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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Soliton bursts and deterministic dissipative Kerr soliton generation in auxiliary-assisted microcavities显示文摘Dissipative Kerr solitons in resonant frequency combs offer a promising route for ultrafast mode-locking,precision spectroscopy and time-frequency standards.The dynamics for the dissipative soliton generation,however,are intrinsically intertwined with thermal nonlinearities,limiting the soliton generation parameter map and statistical success probabilities of the solitary state.Here,via use of an auxiliary laser heating approach to suppress thermal dragging dynamics in dissipative soliton comb formation,we demonstrate stable Kerr soliton singlet formation and soliton bursts.First,we access a new soliton existence range with an inverse-sloped Kerr soliton evolution—diminishing soliton energy with increasing pump detuning.Second,we achieve deterministic transitions from Turinglike comb patterns directly into the dissipative Kerr soliton singlet pulse bypassing the chaotic states.This is achieved by avoiding subcomb overlaps at lower pump power,with near-identical singlet soliton comb generation over twenty instances.Third,with the red-detuned pump entrance route enabled,we uncover unique spontaneous soliton bursts in the direct formation of low-noise optical frequency combs from continuum background noise.The burst dynamics are due to the rapid entry and mutual attraction of the pump laser into the cavity mode,aided by the auxiliary laser and matching well with our numerical simulations.Enabled by the auxiliary-assisted frequency comb dynamics,we demonstrate an application of automatic soliton comb recovery and long-term stabilization against strong external perturbations.Our findings hold potential to expand the parameter space for ultrafast nonlinear dynamics and precision optical frequency comb stabilization. | Heng Zhou Yong Geng Wenwen Cui Shu-Wei Huang Qiang Zhou Kun Qiu Chee Wei Wong | 2019 | Light(Science & Applications)2019，8，1： | 16 |
| 3 | Federated Learning for 6G:Applications,Challenges,and Opportunities显示文摘Standard machine-learning approaches involve the centralization of training data in a data center,where centralized machine-learning algorithms can be applied for data analysis and inference.However,due to privacy restrictions and limited communication resources in wireless networks,it is often undesirable or impractical for the devices to transmit data to parameter sever.One approach to mitigate these problems is federated learning(FL),which enables the devices to train a common machine learning model without data sharing and transmission.This paper provides a comprehensive overview of FL applications for envisioned sixth generation(6G)wireless networks.In particular,the essential requirements for applying FL to wireless communications are first described.Then potential FL applications in wireless communications are detailed.The main problems and challenges associated with such applications are discussed.Finally,a comprehensive FL implementation for wireless communications is described. | Zhaohui Yang Mingzhe Chen Kai-Kit Wong H.Vincent Poor Shuguang Cui | 2022 | Engineering2022，8，1： | 5 |
| 4 | Porous-hollow nanorods constructed from alternate intercalation of carbon and MoS2 monolayers for lithium and sodium storage显示文摘Weak ion diffusion and electron transport due to limited interlayer spacing and poor electrical conductivity have been identified as critical roadbacks for fast and abundant energy storage of both MoS2-based lithium ion batteries (LIBs) and sodium ion batteries (SIBs). In this work, MoS2 porous-hollow nanorods (MoS2/m-C800) have been designed and synthesized via an annealing-followed chemistry-intercalated strategy to solve the two issues. They are uniformly assembled from ultrathin MoS2 nanosheets, deviated to the rod-axis direction, with expanded interlayer spacing due to alternate intercalation of N-doped carbon monolayers between the adjacent MoS2 monolayers. Electrochemical studies of the MoS2/m-C800 sample, as an anode of LIBs, demonstrate that the superstructure can deliver a reversible discharge capacity of 1,170 mAh·g^-1 after 100 cycles at 0.2 A·g^-1 and maintain a reversible capacity of 951 mAh·g^-1 at 1.25 A·g^-1 after 350 cycles. While for SIBs, the superstructure also delivers a reversible discharge capacity of 350 mAh·g^-1 at 0.5 A-g-1 after 500 cycles and exhibits superior rate capacity of 238 mAh·g^-1 at 15 A·g^-1 .The excellent electrochemical performance is closely related with the hierarchical superstructures, including expanded interlayer spacing, alternate intercalation of carbon monolayers and mesoporous feature, which effectively reduce ion diffusion barrier, shorten ion diffusion paths and improve electrical conductivity. | Laiying Jing Gang Lian Junru Wang Mingwen Zhao Xizheng Liu Qilong Wang Deliang Cui Ching-Ping Wong | 2019 | Nano Research2019，12，8： | 3 |
| 5 | Bat origin of a new human coronavirus:there and back again显示文摘A novel coronavirus reported to cause pneumonia in 41 people during December 2019 in Wuhan,the capital of Hubei province,China,was identified and designated as the 2019 novel coronavirus(2019-nCoV)(Zhu et al.,2020;Li et al.,2020).Infection with 2019-nCoV results in clusters of severe respiratory illness similar to that caused by severe acute respiratory syndrome coronavirus(SARS-CoV)and is associated with high mortality(Chen et al.,2020;Huang et al.,2020).This new coronavirus belongs to genus Betacoronavirus,family Coronaviridae,with a single-stranded,positive-sense RNA genome,but genetically distinct from SARS-CoV and Middle East respiratory syndrome coronavirus(MERS-CoV). | Xiang Li Yuhe Song Gary Wong Jie Cui | 2020 | Science China(Life Sciences)2020，63，3： | 3 |
| 6 | Innovation Requirements and Progress of Dialysis Water Treatment System显示文摘With the development of medicine,people are becoming more and more aware of the quality of medical water supply,such as dial ysis water,dental water,preparation water,operating room water,supply room water.Therefore,People are constantly improving the water treatment system and its standardized,and the demand for dialysis water is also becoming more and more strict.Hemodialysis is an effective means of maintaining the life of renal failure patients,120~180L water will be used for a conventional dialysis treatment,and high flux dialysis will consume more. | Jun Ke Lifong Yan Taksui Wong Bo Hu Shuang Cui Sibo Huang Aiyun Cha Jie Huang Hongwei Hu Dawen Yun Shaofeng Huang Jie Shu Mingming Ma Lianghong Yin Xiangnan Dong Chen Yun Zuhui Chen Fanna Liu | 2017 | 临床医学工程2017，24，S1： | 2 |
| 7 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 8 | A three-year experiment confirms continuous immobilization of cadmium and lead in contaminated paddy field with biochar amendment显示文摘 | Rongjun Bian Stephen Joseph Liqiang Cui Genxing Pan Lianqing Li Xiaoyu Liu Afeng Zhang Helen Rutlidge Singwei Wong Chee Chia Chris Marjo Bin Gong Paul Munroe Scott Donne | 2014 | Journal of Hazardous Materials2014，，： | 2 |
| 9 | High Performance Supercapacitors from Hierarchical Porous Carbon Aerogels Based on Sliced Bread显示文摘 | Pin Hao Guanwei Cui Xifeng Shi Junfeng Xie Xinyuan Xia Yuanhua Sang C. P. Wong Hong Liu Bo Tang | 2017 | Chinese Journal of Chemistry2017，35，5： | 2 |
| 10 | Nonlinear Finite Element Simulations to Elucidate the Determinants of Perforator Patency in Propeller Flaps显示文摘 | Chin-Ho Wong Fangsen Cui Bien-Keem Tan Zhuangjian Liu Heow-Pueh Lee C Lu Chee-Liam Foo Colin Song | 2007 | Annals of Plastic Surgery2007，，6： | 2 |
| 11 | The adaptive chirplet transform and visual evoked potentials显示文摘 | Cui Jie Wong W | 2006 | IEEE Trans Biomed Eng2006，53，7： | 1 |
| 12 | Nonlinear finite element simulations to elucidate the determinants of perforator patency in propeller flaps显示文摘 | Wong CH Cui F Tan BK | 2007 | Ann Plast Surg2007，59，6： | 1 |
| 13 | Prevalence of Salmonella on Raw Poultry at Retail Markets in China显示文摘 | Yang Baowei Xi Meili Wang Xin Cui Shenghui Yue Tianli Hao Hongshan Wang Yin Cui Yue Alali W Q Meng Jianghong Walls Isabel Wong D M Lo Fo Doyle M P | 2011 | Journal of Food Protection2011，，10： | 1 |
| 14 | Major eye diseases and risk factors associated with systemic hypertension in an adult Chinese population:the Beijing Eye Study显示文摘 | Wang S Xu L Jonas JB Wong TY Cui T Li Y | | 0，，12： | 1 |
| 15 | Nonlinear finite element simulations to elucidate the determinants of perforator patency in propeller flaps显示文摘 | Wong CH Cui F Tan BK | 2007 | Ann Plast Surg2007，59，6： | 1 |
| 16 | A three-year experiment confirms continuous immobilization of cadmium and lead in contaminatedpaddy field with biochar amendment显示文摘 | Bian R Joseph S Cui L Pan G Li L Liu X Zhang A Rutlidge H Wong S Chia C Marjo C Gong B Munroe P Donne S | 2014 | Journal of Hazardous Materials2014，272，： | 1 |
| 17 | Multistage nanoparticle delivery system for deep penetration into tumor tissue显示文摘 | Wong C Stylianopoulos T Cui J | 2011 | Proc Natl Acad ScL2011，108，6： | 1 |
| 18 | Interplay of dissolution, solubility, and nonsink permeation determines the oral ab- sorption of the Hedgehog pathway inhibitor GDC-0449 in (togs: an investigation using pl~elinieal studies and physio- logically based pharmacokinetic modeling 显示文摘 | Wong H Theil FP Cui Y | 2010 | Drug Metab Dispos2010，38，7： | 1 |
| 19 | Time-frequency analysis of visual evoked potentials by means of matching pursuit with chirplet atoms显示文摘 | Cui J Wong W Mann S | 2004 | IEEE Engineering in Medicine and Biology Society2004，52，1： | 1 |
| 20 | Nonlinear finite element simulations to elucidate the determinations of per- forator patency in propeller flaps显示文摘 | Wong CH Cui F Tan BK | 2007 | Ann Plast Surg2007，59，6： | 1 |
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