Weihua Chen Xiangming Feng Liwei Mi | 2018 | Green Energy & Environment2018，3，3： | 2 |
| 18 | MECHANISM RESEARCH FOR 3D NON-AXISYMMETRIC THIN-WALL TUBE OFFSET SPINNING显示文摘偏移量与常规对称的旋转旋转的差别被分析。A 3D 为偏移量试管的女性的模型旋转颈被建立,旋转进程借助于 ANSYS 被模仿软件。在模拟的动态边界和接触问题被解决。接触区域,在典型的节的节点的短暂种类分发和细工品的种类分发的短暂压力分发最后被达到,快克的地方和膜使用被分析。与偏移量旋转的时间拉紧变化曲线,卡住的 conventionals 被比较。它显示出偏移量旋转并且 conventionals 卡住之间的机制差别。另外,模拟结果显示出怎么拉紧典型的节的分发,一些典型节点的厚度,在三台压路机的左节和力量的轴的扩展随着时间变化。根据变化曲线的学习,沿着光线、正切、轴的方向的材料流动法律被达到,完整的旋转过程被学习。模拟结果无夫的帽子偏移量距离是钥匙生产偏移量有旋转的非对称的试管,和过程 parameters'change 角度。实验数据确实反映不同进程参数的影响在上常规对称并且偏移量旋转力量。实验与模拟一致很好。 | KUANG Weihua XIA Qinxiang RUAN Feng | 2006 | Chinese Journal of Mechanical Engineering2006，19，2： | 2 |
| 19 | Elevated expression level of long noncoding RNA MALAT-1 facilitatescell growth, migration and invasion in pancreatic cancer显示文摘 | Feng Jiao Hai Hu Cuncun Yuan Lei Wang Weihua Jiang Ziliang Jin Zhen Guo Liwei Wang | 2014 | Oncology Reports2014，，6： | 2 |
| 20 | Nonfunctional alleles of long-day suppressor genes independently regulate flowering time显示文摘Due to the remarkable adaptability to various environments, rice varieties with diverse flowering times have abeen domesticated or improved from Oryza rufipogon.Detailed knowledge of the genetic factors controlling flowering time will facilitate understanding the adaptation mechanism in cultivated rice and enable breeders to design appropriate genotypes for distinct preferences. In this study,four genes(Hd1, DTH8, Ghd7 and OsPRR37) in a rice long-day suppression pathway were collected and sequenced in 154, 74,69 and 62 varieties of cultivated rice(Oryza sativa)respectively. Under long-day conditions, varieties with nonfunctional alleles flowered significantly earlier than those with functional alleles. However, the four genes have different genetic effects in the regulation of flowering time: Hd1 and Os PRR37 are major genes that generally regulate rice flowering time for all varieties, while DTH8 and Ghd7 only regulate regional rice varieties. Geographic analysis and network studies suggested that the nonfunctional alleles of these suppression loci with regional adaptability were derived recently and independently. Alleles with regional adaptability should be taken into consideration for genetic improvement. The rich genetic variations in these four genes,which adapt rice to different environments, provide the flexibility needed for breeding rice varieties with diverse flowering times. | Xiao-Ming Zheng Li Feng Junrui Wang Weihua Qiao Lifang Zhang Yunlian Cheng Qingwen Yang | 2016 | Journal of Integrative Plant Biology2016，58，6： | 2 |
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