|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth显示文摘发信号的调停肽的 cell-to-cell 在植物在细胞的功能的协作和定义有关键角色。肽受体匹配为理解位于调停肽的发信号下面的机制是重要的。这里,我们报导根分裂组织生长的指导结构的鉴定为植物开发重要的因素(RGF ) 受体。基于签名 ligand 识别,主题(Arg-x-Arg ) 在充满白氨酸的重复受体 kinases (LRR-RKs ) 的一个亚科保存了的试金识别了机能上地 uncharacterized LRR-RK At4g26540 作为 RGF1 (RGFR1 ) 的受体。我们进一步在 2.6 Å 的一个决定与 RGFR1 的 LRR 领域在建筑群解决了 RGF1 的水晶结构;,它表明 Arg-x-Gly-Gly (RxGG ) 主题为由 RGFR1 的 RGF1 的硫酸盐组的特定的识别负责。基于 RxGG 主题,我们识别了另外四 RGFR。在导致 RGF 的发信号的五 RGFR 的参予被生物化学、基因的数据支持。我们也提供证明 SERK 为 RGF 作为合作受体工作的证据。一起拿,我们的学习识别 RGF 受体,能连接 RGF 的合作受体与他们的下游的部件发信号并且为与他们的肽 ligands 的 LRR-RKs 的基于结构的匹配提供原则的一个证明。 | Wen Song Li Liu Jizong Wang Zhen Wu Heqiao Zhang Jiao Tang Guangzhong Lin Yichuan Wang Xing Wen Wenyang Li Zhifu Han Hongwei Guo Jijie Chai | 2016 | Cell Research2016，26，6： | 20 |
| 2 | Down-staging depth score to predict outcomes in locally advanced rectal cancer achieving ypl stage after neoadjuvant chemo-radiotherapy versus de novo stage pl cohort:A propensity score-matched analysis显示文摘Objective:Prognosis of patients with locally advanced rectal cancer(LARC)but achieving yp T1–2N0 stage after neoadjuvant concurrent chemo-radiotherapy(CRT)has been shown to be favorable.This study aims to determine whether the long-term outcome of yp T1–2N0 cases can be comparable to that of p T1–2N0 cohort that received definitive surgery for early disease.Method:From January 2008 to December 2013,449 consecutive patients with rectal cancer were treated and their outcome maintained in a database.Patients with LARC underwent total mesorectal excision(TME)surgery at4–8 weeks after completion of CRT,and those achieving stage yp I were identified as a group.As a comparison,stage p I group pertains to patients whose initially limited disease was not upstaged after TME surgery alone.After propensity score matching(PSM),comparisons of local regional control(LC),distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were performed using Kaplan-Meier analysis and log-rank test between yp I and p I groups.Down-staging depth score(DDS),a novel method of evaluating CRT response,was used for subset analysis.Results:Of the 449 patients,168 matched cases were generated for analysis.Five-year LC,DMFS,DFS and OS for stage p I vs.yp I groups were 96.7%vs.96.4%(P=0.796),92.7%vs.73.6%(P=0.025),91.2%vs.73.6%(P=0.080)and 93.1%vs.72.3%(P=0.040),respectively.In the DDS-favorable subset of the yp I group,LC,DMFS,DFS and OS resulted in no significant differences in comparison with the p I group(P=0.384,0.368,0.277 and0.458,respectively).Conclusions:LC was comparable in both groups;however,distant metastasis developed more frequently in down-staged LARC than de novo early stage cases,reflecting the need to improve the efficacy of systemic treatment despite excellent pathologic response.DDS can be an indicator to identify a subset of the yp I group whose longterm oncologic outcomes are as good as those of stage p I cohort. | Ning Li Jing Jin Jing Yu Shuai Li Yuan Tang Hua Ren Wenyang Liu Shulian Wang Yueping Liu Yongwen Song Hui Fang Zihao Yu Yexiong Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 3 | Ice-wedge Pseudomorphs Showing Climatic Change Since the Late Pleistocene in the Source Area of the Yellow River, Northeast Tibet显示文摘The source area of the Yellow River is located in the northeastern Tibetan Plateau, and is a high-elevation region with the annual mean temperature of-3.9℃. The ice-wedge pseudomorphs discovered in this region are recognized as two types.One was found in sandy gravel beds of the second terrace of the Yellow River. This ice-wedge pseudomorph is characterized by higher ratio of breadth/depth, and are 1~1.4 m wide and about 1 m deep. The bottom border of the ice-wedge pseudomorph is round arc in section. Another discovered in the pedestal of the second terrace has lower ratio of width/depth, and is 0.3~1.0 m wide and 1~2 m deep. Its bottom border is sharp. Based on the TL dating, the former was formed at the middle Holocene (5.69±0.43 ka BP and 5.43±0.41 ka BP),that is, the Megathermal, and the latter was formed at the late Last Glacial Maximum (13.49± 1.43 ka BP).Additionally, the thawing-freezing folders discovered in the late Late Pleistocene proluvium are 39.83±3.84 ka BP in age. The study on the ice-wedge pseudomorphs showed that the air temperature was lowered by up to 6~7 ℃ in the source area of the Yellow River when the ice-wedge pseudomorphs and thawing-freezing folds developed. | CHENG Jie ZHANG Xujiao TIAN Mingzhong YU Wenyang YU Jiangkuan TANG Dexiang YUE Jianwei | 2005 | Journal of Mountain Science2005，2，3： | 3 |
| 4 | Down-staging depth score could be a survival predictor for locally advanced gastric cancer patients after preoperative chemoradiotherapy显示文摘Objective:The predictive effect of preoperative chemoradiotherapy(CRT)is low and difficult in guiding individualized treatment.We examined a surrogate endpoint for long-term outcomes in locally advanced gastric cancer patients after preoperative CRT.Methods:From April 2012 to April 2019,95 patients with locally advanced gastric cancer who received preoperative concurrent CRT and who were enrolled in three prospective studies were included.All patients were stage T_(3/4) N_(+).Local control,distant metastasis-free survival(DMFS),disease-free survival(DFS)and overall survival(OS)were evaluated.Clinicopathological factors related to long-term prognosis were analyzed using univariate and multivariate analyses.The down-staging depth score(DDS),which is a novel method of evaluating CRT response,was used to predict long-term outcomes.Results:The median follow-up period for survivors was 30 months.The area under the curve(AUC)of the receiver operating characteristic(ROC)curve predicted by the DDS was 0.728,which was better than the pathological complete response(pCR),histological response and ypN0.Decision curve analysis further affirmed that DDS had the largest net benefit.The DDS cut-off value was 4.pCR and ypN0 were associated with OS(P=0.026 and 0.049).Surgery and DDS are correlated with DMFS,DFS and OS(surgery:P=0.001,<0.001 and<0.001,respectively;and DDS:P=0.009,0.013 and 0.032,respectively).Multivariate analysis showed that DDS was an independent prognostic factor of DFS(P=0.021).Conclusions:DDS is a simple,short-term indicator that was a better surrogate endpoint than pCR,histological response and ypN0 for DFS. | Ning Li Xin Wang Yuan Tang Dongbin Zhao Yihebali Chi Lin Yang Liming Jiang Jun Jiang Jinming Shi Wenyang Liu Hua Ren Hui Fang Yu Tang Bo Chen Ningning Lu Hao Jing Shunan Qi Shulian Wang Yueping Liu Yongwen Song Yexiong Li Jing Jin | 2021 | Chinese Journal of Cancer Research2021，33，4： | 1 |
| 5 | Video-based construction vehicles detection and its application in intelligent monitoring system显示文摘 | Wenyang Ji Lingjun Tang Dedi Li Wenming Yang Qingmin Liao | 2016 | CAAI Transactions on Intelligence Technology2016，1，2： | 1 |
| 6 | Coordinating Zirconium Nodes in Metal-Organic Framework with Trifluoroacetic Acid for Enhanced Lewis Acid Catalysis显示文摘Regulating Lewis acid sites with well-defined electronic state and steric environment is still challenging for achieving high catalytic efficiency.Here we show coordinating zirconium nodes in the typical metal-organic framework known as MOF-545 with the monocarboxylate modulators including trifluoroacetic acid(TFA)or benzoic acid(BA)over meso-tetra(4-carboxyphenyl)-porphine(H_(2)TCPP),denoted as MOF-545-TFA or MOF-545-BA.Impressively,MOF-545-TFA shows the significantly enhanced performance for the catalytic ring-opening reaction of various epoxides with alcohols and good recyclability at 40°C in respect with MOF-545-BA and ZrO_(2).This mainly originates from the stronger Lewis acidity and more active zirconium sites induced by the electron-withdrawing TFA,resulting in the increased ability for activation of epoxides.This modulation approach is promising for enlarging the toolbox to extend the MOFs-based Lewis acid catalysis. | WANG Wenyang LIU Hanlin YANG Caoyu FAN Ting CUI Chengqian LU Xiaoquan TANG Zhiyong LI Guodong | 2022 | Chemical Research in Chinese Universities2022，38，5： | 0 |
| 7 | Nomogram for predicting the overall survival of patients after D2/R0 resection and chemoradiotherapy for stage Ⅲ gastric cancer or gastroesophageal junction cancer显示文摘Objective:To explore the independent factors associated with the overall survival(OS)after D2/R0 resection and adjuvant chemoradiotherapy(CRT)for stage Ⅲ gastric cancer(GC)and gastroesophageal junction(GEJ)cancer,and establish and validate a nomogram model to predict the OS in this patient population.Methods:A total of 569 stage Ⅲ GC or GEJ cancer patients who underwent D2/R0 resection and adjuvant CRT at our center from January 2013 to May 2018 were retrospectively enrolled in this study.The patients were randomly divided into training and validation cohorts in a 3:1 ratio.In the training cohort,univariate and multivariate analysis were conducted to identify clinical factors associated with OS,and a nomogram model was established on the basis of the independent factors.The concordance index(C-index)and the calibration curve were used to validate the prediction power of the nomogram.Results:Overall,427 and 142 patients were enrolled in the training and validation cohorts,respectively.In the univariate and multivariate analyses,age,Lauren's classification,TNM stage,and administration of adjuvant CRT were independent factors for OS to construct the nomogram.The C-index values were 0.654 and 0.613 in the training and validation cohorts,respectively.The calibration curves were identical to the actual OS.Risk stratification based on the nomogram model showed good risk stratification for OS in both groups.Conclusion:Our study included adjuvant CRT as a predictive factor and established a nomogram model for predicting the OS in patients with stage III GC or GEJ after D2/R0 resection and adjuvant therapy.This nomogram could facilitate more individualized prediction of OS in clinical practice. | Jinming Shi Wenzhe Kang Songlin Gao Wenyang Liu Yuan Tang Ning Li Qiang Zeng Huiying Ma Haoyue Li Yantao Tian Jing Jin | 2023 | Radiation Medicine and Protection2023，4，3： | 0 |
| 8 | Temperature dependence simulation and characterization for InP/InGaAs avalanche photodiodes显示文摘Based on the newly proposed temperature dependent dead space model,the breakdown voltage and bandwidth of InP/InGaAs avalanche photodiode (APD) have been investigated in the temperature range from -50℃ to 100℃.It was demonstrated that our proposed model is consistent with the experimental results.Our work may provide a guidance to the design of APDs with controllably low temperature coefficient. | Yanli ZHAO Junjie TU Jingjing XIANG Ke WEN Jing XU Yang TIAN Qiang LI Yuchong TIAN Runqi WANG Wenyang LI Mingwei GUO Zhifeng LIU Qi TANG | 2018 | Frontiers of Optoelectronics2018，11，4： | 0 |
| 9 | Gated Fusion Based Transformer Model for Crack Detection on Wind Turbine Blade显示文摘Harsh working environments and wear between blades and other unit components can easily lead to cracks and damage on wind turbine blades.The cracks on the blades can endanger the shafting of the generator set,the tower and other components,and even cause the tower to collapse.To achieve high-precision wind blade crack detection,this paper proposes a crack fault-detection strategy that integratesGated ResidualNetwork(GRN),a fusionmodule and Transformer.Firstly,GRNcan reduce unnecessary noisy inputs that could negatively impact performancewhile preserving the integrity of feature information.In addition,to gain in-depth information about the characteristics of wind turbine blades,a fusionmodule is suggested to implement the information fusion of wind turbine features.Specifically,each fan feature ismapped to a one-dimensional vector with the same length,and all one-dimensional vectors are concatenated to obtain a two-dimensional vector.And then,in the fusion module,the information fusion of the same characteristic variables in the different channels is realized through the Channel-mixing MLP,and the information fusion of different characteristic variables in the same channel is realized through the ColumnmixingMLP.Finally,the fused feature vector is input into the Transformer for feature learning,which enhances the influence of important feature information and improves the model’s anti-noise ability and classification accuracy.Extensive experimentswere conducted on the wind turbine supervisory control and data acquisition(SCADA)data froma domesticwind field.The results show that compared with other state-of-the-artmodels,including XGBoost,LightGBM,TabNet,etc.,the F1-score of proposed gated fusion based Transformer model can reach 0.9907,which is 0.4%-2.09% higher than the comparedmodels.Thismethod provides amore reliable approach for the condition detection and maintenance of fan blades in wind farms. | Wenyang Tang Cong Liu Bo Zhang | 2023 | Energy Engineering2023，120，11： | 0 |
| 10 | Synthesis of Carbon dots from Biomass Chenpi for the Detection of Hg^(2+)显示文摘Biomass-derived carbon dots(C-dots)are considered a very important carbon material in metal ion detection of their small environmental impact,simple preparation process,and relatively low cost.A green approach for synthesizing biomass-derived C-dots from Chenpi using a hydrothermal method without further processing is proposed in the present study.The as-synthesized C-dots show excellent fluorescence properties,superior resistance to UV irradiation photobleaching,and high photostability in salt-containing solutions.The C-dots were used in the form of label-free fluorescent probes for sensitively detecting Hg^(2+)selectively.The outcome relationship behaved linearly and was established based on a given range between 10–300 nM concentration,with a detection limit of 7.0 nM.This green strategy obtains a high C-dot quantum yield of 10.8%and satisfactory results in detecting Hg^(2+)in actual water samples. | Jun Xiang Xiaoqing Chen Qi Liu Huihua Jing Tongqiang Chen Wanli Tang Wenyang Xu | 2023 | Journal of Renewable Materials2023，11，10： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员