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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Crustal and upper mantle structure and the deep seismogenic environment in the source regions of the Lushan earthquake and the Wenchuan earthquake显示文摘Following the M w 7.9 Wenchuan earthquake, the M w 6.6 Lushan earthquake is another devastating earthquake that struck the Longmenshan Fault Zone (LFZ) and caused severe damages. In this study, we collected continuous broadband ambient noise seismic data and earthquake event data from Chinese provincial digital seismic network, and then utilized ambient noise tomography method and receiver function method to obtain high resolution shear wave velocity structure, crustal thickness, and Poisson ratio in the earthquake source region and its surroundings. Based on the tomography images and the receiver function results, we further analyzed the deep seismogenic environment of the LFZ and its neighborhood. We reveal three main findings: (1) There is big contrast of the shear wave velocities across the LFZ. (2) Both the Lushan earthquake and the Wenchuan earthquake occurred in the regions where crustal shear wave velocity and crustal thickness change dramatically. The rupture faults and the aftershock zones are also concentrated in the areas where the lateral gradients of crustal seismic wave speed and crustal thickness change significantly, and the focal depths of the earthquakes are concentrated in the transitional depths where shear wave velocities change dramatically from laterally uniform to laterally non-uniform. (3) The Wenchuan earthquake and its aftershocks occurred in low Poisson ratio region, while the Lushan earthquake sequences are located in high Poisson ratio zone. We proposed that the effect of the dramatic lateral variation of shear wave velocity, and the gravity potential energy differences caused by the big contrast in the topography and the crustal thickness across the LFZ may constitute the seismogenic environment for the strong earthquakes in the LFZ, and the Poisson ratio difference between the rocks in the south and north segments of the Longmenshan Fault zone may explain the 5 years delay of the occurrence of the Lushan earthquake than the Wenchuan earthquake. | ZHENG Yong GE Can XIE ZuJun YANG YingJie XIONG Xiong HSU HouTze | 2013 | Science China Earth Sciences2013，56，7： | 37 |
| 3 | Source parameters inversion of the 2013 Lushan earthquake by combining teleseismic waveforms and local seismograms显示文摘On April 20, 2013, a magnitude M s 7.0 earthquake occurred in Lushan, Sichuan Province, China, and caused heavy casualties and economic losses. Based on the local broadband waveforms in Sichuan and adjacent provinces regional networks and teleseismic broadband records from IRIS stations, the focal mechanism and the focal depth are determined by the CAP (Cut And Paste) and its upgraded methods, CAPtele and CAPjoint, respectively. The results show that the focal mechanisms and depth from different methods are steady, and the best double couple solution derived from the joint inversion is 210°, 44°, and 91° for strike, dip, and rake angles respectively for one nodal plane and 29°, 46°, and 89° for another with 16 km focal depth and M w 6.66 moment magnitude. In order to verify the reliability of the results, a number of tests are performed based on local seismograms with different velocity models. They indicate that there is about 10 degree's fluctuation in focal mechanisms and about 2 km variation in focal depth with a complex velocity structure. Furthermore, inverted by re-sampling the teleseismic waveforms on the basis of epicentral distance, the solutions are consistent with each other, which manifests that the teleseismic records are effective for constraining source parameters of the Lushan earthquake. | XIE ZuJun JIN BiKai ZHENG Yong GE Can XIONG Xiong XIONG Cheng HSU HouTze | 2013 | Science China Earth Sciences2013，56，7： | 35 |
| 4 | Measurement of in-vehicle volatile organic compounds under static conditions显示文摘在车辆内的不稳定的有机化合物(VOC ) 的类型和数量用 theThermodesorber 气体在静态的条件下面在一新车辆和二旧车辆被决定了用色层法分离 / 集中分光计(TD-GC/MS ) 。空气采样和分析在 USEPA 方法 TO-17.A 房间尺寸的要求下面被进行,环境测试房间被利用提供要求的环境条件(温度,湿度,水平、垂直的气流速度,和背景 VOCsconcentration ) 的稳定、精确的控制。尽管在每车辆以内检测的全部的不稳定的有机化合物( TVOC )的数量是相对不同的,静态的车辆测试表明了那(在新车辆 A ,在使用的车辆 B 的 1240 亩 g/m^3 ,和在使用的车辆 C 的 132 ng/m^3 的 4940 u.g/m^3 ),甲苯,二甲苯,一些芳香族化合物,和各种各样的C_7-C_( 12 )链烷在在测试的所有三车辆的占优势的 VOC 种类之中。另外, tetramethyl succinonitrile,可能源于泡沫垫子在车辆 B.The 类型被检测, VOC 的数量根据因素的各种各样的类型更加变化了,例如,车辆年龄,车辆模型,温度,空气汇率,和环境气流速度。例如,如果气流速度从 0.1 m/s 增加到 0.7 m/s, vehicle'sair 汇率从 0.15 h~ 增加(-1)to 0.67 h^( 从 1780 ~ 1201 ng/m^3 的 -1),and 在里面车辆 TVOC 集中减少。 | YOU Ke-wei GE Yun-shan HU Bin NING Zhan-wu ZHAO Shou-tang ZHANG Yan-ni XIE Peng | 2007 | Journal of Environmental Sciences2007，19，10： | 27 |
| 5 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 6 | Ratios of T-helper 2 Cells to T-helper 1 Cells and Cytokine Levels in Patients with Hepatitis B显示文摘 | Ming-Hui Li Dan Zhang Lu Zhang Xiao-Jing Qu Yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu Liu Lei-Ping Hu Hong-Xiao Hao Wen-Hao Hua Shu-Jing Song Gang Wan Shun-Ai Liu Yao Xie | 2017 | Chinese Medical Journal2017，，15： | 21 |
| 7 | Viral effector protein manipulates host hormone signaling to attract insect vectors显示文摘 | Dewei Wu Tiancong Qi Wan-Xiang Li Haixia Tian Hua Gao Jiaojiao Wang Jin Ge Ruifeng Yao Chunmei Ren Xian-Bing Wang Yule Liu Le Kang Shou-Wei Ding Daoxin Xie | 2017 | Cell Research2017，27，3： | 20 |
| 8 | Kinetics of Hepatitis B Surface Antigen Level in Chronic Hepatitis B Patients who Achieved Hepatitis B Surface Antigen Loss during Pegylated Interferon Alpha-2a Treatment显示文摘 | Ming-Hui Li Lu Zhang Xiao-Jing Qu Yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu Liu Lei-Ping HU Zhen-Zhen Li Wen-Hao Hua Shu-Jing Song Yao Xie | 2017 | Chinese Medical Journal2017，，5： | 18 |
| 9 | Liuwei Dihuang Pill(六味地黄丸)Treats Postmenopausal Osteoporosis with Shen(Kidney) Yin Deficiency via Janus Kinase/Signal Transducer and Activator of Transcription Signal Pathway by Up-regulating Cardiotrophin-Like Cytokine Factor 1 Expression显示文摘Objectives: To investigate the mechanism of Liuwei Dihuang Pill(六味地黄丸, LDP) in treating postmenopausal osteoporosis(PMOP) with Shen(Kidney) yin deficiency. Methods: In this study, 205 cases of PMOP were divided into the PMOP Shen-yin deficiency group(Group A), PMOP Shen-yang deficiency group(Group B), PMOP without Shen deficiency group(Group C), and control group(Group N). Real-time polymerase chain reaction(RT-PCR) and Western blot techniques were used to observe the effects of LDP treatment on the cardiotrophin-like cytokine factor 1(CLCF1), ankyrin repeat and SOCS box containing 1(ASB1), and prokineticin 2(PROK2) genes and the Janus kinase/signal transducer and activator of transcription(JAK/STAT) signaling pathway. Results: The m RNA(P<0.05) and protein(P<0.01) expression levels of the CLCF1 gene in Group A were significantly lower than the corresponding levels in Group N. After LDP treatment for 3 months, the m RNA expression levels of the CLCF1 gene were obviously up-regulated(P<0.01). After 6-month treatment, the expression levels of CLCF1 m RNA and protein were significantly up-regulated(both P<0.01), and the average bone density of the top femur had significantly increased(P<0.05). In vitro, CLCF1 overexpression resulted in a significant increase in the total protein and phosphorylated protein levels of JAK2 and STAT3. Conclusions: The CLCF1 gene is an important gene associated with PMOP Shen-yin deficiency and the therapeutic effects of LDP may be mediated by up-regulation of CLCF1 gene expression and activation of the JAK/STAT signaling pathway. | GE Ji-rong XIE Li-hua CHEN Juan LI Sheng-qiang XU Hui-juan LAI Yu-lian QIU Long-long NI Chen-bo | 2018 | Chinese Journal of Integrative Medicine2018，24，6： | 17 |
| 10 | Association of Cytokines with Alanine Aminotransferase, Hepatitis B Virus Surface Antigen and Hepatitis B Envelope Antigen Levels in Chronic Hepatitis B显示文摘 | Ming-Hui Li Yao Lu Lu Zhang Xing-Yue Wang Chong-Ping Ran Hong-Xiao Hao Dan Zhang Xiao-Jing Qu Ge Shen Shu-Ling Wu Wei-Hua Cao Tian-Lin Qi Ru-Yu Liu Lei-Ping Hu Min Chang Wen-Hao Hua Shun-Ai Liu Gang Wan Yao Xie | 2018 | Chinese Medical Journal2018，，15： | 17 |
| 11 | Plasmacytoid Dendritic Cell Function and Cytokine Network Profiles in Patients with Acute or Chronic Hepatitis B Virus Infection显示文摘 | Ming-Hui Li Lu Zhang Dan Zhang Wei-Hua Cao Tian-Lin Qi Hong-Xiao Hao Xing-Yue Wang Chong-Ping Ran Xiao-Jing Qu Shun-Ai Liu Yao Lu Ge Shen Shu-Ling Wu Min Chang Ru-Yu Liu Lei-Ping Hu Wen-Hao Hua Gang Wan Jun Cheng Yao Xie | 2018 | Chinese Medical Journal2018，，1： | 16 |
| 12 | Hepatitis B surface antigen clearance in inactive hepatitis B surface antigen carriers treated with peginterferon alfa-2a显示文摘AIM: To examine the association between interferon(IFN) therapy and loss of hepatitis B surface antigen(HBs Ag) in inactive HBs Ag carriers. METHODS: This was a retrospective cohort study in inactive HBs Ag carriers, who were treatment-naive, with a serum HBs Ag level < 100 IU/m L and an undetectable hepatitis B virus(HBV) DNA level(< 100 IU/m L). All the 20 treated patients received subcutaneous PEG-IFN alfa-2a 180 μg/wk for 72 wk and were then followed for 24 wk. There were 40 untreated controls matched with 96 wk of observation. Serum HBs Ag, HBV DNA, and alanine aminotransferases were monitored every 3 mo in the treatment group and every 3-6 mo in the control group. RESULTS: Thirteen(65.0%) of 20 treated patients achieved HBs Ag loss, 12 of whom achieved HBs Ag seroconversion. Mean HBs Ag level in treated patients decreased to 6.69 ± 13.04 IU/m L after 24 wk of treatment from a baseline level of 26.22 ± 33.00 IU/m L. Serum HBV DNA level remained undetectable(< 100 IU/m L) in all treated patients during the study. HBs Ag level of the control group decreased from 25.72 ± 25.58 IU/m L at baseline to 17.11 ± 21.62 IU/m L at week 96(P = 0.108). In the control group, no patient experienced HBs Ag loss/seroconversion, and two(5.0%) developed HBV reactivation.CONCLUSION: IFN treatment results in HBs Ag loss and seroconversion in a considerable proportion of inactive HBs Ag carriers with low HBs Ag concentrations. | Ming-Hui Li Yao Xie Lu Zhang Yao Lu Ge Shen Shu-Ling Wu Min Chang Cai-Qin Mu Lei-Ping Hu Wen-Hao Hua Shu-Jing Song Shu-Feng Zhang Jun Cheng Dao-Zhen Xu | 2016 | World Journal of Hepatology2016，8，15： | 15 |
| 13 | The Predictive Value of Baseline HBs Ag Level and Early Response for HBs Ag Loss in Patients with HBe Ag-positive Chronic Hepatitis B during Pegylated Interferon Alpha-2a Treatment显示文摘Objective To explore the predictive value of baseline HBsAg level and early response for HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. Methods A total of 121 patients with HBeAg-positive chronic hepatitis B who achieved HBsAg loss were enrolled; all patients were treated with PEG-IFNα-2a 180 μg/week. Serum HBV DNA and serological indicators(HBsAg, anti-HBs, HBeAg, and anti-HBe) were determined before and every 3 months during treatment. Results The median treatment time for HBsAg loss was 84 weeks(7-273 weeks), and 74.38%(90 cases) of the patients needed extended treatment(> 48 weeks). The correlation between baseline HBsAg levels and the treatment time of HBsAg loss was significant(B = 14.465, t = 2.342, P = 0.021). Baseline HBsAg levels together with the decline range of HBsAg at 24 weeks significantly correlated with the treatment time of HBsAg loss(B = 29.862, t = 4.890, P = 0.000 and B = 27.993, t = 27.993, P = 0.005). Conclusion Baseline HBsAg levels and extended therapy are critical steps toward HBsAg loss. Baseline HBsAg levels together with early response determined the treatment time of HBsAg loss in patients with HBeAg-positive chronic hepatitis B during pegylated interferon alpha-2a treatment. | LI Ming Hui ZHANG Lu QU Xiao Jing LU Yao SHEN Ge LI Zhen Zhen WU Shu Ling LIU Ru Yu CHANG Min HU Lei Ping HUA Wen Hao SONG Shu Jing WAN Gang XIE Yao | 2017 | Biomedical and Environmental Sciences2017，30，3： | 14 |
| 14 | Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents显示文摘Scavenging reactive oxygen species(ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury(CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Among these compounds, the most active 33 not only conferred cytoprotection of H2 O2-induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. More importantly, in comparison with mono-antioxidant mechanism compounds, 33 exhibited higher cytoprotective and neuroprotective potential in vitro and in vivo. Overall, our findings showed compound 33 couldemerge as a promising anti-ischemic stroke drug candidate and provided novel dual-antioxidant mechanism strategies and concepts for oxidative stress-related diseases treatment. | Jiabing Wang Lili Huang Chanchan Cheng Ge Li Jingwen Xie Mengya Shen Qian Chen Wulan Li Wenfei He Peihong Qiu Jianzhang Wu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 13 |
| 15 | m^6A-dependent biogenesis of circular RNAs in male germ cells显示文摘The majority of circular RNAs(circRNAs)spliced from coding genes contain open reading frames(ORFs)and thus,have protein coding potential.However,it remains unknown what regulates the biogenesis of these ORF-containing circRNAs,whether they are actually translated into proteins and what functions they play in specific physiological contexts.Here,we report that a large number of circRNAs are synthesized with increasing abundance when late pachytene spermatocytes develop into round and then elongating spermatids during murine spermatogenesis.For a subset of circRNAs,the back splicing appears to occur mostly at m^6A-enriched sites,which are usually located around the start and stop codons in linear mRNAs.Consequently,approximately a half of these male germ cell circRNAs contain large ORFs with m^6A-modified start codons in their junctions,features that have been recently shown to be associated with protein-coding potential.Hundreds of peptides encoded by the junction sequences of these circRNAs were detected using liquid chromatography coupled with mass spectrometry,suggesting that these circRNAs can indeed be translated into proteins in both developing(spermatocytes and spermatids)and mature(spermatozoa)male germ cells.The present study discovered not only a novel role of m^6A in the biogenesis of coding circRNAs,but also a potential mechanism to ensure stable and long-lasting protein production in the absence of linear mRNAs,i.e.,through production of circRNAs containing large ORFs and m^6A-modified start codons in junction sequences. | Chong Tang Yeming Xie Tian Yu Na Liu Zhuqing Wang Rebekah J.Woolsey Yunge Tang Xinzong Zhang Weibing Qin Ying Zhang Ge Song Weiwei Zheng Juan Wang Weitian Chen Xiongyi Wei Zhe Xie Rachel Klukovich Huili Zheng David R.Quilici Wei Yan | 2020 | Cell Research2020，30，3： | 12 |
| 16 | Liberation characteristics of coal middlings comminuted by jaw crusher and ball mill显示文摘The associated minerals make coal middlings possess a relatively high ash content.Subsequent liberation through size reduction can cause recovery increase.However,effect of comminution facilities on mineral liberation of middlings was ignored.This paper studied the liberation characteristics of middlings crushed with different kinds of fragmentation forces.Middlings of 3 mm+0.5 mm sampled from a dense medium cyclone were comminuted by a jaw crusher and a ball mill to 0.5 mm with similar size distribution respectively.The generating mechanism of fnes was also analyzed.Full densimetric analyses indicate that mineral liberation of the product crushed by the jaw crusher is better than that by the ball mill at each fraction.For sizes of 0.125 mm+0.074 mm and 0.074 mm,yields of the product with ash content 11%comminuted by jaw crusher are nearly 20%higher than that by the ball mill.Sectional micrographs observed by the scanning electron microscopy(SEM)also show the same law for these two fractions and some intergrowth particles still exist in the fraction of 0.5 mm+0.25 mm. | Xie Weining He Yaqun Zhu Xiangnan Ge Linhan Huang Yajun Wang Haifeng | 2013 | International Journal of Mining Science and Technology2013，23，5： | 12 |
| 17 | Association between Chinese Medicine Therapy and Survival Outcomes in Postoperative Patients with NSCLC: A Multicenter, Prospective, Cohort Study显示文摘Objective:To evaluate the association between Chinese medicine(CM)therapy and disease-free survival(DFS)outcomes in postoperative patients with non-small cell lung cancer(NSCLC).Methods:This multiple-center prospective cohort study was conducted in 13 medical centers in China.Patients with stage I,II,or IDA NSCLC who had undergone radical resection and received conventional postoperative treatment according to the National Comprehensive Cancer Network(NCCN)guidelines were recruited.The recruited patients were divided into a CM treatment group and a control group according to their wishes.Patients in the CM treatment group received continuous CM therapy for more than 6 months or until disease progression.Patients in the control group received CM therapy for less than 1 month.Follow-up was 8nducted over 3 years.The primary outcome was DFS,with recurrence/metastasis rates as a secondary outcome.Results:Between May 2013 and August 2016,503 patients were enrolled into the cohort;266 were classified in the CM treatment group and 237 in the control group.Adjusting for covariates,high exposure to CM was associated with better DFS[hazard ratio(HR)=0.417,95%confidential interval(Cl):0.307-0.567)].A longer duration of CM therapy(6-12 months,12-18 months,>24 months)was associated with lower recurrence and metastasis rates(HR=0.225,0.119 and 0.083,respectively).In a subgroup exploratory analysis,CM therapy was also a protective factor of cancer recurrence and metastasis in both stage n-MA(HR=0.50,95%Cl:0.37-0.67)and stage IDA NSCLC postoperative patients(HR=0.48,95%Cl:0.33-0.71),DFS was even longer among CM treatment group patients.Conclusions:Lon ger duration of CM therapy could be 8nsidered a protective factor of cancer recurrence and metastasis.CM treatment is associated with improving survival outcomes of postoperative NSCLC patients in China. | WANG Xue-qian ZHANG Ying HOU Wei WANG Ying-tian ZHENG Jia-bin LI Jie LIN Li-zhu JIANG Yi-lan WANG Shen-yu XIE Ying ZHANG Hong-liang SHU Qi-jin LI Ping WANG Wei YOU Jian-liang LI Ge LIU Jie FAN Hui-ting ZHANG Mei-ying LIN Hong-sheng | 2019 | Chinese Journal of Integrative Medicine2019，25，11： | 12 |
| 18 | Bench-to-bedside strategies for osteoporotic fracture: from osteoimmunology to mechanosensation显示文摘Osteoporosis is characterized by a decrease in bone mass and strength, rendering people prone to osteoporotic fractures caused by low-energy forces. The primary treatment strategy for osteoporotic fractures is surgery;however, the compromised and comminuted bones in osteoporotic fracture sites are not conducive to optimum reduction and rigid fixation. In addition, these patients always exhibit accompanying aging-related disorders, including high inflammatory status, decreased mechanical loading and abnormal skeletal metabolism, which are disadvantages for fracture healing around sites that have undergone orthopedic procedures. Since the incidence of osteoporosis is expected to increase worldwide, orthopedic surgeons should pay more attention to comprehensive strategies for improving the poor prognosis of osteoporotic fractures. Herein, we highlight the molecular basis of osteoimmunology and bone mechanosensation in different healing phases of elderly osteoporotic fractures, guiding perioperative management to alleviate the unfavorable effects of insufficient mechanical loading, high inflammatory levels and pathogen infection. The well-informed pharmacologic and surgical intervention, including treatment with anti-inflammatory drugs and sufficient application of antibiotics, as well as bench-to-bedside strategies for bone augmentation and hardware selection, should be made according to a comprehensive understanding of bone biomechanical properties in addition to the remodeling status of osteoporotic bones, which is necessary for creating proper biological and mechanical environments for bone union and remodeling. Multidisciplinary collaboration will facilitate the improvement of overall osteoporotic care and reduction of secondary fracture incidence. | Yong Xie Licheng Zhang Qi Xiong Yanpan Gao Wei Ge Peifu Tang | 2019 | Bone Research2019，7，3： | 10 |
| 19 | Chemical characteristics of haze particles in Xi'an during Chinese Spring Festival: Impact of fireworks burning显示文摘Fireworks burning releases massive fine particles and gaseous pollutants, significantly deteriorating air quality during Chinese Lunar New Year(LNY) period. To investigate the impact of the fireworks burning on the atmospheric aerosol chemistry, 1-hr time resolution of PM_(2.5) samples in Xi'an during the winter of 2016 including the LNY were collected and detected for inorganic ions, acidity and liquid water content(LWC) of the fine aerosols. PM_(2.5) during the LNY was 167 ± 87 μg/m^3, two times higher than the China National Ambient Air Quality Standard(75 μg/m^3). K^+(28 wt.% of the total ion mass) was the most abundant ion in the LNY period, followed by SO_4^(2-)(25 wt.%) and Cl-(18 wt.%). In contrast, NO_3^-(34 wt.%) was the most abundant species in the haze periods(hourly PM32-2.5> 75 μg/m), followed by SO_4(29.2 wt.%) and NH_4^+(16.3 wt.%), while SO_4^(2-)(35 wt.%) was the most abundant species in the clean periods(hourly PM_(2.5)< 75 μg/m^3), followed by NO_3^-(23.1 wt.%) and NH_4^+(11 wt.%). Being different from the acidic nature in the non-LNY periods, aerosol in the LNY period presented an alkaline nature with a pH value of 7.8 ± 1.3. LWC during the LNY period showed a robust linear correlation with K_2SO_4 and KCl, suggesting that aerosol hygroscopicity was dominated by inorganic salts derived from fireworks burning. Analysis of correlations between the ratios of NO--3/SO_4^(2-) and NH_4^+/SO_4^(2-) indicated that heterogeneous reaction of HNO_3 with NH_3 was an important formation pathway of particulate nitrate and ammonium during the LNY period. | Can Wu Gehui Wang Jiayuan Wang Jianjun Li Yanqin Ren Lu Zhang Cong Cao Jin Li Shuagshuang Ge Yuning Xie Xinpei Wang Guoyan Xue | 2018 | Journal of Environmental Sciences2018，30，9： | 10 |
| 20 | The effect of vitamin D on sperm motility and the underlying mechanism显示文摘Vitamin D deficiency is a common health issue around the world. We therefore evaluated the associations of semen quality with both serum and seminal plasma vitamin D levels and studied the mechanisms underlying these by incubating spermatozoa with 1,25(OH)2D in vitro. Two hun dred and twenty-two men were in eluded in our study. Vitamin D was detected using an electrochemilumi nesce nee method. Spermatozoa used for in vitro experiments were isolated by density gradient centrifugation. Positive relationships of serum 25(OH)D with semen volume and seminal plasma fructose were identified. Seminal plasma 25(OH)D level showed no relationship with serum 25(OH)D level, while it was inversely associated with sperm concentration and positively correlated with semen volume and sperm kinetic values. In vitro, sperm kinetic parameters in creased after in cubation with 1,25(OH)2D, especially upon in cubation for 30 min with it at a concen tration of 0.1 nmol l-1. Under these in cubation conditions, the upward migratio n of spermatozoa in creased remarkably with increasing ade nosine triphosphate (ATP) con centratio n. The concentrati on of cyclic ade nosine mono phosphate (cAMP) and the activity of protei n kinase A (PKA) were both elevated, and the PKA inhibitor, N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochloride (H89) reversed the in crease of ATP producti on. The conce ntrations of cytoplasmic calcium ions and n icotinamide adenine dinucleotide (NADH) were both enhanced, while mitochondrial calcium uniporter (MCU) inhibitor, Ruthenium 360 (Ru360) did not reverse the increase of ATP production. Therefore, seminal plasma vitamin D may be invoIved in regulating sperm motility, and 1,25(OH)2D may enhance sperm motility by promoting the synthesis of ATP both through the cAMP/PKA pathway and the in crease in in tracellular calcium ions. | Kadiliya Jueraitetibaike Zheng Ding Dan-Dan Wang Long-Ping Peng Jun Jing Li Chen Xie Ge Xu-Hua Qiu Bing Yao | 2019 | Asian Journal of Andrology2019，21，4： | 10 |
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