|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 2 | Combined treatment with erythropoietin and granulocyte colony-stimulating factor enhances neovascularization and improves cardiac function after myocardial infarction显示文摘 | Xue Jingyi Du Guoqing Shi Jing Li Yue Masahiro Yasutake Liu Lei Li Jianqiang Kong Yihui Wang Shuxian Yun Fengxiang Li Weimin | 2014 | Chinese Medical Journal2014，，9： | 12 |
| 3 | Newborn screening with targeted sequencing:a multicenter investigation and a pilot clinical study in China显示文摘Different newborn screening(NBS) programs have been practiced in many countries since the 1960 s. It is of considerable interest whether next-generation sequencing is applicable in NBS. We have developed a panel of 465 causative genes for 596 early-onset, relatively high incidence, and potentially actionable severe inherited diseases in our Newborn Screening with Targeted Sequencing(NESTS) program to screen 11,484 babies in 8 Women and Children’s hospitals nationwide in China retrospectively. The positive rate from preliminary screening of NESTS was 7.85%(902/11,484). With 45.89%(414/902) follow-up of preliminary positive cases, the overall clinically confirmative diagnosis rate of monogenic disorders was 12.07%(50/414), estimating an average of 0.95%(7.85% × 12.07%) clinical diagnosis rate, suggesting that monogenic disorders account for a considerable proportion of birth defects. The disease/gene spectrum varied in different regions of China. NESTS was implemented in a hospital by screening 3923 newborns to evaluate its clinical application. The turn-around time of a primary report, including the sequencing period of < 7 days, was within 11 days by our automatic interpretation pipeline. Our results suggest that NESTS is feasible and cost-effective as a first-tier NBS program, which will change the status of current clinical practice of NBS in China. | Chanjuan Hao Ruolan Guo Xuyun Hu Zhan Qi Qi Guo Xuanshi Liu Yuanhu Liu Yanhua Sun Xiaofen Zhang Feng Jin Xiujie Wu Ren Cai Dingyuan Zeng Xijiang Hu Xiaohua Wang Xiaoping Ji Wenjie Li Quansheng Xing Lanfang Mu Xiulian Jiang Xue Yang Weimin Yang Yan Zhang Qianli Yin Xin Ni Wei Li | 2022 | Journal of Genetics and Genomics2022，49，1： | 7 |
| 4 | Stability analysis and optimization of excavation method of double-arch tunnel with an extra-large span based on numerical investigation显示文摘The Xiamen Haicang double-arch tunnel has a maximum span of 45.73 m and a minimum burial depth of 5.8 m.A larger deformation or collapse of the tunnel is readily encountered during tunnel excavation.It is therefore necessary to select a construction approach that is suitable for double-arch tunnel projects with an extra-large span.In this study,three construction methods for double-arch tunnels with extra-large spans were numerically simulated.Subsequently,the deformation behavior and stress characteristics of the surrounding rock were obtained and compared.The results showed that the double-side-drift method with temporary vertical support achieves better adaptability in the construction of such tunnels,which can be observed from both the numerical results and in situ monitoring data.In addition,the improved temporary support plays a critical role in controlling the surrounding rock deformation.In addition,the disturbance resulting from the excavation of adjacent drifts was obvious,particularly the disturbance of the surrounding rock caused by the excavation of the middle drift.The present findings can serve as the initial guidelines for the construction of ultra-shallowly buried double-arch tunnels with extra-large spans. | Yiguo XUE Huimin GONG Fanmeng KONG Weimin YANG Daohong QIU Binghua ZHOU | 2021 | Frontiers of Structural and Civil Engineering2021，15，1： | 4 |
| 5 | A new method for simulating human emotions显示文摘How to make machines express emotions would be instrumental in establishing a completely new paradigm for man ma-chine interaction. A new method for simulating and assessing artificial psychology has been developed for the research of the emo-tion robot. The human psychology activity is regarded as a Markov process. An emotion space and psychology model is constructedbased on Markov process. The conception of emotion entropy is presented to assess the artificial emotion complexity. The simulatingresults play up to human psychology activity. This model can also be applied to consumer-friendly human-computer interfaces, andinteractive video etc. | Weimin Xue, Zhiliang Wang, Wenhong Xia, and Wenbo MengInformation Engineering School, University of Science and Technology Beijing, Beijing 100083, China | 2003 | Journal of University of Science and Technology Beijing2003，10，2： | 4 |
| 6 | Updating preconditioner for iterative method in time domain simulation of power systems显示文摘The numerical solution of the differential-algebraic equations(DAEs) involved in time domain simulation(TDS) of power systems requires the solution of a sequence of large scale and sparse linear systems.The use of iterative methods such as the Krylov subspace method is imperative for the solution of these large and sparse linear systems.The motivation of the present work is to develop a new algorithm to efficiently precondition the whole sequence of linear systems involved in TDS.As an improvement of dishonest preconditioner(DP) strategy,updating preconditioner strategy(UP) is introduced to the field of TDS for the first time.The idea of updating preconditioner strategy is based on the fact that the matrices in sequence of the linearized systems are continuous and there is only a slight difference between two consecutive matrices.In order to make the linear system sequence in TDS suitable for UP strategy,a matrix transformation is applied to form a new linear sequence with a good shape for preconditioner updating.The algorithm proposed in this paper has been tested with 4 cases from real-life power systems in China.Results show that the proposed UP algorithm efficiently preconditions the sequence of linear systems and reduces 9%-61% the iteration count of the GMRES when compared with the DP method in all test cases.Numerical experiments also show the effectiveness of UP when combined with simple preconditioner reconstruction strategies. | WANG Ke XUE Wei LIN HaiXiang XU ShiMing ZHENG WeiMin | 2011 | Science China(Technological Sciences)2011，54，4： | 3 |
| 7 | Proteomic analysis of blast-resistant near-isogenic lines derived from japonica rice, var. Yunyin, infected with Magnaporthe oryzae显示文摘Rice blast is one of the most devastating diseases in the world and outbreaks occur frequently.The differences in protein expression between blast resistant and susceptible near-isogenic lines(NILs)of japonica rice var.Yunyin infected with Magnaporthe oryzae were analyzed using proteomics,indicated that 67 different proteins were identified from 75 obtained proteins using the matrixassisted laser desorption/ionization time-of-flight mass spectrometry technique.Seven specific expression proteins,43 up-regulated proteins and 17 down-regulated proteins were identified among the 67 proteins.The bioinformatical analysis demonstrated that these 67 different proteins were involved in many biological physiological processes including five proteins related to photosynthesis,25 proteins related to metabolism,six proteins related to antioxidants,10 proteins related to protein synthesis and modification,five proteins related to signal transduction,four proteins related to adversity stress and 12 non-functional proteins.These identified proteins were directly or indirectly related to stress.Five proteins related to different physiological processes were selected.Their cDNA sequences were predicted and their expression patterns were analyzed using real-time PCR,demonstrated that the genes would response to M.oryzae and the response blindingly different between blast resistant and blast susceptible NILs. | Weimin Xue Xiaohui Mao Yidong Wei Lian Ling Yongsheng Zhu Shuilin He Jianfu Zhang Huaan Xie | 2014 | Chinese Science Bulletin2014，59，32： | 2 |
| 8 | The Tribochemical Study of Some N-Containing Heterocyclic Compounds as Lubricating Oil Additives显示文摘 | Zhongyi He Wenqi Rao Tianhui Ren Weimin Liu Qunji Xue | 2002 | Tribology Letters2002，，2： | 1 |
| 9 | Early detec- tion of spontaneous combustion of coal in underground coal mines with development of an ethylene enriching sys- tem显示文摘 | Jun Xie Sheng Xue Weimin Cheng | 2011 | International Journal of Coal Geology2011，85，1： | 1 |
| 10 | The friction and wear characteristics of nanometer SiC and polytetra-fluoroethylene filled polyetheretherketone显示文摘 | Xue Qunji Liu Weimin | 2000 | Wear2000，243，： | 1 |
| 11 | Regular algebraic curve seg- ments (I) : definitions and characteristics显示文摘 | Xu Guoliang Bajaj C L Xue Weimin | 2000 | Computer Aided Geo- metric Design2000，17，： | 1 |
| 12 | The effect of molecular structure of heterocyclic compounds containing N, O and S on their tribological performance显示文摘 | Junyan Zhang Weimin Liu Qunji Xue | 1999 | Wear1999，，1： | 1 |
| 13 | Friction and wear properties of a surface-modified nanoparticle as an addi- tive in liquid paraffin显示文摘 | Xue Qunji Liu Weimin Zhang Zhijun | 1997 | Wear1997，213，： | 1 |
| 14 | Hopfian and co-Hopfian modules显示文摘 | Xue Weimin | | 0，，： | 1 |
| 15 | Friction and wear properties of Surface-modified namoparticle as an additive in liquid paraffin显示文摘 | Xue Qunji Liu Weimin Zhang Zhijun | 1997 | Wear1997，213，1： | 1 |
| 16 | An analytic relation for the thickness of accretion flows显示文摘We take the vertical distribution of the radial and azimuthal velocities into account in spherical coordinates,and find that the analytic relation cs0/υKΘ = [(γ-1)/2γ]1/2 is valid for both geometrically thin and thick accretion flows,where cs0 is the sound speed on the equatorial plane,υK is the Keplerian velocity,Θ is the half-opening angle of the flow,and γ is the adiabatic index. | CAI ZhenYi,GU WeiMin,XUE Li & LU JuFu Department of Physics and Institute of Theoretical Physics and Astrophysics,Xiamen University,Xiamen 361005,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，S1： | 1 |
| 17 | Facial expression recognition based on Gabor filter and SVM显示文摘 | Xue Weimin | 2006 | Chinese Journal of Electronics2006，15，4： | 1 |
| 18 | Tribochemieal investigation of tungsten carbidertitanium alloy tribo-couples under aqueous |ubricationj 显示文摘 | La Peiqing Xue Qunji Liu Weimin | 2001 | Wear2001，249，： | 1 |
| 19 | Constructing a large-scale Chinese-English parallel corpus 显示文摘 | Le Sun Song Xue Weimin Qu Xiaofeng Wang Yufang Sun | 2002 | Coiling-2002: Third Workshop on Asian Language resources and International Standarization2002，31，： | 1 |
| 20 | Action of transfer film in improving friction and wear behaviors of iron- and copper-filled poly (ether ether ketone) composites 显示文摘 | Yu Laigui Yang Shengrong Liu Weimin Xue Qunji Bahadur S | 2000 | Journal of Applied Polymer Science2000，76，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员