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| 1 | Polymorphisms in PPARD,PPARG and APM1 associated with four types of Traditional Chinese Medicine constitutions显示文摘Based on the theory of constitution of Traditional Chinese Medicine (TCM), the human population is divided into nine constitutions including one balanced constitution (Normality) and eight unbalanced constitutions (Yang-deficiency, Yin-deficiency, Phlegm-wetness, Qi-deficiency, Wetness-heat, Blood stasis, Depressed constitution, and Inherited special constitution). Different constitutions have specific metabolic features and different susceptibility to certain diseases. However, whether a genetic basis accounts for such constitution classifica-tion is yet to be determined. Here we performed a genetic study to assess the association between genetic variations of metabolic genes in-cluding PPARD, PPARG and APM1 and the constitutions. A total of 233 individuals of the Han population in China were classified into four groups, Normality, Yang-deficiency, Yin-deficiency and Phlegm-wetness with whom 23 single nucleotide polymorphisms (SNPs) in the three genes were genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Biased distri-bution of PPARD rs2267669 and rs2076167, APM1 rs7627128 and rs1063539 in Yang-deficiency, PPARG Pro12Ala in Yin-deficiency and PPARD rs2076167, APM1 rs266729 and rs7627128 in Phlegm-wetness were observed. The frequencies of Haplotype13 (Hap13) of PPARG in Yin-deficiency, Hap25 of APM1 in Yang-deficiency and Hap2 of PPARD and Hap14 of PPARG in Phlegm-wetness, were significantly different from those in Normality, suggesting those might be group-associated haplotypes. These results suggested that single SNP and hap-lotypes of PPARD, PPARG and APM1 may underlie the genetic basis of the constitutions classified in TCM. | Yanrui Wu Yina Cun Jing Dong Jingru Shao Shengjun Luo Shengjie Nie Haijing Yu Bingrong Zheng Qi Wang Chunjie Xiao | 2010 | Journal of Genetics and Genomics2010，37，6： | 36 |
| 2 | Overexpression of miR-30a in lung adenocarcinoma A549 cell line inhibits migration and invasion via targeting EYA2显示文摘MicroRNAs (miRNAs ) 是与癌症的致病有关的小非编码的 RNA 并且仔细的一个班。增加的证据显示 miR-30a 在癌症的发展期间起一个深刻作用。然而,在 non-small-cell 肺癌症(NSCLC ) 的 miR-30a 的功能仍然是模糊的。这里,我们发现 miR-30a 被 qRT-PCR 从 14 个病人在肺腺癌 A549 房间并且在织物样品减少,并且也发现在 A549 房间的 miR-30a 的 overexpression 由愈合创伤的试金禁止了移植和侵略然而并非房间增长和房间周期前进, matrigel 侵略试金,基于山的房间增长试金,和流动 基于cytometry 的房间周期分析分别地。我们进一步在肺腺癌房间行探索了 miR-30a-mediated 基因规定的潜在的机制。EYA2 是 miR-30a 的一个预言的目标,并且 EYA2 表示被 miR-30a 在乳癌房间禁止,这被发现了。我们证明 EYA2 是由在 A549 房间使用双酶的记者试金的 miR-30a 的一个直接目标并且证明 EYA2 蛋白质层次相反地在 A549 和 BEAS-2B 房间与 miR-30a 表示被相关。另外,我们也与表示向量和 miR-30a 模仿的 EYA2 由 cotransfection 在 A549 房间证实了 EYA2 overexpression 的营救效果。一起拿,我们的结果证明在肺腺癌 A549 房间的 miR-30a 的 overexpression 能禁止房间移植和侵略,它部分被归因于 EYA2 的减少表示。我们的调查结果建议 miR-30a 以后可以为肺腺癌的治疗被用作一个新潜在的目标。 | Yuncang Yuan Shangyong Zheng Qian Li Xudong Xiang Tangxin Gao Pengzhan Ran Lijuan Sun Qionglin Huang Fei Xie Jing Du Chunjie Xiao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，3： | 12 |
| 3 | Gene admixture in ethnic populations in upper part of Silk Road revealed by mtDNA polymorphism显示文摘To evaluate the gene admixture on the current genetic landscape in Gansu Corridor (GC) in China, the upper part of the ancient Silk Road which connects the Eastern and Central Asia, we examined mitochondrial DNA (mtDNA) polymorphisms of five ethnic populations in this study. Using PCR-RFLP and sequencing, we analyzed mtDNA haplotypes in 242 unrelated samples in three ethnic populations from the GC region and two ethnic populations from the adjacent Xinjiang Uygur Autonomous Region of China. We analyzed the data in comparison with the previously reported data from Eastern, Central and Western Asia and Europe. We found that both European-specific haplogroups and Eastern Asian-specific haplogroups exist in the Gansu Corridor populations, while a modest matrilineal gene flow from Europeans to this region was revealed. The Gansu Corridor populations are genetically located between Eastern Asians and Central Asians, both of who contributed significantly to the maternal lineages of the GC populations. This study made the landscape of the gene flow and admixture along the Silk Road from Europe, through Central Asia, to the upper part of the Silk Road more complete. | YANG LiuQi, TAN SiJie, YU HaiJing, ZHENG BingRong, QIAO EnFa, DONG YongLi, ZAN RuiGuang & XIAO ChunJie Key Laboratory of Bioresources Conservation and Utilization & Human Genetics Center, Yunnan University, Kunming 650091, China | 2008 | Science China(Life Sciences)2008，51，5： | 7 |
| 4 | Association of WNK1 exon 1 polymorphisms with essential hypertension in Hani and Yi minorities of China显示文摘在有在少数的必要高血压的 1 WNK1 基因中国的 Hani 和 Yi 组织的 exon 的多型性的协会在盒子控制学习被调查。包含 WNK1 基因 exon 的 1257 bp 的顺序 1 在 1307 个个人(649 个必要高血压题目和 658 控制) 被决定在 Hani 和 Yi 少数组识别 SNP。十一以前已知的 SNP (rs3168640, rs11885, rs11554421 和 rs34880640 ) 中的四个被识别。SNP 分析显示 SNP rs11885 和 rs11554421 显著地在 Hani 和 Yi 人口与高血压被联系,并且 rs34880640 显著地在 Hani 然而并非在 Yi 人口与高血压被联系,为 covariates 调整了。Haplotype 分析显示 haplotype H1 显著地减少了在两张人口的高血压的风险。这些结果建议 WNK1 多型性在 Hani 和 Yi 人口涉及必要高血压的倾向,它的效果显示出清楚的人口特性。这发现在决定基因因素把疾病治疗与疾病并且这样联系了支持了人口特性的重要性。 | Yina Cun Jin Li Wenru Tang Xiaozhi Sheng Haijing Yu Bingrong Zheng Chunjie Xiao | 2011 | Journal of Genetics and Genomics2011，38，4： | 7 |
| 5 | Y chromosome haplotypes reveal prehistorical migrations to the Himalayas显示文摘 | XIAO CHUNJIE DEKA RANJAN | 2000 | Hum Genet2000，107，： | 1 |
| 6 | Evolutionary characteristics of exons expressed at different abundance levels in mammals显示文摘With comparative genomics approaches, we evaluated the evolutionary characteristics of conservation of exons which are expressed abundantly, moderately or lowly in mammals. Using non-coding regions and pseudogenes as controls, sequence identity, phastCons and Ka/Ks analyses were carried out and our results showed that as the exons of high abundance are highly conserved, the minor and low exons also showed conservative characteristics in evolution. Our findings suggested that the exons with less abundance which constitute a large proportion of distinct species in transcriptome of organisms are under functional constraint and might play certain roles in enriching biological complexity in the evolution of organisms. | YU HaiJing FANG Lin LI Xin ZHANG XiaoYan YE Jia LI Jie HU WeiHong ZHENG BingRong XIAO ChunJie | 2009 | Chinese Science Bulletin2009，54，19： | 1 |
| 7 | Y chromosome haplotypes reveal prehistorical migrations to the Himalayas显示文摘 | Su Bing Xiao ChunJie Deka R | 2000 | Hum Genet2000，107，： | 1 |
| 8 | Model Construction of Efficiency Evaluation of Family Farms by DEA显示文摘 | Efang Xiao Chunjie Qi | 2015 | Journal of Interdisciplinary Mathematics2015，18，3： | 1 |
| 9 | Ethnobotanical survey of medicinal plants at periodic markets of Honghe Prefecture in Yunnan Province, SW China显示文摘 | Sangwoo Lee Chunjie Xiao Shengji Pei | 2008 | Journal of Ethnopharmacology2008，，2： | 1 |
| 10 | The Relationship between CYP17 -34T/C Polymorphism and Ache in Chinese Subjects Revealed by Sequencing显示文摘 | Li He Zhi Yang Haijing Yu Baoweng Cheng Wenru Tang Yongli Dong Chunjie Xiao | 2006 | Dermatology2006，212，： | 1 |
| 11 | Y chromosome haplotypes reveal prehistorical migrations to the Himalayas显示文摘 | Bing Su Chunjie Xiao Ranjan Deka Mark T. Seielstad Daoroong Kangwanpong Junhua Xiao Daru Lu Peter Underhill Luca Cavalli-Sforza Ranajit Chakraborty Li Jin | 2000 | Human Genetics2000，，6： | 1 |
| 12 | Association of the β2-adrenergic receptor gene with essential hypertension in the non-Han Chinese Yi minority human population显示文摘 | Hongyan Wu Wenru Tang Chunjie Xiao | 2006 | Hypertension2006，24，6： | 1 |
| 13 | Synthesis and properties of soluble sulfonated polybenzimidazoles from 3,3'-disulfonate-4,4'-dicarboxylbiphenyl as proton exchange membranes显示文摘 | Kang Sen Zhang Chunjie Xiao Guyu | 2009 | Journal of Membrane Science2009，334，： | 1 |
| 14 | Themis suppresses the effector function of CD8^(+)T cells in acute viral infection显示文摘CD8^(+)T cells play a central role in antiviral immune responses.Upon infection,naive CD8^(+)T cells differentiate into effector cells to eliminate virus-infected cells,and some of these effector cells further differentiate into memory cells to provide long-term protection after infection is resolved.Although extensively investigated,the underlying mechanisms of CD+T-cell differentiation remain incompletely understood.Themis is a T-cell-specific protein that plays critical roles in T-cell development.Recent studies using Themis T-cell conditional knockout mice also demonstrated that Themis is required to promote mature CD8^(+)T-cell homeostasis,cytokine responsiveness,and antibacterial responses.In this study,we used LCMV Armstrong infection as a probe to explore the role of Themis in viral infection.We found that preexisting CD8^(+)T-cell homeostasis defects and cytokine hyporesponsiveness do not impair viral clearance in Themis T-cell conditional knockout mice.Further analyses showed that in the primary immune response,Themis deficiency promoted the differentiation of CD8^(+)effector cells and increased their TNF and IFNy production.Moreover,Themis deficiency impaired memory precursor cell(MPEC)differentiation but promoted short-lived effector cell(SLEC)differentiation.Themis deficiency also enhanced effector cytokine production in memory CD8^(+)T cells while impairing central memory CD8^(+)T-cell formation.Mechanistically,we found that Themis mediates PD-1 expression and its signaling in effector CD8^(+)T cells,which explains the elevated cytokine production in these cells when Themis is disrupted. | Jian Tang Xian Jia Jian Li Junchen Dong Jiayu Wang Wanyun Li Yuzhen Zhu Yanyan Hu Bowen Hou Chunjie Lin Yu Cong Tong Ren Changsheng Yan Hongying Yang Qian Lai Haiping Zheng Yuzhou Bao Namrata Gautam Hong-Rui Wang Bing Xu Xiao Lei Chen Qing Li Nicholas R.J.Gascoigne Guo Fu | 2023 | Cellular & Molecular Immunology2023，20，5： | 0 |
| 15 | Association of Renin Binding Protein(RnBP) Gene Polymorphisms with Essential Hypertension in the Hani Minority of Southwestern China显示文摘Essential hypertension is one of the most common multifactorial diseases,affecting 20%-30%of the human population (Ibrahim and Damasceno,2012).Based on the results of twin studies,adoption studies and statistical analyses of blood pressure(BP) across various pedigrees,it has been estimated that 30%-50%of the variability in blood pressure among the general population is genetically determined(Garcia et al., 2003).Although the genetic mechanisms of essential hypertension have not been studied well,investigations for the genes that constitute the renin-angiotensin system(RAS) appear to be particularly promising,since this system plays a central role in the regulation of blood pressure(Ferrario,2010). As the first and rate-limiting enzyme in initiating the endocrine cascade of RAS,rennin was considered to be an essential regulator in BP control,and thus much attention has focused on elucidating the mechanisms by which renin activity may be regulated.Previously,a 46-kDa protein named renin binding protein(RnBP) was proposed to play a role in | Yilong Dong Yun Ding Yina Cun Chunjie Xiao | 2013 | Journal of Genetics and Genomics2013，40，8： | 0 |
| 16 | Twin peaks of in-hospital mortality among patients with STEMI across five phases of COVID-19 outbreak in China:a nation-wide study显示文摘Lockdown and re-opening may become cyclical due to the recurrent waves of the COVID-19 epidemic.Few studies have examined temporal trends and determinants of in-hospital mortality among patients with ST-segment elevation myocardial infarction(STEMI),a life-threatening condition that requires emergency medical care.Using nation-wide data before,during and after the Wuhan lockdown,we aimed to depict temporal patterns and major determinants of STEMI in-hospital mortality in China across five time periods of the COVID-19 epidemic.We analyzed the data of 283,661 STEMI patients who were admitted to 4,487 chest-pain-centers across China,from January 1,2019 to May 31,2020.Compared with the period before the lockdown,STEMI in-hospital mortality increased by 25%(OR 1.25,95%CI 1.16–1.34)during Early Lockdown,by 12%(OR 1.12,95%CI 1.03–1.22)during Later Lockdown,by 35%(OR 1.35,95%CI 1.21–1.50)during Early Lift,and returned to pre-COVID risk(OR 1.04,95%CI 0.95–1.14)during Later Lift.For each time-period,we observed a clear mortality gradient by timing and types of revascularization procedure.In conclusion,the COVID-19 epidemic had a significant adverse impact on STEMI in-hospital mortality,with bimodal peaks during early lockdown and early lift periods and clear mortality gradients by timing and types of revascularization procedure,independent of the time periods. | Jianping Li Nan Zhang Ziyi Zhou Xiao Huang Weiyi Fang Hongbing Yan Jiyan Chen Weimin Wang Dingcheng Xiang Xi Su Bo Yu Yan Wang Yawei Xu Lefeng Wang Chunjie Li Kai Huang Xiaobin Wang Yong Huo Junbo Ge | 2022 | Science China(Life Sciences)2022，65，9： | 0 |
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