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| 1 | Two Comparable Earthquakes Produced Greatly Different Coseismic Landslides:The 2015 Gorkha,Nepal and 2008 Wenchuan,China Events显示文摘The 2015 Gorkha Earthquake in Nepal and the 2008 Wenchuan Earthquake in China occurred at the south and southeast margins of the Tibetan Plateau, respectively. Both earthquakes had similar magnitudes of Mw 7.8 and 7.9, caused catastrophic loss of life and damage to property, and generated tens of thousands of landslides. Comparisons of pre- and post-quake satellite images supported by field investigations show that the Gorkha Earthquake triggered at least 2 064 large landslides(defined as covering an area ≥10 000 m^2) over a ~35 600 km^2 region with a volume of(444–584)×10~6(average 509×10~6) m^3 and total area of 44.78×10~6 m^2. In contrast, the Wenchuan Earthquake triggered 25 580 large landslides over a region of ~44 000 km^2 with a volume of(7 128–9 479)×10~6(average 8 219×10~6) m^3 and a total area of about 670.65×10~6 m^2. Several controlling factors including topographic relief, slope steepness, and regional peak ground acceleration(PGA) were investigated to try to explain the great differences between the number, volume and area of the coseismic landslides associated with the two similar earthquakes. We found that the differences primarily arose from an unexpected factor, the dip angle of the seismogenic fault. This discovery should aid understanding the failure mechanisms of quake-triggered landslides, and suggests that more factors should be taken into consideration in estimating coseismic landslide volumes from earthquake magnitudes. | Chong Xu Xiwei Xu Yingying Tian Lingling Shen Qi Yao Xueqiang Huang Junxue Ma Xi Chen Siyuan Ma | 2016 | Journal of Earth Science2016，27，6： | 14 |
| 2 | Fabrication of organically modified oxygen sensing film based on fluorescent quenching显示文摘An organically modified silicate (ORMOSIL) as a matrix for oxygen-sensitive sensor, in which di-methyldimethoxysilane was selected as an organic modifier in the precursor, is described. The sensing film with tris-(4,7-diphenyl-1,10-phenanthroline) ruthenium(II) as an indicator developed in this paper was characterized by efficient quenching by oxygen. Blue light-emitting diodes (λmax = 475 nm) were employed as light excitation source. The linear range of the dissolved oxygen was from 0.5 to 16 μg/mL. The measured RSD was 2%, the response time (t95) was 60 s, and the determination limit was 0.2 μg/mL. A portable and inexpensive luminescence-based sensor was established and applied to the determina-tion of dissolved oxygen in the surface water. | XIN LingLing XIAO LaiLong ZHAO Li CHEN Xi WANG XiaoRu | 2007 | Chinese Science Bulletin2007，52，2： | 4 |
| 3 | 冷冻干燥更适合土壤活性氮气体(HONO和NO)排放的研究?显示文摘土壤活性氮气体(HONO和NO)排放是全球氮循环的关键过程,对大气化学具有重要意义。本研究采集了农田,草地和森林三种不同土地利用类型的土壤样品,分别对样品进行了风干,冻干和烘干三种处理,并与未处理的新鲜土壤进行比较研究。结果表明,三种类型土壤的冻干土与新鲜土样品的p H值差异最小。总的来说,三种干燥处理都能提高新鲜土壤NH4+-N, NO3--N和溶解态有机N的含量。与新鲜土壤相比,冻干土壤HONO和NO的最大排放通量及完整干湿交替循环的总排放量没有显著增加,而风干和烘干土壤显著增加。因此,冷冻干燥方法可能更适合涉及土壤活性氮气体排放通量的研究。这一发现的重要启示是,我们需要慎重评价以往基于不同干燥方法得到的有关陆地–大气界面活性氮交换过程和生物地球化学氮循环机制的认识。 | WU Dianming DENG Lingling LIU Yanzhuo XI Di ZOU Huilan WANG Ruhai SHA Zhimin PAN Yuepeng HOU Lijun LIU Min | 2020 | Atmospheric and Oceanic Science Letters2020，13，3： | 3 |
| 4 | UPLC-MS metabolomics provides insights into the diff erences between black- and white-shelled Pacifi c oysters Crassostrea gigas显示文摘A variety of shell colors are one of the most fundamental characteristics of molluscs,which have importantly ecological and economic signifi cance.The Pacifi c oyster Crassostrea gigas is distributed in many sea areas around the world and also an aquacultured mollusc with high nutritional value.In this study,the whole soft body and the mantle tissue of black-shelled Pacifi c oyster(BSO)and white-shelled Pacifi c oyster(WSO)with starkly diff erent melanin contents were compared,and the diff erences in physiology and metabolism between BSO and WSO were analyzed.The results of physiological indicators suggested BSO show more melanin,more dry matter,more crude lipid content,and stronger ability to scavenge free radicals than WSO.The altered metabolites of glycerophospholipids,fatty acyls,and steroids revealed diff erent regulatory mechanisms of lipids.The correlation analysis of metabolomics and previously published RNAseq data suggested that BSO and WSO mainly diff ered in the basal metabolic processes,such as lipid,amino acid and purine metabolisms.This study provides insights into the changes in the physiological indictors and the metabolites of oysters with varying melanin content. | Xi CHEN Qiuyun JIANG Hongce SONG Lingling LI Chaoyi XIE Baoyu HUANG Yaqiong LIU Meiwei ZHANG Lei WEI Xiaotong WANG | 2021 | Journal of Oceanology and Limnology2021，39，1： | 2 |
| 5 | Dynamic features of near-inertial oscillations in the Northwestern Pacific derived from mooring observations from^2015 to 2018显示文摘Near-inertial oscillation is an important physical process transferring surface wind energy into deep ocean.We investigated the near-inertial kinetic energy(NIKE)variability using acoustic Doppler current profiler measurements from a mooring array deployed in the tropical western Pacific Ocean along 130°E at 8.5°N,11°N,12.6°N,15°N,and 17.5°N from September 2015 to January 2018.Spatial features,decay timescales,and significant seasonal variability of the observed NIKE were described.At the mooring sites of 17.5°N,15°N,and 12.6°N,the NIKE peaks occurred in boreal autumn and the NIKE troughs were observed in boreal spring.By contrast,the NIKE at 11°N and 8.5°N showed peaks in winter and troughs in summer.Tropical cyclones and strong wind events played an important role in the emergence of high-NIKE events and explained the seasonality and latitudinal characteristics of the observed NIKE. | HU Shijian LIU Lingling GUAN Cong ZHANG Linlin WANG Jianing WANG Qingye MA Jie WANG Fujun JIA Fan FENG Junqiao LU Xi WANG Fan HU Dunxin | 2020 | Journal of Oceanology and Limnology2020，38，4： | 2 |
| 6 | HOW DO THE RATES OF HALOPHILIC ATTACKS COMPARE WITH THE RATES OF PROTOPHILIC ATTACKS?显示文摘The measured relative rates of halophilic and protophilic attacks (k_X/k_H) indicate that the rates of halophilic attacks are comparable in magnitude to those of protophilic attacks (deprotonations). | Xing Ya LI, Ming. Hu TU and Xi Kui JIANG~* Shanghai Institute of Organic Chemistry, Academia Sinica, 345 Lingling Lu, Shanghai 200032 | 1993 | Chinese Chemical Letters1993，4，5： | 2 |
| 7 | Engineering tailorable TiO_(2) nanotubes for NIR-controlled drug delivery显示文摘Infectious diseases caused by bacteria are a global threat to the human health. Here, we propose a solvent “irrigation” technique to endow TiO_(2) nanotubes (NTs) to precisely modify with functional nanomaterials, and apply them in constructing a near-infrared (NIR) light controlled drug-delivery system for rapid necrosis of bacteria. In this design, the NIR stimuli-responsive functional shell is located on the external tube wall of TiO_(2) NT;the internal tube wall offers sufficient binding sites for drug loading. Using kanamycin as a model drug, we demonstrate that the reactive oxygen species generated in photocatalysis not only controllably release the loaded drug by scissoring the linked chains, but also effectively compromise bacteria membrane integrity by damaging the cell wall. Benefiting from the damages, antibiotics rapidly enter the bacteria and reach ≥99.9% reduction in Escherichia coli colony within only 2 h. Importantly, such a covalently conjugation-based delivery system can efficiently relieve radical-induced inflammation and cytotoxicity. This study provides an innovative design strategy for engineering delivery systems with tailorable components, enduring stimuli-response by multiple triggers. | Yue Xu Chenxi Zhao Xi Zhang Jingwen Xu Lingling Yang Zhechen Zhang Zhida Gao Yan-Yan Song | 2021 | Nano Research2021，14，11： | 1 |
| 8 | Analysis of social vulnerability to hazards in China显示文摘 | Yi Lixin Zhang Xi Ge Lingling Zhao Dong | 2014 | Environmental Earth Sciences2014，，7： | 1 |
| 9 | Electrocatalytic oxidation of ascorbic acid on quaternized carbon nanotubes/ionic liquid-polyaniline composite film modified glassy carbon electrode显示文摘 | Xi Lingling Zhu Zuoyi Wang Fengli | 2013 | Journal of the Electrochemical Society2013，160，6： | 1 |
| 10 | Ion-exchange chromatography combined with direct current amperometric detection at CuNPs/reduced graphene oxide–chitosan composite film modified electrode for determination of monosaccharide composition of polysaccharides from Phellinus igniarius显示文摘 | Lingling Xi Fengli Wang Zuoyi Zhu Zhongping Huang Yan Zhu | 2014 | Talanta2014，，： | 1 |
| 11 | Milk-derived exosomes exhibit versatile effects for improved oral drug delivery显示文摘As endogenous courier vesicles,exosomes play crucial roles in macromolecule transmission and intercellular communication.Therefore,exosomes have drawn increasing attention as biomimetic drug-delivery vehicles over the past few years.However,few studies have investigated the encapsulation of peptide/protein drugs into exosomes for oral administration.Additionally,the mechanisms underlying their biomimetic properties as oral delivery vehicles remain unknown.Herein,insulin-loaded milk-derived exosomes(EXO@INS)were fabricated and the in vivo hypoglycemic effect was investigated on type I diabetic rats.Surprisingly,EXO@INS(50 and 30 IU/kg)elicited a more superior and more sustained hypoglycemic effect compared with that obtained with subcutaneously injected insulin.Further mechanism studies indicated that the origin of excellent oral-performance of milk-derived exosomes combined active multi-targeting uptake,pH adaptation during gastrointestinal transit,nutrient assimilation related ERK1/2 and p38 MAPK signal pathway activation and intestinal mucus penetration.This study provides the first demonstration that multifunctional milk-derived exosomes offer solutions to many of the challenges arising from oral drug delivery and thus provide new insights into developing naturally-equipped nanovehicles for oral drug administration. | Lei Wu Lingling Wang Xi Liu Yuli Bai Ruinan Wu Xiang Li Yutong Mao Ling Zhang Yongxiang Zheng Tao Gong Zhirong Zhang Yuan Huang | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 1 |
| 12 | Determination of phenols with ion chromatography- on- line electrochemical derivatization based on porous elec- trode-fluorescence detection 显示文摘 | WU Shuchao YANG Bingcheng XI Lingling | 2012 | Journal of Chromatog- raphy A2012，1229，： | 1 |
| 13 | Simultaneous determination of glucose, d -gluconic, 2-keto- d -gluconic and 5-keto- d -gluconic acids by ion chromatography-pulsed amperometric detection with column-switching technique显示文摘 | Zuoyi Zhu Lingling Xi Qamar Subhani Zhongping Huang Yan Zhu | 2013 | Talanta2013，，： | 1 |
| 14 | Milk-derived exosomes as a promising vehicle for oral delivery of hydrophilic biomacromolecule drugs显示文摘Exosomes,as promising vehicles,have been widely used in the research of oral drug delivery,but the generally low drug loading efficiency of exosomes seriously limits its application and transformation.In this study,we systematically investigated the effects of drug loading methods and physicochemical properties(lipophilicity and molecular weight)on drug loading efficiency of milk-derived exosomes to explore the most appropriate loading conditions.Our finding revealed that the drug loading efficiency of exosomes was closely related to the drug loading method,drug lipophilicity,drug molecular weight and exosome/drug proportions.Of note,we demonstrated the universality that hydrophilic biomacromolecule drugs were the most appropriate loading drugs for milk-derived exosomes,which was attributed to the efficient loading capacity and sustained release behavior.Furthermore,milk-derived exosomes could significantly improve the transepithelial transport and oral bioavailability of model hydrophilic biomacromolecule drugs(octreotide,exendin-4 and salmon calcitonin).Collectively,our results suggested that the encapsulation of hydrophilic biomacromolecule drugs might be the most promising direction for milk exosomes as oral drug delivery vehicles. | Yuting Li Liyun Xing Lingling Wang Xi Liu Licheng Wu Mingjie Ni Zhou Zhou Lian Li Xiuxiu Liu Yuan Huang | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，2： | 1 |
| 15 | Electromagnetic Radiation Mechanism Analysis and Field Strength Prediction of an Elementary Digital Inverter with Cables显示文摘In this paper,common mode(CM)and differential mode(DM)far-field radiation models of a typical digital inverter with cables are built up to predict electromagnetic field strength and analyze field characteristics.The CM current model and its analyses are based on the imbalance difference method.It is found out that the voltage between the drain and the source electrodes of upper transistor is the key equivalent source of electromagnetic interference(EMI).Far-field radiation strength of the digital inverter in free space is predicted by using the asymmetrical antenna radiation method and current loop radiation method.The accuracy of these methods is verified by the CST electromagnetic simulation results in the frequency range from 1 MHz to 400 MHz.Furthermore,the radiation models are improved by using the mirror method,which enables to include the reflection effect of the metal ground plane at the electromagnetic compatibility(EMC)test site.Both the results of measurements in a semi-anechoic chamber and the simulation results confirm the proposed electromagnetic radiation prediction method. | Junping He Xin Li Sili Tao Lingling Cao Xi Wang | 2022 | Chinese Journal of Electrical Engineering2022，8，3： | 0 |
| 16 | SAMARIUM DIIODIDE INDUCED OF PHOSPHORYL ALLYLIC CATIONS显示文摘The reaction of phosphoryl π-allylic palladium species with aldehydes or ketonesin the presence of samarium diiodide was carefully studied. | Sheng Ming MA Xi Yan LU Shanghai Institute of Organic Chemistry,Academia Sinica 345 Lingling Lu,Shanghai 200032 | 1991 | Chinese Chemical Letters1991，2，9： | 0 |
| 17 | Spherical cationic polymer networks with porphyrin photosensitizer for sustainable and efficient photocatalysis显示文摘The continuous and sustainable photo-activity on micro-or nano-carriers has always been a key stepping stone in the industrialization of photo-catalysis,photo-synthesis,and photo-degradation.Herein,we report a new series of positively charged hollow microspheres carrying porphyrin moieties.Such hollow spheres are formed through crosslinking of well-ordered porous thin laminates,initiated by co-assembly of regular monomers and those decorated with porphyrin moieties.On the surface of an individual sphere,densely distributed positive sites attract anionic reactants.The superficial porphyrin decomposes the accumulated reactants under 1 Sun.After degradation and release of products,the photoactive sites are thereby renewed.We demonstrate that polymer network(1:10)exhibited superior sustainable photocatalytic performance with complete degradation of methyl orange(MO)in 40 min with no observable performance deterioration after six cycles.The established close loop of adsorption-reaction-release cycle makes possible many efficient and continuous photo-catalytic processes. | Lingling Zhang Liwei Wu Junhui Bao Longhui Li Zejun Liu Feng Bai Jie Ju Xi Yao | 2024 | Nano Research2024，17，5： | 0 |
| 18 | A Numerical Study on the Mechanisms Producing Forces on Cylinders Interacting with Stratified Shear Environments显示文摘A three dimensional(3D)numerical wave flume is used to investigate carefully the ISWs(Internal solitary wave)forces acting on cylinders interacting with a stratified shear environment.Using the Large-Eddy Simulation(LES)approach and analyzing the distribution of shear stress and pressure along the surface of the cylinder,the differential pressure resistance and the viscous force are obtained.The method of multiple linear regression analysis is adopted and a comprehensive influence coefficient is determined accordingly to account for the dimensionless forces acting on the cylinder.Results show that the differential pressure resistance on a square cylinder is 1.5 times higher than that on a circular cylinder in the upper layer,while the differential pressure resistance on a square cylinder is 3.5 times larger than that on a circular cylinder in the lower layer.The viscous force is 1–2 orders of magnitude smaller than the differential pressure resistance,which means that the viscous force could be ignored.The comprehensive influence coefficient shows positive correlation with the relative wave height and negative correlation with upper and lower water depth ratio. | Yin Wang Lingling Wang Yong Ji Zhicheng Xi Wenwen Zhang | 2021 | Fluid Dynamics & Materials Processing2021，17，2： | 0 |
| 19 | S19W,T27W,and N33OY mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis显示文摘SARS-CoV-2 recognizes,via its spike receptor-binding domain(S-RBD),human angiotensin-converting enzyme 2(ACE2)to initiate infection.Ecto-domain protein of ACE2 can therefore function as a decoy.Here we show that mutations of S19W,T27W,and N330Y in ACE2 could individually enhance SARS-CoV-2 S-RBD binding.Y330 could be synergistically combined with either W19 or W27,whereas W19 and W27 are mutually unbeneficial.The structures of SARS-CoV-2S-RBD bound to the ACE2 mutants reveal that the enhan ced binding is mainly con tributed by the van der Waals interactio ns mediated by the aromatic side-chai ns from W19,W27,and Y330.While Y330 and W19/W27 are distantly located and devoid of any steric interference,W19 and W27 are shown to orient their side-chains toward each other and to cause steric conflicts,explai ning their in compatibility.Finally,using pseudotyped SARS-CoV-2 viruses,we dem on strate that these residue substitutions are associated with dramatically improved entry-inhibition efficacy toward both wild-type and antibody-resistant viruses.Taken together,our biochemical and structural data have delineated the basis for the elevated S-RBD binding associated with S19W,T27W,and N330Y mutations in ACE2,paving the way for potential application of these mutants in dinical treatment of COVID-19. | Fei Ye Xi Lin Zimin Che Fanli Yang Sheng Lin Jing Yang Hua Chen Honglu Sun Lingling Wang Ao Wen Xindan Zhang Yushan Dai Yu Cao Jingyun Yang Guobo Shen Li Yang Jiong Li Zhenling Wang Wei Wang Xiawei Wei Guangwen Lu | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 20 | In situ Synthesis of Ultrasmall Au Clusters on Thiol-modified CeO_(2) with Enhanced Stability and CO Oxidation Activity显示文摘Gold(Au)nanoclusters supported on various supports have been widely used in the fields of energy and catalysis.However,the poor thermal stability of Au nanoclusters on the support interface usually leads to a reduction or even loss of catalytic activity.Herein,we used an in situ reduction method to synthesize Au nanoclusters on ceria(CeO_(2))carriers.In this method,sulfhydryl groups were used to modify CeO_(2) nanospheres first,and then Au clusters with an average diameter of 1.5 nm were grown on the surface of ceria reduced with sodium borohydride.The presence of the Au-S-Ce structure enhances the electron transfer efficiency,making the material exhibit high CO oxidation activity at room temperature.Furthermore,due to the strong binding energy of S and Au,the material exhibits a high stability for long time running process.This strategy provides an idea for designing stable and active supported ultrasmall Au nanoclusters catalytic materials. | LI Lingling XU Jinhui LIANG Xi WU Xueting WANG Xiao SONG Shuyan ZHANG Hongjie | 2023 | Chemical Research in Chinese Universities2023，39，6： | 0 |
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