|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘 | Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou | 2015 | Cell Research2015，25，2： | 39 |
| 2 | LncRNA-HOTAIR inhibition aggravates oxidative stress-induced H9c2 cells injury through suppression of MMP2 by miR-125显示文摘 | Linlin Li Mengna Zhang Weizhen Chen Ruirui Wang Zi Ye Yanyan Wang Xiao Li Cheguo Cai | 2018 | Acta Biochimica et Biophysica Sinica2018，50，10： | 20 |
| 3 | Psychological impact of the COVID-19 pandemic on healthcare workers:a cross-sectional study in China显示文摘Background Healthcare workers fighting against the coronavirus disease 2019(COVID-19)pandemic are under tremendous pressure,which puts them at an increased risk of developing psychological problems.Aims This study aimed to investigate the prevalence of psychological problems in different healthcare workers(ie,physicians,medical residents,nurses,technicians and public health professionals)during the COVID-19 pandemic in China and explore factors that are associated with the onset of psychological problems in this population during this public health crisis.Methods A cross-sectional,web-based survey was conducted in February 2020 among healthcare workers during the COVID-19 pandemic.Psychological problems were assessed using the Generalized Anxiety Disorder Scale,Patient Health Questionnaire and Insomnia Severity Index.Logistic regression analyses were used to explore the factors that were associated with psychological problems.Results The prevalence of symptoms of anxiety,depression,insomnia and the overall psychological problems in healthcare workers during the COVID-19 pandemic in China was 46.04%,44.37%,28.75%and 56.59%,respectively.The prevalence of the overall psychological problems in physicians,medical residents,nurses,technicians and public health professionals was 60.35%,50.82%,62.02%,57.54%and 62.40%,respectively.Compared with healthcare workers who did not participate in front-line work,front-line healthcare workers had a higher risk of anxiety,insomnia and overall psychological problems.In addition,attention to negative or neutral information about the pandemic,receiving negative feedback from families and friends who joined front-line work,and unwillingness to join front-line work if given a free choice were three major factors for these psychological problems.Conclusions Psychological problems are pervasive among healthcare workers during the COVID-19 pandemic.Receiving negative information and participating in front-line work appear to be.important risk factors for psychological problems.The psychological health of different healthcare workers should be protected during the COVID-19 pandemic with timely interventions and proper information feedback. | Jianyu Que Le Shi Jiahui Deng Jiajia Liu Li Zhang Suying Wu Yimiao Gong Weizhen Huang Kai Yuan Wei Yan Yankun Sun Maosheng Ran Yanping Bao Lin Lu | 2020 | General Psychiatry2020，33，3： | 8 |
| 4 | Wet-chemistry synthesis of cobalt carbide nanoparticles as highly active and stable electrocatalyst for hydrogen evolution reaction显示文摘转变金属碳化物(TMC ) nanomaterials 正在答应选择到磅,并且广泛地为电气化学的氢进化反应被用作异构的 electrocatalysts (她的) 。在这个工作,综合的导致溴化物的湿化学的策略公司 2 C nanoparticles (NP ) 被开发。如此的 NP 展出了高 electrocatalytic 活动(= 为 j = 的 181 mV 10 | Siwei Li Ce Yang Zhen Yin Hanjun Yang Yifu Chen Lili Lin Mengzhu Li Weizhen Li Gang HU Ding Ma | 2017 | Nano Research2017，10，4： | 7 |
| 5 | mTOR and the differentiation of mesenchymal stem cells显示文摘rapamycin (mTOR ) 的哺乳动物的目标, evolutionarily 保存的 serinethreonine 蛋白质 kinase,属于 phosphoinositide 3-kinase (PI3K ) 联系了 kinase 家庭,它在他们的 C 终端区域以内包含一个类脂化合物象 kinase 一样领域。当一个批评细胞内部的分子能察觉到细胞外的精力地位并且在许多房间和纸巾调整房间生长和增长,最近的研究揭示了那 mTOR。这评论在房间区别和织物开发上关于 mTOR 的效果总结我们的当前的理解,与间充质的干细胞的系决心上的一个重音。mTOR 能在白 adipocytes,棕色的 adipocytes,和肌肉卫星房间支持 adipogenesis,当 rapamycin 禁止 mTOR 的 adipogenic 功能时。发信号的 mTOR 可以工作然而,影响造骨细胞增长和区别 rapamycin 被报导了禁止或支持成骨。尽管精确机制仍然保持不清楚, mTOR 为 myogenesis 是不可缺少的。取决于房间别打, rapamycin 被报导了禁止,支持,或有 myogenesis 上的效果。 | Xinxin Xiang Jing Zhao Geyang Xu Yin Li Weizhen Zhang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 6 |
| 6 | Low frequency oscillation characteristics of East China Power Grid after commissioning of Huai-Hu ultra-high voltage alternating current project显示文摘The low frequency oscillation characteristics of East China Power Grid after commissioning of the first ultra-high voltage alternating current(UHVAC)project-the Huai-Hu UHVAC project are studied.Several low frequency oscillation cases occurred in East China Power Grid in the past few years are reviewed and summarized.Based on the analysis of the different typical operation modes,the main low frequency oscillation modes in East China Power Grid in the early stages of development of ultra-high voltage(UHV)are summarized,and the impacts of the significant power grid maintenance on low frequency oscillation characteristics are analyzed.Besides,the oscillation mode of UHV generators to East China Power Grid is researched,and the importance of the power system stabilizator(PSS)is emphasized.Furthermore,the comparative analysis between the time domain and the frequency domain is carried out,and the influences of the governing system on low frequency oscillation characteristics are revealed.Finally,both the focus and the direction of low frequency oscillation research are presented. | Chao WANG Yang LV Hongyang HUANG Jing ZHANG Jihong LI Yingyi LI Weizhen SUN Yong CHANG | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，3： | 6 |
| 7 | Comparative analysis of A,B,C and D genomes in the genus Oryza with C_(0)t-1 DNA of C genome显示文摘Fluorescence in situ hybridization (FISH)was applied to somatic chromosomes preparations of Oryza officinalis Wall. (CC), O. sativa L. (AA)×O. offi-cinalis F1 hybrid (AC), backcross progenies BC1 (AAC and ACC), O. latifolia Desv. (CCDD), O. alta Swallen (CCDD) and O. punctata Kotschy (BBCC) with a labelled probe of C0t-1 DNA from O. officinalis. In O. officinalis, the homologous chromosomes showed similar signal bands probed by C0t-1 DNA and karyotype analysis was conducted based on the band patterns. Using no blocking DNA, the probe identified the chromosomes of C genome clearly, but detected few signals on chromosomes of A genome in the F1 hybrid and two backcross progenies of BC1. It is obvious that the highly and moderately repetitive DNA sequences were considerably different between C and A genomes. The chromosomes of C genome were also discriminated from the chromosomes of D- and B-genome in the tetraploid species O. latifolia, O. alta and O. punctata by C0t-1 DNA-FISH. Compari-son of the fluorescence intensity on the chromo-somes of B, C and D genomes in O. latifolia, O. alta, and O. punctata indicated that the differentiations between C and D genomes are less than that be-tween C and B genomes. The relationship between C and D genomes in O. alta is closer than that of C and D genomes in O. latifolia. This would be one of thecauses for the fact that both the genomes are of the same karyotype (CCDD) but belong to different spe-cies. The above results showed that the C0t-1 DNA had a high specificity of genome and species. In this paper, the origin of allotetraploid in genus Oryza is also discussed. | LAN Weizhen QIN Rui LI Gang HE Guangcun | 2006 | Chinese Science Bulletin2006，51，14： | 6 |
| 8 | Fe5C2 nanoparticles as low-cost HER electrocatalyst:the importance of Co substitution显示文摘Constructing and understanding the doping effect of secondary metal in transition metal carbide(TMC)catalysts is pivotal for the design of low-cost hydrogen evolution reaction(HER) electrocatalysts. In this work, we developed a wet-chemistry strategy for synthesizing Co-modified Fe_5C_2 nanoparticles((Fe_(1-x)Cox)_5C_2 NPs) as highly active HER electrocatalysts in basic solution. The structure of(Fe_(1-x)Cox)_5C_2 NPs was characterized by X-ray diffraction(XRD), extended X-ray absorption fine structure spectra(EXAFS) and scanning/transmission electron microscopy(S/TEM), indicating that the isomorphous substitution of cobalt in the lattice of Fe_5C_2.(Fe_(0.75) Co_(0.25))_5C_2 exhibited the best HER activity(174 mV for j = -10 mA/cm^2). Computational calculation results indicate that Co provides the most active site for HER. X-ray adsorption spectra(XAS) studies further suggested that the electron transfer in Fe–C bonds are enhanced by the substitution of Co, which modulates the hydrogen adsorption on the adjacent electronic-enriched carbon, and therefore promotes HER activity. Our results affirm the design of lowcost bimetallic TMCs based HER catalysts. | Siwei Li Pengju Ren Ce Yang Xi Liu Zhen Yin Weizhen Li Hanjun Yang Jian Li Xiaoping Wang Yi Wang Ruochen Cao Lili Lin Siyu Yao Xiaodong Wen Ding Ma | 2018 | Science Bulletin2018，63，20： | 6 |
| 9 | Chromosome-scale genome assembly of sweet cherry(Prunus avium L.)cv.Tieton obtained using long-read and Hi-C sequencing显示文摘Sweet cherry(Prunus avium)is an economically significant fruit species in the genus Prunus.However,in contrast to other important fruit trees in this genus,only one draft genome assembly is available for sweet cherry,which was assembled using only Illumina short-read sequences.The incompleteness and low quality of the current sweet cherry draft genome limit its use in genetic and genomic studies.A high-quality chromosome-scale sweet cherry reference genome assembly is therefore needed.A total of 65.05 Gb of Oxford Nanopore long reads and 46.24 Gb of Illumina short reads were generated,representing~190x and 136x coverage,respectively,of the sweet cherry genome.The final de novo assembly resulted in a phased haplotype assembly of 344.29 Mb with a contig N50 of 3.25 Mb.Hi-C scaffolding of the genome resulted in eight pseudochromosomes containing 99.59%of the bases in the assembled genome.Genome annotation revealed that more than half of the genome(59.40%)was composed of repetitive sequences,and 40,338 protein-coding genes were predicted,75.40%of which were functionally annotated.With the chromosomescale assembly,we revealed that gene duplication events contributed to the expansion of gene families for salicylic acid/jasmonic acid carboxyl methyltransferase and ankyrin repeat-containing proteins in the genome of sweet cherry.Four auxin-responsive genes(two GH3s and two SAURs)were induced in the late stage of fruit development,indicating that auxin is crucial for the sweet cherry ripening process.In addition,772 resistance genes were identified and functionally predicted in the sweet cherry genome.The high-quality genome assembly of sweet cherry obtained in this study will provide valuable genomic resources for sweet cherry improvement and molecular breeding. | Jiawei Wang Weizhen Liu Dongzi Zhu Po Hong Shizhong Zhang Shijun Xiao Yue Tan Xin Chen Li Xu Xiaojuan Zong Lisi Zhang Hairong Wei Xiaohui Yuan Qingzhong Liu | 2020 | Horticulture Research2020，7，1： | 4 |
| 10 | Ghrelin fluctuation, what determines its production?显示文摘Ghrelin, 28 氨基酸内脏大脑肽,为它的受体充当内长的 ligand,生长荷尔蒙促泌素受体,行使从生长的刺激的许多功能荷尔蒙分泌物,胃口的规定和精力新陈代谢,和到发炎的调整的房间保护。这评论在 ghrelin 表示和分泌物的规定总结进展。我们介绍 ghrelin 倡导者,在这些过程处理和 ghrelin 先锋,和规定机制的修正的结构。然后,我们讨论发现在 ghrelin 生产的规定重要的因素,包括营养素,荷尔蒙,和自治神经系统。最后,我们在某些生理、病理学的地位在 ghrelin 的水平构画出改变。 | Xuefeng Yin Yin Li Geyang Xu Wenjiao An Weizhen Zhang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 4 |
| 11 | HEIHE WATERSHED ALLIED TELEMETRY EXPERIMENTAL RESEARCH (HiWATER): Scientific Objectives and Experimental Design显示文摘 | Li Xin Cheng Guodong Liu Shaomin Xiao Qing Ma Mingguo Jin Rui Che Tao Liu Qinhuo Wang Weizhen Qi Yuan Wen Jianguang Li Hongyi Zhu Gaofeng Guo Jianwen Ran Youhua Wang Shuoguo Zhu Zhongli Zhou Jian Hu Xiaoli Xu Ziwei | 2013 | Bulletin of the American Meteorological Society2013，，8： | 3 |
| 12 | Ghrelin and cell differentiation显示文摘Ghrelin,为生长荷尔蒙促泌素受体的内长的 ligand,是被发现了有许多生物功能的胃的荷尔蒙。这评论在房间区别和织物开发上总结我们 ghrelin 的效果的当前的理解,与间充质的干细胞的系决心上的一个重音。 | Geyang Xu Yin Li Wenjiao An Weizhen Zhang | 2008 | Acta Biochimica et Biophysica Sinica2008，40，10： | 3 |
| 13 | A finite-element simulation on deformational energy in structural deformed zone显示文摘Under the same conditions of external force, simulations on differences of deformational energy in structural zones, which have different deformational behavior, and that on the distribution of the differences have been carried out by means of finite-element method. Shear deformational energy U_w is higher than volume deformational energy U_T by about one order of magnitude, and deformationat energy U_B( = U_w + U_T) and U_w show a trend to be larger→largest→small in quantity in structural zones of different deformational properties, which correspond to compressive, shear, tensile zones, respectively, but U_T shows a trend to be large→small gradually. This has a considerable significance in the study of tectonic heat and mineral liquid migration in association with the research on tectonic additional hydrostatic pressure. | Guxian Lü Hongcai Wang Weizhen Peng Xiaobo Li Tao Guo Chusun Guo | 1999 | Chinese Science Bulletin1999，44，11： | 3 |
| 14 | Ghrelin O-acyltransferase(GOAT) and energy metabolism显示文摘Ghrelin O-acyltransferase(GOAT), a member of MBOATs family, is essential for octanoylation of ghrelin, which is required for active ghrelin to bind with and activate its receptor. GOAT is expressed mainly in the stomach, pancreas and hypothalamus. Levels of GOAT are altered by energy status. GOAT contains 11 transmembrane helices and one reentrant loop. Its invariant residue His-338 and conserved Asn-307 are located in the endoplasmic reticulum lumen and cytosol respectively. GOAT contributes to the regulation of food intake and energy expenditure, as well as glucose and lipids homeostasis. Deletion of GOAT blocks the acylation of ghrelin leading to subsequent impairment in energy homeostasis and survival when mice are challenged with high energy diet or severe caloric restriction. GO-Co A-Tat, a peptide GOAT inhibitor, attenuates acyl-ghrelin production and prevents weight gain induced by a medium-chain triglycerides-rich high fat diet. Further, GO-Co A-Tat increases glucose-induced insulin secretion. Overall, inhibition of GOAT is a novel strategy for treatment of obesity and related metabolic disorders. | Ziru Li Michael Mulholland Weizhen Zhang | 2016 | Science China(Life Sciences)2016，59，3： | 3 |
| 15 | Promoting effect of chloride ions on selective oxidation of methanol to methyl formate over zirconia-supported ruthenium oxide catalysts显示文摘The effect of chloride ions on a monoclinic ZrO2-supported RuOx(RuOx/m-ZrO2) catalyst with a Ru surface density of 0.3 Ru/nm2 was studied in the selective oxidation of methanol to methyl formate(MF) at a low temperature of 373 K.The m-ZrO2 support was Cl-free,and Cl- ions were introduced into the RuOx/m-ZrO2 catalyst by impregnation with zirconium oxychloride or ammonium chloride and subsequent thermal treatment in air at 673 K.The structures of these catalysts were characterized by X-ray diffraction,Raman and X-ray photoelectron spectroscopies.Their reducibility was probed by temperature-programmed reduction in H2.The RuOx domains were present as highly dispersed RuO42- structure on m-ZrO2 with similar reducibility for the RuOx/m-ZrO2 samples irrespective of modification with or without Cl- ions.Introduction of appropriate amounts of zirconium oxychloride into RuOx/m-ZrO2 led to a remarkable increase in the methanol oxidation rate and MF selectivity,whereas introduction of ammonium chloride or zirconyl nitrate significantly inhibited the catalytic performance of RuOx/m-ZrO2.The promoting effect of Cl- ions derived from zirconium oxychloride can be tentatively attributed to their roles in facilitating the adsorption of methanol and desorption of MF product or its intermediates.This finding provides novel insights into the promoting effect of Cl ions on oxides-based catalysts for selective oxidation reactions. | Weizhen Li Hongpeng Zhang Xiaohui He Haichao Liu | 2013 | Journal of Energy Chemistry2013，22，3： | 2 |
| 16 | SecIngress:An API Gateway Framework to Secure Cloud Applications Based on N-Variant System显示文摘Based on the diversified technology and the cross-validation mechanism,the N-variant system provides a secure service architecture for cloud providers to protect the cloud applications from attacks by executing multiple variants of a single software in parallel and then checking their behaviors’consistency.However,it is complex to upgrade current Software as a Service(SaaS)applications to adapt N-variant system architecture.Challenges arise from the inability of tenants to adjust the application architecture in the cloud environment,and the difficulty for cloud service providers to implement N-variant systems using existing API gateways.This paper proposes SecIngress,an API gateway framework,to overcome the challenge that it is hard in the cloud environment to upgrade the applications based on N-variants system.We design a two-stage timeout processing method to lessen the service latency and an Analytic Hierarchy Process Voting under the Metadata mechanism(AHPVM)to enhance voting accuracy.We implement a prototype in a testbed environment and analyze the security and performance metrics before and after deploying the prototype to show the effectiveness of SecIngress.The results reveal that SecIngress enhances the reliability of cloud applications with acceptable performance degradation. | Dacheng Zhou Hongchang Chen Guozhen Cheng Weizhen He Lingshu Li | 2021 | China Communications2021，18，8： | 2 |
| 17 | PVT1 affects ENIT and cell proliferation and migration via regulating p21 in triple-negative breast cancer cells cultured with mature adipogenic medium显示文摘Excessive adiposity has long been proved to be associated with greater incidence and mortality of breast cancer in post-menopausal women.However,the effects and underlying mechanisms of human adipocytes on breast cancer cells remain largely unknown.In recent years,several reports have revealed the oncogenic role of long non-coding RNA PVT1 in breast cancer.Here,we aimed to investigate the role and underlying mechanisms of PVT1 in triple-negative breast cancer (TNBC)cells cultured with mature adipogenic medium.At first,we successfully induced adipogenic differentiation from human adipose-derived mesenchymal stern cells and collected the mature adipogenic medium to mimic excessive adiposity.Our results demonstrated that the mature adipogenic medium promoted the epithelial-mesenchymal transition,enhanced the cell viability and migration potential of TNBC cells.In addition,we proved that mature adipogenic medium affected the PVT1 expression and inhibition of the PVT1 disturbed the role of mature adipogenic medium in TNBC cells.Finally,we illustrated that repression of p21 restored the phenotype caused by PVT1 knockdown in TNBC cells treated with mature adipogenic medium.Taken together,our results demonstrated that PVT1 affected the role of mature adipogenic medium in TNBC cells via modulating p21 expression. | Lingli Wang Ruirui Wang Zi Ye Yanyan Wang Xiao Li Weizhen Chen Mengna Zhang Cheguo Cai | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 2 |
| 18 | Temporal and spatial variability of soil moisture based on WSN显示文摘 | Man Zhang Minzan Li Weizhen Wang Chunhong Liu Hongju Gao | 2013 | Mathematical and Computer Modelling . 2013 (3-4)2013，，3： | 1 |
| 19 | Noninvasive identificational diagnosis of diabetic nephropathy and non-diabetic renal disease based on clinical characteristics of Traditional Chinese Medicine symptom pattern and conventional medicine显示文摘OBJECTIVE:To study the clinical characteristics relating to differential diagnosis of diabetic nephropathy(DN) and non-diabetic renal disease(NDRD).METHODS:The subjects were patients with type 2 diabetes mellitus(T2DM) complicated with chronic kidney disease(CKD).Western medical history data and Traditional Chinese Medicine(TCM) symptom pattern were collected,and logistic regression was used to analyze.RESULTS:Blood deficiency pattern [odds ratio(OR) = 2.269,P = 0.017] and Qi stagnation pattern(OR = 1.999,P = 0.041) are independently related to DN.CONCLUSIONS:TCM factors blood deficiency pattern and Qi stagnation pattern are relating to differential diagnosis of DN and NDRD. | QU Yilun CHENG Haimei WANG Qian LI Shuang DUAN Shuwei FENG Zhe LI Weizhen JIANG Shuangshuang YANG Hongtao MAO Yonghui GENG Yanqiu LI Jijun LIU Yuning TIAN Jinzhou LIU Hongfang DONG Zheyi CHEN Xiangmei | 2023 | Journal of Traditional Chinese Medicine2023，43，3： | 1 |
| 20 | One-pot synthesis of 2,5-bis(hydroxymethyl)furan from biomass derived 5-(chloromethyl)furfural in high yield显示文摘5-(Chloromethyl)furfural(CMF),as a new platform molecular,has become a hot topic in the field of biorefinery.Herein,the one-pot conversion of CMF to 2,5-bis(hydroxymethyl)furan(BHMF)in the water phase was demonstrated for the first time.A 91%BHMF yield was obtained over Ru/Cu Oxcatalyst,and BHMF was mainly produced by the consecutive hydrolysis and hydrogenation of CMF with 5-hydroxymethylfurfural(HMF)as an intermediate.Kinetic studies revealed that the conversion of HMF to BHMF was the rate-determining step.Remarkably,the characterizations and density functional theory(DFT)calculations further revealed the lower electron density of Ru NPs in Ru/Cu Oxcatalyst,resulting in a larger adsorption energy and a smaller free energy difference for the formation of alcohols.The present findings offered a new pathway for biomass-derived diol production through CMF as a potential source. | Binglin Chen Yunchao Feng Sen Ma Weizhen Xie Guihua Yan Zheng Li Jonathan Sperry Shuliang Yang Xing Tang Yong Sun Lu Lin Xianhai Zeng | 2023 | Journal of Energy Chemistry2023，，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员