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| 1 | Anti-inflammatory and anti-thrombogenic effects of atorvastatin in acute ischemic stroke显示文摘Atorvastatin decreases inflammation and thrombogenesis in patients with carotid artery plaque. Atorvastatin is administered to lower lipid levels, but its anti-inflammatory and anti-thrombogenic effects remain unclear. Eighty-nine patients from northeastern China with acute ischemic stroke caused by large-artery atherosclerosis were randomly divided into the study and control groups. All patients received routine treatment, including antiplatelet therapy, circulatory support, and symp-tomatic treatment. The study group (n=43) also received daily atorvastatin 20 mg/d, and the control group (n=46) received daily placebo pills containing glucose. After 4 weeks, the levels of C-reactive protein, fibrinogen, and D-dimer were significantly lower in the study group than in the control group. Decreases in the levels of C-reactive protein, fibrinogen, and D-dimer were not associated with de-creases in the levels of triacylglycerol and low-density lipoprotein cholesterol. These results suggest that atorvastatin reduces inflammation and thrombogenesis independent of its lipid-lowering effects in patients with acute ischemic stroke caused by large-artery atherosclerosis. | Lianqiu Min Shuai Shao Xiaoning Wu Lin Cong Ping Liu Haiping Zhao Yumin Luo | 2013 | Neural Regeneration Research2013，8，23： | 19 |
| 2 | A de novo Genome of a Chinese Radish Cultivar显示文摘Here, we report a high-quality draft genome of a Chinese radish(Raphanus sativus) cultivar. This draft contains 387.73 Mb of assembled scaffolds, 83.93% of the scaffolds were anchored onto nine pseudochromosomes and 95.09% of 43 240 protein-coding genes were functionally annotated. 184.75 Mb(47.65%) of repeat sequences was identified in the assembled genome. By comparative analyses of the radish genome against 10 other plant genomes, 2 275 genes in 780 gene families were found unique to R. sativus. This genome is a good reference for genomic study and of great value for genetic improvement of radish. | ZHANG Xiaohui YUE Zhen MEI Shiyong QIU Yang YANG Xinhua CHEN Xiaohua CHENG Feng WU Zhangyan SUN Yuyan JING Yi LIU Bo SHEN Di WANG Haiping CUI Na DUAN Yundan WU Jian WANG Jinglei GAN Caixia WANG Jun WANG Xiaowu LI Xixiang | 2015 | Horticultural Plant Journal2015，1，3： | 10 |
| 3 | Hierarchical Honeycomb-Structured Electret/Triboelectric Nanogenerator for Biomechanical and Morphing Wing Energy Harvesting显示文摘Flexible,compact,lightweight and sustainable power sources are indispensable for modern wearable and personal electronics and small-unmanned aerial vehicles(UAVs).Hierarchical honeycomb has the unique merits of compact mesostructures,excellent energy absorption properties and considerable weight to strength ratios.Herein,a honeycomb-inspired triboelectric nanogenerator(h-TENG)is proposed for biomechanical and UAV morphing wing energy harvesting based on contact triboelectrification wavy surface of cellular honeycomb structure.The wavy surface comprises a multilayered thin film structure(combining polyethylene terephthalate,silver nanowires and fluorinated ethylene propylene)fabricated through high-temperature thermoplastic molding and wafer-level bonding process.With superior synchronization of large amounts of energy generation units with honeycomb cells,the manufactured h-TENG prototype produces the maximum instantaneous open-circuit voltage,short-circuit current and output power of 1207 V,68.5μA and 12.4 mW,respectively,corresponding to a remarkable peak power density of 0.275 mW cm^(−3)(or 2.48 mW g^(−1))under hand pressing excitations.Attributed to the excellent elastic property of self-rebounding honeycomb structure,the flexible and transparent h-TENG can be easily pressed,bent and integrated into shoes for real-time insole plantar pressure mapping.The lightweight and compact h-TENG is further installed into a morphing wing of small UAVs for efficiently converting the flapping energy of ailerons into electricity for the first time.This research demonstrates this new conceptualizing single h-TENG device’s versatility and viability for broad-range real-world application scenarios. | Kai Tao Zhensheng Chen Haiping Yi Ruirong Zhang Qiang Shen Jin Wu Lihua Tang Kangqi Fan Yongqing Fu Jianmin Miao Weizheng Yuan | 2021 | Nano-Micro Letters2021，13，8： | 7 |
| 4 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 5 | Polypeptide dendrimers: Self-assembly and drug delivery显示文摘Amphiphilic dendritic poly(glutamic acid)-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly(glutamic acid) as the macroinitiator in the ring-opening polymerization of NCA-Phe.The block copolymers self-assembled micelles with polyphenylalanine segments as core and dendritic poly(glutamic acid) segments as shell.The biocompatibility of the micelles was studied.The release of the anticancer drug doxorubicin from the micelles was investigated in vitro.The results showed that the sustaining release of the drug could last for 60 h.The micellar drug release system was efficient in inhibiting the proliferation of HepG2 liver cancer cells,75% cancer cells were killed under appropriate in vitro incubation. | XU XiangHui LI CaiXia LI HaiPing LIU Rong JIANG Chao WU Yao HE Bin GU ZhongWei | 2011 | Science China Chemistry2011，54，2： | 6 |
| 6 | Miura-origami-inspired electret/triboelectric power generator for wearable energy harvesting with water-proof capability显示文摘One of the critical issues for electret/triboelectric devices is the poor charge viability and stability in humid environments.Herein,we propose a new origami-inspired“W-tube”-shaped triboelectric nanogenerator(W-TENG)with two thin-film electrets folded based on Miura-origami.The Miura-origami fold is capable of transforming flat materials with large surface areas into reduced and compressed complex 3D structures with parallelogram tessellations.The triboelectric power generation components can thus be hermetically sealed inside the“W-tube”to avoid contact with the external humid environment.Furthermore,the elastic nature of the Miura-origami fold endows the proposed W-TENG device with excellent deformability,flexibility,and stretchability.Therefore,it is capable of harvesting kinetic energy from various directions and forms of movement,including horizontal pressing,vertical tapping,and lateral bending.The compact,light weight,and self-rebounding properties of the origami structure also make it convenient for integration into wearable devices.Various parameters of the W-TENG are intensively investigated,including the number of power generation units,original height of the device,acceleration magnitude,excitation direction,and water-proof capability.Triggered by hand tapping impulse excitation in the horizontal and vertical directions,the instantaneous open-circuit voltages can reach 791 V and 116 V with remarkable optimum powers of 691μW at 50MΩand 220μW at 35 MΩ,respectively.The outcomes of this work demonstrate the fusion of the ancient art of origami,material science,and energy conversion techniques to realize flexible,multifunctional,and water-proof TENG devices. | Kai Tao Haiping Yi Yang Yang Lihua Tang Zhaoshu Yang Jin Wu Honglong Chang Weizheng Yuan | 2020 | Microsystems & Nanoengineering2020，6，1： | 6 |
| 7 | A study on accumulation and distribution of gas in southern Songliao Basin显示文摘A number of isolated fault sags in Late Jurassic--Early Cretaceous were developed in the early stage of southern Songliao Basin,and unified to a depression basin in the late stage.Therefore,multiple isolated lower petroliferous systems were formed with fault sags as source rocks.The source rocks of fault sags in Late Jurassic--Early Cretaceous were mainly described with gas generation as favorable source rocks,leading to the southern Songliao Basin rich in natural gas resources combined with organic gas resources in Nenjiang Formation.A number of tectonic movements in southern Songliao Basin led to the formation of abundant structural traps and complex fault systems,and controlled the distribution strata and positions of sources rocks in Late Jurassic--Early Cretaceous fault sags.The oil-gas reservoirs can be divided into two types,i.e.,primary and secondary ones.The primary oil-gas reservoirs were distributed in the fault sag strata and the bottom of overlying depression strata(lower Quan-1 Member).The oil-gas reservoir accumulation depended on the trap development situation and the distance from source rocks.The preservation conditions of oil-gas reservoirs depended on the degree of reconstruction in the late tectonism.The secondary oil-gas reservoirs were distribution in the Quantou Formation of depression strata,where oil and gas reservoir accumulation depended on three conditions,i.e.,trap development situation,deep gas sources and the fault to connect the shallow traps and deep gas sources.The southern Songliao Basin is rich in lower coal type gas,upper oil-gas and biogas resources,which are important resources in the future. | WANG Dehai KANG Haiping ZHAO Yanwei ZHAO Dalin LV Shicong WU Jianan CHEN Chunguang | 2013 | Global Geology2013，16，1： | 4 |
| 8 | Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2显示文摘Rescuing cells from stress damage emerges a potential therapeutic strategy to combat myocardial infarction.Protocatechuic aldehyde(PCA)is a major phenolic acid in Chinese herb Danshen(Salvia miltiorrhiza root).This study investigated whether PCA regulated nuclear pyruvate kinase isoform M2(PKM2)function to protect cardiomyocytes.In rats subjected to isoprenaline,PCA attenuated heart injury and protected cardiomyocytes from apoptosis.Through DARTS and CETSA assays,we identified that PCA bound and promoted PKM2 nuclear translocation in cardiomyocytes exposed to oxygen/glucose deprivation(OGD).In the nucleus,PCA increased the binding of PKM2 to β-Catenin via preserving PKM2 acetylation,and the complex,in cooperation with T-cell factor 4(TCF4),was required for transcriptional induction of genes encoding anti-apoptotic proteins,contributing to rescuing cardiomyocyte survival.In addition,PCA ameliorated mitochondrial dysfunction and prevented mitochondrial apoptosis dependent on PKM2.Consistently,PCA increased the binding of PKM2 to β-Catenin,improved heart contractive function,normalized heart structure and attenuated oxidative damage in mice subjected to artery ligation,but the protective effects were lost in Pkm2-deficient heart.Together,we showed that PCA regulated nuclear PKM2 function to rescue cardiomyocyte survival via β-Catenin/TCF4 signaling cascade,suggesting the potential of pharmacological intervention of PKM2 shuttle to protect the heart. | Xunxun Wu Lian Liu Qiuling Zheng Haiping Hao Hui Ye Ping Li Hua Yang | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 4 |
| 9 | The pleiotropic ABNORMAL FLOWER AND DWARF1 affects plant height, floral development and grain yield in rice显示文摘Moderate plant height and successful establishment of reproductive organs play pivotal roles in rice grain production. The molecular mechanism that controls the two aspects remains unclear in rice. In the present study,we characterized a rice gene, ABNORMAL FLOWER AND DWARF1(AFD1) that determined plant height, floral development and grain yield. The afd1 mutant showed variable defects including the dwarfism, long panicle, low seed setting and reduced grain yield. In addition, abnormal floral organs were also observed in the afd1 mutant including slender and thick hulls, and hull-like lodicules.AFD1 encoded a DUF640 domain protein and was expressed in all tested tissues and organs. Subcellular localization showed AFD1-green fluorescent fusion protein(GFP) was localized in the nucleus. Meantime, our results suggested that AFD1 regulated the expression of cell division and expansion related genes. | Deyong Ren Yuchun Rao Liwen Wu Qiankun Xu Zizhuang Li Haiping Yu Yu Zhang Yujia Leng Jiang Hu Li Zhu Zhenyu Gao Guojun Dong Guangheng Zhang Longbiao Guo Dali Zeng Qian Qian | 2016 | Journal of Integrative Plant Biology2016，58，6： | 4 |
| 10 | Influence of filler morphology on percolation threshold of isotropical conductive adhesives (ICA)显示文摘Different aspect ratio silver nano-structured materials including nanocubes,nanorods and nanowires were prepared by micro-waved assisted glycol reduction method.Different characterization methods including SEM and XRD were processed on these nanomaterials.Isotropical conductive adhesives(ICA) were developed by using these Ag nanomaterials as conductive fillers.It was found that the conductivity and thermal conductivity percolation threshold of the ICA depended on the morphologies of the fillers,lower percolation threshold could be obtained by using higher aspect ratio filler.A modified percolation threshold theory was put forward to explain and simulate the experiment results,the simulated results could match the experiment results very well. | TAO Yu YANG ZhenGuo LU XiaoLu TAO GuoLiang XIA YanPing WU HaiPing | 2012 | Science China(Technological Sciences)2012，55，1： | 4 |
| 11 | Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis显示文摘Disturbance of macrophage-associated lipid metabolism plays a key role in atherosclerosis.Crosstalk between autophagy deficiency and inflammation response in foam cells(FCs) through epigenetic regulation is still poorly understood. Here, we demonstrate that in macrophages, oxidized lowdensity lipoprotein(ox-LDL) leads to abnormal crosstalk between autophagy and inflammation,thereby causing aberrant lipid metabolism mediated through a dysfunctional transcription factor EB (TFEB)-P300-bromodomain-containing protein 4(BRD4) axis. ox-LDL led to macrophage autophagy deficiency along with TFEB cytoplasmic accumulation and increased reactive oxygen species generation. This activated P300 promoted BRD4 binding on the promoter regions of inflammatory genes, consequently contributing to inflammation with atherogenesis. Particularly, ox-LDL activated BRD4-dependent super-enhancer associated with liquid-liquid phase separation(LLPS) on the regulatory regions of inflammatory genes. Curcumin(Cur) prominently restored FCs autophagy by promoting TFEB nuclear translocation, optimizing lipid catabolism, and reducing inflammation. The consequences of P300 and BRD4 on super-enhancer formation and inflammatory response in FCs could be prevented by Cur. Furthermore, the anti-atherogenesis effect of Cur was inhibited by macrophage-specific Brd4 overexpression or Tfeb knock-out in Apoe knock-out mice via bone marrow transplantation. The findings identify a novel TFEB-P300-BRD4 axis and establish a new epigenetic paradigm by which Cur regulates autophagy, inhibits inflammation, and decreases lipid content. | Xuesong Li Ruigong Zhu Hong Jiang Quanwen Yin Jiaming Gu Jiajing Chen Xian Ji Xuan Wu Haiping Fu Hui Wang Xin Tang Yuanqing Gao Bingjian Wang Yong Ji Hongshan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 12 | Pathological features of COVID-19-associated lung injury:a preliminary proteomics report based on clinical samples显示文摘The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality.However,the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unknown.To characterize molecular mechanisms underlying COVID-19 pathogenesis in the lung tissue using a proteomic approach,fresh lung tissues were obtained from newly deceased patients with COVID-19 pneumonia.After virus inactivation,a quantitative proteomic approach combined with bioinformatics analysis was used to detect proteomic changes in the SARS-CoV-2-infected lung tissues.We identified significant differentially expressed proteins involved in a variety of fundamental biological processes including cellular metabolism,blood coagulation,immune response,angiogenesis,and cell microenvironment regulation.Several inflammatory factors were upregulated,which was possibly caused by the activation of NF-κB signaling.Extensive dysregulation of the lung proteome in response to SARS-CoV-2 infection was discovered.Our results systematically outlined the molecular pathological features in terms of the lung response to SARS-CoV-2 infection,and provided the scientific basis for the therapeutic target that is urgently needed to control the COVID-19 pandemic. | Ling Leng Ruiyuan Cao Jie Ma Danlei Mou Yunping Zhu Wei Li Luye Lv Dunqin Gao Shikun Zhang Feng Gong Lei Zhao Bintao Qiu Haiping Xiang Zhongjie Hu Yingmei Feng Yan Dai Jiang Zhao Zhihong Wu Hongjun Li Wu Zhong | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 13 | Leveraging proficiency and preference for online Karaoke recommendation显示文摘Recently,many online Karaoke(KTV)platforms have been released,where music lovers sing songs on these platforms.In the meantime,the system automatically evaluates user proficiency according to their singing behavior.Recommending approximate songs to users can initialize singers5 participation and improve users,loyalty to these platforms.However,this is not an easy task due to the unique characteristics of these platforms.First,since users may be not achieving high scores evaluated by the system on their favorite songs,how to balance user preferences with user proficiency on singing for song recommendation is still open.Second,the sparsity of the user-song interaction behavior may greatly impact the recommendation task.To solve the above two challenges,in this paper,we propose an informationfused song recommendation model by considering the unique characteristics of the singing data.Specifically,we first devise a pseudo-rating matrix by combing users’singing behavior and the system evaluations,thus users'preferences and proficiency are leveraged.Then we mitigate the data sparsity problem by fusing users*and songs'rich information in the matrix factorization process of the pseudo-rating matrix.Finally,extensive experimental results on a real-world dataset show the effectiveness of our proposed model. | Ming HE Hao GUO Guangyi LV Le WU Yong GE Enhong CHEN Haiping MA | 2020 | Frontiers of Computer Science2020，14，2： | 3 |
| 14 | Overexpression of SIRT3 disrupts mitochondrial proteostasis and cell cycle progression显示文摘 | Xiaofei Wang Haiping Tang Yuling Chen Binghuan Chi Shiyu Wang Yang Lv Di WU Renshan Ge Haiteng Deng | 2016 | Protein & Cell2016，7，4： | 3 |
| 15 | Precise robust motion control of cell puncture mechanism driven by piezoelectric actuators with fractional-order nonsingular terminal slidingmode control显示文摘A novel robust controller is proposed in this study to realize the precise motion control of a cell puncture mechanism(CPM)driven by piezoelectric ceramics(PEAs).The entire dynamic model of CPM is constructed based on the Bouc–Wen model,and the nonlinear part of the dynamic model is optimized locally to facilitate the construction of a robust controller.A model-based,nonlinear robust controller is constructed using time-delay estimation(TDE)and fractional-order nonsingular terminal sliding mode(FONTSM).The proposed controller does not require prior knowledge of unknown disturbances due to its real-time online estimation and compensation of unknown terms by using the TDE technology.The controller also has finite-time convergence and high-precision trajectory tracking capabilities due to FONTSM manifold and fast terminal sliding mode-type reaching law.The stability of the closed-loop system is proved by Lyapunov stability theory.Computer simulation and hardware-in-loop simulation experiments of CPM verify that the proposed controller outperforms traditional terminal sliding mode controllers,such as the integer-order or model-free controller.The proposed controller can also continuously output without chattering and has high control accuracy.Zebrafish embryo is used as a verification target to complete the cell puncture experiment.From the engineering application perspective,the proposed control strategy can be effectively applied in a PEA-driven CPM. | Shengdong Yu Hongtao Wu Mingyang Xie Haiping Lin Jinyu Ma | 2020 | Bio-Design and Manufacturing2020，3，4： | 2 |
| 16 | Resid Contact Cracking and Coke Gasification Integrated Technology显示文摘In order to utilize petroleum resources efficiently and greenly,and solve the problems of high coke yield,highsulfur coke utilization,and environmental protection concerns in China’s refineries,a resid contact cracking and coke gasification integrated technology is being developed by the Research Institute of Petroleum Processing(RIPP).Based on the three technical characteristics including thin films cracking,partial oxidation,and rapid cracking,this technology not only can reduce the production rate of coke and dry gas formed during the process,but also can increase the liquid yield.Moreover,the in-situ low-temperature gasification technology is used to solve the clean utilization of high-sulfur petroleum coke,which can play the role of“Utility Island”and is a green and low-carbon technology for low-quality heavy oil upgrading. | Li Yanjun Zhang Shuhong Ren Lei Shen Haiping Wu Lei Wang Xieqing | 2021 | China Petroleum Processing & Petrochemical Technology2021，23，1： | 2 |
| 17 | p38α MAP kinase phosphorylates RCAN1 and regulates its interaction with calcineurin显示文摘RCAN1,also known as DSCR1,is an endogenous regulator of calcineurin,a serine/threonine protein phosphatase that plays a critical role in many physiological processes.In this report,we demonstrate that p38 MAP kinase can phosphorylate RCAN1 at multiple sites in vitro and show that phospho-RCAN1 is a good protein substrate for calcineurin.In addition,we found that unphosphorylated RCAN1 noncompetitively inhibits calcineurin protein phosphatase activity and that the phosphorylation of RCAN1 by p38 MAP kinase decreases the binding affinity of RCAN1 for calcineurin.These findings reveal the molecular mechanism by which p38 MAP kinase regulates the function of RCAN1/calcineurin through phosphorylation. | MA Lei TANG HaiPing REN Yan DENG HaiTeng WU JiaWei WANG ZhiXin | 2012 | Science China(Life Sciences)2012，55，7： | 2 |
| 18 | Effects of greenness on preterm birth: A national longitudinal study of 3.7 million singleton births显示文摘Exposure to greenness may lead to a wide range of beneficial health outcomes.However,the effects of greenness on preterm birth(PTB)are inconsistent,and limited studies have focused on the subcategories of PTB.A total of 3,751,672 singleton births from a national birth cohort in China's Mainland were included in this study.Greenness was estimated using the satellitebased Normalized Difference Vegetation Index(NDVI)and Enhanced Vegetation Index with 500-m and 1,000-m buffers around participants’addresses.The subcategories of PTB(20-36 weeks)included extremely PTB(EPTB,20-27 weeks). | Lina Zhang Shuyan Shi Shenpeng Wu Ying Yang Jihong Xu Ya Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai Yan Zuoqi Peng Cong Liu Weidong Wang Yixuan Jiang Su Shi Renjie Chen Haidong Kan Yuan He Xia Meng Xu Ma | 2022 | The Innovation2022，3，3： | 2 |
| 19 | A Hybrid Neural Network Model for Marine Dissolved Oxygen Concentrations Time-Series Forecasting Based on Multi-Factor Analysis and a Multi-Model Ensemble显示文摘Dissolved oxygen(DO)is an important indicator of aquaculture,and its accurate forecasting can effectively improve the quality of aquatic products.In this paper,a new DO hybrid forecasting model is proposed that includes three stages:multi-factor analysis,adaptive decomposition,and an optimizationbased ensemble.First,considering the complex factors affecting DO,the grey relational(GR)degree method is used to screen out the environmental factors most closely related to DO.The consideration of multiple factors makes model fusion more effective.Second,the series of DO,water temperature,salinity,and oxygen saturation are decomposed adaptively into sub-series by means of the empirical wavelet transform(EWT)method.Then,five benchmark models are utilized to forecast the sub-series of EWT decomposition.The ensemble weights of these five sub-forecasting models are calculated by particle swarm optimization and gravitational search algorithm(PSOGSA).Finally,a multi-factor ensemble model for DO is obtained by weighted allocation.The performance of the proposed model is verified by timeseries data collected by the pacific islands ocean observing system(PacIOOS)from the WQB04 station at Hilo.The evaluation indicators involved in the experiment include the Nash–Sutcliffe efficiency(NSE),Kling–Gupta efficiency(KGE),mean absolute percent error(MAPE),standard deviation of error(SDE),and coefficient of determination(R^(2)).Example analysis demonstrates that:①The proposed model can obtain excellent DO forecasting results;②the proposed model is superior to other comparison models;and③the forecasting model can be used to analyze the trend of DO and enable managers to make better management decisions. | Hui Liu Rui Yang Zhu Duan Haiping Wu | 2021 | Engineering2021，7，12： | 2 |
| 20 | Compound Gaoziban tablet(复方高滋斑片) alleviates depression via toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B pathway显示文摘OBJECTIVE: To evaluate the effect of compound Gaoziban tablet(复方高滋斑片, CGZBT) on depression, and to investigate the underlying mechanism. METHODS: The components of CGZBT were analysed by high-performance liquid chromatography. Then, we assessed the effects of varying doses of CGZBT on an established chronic unpredictable mild stress(CUMS) model in rats. Whether animals were depressed was evaluated by sucrose preference test, open field test and forced swimming test. Neurotransmitters of hippocampus were detected by liquid chromatography-mass spectrometry. Serum levels of tumor necrosis factor-alpha(TNF-α), interleukin(IL)-1β, IL-6, IL-4, and IL-10 were measured by enzyme-linked immunosorbent assay. Expressions of toll-like receptor 4(TLR4), myeloid differentiation factor 88(My D88), phospho-nuclear factorkappa B(p-NF-κB), cyclooxygenase-2(COX-2), ionized calcium binding adapter molecule-1(IBA-1) were assessed by immunohistochemical staining and western blotting. RESULTS: Eight compounds were identified from CGZBT, moreover, our results showed that CGZBT effectively reversed the CUMS-induced decrease in sucrose preference, shortened the movement distance and prolonged immobility time. CGZBT significantly increased levels of 5-hydroxytryptamine, dopamine, norepinephrine, 5-hydroxyindoleacetic acid levels, and reduced the expression of TNF-α, IL-1β, IL-6, yet increased IL-4 and IL-10. Furthermore, the expressions of TLR4, My D88, COX-2, p-NF-κB and IBA-1 in hippocampus were effectively reversed after treatment with CGZBT. CONCLUSIONS: These results indicated that CGZBT could, at least in part, alleviate depression induced by CUMS via the TLR4/My D88/NF-κB pathway, suggesting its potential as an antidepressant drug. | ZOU Xinshuang SHI Lei YIN Hailong LI Haiping WANG Mengheng SONG Wanci LUO Laichun WU Hezhen YANG Yanfang ZAN Junfeng LIU Yanwen DAN Hanxiong YIN Qiang YOU Pengtao | 2022 | Journal of Traditional Chinese Medicine2022，42，6： | 2 |
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