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| 1 | A Rare Allele of GS2 Enhances Grain Size anc Grain Yield in Rice显示文摘谷物尺寸决定谷物重量并且影响谷物质量。调整谷物尺寸的几主要量的特点 loci (QTL ) 被克隆;然而,我们调整米饭谷物的尺寸的内在的机制的理解仍然保持碎片。这里,我们报导克隆和主导的 QTL 的描述,染色体 2 上的谷物尺寸(GS2 ) 编码调整生长的因素 4,一个 transcriptional 管理者。GS2 本地化到原子核并且可以充当抄写使活跃之物。影响 microRNA 的有约束力的地点的 GS2 的一个稀罕变化, OsmiR396c,原因提高了 GS2/OsGRF4 的表示。GS2 表示的增加导致更大的房间和房间的增加的数字,它因此提高谷物重量和产量。进米饭栽培变种的 GS2/OsGRF4 的这稀罕等位基因的介绍能显著地提高谷物重量和增加谷物产量,用在引起产量很高的米饭变化的可能的应用。 | Jiang Hu Yuexing Wang Yunxia Fang Longjun Zeng Jie Xu Haiping Yu Zhenyuan Shi Jiangjie Pan Dong Zhang Shujing Kang Li Zhu Guojun Dong Longbiao Guo Dali Zeng Guangheng Zhang Lihong Xie Guosheng Xiong Jiayang Li Qian Qian | 2015 | Molecular Plant2015，8，10： | 57 |
| 2 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 3 | Comprehensive analysis of NAC domain transcription factor gene family in Vitis vinifera显示文摘 | Nian Wang Yu Zheng Haiping Xin Linchuan Fang Shaohua Li | 2013 | Plant Cell Reports2013，，1： | 4 |
| 4 | The pleiotropic ABNORMAL FLOWER AND DWARF1 affects plant height, floral development and grain yield in rice显示文摘Moderate plant height and successful establishment of reproductive organs play pivotal roles in rice grain production. The molecular mechanism that controls the two aspects remains unclear in rice. In the present study,we characterized a rice gene, ABNORMAL FLOWER AND DWARF1(AFD1) that determined plant height, floral development and grain yield. The afd1 mutant showed variable defects including the dwarfism, long panicle, low seed setting and reduced grain yield. In addition, abnormal floral organs were also observed in the afd1 mutant including slender and thick hulls, and hull-like lodicules.AFD1 encoded a DUF640 domain protein and was expressed in all tested tissues and organs. Subcellular localization showed AFD1-green fluorescent fusion protein(GFP) was localized in the nucleus. Meantime, our results suggested that AFD1 regulated the expression of cell division and expansion related genes. | Deyong Ren Yuchun Rao Liwen Wu Qiankun Xu Zizhuang Li Haiping Yu Yu Zhang Yujia Leng Jiang Hu Li Zhu Zhenyu Gao Guojun Dong Guangheng Zhang Longbiao Guo Dali Zeng Qian Qian | 2016 | Journal of Integrative Plant Biology2016，58，6： | 4 |
| 5 | Influence of filler morphology on percolation threshold of isotropical conductive adhesives (ICA)显示文摘Different aspect ratio silver nano-structured materials including nanocubes,nanorods and nanowires were prepared by micro-waved assisted glycol reduction method.Different characterization methods including SEM and XRD were processed on these nanomaterials.Isotropical conductive adhesives(ICA) were developed by using these Ag nanomaterials as conductive fillers.It was found that the conductivity and thermal conductivity percolation threshold of the ICA depended on the morphologies of the fillers,lower percolation threshold could be obtained by using higher aspect ratio filler.A modified percolation threshold theory was put forward to explain and simulate the experiment results,the simulated results could match the experiment results very well. | TAO Yu YANG ZhenGuo LU XiaoLu TAO GuoLiang XIA YanPing WU HaiPing | 2012 | Science China(Technological Sciences)2012，55，1： | 4 |
| 6 | A parallel and robust object tracking approach synthesizing adaptive Bayesian learning and improved incremental subspace learning显示文摘This paper presents a novel tracking algorithm which integrates two complementary trackers. Firstly, an improved Bayesian tracker(B-tracker) with adaptive learning rate is presented. The classification score of B-tracker reflects tracking reliability, and a low score usually results from large appearance change. Therefore, if the score is low, we decrease the learning rate to update the classifier fast so that B-tracker can adapt to the variation and vice versa. In this way, B-tracker is more suitable than its traditional version to solve appearance change problem. Secondly, we present an improved incremental subspace learning method tracker(Stracker). We propose to calculate projected coordinates using maximum posterior probability, which results in a more accurate reconstruction error than traditional subspace learning tracker. Instead of updating at every time, we present a stopstrategy to deal with occlusion problem. Finally, we present an integrated framework(BAST), in which the pair of trackers run in parallel and return two candidate target states separately. For each candidate state, we define a tracking reliability metrics to measure whether the candidate state is reliable or not, and the reliable candidate state will be chosen as the target state at the end of each frame. Experimental results on challenging sequences show that the proposed approach is very robust and effective in comparison to the state-of-the-art trackers. | Kang LI Fazhi HE Haiping YU Xiao CHEN | 2019 | Frontiers of Computer Science2019，13，5： | 3 |
| 7 | MULTI-TILLERING DWARF1, a new allele of BRITTLE CULM 12, affects plant height and tiller in rice显示文摘Plant height and tillering are crucial factors determining rice plant architecture and influencing rice grain production. In this study, multi-tillering dwarf1(mtd1), a stable multi-tiller and dwarf mutant, was screened from the ethylmethane sulfonate-treated japonica rice variety Wuyunging7. Compared with the wild type, mtd1 mutant exhibited pleiotropic phenotypes, including dwarfism, more tillers, brittle culms and delayed heading date.By employing map-based cloning strategy, the gene MTD1 was finally mapped to an approximately 66-kb region on the short arm of chromosome 9. Sequencing results showed that the gene LOC_Os09g02650(BC12) in mtd1 mutant had a single nucleotide substitution(G to A), which generated a premature translation stop. Over-expressing MTD1/BC12 coding sequence rescued all the phenotypes of mtd1 mutants including plant height and tillers, which confirms that BC12 is the mutated gene in mtd1 mutant.Quantitative reverse transcription-PCR analysis showed that MTD1/BC12 could negatively regulate the expression of MONOCULM 1, IDEAL PLANT ARCHITECTURE1 and Tillering and Dwarf 1, and control rice tillering. Remarkably, a-amylase activity analysis and gibberellic acid(GA)treatment showed that the dwarf phenotype of mtd1 mutant was dependent on GA biosynthesis pathway. These results facilitated to further uncover the molecular mechanism of the growth and development in rice. | Haiping Yu Deyong Ren Yangzhou Zhu Jiangmin Xu Yuexing Wang Ruifang Liu Yunxia Fang Zhenyuan Shi Jiangjie Pan Mei Lu Bojun Ma Jiang Hu Yuchun Rao | 2016 | Science Bulletin2016，61，23： | 3 |
| 8 | Effects of temperature on the mechanical properties of Ti6Al4V powder compacts prepared by magnetic pulse compaction显示文摘The effects of temperature (0-500°C) on the compressive strength,hardness,average relative density,and microstructure of Ti6Al4V powder green compacts prepared by magnetic pulse compaction were investigated.The results show that with increasing heating temperature,the compressive strength first increases and then decreases with the maximum value of 976.74 MPa at 400°C.The average relative density and hardness constantly increase,and their values reach 96.11% and HRA 69.8 at 500°C,respectively.The increase of partial welding is found among the junctions of particles inside the compacts;there is no obvious grain growth inside the compacts within the temperature range. | LI Mini YU Haiping LI Chunfeng | 2010 | Rare Metals2010，29，3： | 3 |
| 9 | A correlative denoising autoencoder to model social influence for top-N recommender system显示文摘In recent years,there are numerous works been proposed to leverage the techniques of deep learning to improve social-aware recommendation performance.In most cases,it requires a larger number of data to train a robust deep learning model,which contains a lot of parameters to fit training data.However,both data of user ratings and social networks are facing critical sparse problem,which makes it not easy to train a robust deep neural network model.Towards this problem,we propose a novel correlative denoising autoencoder(CoDAE)method by taking correlations between users with multiple roles into account to learn robust representations from sparse inputs of ratings and social networks for recommendation.We develop the CoDAE model by utilizing three separated autoencoders to learn user features with roles of rater,truster and trustee,respectively.Especially,on account of that each input unit of user vectors with roles of truster and trustee is corresponding to a particular user,we propose to utilize shared parameters to learn common information of the units that corresponding to same users.Moreover,we propose a related regularization term to learn correlations between user features that learnt by the three subnetworks of CoDAE model.We further conduct a series of experiments to evaluate the proposed method on two public datasets for Top-N recommendation task.The experimental results demonstrate that the proposed model outperforms state-of-the-art algorithms on rank-sensitive metrics of MAP and NDCG. | Yiteng PAN Fazhi HE Haiping YU | 2020 | Frontiers of Computer Science2020，14，3： | 3 |
| 10 | Identification and characterization of Mini1, a gene regulating rice shoot development显示文摘The aerial parts of higher plants are generated from the shoot apical meristem(SAM). In this study, we isolated a small rice(Oryza sativa L.) mutant that showed premature termination of shoot development and was named mini rice 1(mini1). The mutant was first isolated from a japonica cultivar Zhonghua11(ZH11) subjected to ethyl methanesulfonate(EMS)treatment. With bulked segregant analysis(BSA) and map-based cloning method, Mini1 gene was finally fine-mapped to an interval of 48.6 kb on chromosome 9. Sequence analyses revealed a single base substitution from G to A was found in the region, which resulted in an amino acid change from Gly to Asp.The candidate gene Os09g0363900 was predicted to encode a putative adhesion of calyx edges protein ACE(putative HOTHEAD precursor) and genetic complementation experiment confirmed the identity of Mini1. Os09g0363900 contains glucose-methanol-choline(GMC) oxidoreductase and NAD(P)-binding Rossmann-like domain, and exhibits high similarity to Arabidopsis HOTHEAD(HTH). Expression analysis indicated Mini1 was highly expressed in young shoots but lowly in roots and the expression level of most genes involved in auxin biosynthesis and signal transduction were reduced in mutant.We conclude that Mini1 plays an important role in maintaining SAM activity and promoting shoot development in rice. | Yunxia Fang Jiang Hu Jie Xu Haiping Yu Zhenyuan Shi Guosheng Xiong Li Zhu Dali Zeng Guangheng Zhang Zhenyu Gao Guojun Dong Meixian Yan Longbiao Guo Yonghong Wang Qian Qian | 2015 | Journal of Integrative Plant Biology2015，57，2： | 3 |
| 11 | Sinorhizobium meliloti nifA gene exerts a pleiotropic effect on nodulation through the enhanced plant defense response显示文摘Sinorhizobium meliloti nifA gene is required for the expression of a bunch of nif and fix genes. Here, we report its pleiotropic effects on the nodule formation. Compared with wild type strain, nifA mutant sig- nificantly reduced nodule suppression rate in split-root system. The plants inoculated with mutant strain produced lower amount of daidzein and less necrotic cells on their roots. In addition, the defense genes failed to be evoked by nifA mutant at the early nodulation stage. These findings indicated that host defense response was one of the mechanisms mediated by nifA gene to regulate nodule formation during symbiosis. Even though nifA mutant could increase the number of nodules in host plant, it synthesized lower Nod factors than wild type. This suggested that nifA gene mediated multiple and diverse instances in nodulation formation. | CHEN XiaoTao ZOU HuaSong YAO ZhenHua CHENG HaiPing DAI XiaoMi ZHU JiaBi YU GuanQiao | 2007 | Chinese Science Bulletin2007，52，21： | 2 |
| 12 | Precise robust motion control of cell puncture mechanism driven by piezoelectric actuators with fractional-order nonsingular terminal slidingmode control显示文摘A novel robust controller is proposed in this study to realize the precise motion control of a cell puncture mechanism(CPM)driven by piezoelectric ceramics(PEAs).The entire dynamic model of CPM is constructed based on the Bouc–Wen model,and the nonlinear part of the dynamic model is optimized locally to facilitate the construction of a robust controller.A model-based,nonlinear robust controller is constructed using time-delay estimation(TDE)and fractional-order nonsingular terminal sliding mode(FONTSM).The proposed controller does not require prior knowledge of unknown disturbances due to its real-time online estimation and compensation of unknown terms by using the TDE technology.The controller also has finite-time convergence and high-precision trajectory tracking capabilities due to FONTSM manifold and fast terminal sliding mode-type reaching law.The stability of the closed-loop system is proved by Lyapunov stability theory.Computer simulation and hardware-in-loop simulation experiments of CPM verify that the proposed controller outperforms traditional terminal sliding mode controllers,such as the integer-order or model-free controller.The proposed controller can also continuously output without chattering and has high control accuracy.Zebrafish embryo is used as a verification target to complete the cell puncture experiment.From the engineering application perspective,the proposed control strategy can be effectively applied in a PEA-driven CPM. | Shengdong Yu Hongtao Wu Mingyang Xie Haiping Lin Jinyu Ma | 2020 | Bio-Design and Manufacturing2020，3，4： | 2 |
| 13 | Numerical Simulation of Magnetic Pressure in Tube-electromagnetic Bulging with Die显示文摘Calculation of magnetic pressure is the basis of application of electromagnetic forming (EMF). This paper carries out a numerical simulation of magnetic pressure under the influence of die by means of finite element method. The analysis model of electromagnetic bulging with die is created by using ANSYS, and the distribution of magnetic pressure acting on the tube and the die is obtained. The differences between EMF and other technologies and the effect of die on tube formability are analyzed. The die has important influence upon the calculation accuracy. The simulating conclusions with different discharge energy and current frequency are verified through the technologic tests. The distribution of magnetic pressure acting on the tube agrees well with the measurements of the deformed tube. | Hongwei JIANG Chunfeng LI Haiping YU Zhiheng ZHAO | 2003 | Journal of Materials Science & Technology2003，19，z1： | 2 |
| 14 | Mechanical property and microstructure of aluminum alloy-steel tubes joint by magnetic pulse welding显示文摘 | Haiping Yu Zhidan Xu Zhisong Fan Zhixue Zhao Chunfeng Li | 2013 | Materials Science & Engineering A2013，，： | 2 |
| 15 | Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke显示文摘Stroke is the second leading cause of death and long-term disability worldwide,which lacks effective treatment.Perioperative stroke is associated with much higher rates of mortality and disability.The neuroprotective role of dexmedetomidine(Dex),a highly selective agonist of alpha2-adrenergic receptor,has been reported in a stroke rat model,and it was found that pretreatment of Dex before stroke could alleviate blood–brain barrier(BBB)breakdown.However,the underlying mechanisms are still unknown.As the brain endothelial cells are the main constituents of BBB and in high demand of energy,mitochondrial function of endothelial cells plays an important role in the maintenance of BBB.Given that dynamin-related protein 1(Drp1)is a protein mediating mitochondrial fission,with mitochondrial fusion that balances mitochondrial morphology and ensures mitochondria function,the present study was designed to investigate the possible role of Drp1 in endothelial cells involved in the neuroprotective effects of Dex in ischemic stroke.Our results showed that preconditioning with Dex reduced infarction volume,alleviated brain water content and BBB damage,and improved neurological scores in middle cerebral artery occlusion rats.Meanwhile,Dex enhanced cell activity and decreased cell apoptosis in oxygen-glucose deprivation human brain microvascular endothelial cells in vitro.These protective effects of Dex were correlated with the mitochondrial morphology integrality of endothelial cells,mediated by increased phosphorylation of serine 637 in Drp1,and could be reversed byα2-adrenergic receptor antagonist Yohimbine and AMP-activated protein kinase inhibitor Compound C.These findings suggest new molecular pathways involved in the neuroprotective effects of Dex in ischemic stroke.As Dex is routinely used as a sedative drug clinically,our findings provide molecular evidence that it has perioperative neuroprotection from ischemic stroke. | Wei Zhou Yunchun Zhang Yingfu Jiao Wen Yin Haiping Dong Saihong Xu Dan Tang Junli Jiang Jianlin Shao Zhenhong Wang Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，9： | 2 |
| 16 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 17 | Population control of the yellow-spined bamboo locust,Ceracris kiangsu,using urine-borne chemical baits in bamboo forest显示文摘 | YU Haiping SHEN Ke WANG Zhitian | 2011 | Entomologia Experimentalis et Applicata2011，138，1： | 1 |
| 18 | High-metallic-phase-concentration MO1-xWxS2 nanosheets with expanded interlayers as efficient electrocatalysts显示文摘 | Qun He Yangyang Wan Hongliang Jiang Chuanqiang Wu Zhongti Sun Shuangming Chen Yu Zhou Haiping Chen Daobin Liu Yasir A. Haleem Binghui Ge Xiaojun Wu Li Song | 2018 | Nano Research2018，11，3： | 1 |
| 19 | Hygropreference behaviour and humidity detection in the yellow-spined bamboo locust,Ceracris kiangsu显示文摘 | YU Haiping XIAO Kai MU Lili | 2010 | Physiological Entomology2010，35，4： | 1 |
| 20 | Magnetic pressure in electromagnetic aluminum tubecompression forming显示文摘 | YU Haiping LI Chunfeng ZHAO Zhiheng | | 0，，： | 1 |
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