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| 1 | Environmental changes reflected by n-alkanes of lake core in Nam Co on the Tibetan Plateau since 8.4 kaB.P.显示文摘The n-alkanes are extracted from NMLC-1 core that was drilled in the Nam Co, central Tibet. They are measured by using Gas Chromatography and Mass Spectrometry (GC/MS) for componential and quantitative analyses. According to the constructed depth-age model, the component and concentration of n-alkanes, together with total organic carbon (TOC), total nitrogen (TN) and carbonate are used to elu- cidate palaeoenvironmental changes of Nam Co during the past 8.4 ka. The results indicate that Holo- cene environment performs three stages in the lake area. In the stage of 8.4―6.7 kaB.P., it was warmer while precipitation slightly increased. This stage was ended by an obvious cold/dry event. During 6.7― 5.8 kaB.P., temperature increased rapidly and reached its maximum values at about 6.0 kaB.P. The environments were warm/wet optimum for the blooming of terrestrial plants and submerged aquatic plants. After that, temperature decreased continuously and showed the lowest values at about 3.0 kaB.P. From 2.9 kaB.P. to the present, temperature rose again but alternated with cold and warm. The lake area tended to be dry after 1.4 kaB.P. During 600―400 aB.P., the environmental feature was the reflection of 'Little Ice Age'. | LIN Xiao ZHU LiPing WANG Yong WANG JunBo XIE ManPing JU JianTing Roland MAUSBACHER Antje SCHWALB | 2008 | Chinese Science Bulletin2008，53，19： | 14 |
| 2 | Composition, spatial distribution, and environmental significance of water ions in Pumayum Co catchment, southern Tibet显示文摘主要阳离子(Mg2+ , Ca2+ , Na+ ,和 K+) 和阴离子的化学(HCO3 ? , SO4 2 ? ,并且 Cl ?) 在普麦乌姆湖的水里,公司和它的流入河被学习,在各种各样的流入河和湖之中揭示明显的离子的差别。湖水的化学类型是 Mg2+-Ca2+-HCO3 ?-SO4 2+ ,但是主要流入河的主要离子是 Ca2+-Mg2+-HCO3 ? 。在 Jiaqu 河的湖入口,主要流入河,有在深度以内的水化学的重要变化不到 2 m。然而,它在湖的另外的区域是几乎同类的。与水化学和湖水的氧同位素的分发的证据,因此,一个结论能被构画出那条 Jiaqu 河在沉没三角洲上在水的 hydrochemistry 上有不同效果,而这为另外的河不是事实。吉布斯阴谋表明负责控制湖水的化学作文的主导的机制是在排水区域捱过的岩石。离子比率和第三的阴谋进一步探索了控制集水的水化学的主要过程,即,捱过的碳酸盐,捱过的黄铁矿,并且硅酸盐捱过。在河水和湖水之间的不同 hydrochemistry 特征可以源于 CaCO3 降水。调查结果将在湖在 paleolimnological 研究有益于碳酸盐的环境意义的解释。 | ZHU Liping JU Jianting WANG Yong XIE Manping WANG Junbo PENG Ping ZHEN Xiaolin LIN Xiao | 2010 | Journal of Geographical Sciences2010，20，1： | 9 |
| 3 | Resilience-based retrofitting of existing urban RC-frame buildings using seismic isolation显示文摘The improvement of the seismic resilience of existing reinforced-concrete(RC) frame buildings, which is essential for the seismic resilience of a city, has become a critical issue. Although seismic isolation is an effective method for improving the resilient performance of such buildings, target-oriented quantitative improvements of the resilient performance of these buildings have been reported rarely. To address this gap, the seismic resilience of two existing RC frame buildings located in a high seismic intensity region of China were assessed based on the Chinese Standard for Seismic Resilience Assessment of Buildings. The critical engineering demand parameters(EDPs) affecting the seismic resilience of such buildings were identified. Subsequently, the seismic resilience of buildings retrofitted with different isolation schemes(i.e., yield ratios) were evaluated and compared, with emphasis on the relationships among yield ratios, EDPs, and levels of seismic resilience. Accordingly, to achieve the highest level of seismic resilience with respect to the Chinese standard, a yield ratio of 3% was recommended and successfully applied to the target-oriented design for the seismic-resilience improvement of an existing RC frame building. The research outcome can provide an important reference for the resilience-based retrofitting of existing RC frame buildings using seismic isolation in urban cities. | Yang Cantian Xie Linlin Li Aiqun Zeng Demin Jia Junbo Chen Xi Chen Min | 2020 | Earthquake Engineering and Engineering Vibration2020，19，4： | 7 |
| 4 | Hydrodynamic process of Tibetan Plateau lake revealed by grain size:Case study of Pumayum Co显示文摘Under the background of global warming,some lakes on the Tibetan Plateau(TP) are potentially sensitive to temperature change.With a case study of Pumayum Co,where glacier meltwater is important to supply(we call this a glacier-fed lake hereafter),we analyze the sensitivity of lake sediment grain size to temperature change.This is done by resolving the modern hydrodynamic process,coupled with comparison of paleoclimatic proxies.According to the spatial distributions of parameters,percentage of grain size and the grain size frequency distribution curve,hydrodynamic processes are analyzed.Five clastic sedimentation types are thereby discriminated.In the open lake area,suspended load transport is the main transport agent.Grain Size Trend Analysis(GSTA),a sediment dynamics model,reveals a trend toward eastward transport.This indicates that the largest and glacier-fed river,the Jiaqu River,influences the entire lake(not just the subsurface alluvial fan),and that lake sediment grain size may serve as a temperature indicator.Time series comparison between grain size of a short core from the central lake and meteorological data confirms this temperature indication,which in turn shows reliability of the method discriminating the hydrodynamic process.This case study will improve the ability of paleoclimatic reconstruction using lake sediment in glacier-fed lakes on the Tibetan Plateau. | JU JianTing ZHU LiPing FENG JinLiang WANG JunBo WANG Yong XIE ManPing PENG Ping ZHEN XiaoLin LÜXinMiao | 2012 | Chinese Science Bulletin2012，57，19： | 7 |
| 5 | How functional foods play critical roles in human health显示文摘How do functional foods affect human health?To answer this question it is important to understand what happens when food is digested and taken up by the gastrointestinal(GI)tract.The gut is a selective nutrient absorption system and the most important signal transduction and information exchange system within the body.It acts as a signal transducer,a neuroendocrine sensor,and an immunological recognition and presentation system.It is also a complex information exchange system comprising a number of signaling networks involving GI cells and cells immobilized in organs or transported in blood.The bioactivity of functional foods in vivo may be due to their effects on such networks,but this raises the question of what signaling pathways are used by non-nutrients that cannot be absorbed by the gut.The purpose of this review is to describe intestinal nutrient transportation,identify a number of widely expressed receptors and signal transduction pathways,and outline our current understanding of the mechanisms involved in health and disease.At the end of the review,a method for developing a cell communication network is described.This network is convenient for investigating the effects of oral administration of experimental medicines,drugs,or functional foods on cytokines of interest.Because cytokines and chemokines are transported via the circulatory system,a simple 2–3 mL blood sample from a volunteer is a rich source of information.This method may become the gold standard for evaluating the effects of functional foods or medicines in vivo.©2012 Production and hosting by Elsevier B.V.on behalf of Beijing Academy of Food Sciences. | Guangchang Pang Junbo Xie Qingsen Chen Zhihe Hu | 2012 | Food Science and Human Wellness2012，1，1： | 4 |
| 6 | On the Unusual Holocene Carbonate Sediment in Lake Nam Co,Central Tibet显示文摘In lacustrine sediments,aragonite is a widespread mineral,whereas monohydrocalcite is a rare carbonate mineral. In the cold and high-attitude Xizang (Tibetan) Plateau,where aragonite has been commonly found in lacustrine sediments,there is no aragonite,but low-Mg calcite,monohydrocalcite and trace dolomite. The lake receives solutes primarily from surface runoffs and remains fairly constant water chemistry for a long time. The total CaCO3 percentage in sediments could be controlled by evaporation and inflow of detrital materials. The absence of aragonite is unusual when compared to other lacustrine sediments from the Tibetan Plateau. This could be due to low Ca/Mg ratio,low salinity,low Mg and Ca concentration. Monohydrocalcite might precipitate from the lake water mediated by biological activities. Low-Mg calcite originated from minor ostracoda shell and the precipitation of lake water with biological activities. | LI Minghui KANG Shichang ZHU Liping WANG Feiyue WANG Junbo YI Chaolu FANG Xiaomin XIE Manping | 2009 | Journal of Mountain Science2009，6，4： | 3 |
| 7 | Comparisons between the chemical compositions of lake water, inflowing river water, and lake sediment in Nam Co, central Tibetan Plateau, China and their controlling mechanisms显示文摘 | Junbo Wang Liping Zhu Yong Wang Jianting Ju Manping Xie Gerhard Daut | 2010 | Journal of Great Lakes Research2010，，4： | 1 |
| 8 | REMOVAL OF ORGANIC POLLUTANTS USING TITANIUM DIOXIDE MEDIATED PHOTOCATALYTIC OXIDATION显示文摘A simple and effective method of removing polluted organics in water isreported here.Titanium dioxide is a catalyst in photo-oxidation of monocrotophos.Themechanism of photocatalytic oxidation and the kinetics of the reaction were studied.This same principle also leads to the construction of instrument of PTR-FIA analysisfor monitoring organic phosphorus and phosphate in water. | Manping ZHANG Zongfeng XIA Shinan XIE Peipei LI Junbo BAO Juying WANG Daiwen KANG (Department of Marine Chemistry,Ocean University of Qingdao,Qingdao.266003) Yujun WANG Nianhong CHEN Lidong YU (Institute of Oceanography,Academia Sinica,Oingdao,266003) G.K-C LOW (CSIRO Division of Feul Technology,Lucas Heights Research laboratories,PMB 7,M nai,2234 NSW,Australia) | 1990 | Chinese Chemical Letters1990，1，3： | 1 |
| 9 | Composition of fatty oils from Semen Ziziphi Spinosae and its cardiotonic effect on isolated toad hearts显示文摘 | XIE Junbo ZHANG Yanqing WANG Lijuan | 2012 | Natural Product Research2012，26，5： | 1 |
| 10 | Simultaneous determination of jujuboside A, B and betulinic acid in Semen Ziziphi Spinosae by high performance liquid chromatography-evaporative light scattering detection显示文摘 | ZHANG Mingchun ZHANG Yanqing XIE Junbo | 2008 | Journal of Pharmaceutical and Biomedical Analysis2008，48，5： | 1 |
| 11 | Simultaneous analysis of glycyrrhizin, paeoniflorin, quercetin, ferulic acid, liquiritin, formononetin, benzoic acid and isoliquiritigenin in the Chinese proprietary medicine Xiao Yao Wan by HPLC 显示文摘 | Xie Junbo Wang Wenquan Zhang Yanqing | 2007 | J Pharm Biomed Anal2007，45，： | 1 |
| 12 | Modulation effect of Semen Ziziphi Spinosae extracts on IL-1β, IL-4, IL-6, IL-10, TNF-α and IFN-γ in mouse serum显示文摘 | Junbo Xie Li Guo Guangchang Pang Xin Wu Mingchun Zhang | 2011 | Natural Product Research2011，，4： | 1 |
| 13 | A novel evolutionary method for parameter-free MEMS structural design and its application in piezoresistive pressure sensors显示文摘In this paper,a novel simulation-based evolutionary method is presented for designing parameter-free MEMS structures with maximum degrees of freedom.This novel design method enabled semiautomatic structure evolution by weighing the attributes of each segment of the structure and yielded an optimal design after multiple iterations.The proposed method was utilized to optimize the pressure-sensitive diaphragm of a piezoresistive pressure sensor(PPS).Finite element method(FEM)simulations revealed that,in comparison to conventional diaphragms without islands and with square islands,the optimized diaphragm increased the stress by 10%and 16%and reduced the nonlinearity by 57%and 77%,respectively.These improvements demonstrate the value of this method.Characterization of the fabricated PPS revealed a high sensitivity of 8.8 mV V−1 MPa−1 and a low nonlinearity of 0.058%FS at 20°C,indicating excellent sensor performance. | Qinggang Meng Junbo Wang Deyong Chen Jian Chen Bo Xie Yulan Lu | 2023 | Microsystems & Nanoengineering2023，9，5： | 0 |
| 14 | Energy intake,metabolic homeostasis,and human health显示文摘The energy substances(mainly carbohydrates and fats)are the basis and guarantee of life activity,especially the oxidative phosphorylation for energy supply.However,excessive absorption and accumulation of these substances can lead to metabolic diseases such as obesity,hyperlipidemia,diabetes,and cancers.A large amount of studies demonstrate that G protein-coupled receptors(GPCRs)play a key role in identification and absorption of energy substances,and the signaling network of nerves,immune,and endocrine regulates their storage and utilization.The gastrointestinal mucus layer not only identifies these substances through identification in diet components but also transfers immune,metabolic,and endocrine signals of hormones,cytokines,and chemokines by promoting interactions between receptors and ligands.These signaling molecules are transferred to corresponding organs,tissues,and cells by the circulatory system,and cell activity is regulated by amplifying of cell signals that constitute the wireless communication network among cells in the body.Absorption,accumulation,and utilization of energy substances in the body obey the law of energy conservation.Energy is stored in the form of fat,and meets the demand of body via two coupled mechanisms:catabolism and oxidative phosphorylation.Under normal physiological conditions,fat consumption involves ketone body metabolism through the circulatory system and glucose consumption requires blood lactic acid cycle.Accumulation of excessive energy leads to the abnormal activation of mammalian target of rapamycin(mTOR),thus promoting the excretion of glucose or glycogen in the form of blood glucose and urine glucose.Alternatively,the body cancels the intercellular contact inhibition and promotes cell proliferation to induce carcinogenesis,which can induce the consumption of large amounts of glucose.Intercellular communication is performed by signaling molecules via sensing,absorption,accumulation,and utilization of energy substances,and anabolism and catabolism are controlled by the central metabolic pathway.Therefore,slower catabolism will result in longer life expectancy,whereas faster catabolism results in shorter life expectancy.Energy substances in diet influence the balance between energy and metabolism in the body through the sensing function of the gastrointestinal system at two levels:cellular communication network and metabolic network.The present review of studies aims to strengthen our knowledge on cellular communication and metabolic networks to offer a dietary guidance on the metabolism and communication role of various foods. | Guangchang Pang Junbo Xie Qingsen Chen Zhihe Hu | 2014 | Food Science and Human Wellness2014，3，3： | 0 |
| 15 | Avian influenza viruses suppress innate immunity by inducingtrans-transcriptional readthrough via SSU72显示文摘Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can betterescape host innate immune responses than the less virulent seasonal H1N1 virus. Here, we report a mechanism by whichtranscriptional readthrough (TRT)-mediated suppression of innate immunity occurs post AIV infection. By using cell lines, mouselungs, and patient PBMCs, we showed that genes on the complementary strand (“trans” genes) influenced by TRT were involved inthe disruption of host antiviral responses during AIV infection. The trans-TRT enhanced viral lethality, and TRT abolishmentincreased cell viability and STAT1/2 expression. The viral NS1 protein directly bound to SSU72, and degradation of SSU72 inducedTRT. SSU72 overexpression reduced TRT and alleviated mouse lung injury. Our results suggest that AIVs infection induce TRT byreducing SSU72 expression, thereby impairing host immune responses, a molecular mechanism acting through the NS1-SSU72-trans-TRT-STAT1/2 axis. Thus, restoration of SSU72 expression might be a potential strategy for preventing AIV pandemics. | Yan Zhao Fengming Huang Zhen Zou Yuhai Bi Yang Yang Cong Zhang Qiang Liu Daozhen Shang Yiwu Yan Xiangwu Ju Song Mei Peng Xie Xiao Li Mingyao Tian Shuguang Tan Huijun Lu Zongsheng Han Kangtai Liu Yuqing Zhang Junbo Liang Zhu Liang Qingchao Zhang Jiahui Chang William JLiu Cong Feng Tanshi Li Michael Q.Zhang Xiaoyue Wang George FGao Yingxia Liu Ningyi Jin Chengyu Jiang | 2022 | Cellular & Molecular Immunology2022，19，6： | 0 |
| 16 | Layer-dependent charge density wave phase transition stiffness in 1T-TaS_(2)nanoflakes evidenced by ultrafast carrier dynamics显示文摘Novel physical properties emerge when the thickness of charge density wave(CDW)materials is reduced to the atomic level,owing to the significant modification of the electronic band structure and correlation effects.Here,we investigate the layer-dependent CDW phase transition and evolution of the nonequilibrium state of 1T-TaS_(2)nanoflakes using pump-probe spectroscopy.Both the low-energy single-particle and collective excitation relaxations exhibit sharp changes at〜210 K,indicating a phase transition from commensurate CDW to nearly commensurate CDW state.The single particle process reveals that the phase transition stiffness(PTS)is thickness-dependent.Moreover,a small PTS is observed in thin nanoflakes,which is attributed to the reduced thickness that increases the fluctuation and inhibits the nucleation and growth of discommensurations.In addition,the phase mode vanishes when the discommensuration network appears.Our results suggest that the carrier dynamics could be an efficient operational approach to measuring the quantum phase transition in correlated materials. | Rui Wang Junbo Zhou Xinsheng Wang Liming Xie Jimin Zhao Xiaohui Qiu | 2021 | Nano Research2021，14，4： | 0 |
| 17 | Au maskless patterning for vacuum packaging using the electrochemical method显示文摘The interconnection of wires is an important issue in vacuum-packaged microelectromechanical systems devices because of the difficulties of hermetical sealing and electrical insulation.This paper presents an approach of Au film selective patterning on highly uneven surfaces for wire interconnections of devices in which silicon-oninsulator(SOI)wafers are anodically bonded to glass.The Au film on the handle layer,functioned as an anode,was selectively removed with electrochemical dissolution in a chloride solution.The choice of etchant solution and etching conditions were optimized to improve the process efficiency,resulting in a high yield of gold portions within the via holes for wire interconnection.The proposed wire interconnection technology was employed to fabricate a vacuum-packaged resonant pressure sensor as a proof-of-concept demonstration.Reliable wire bonding and vacuum package were achieved as well as a Q factor that does not decrease over a year.As a platform technology,this method provides a new approach of wire interconnection for vacuum-packaged devices based on SOI–glass anodic bonding. | Bo Xie Deyong Chen Junbo Wang Jian Chen Wen Hong | 2018 | Nanotechnology and Precision Engineering2018，1，3： | 0 |
| 18 | Hippo pathway-manipulating neutrophil-mimic hybrid nanoparticles for cardiac ischemic injury via modulation of local immunity and cardiac regeneration显示文摘The promise of regeneration therapy for restoration of damaged myocardium after cardiac ischemic injury relies on targeted delivery of proliferative molecules into cardiomyocytes whose healing benefits are still limited owing to severe immune microenvironment due to local high concentration of proinflammatory cytokines.Optimal therapeutic strategies are therefore in urgent need to both modulate local immunity and deliver proliferative molecules.Here,we addressed this unmet need by developing neutrophil-mimic nanoparticles NM@miR,fabricated by coating hybrid neutrophil membranes with artificial lipids onto mesoporous silica nanoparticles(MSNs)loaded with microRNA-10b.The hybrid membrane could endow nanoparticles with strong capacity to migrate into infammatory sites and neutralize proinfammatory cytokines and increase the delivery efficiency of microRNA-1Ob into adult mammalian cardiomyocytes(CMs)by fusing with cell membranes and leading to the release of MSNs-miR into cytosol.Upon NM@miR administration,this nanoparticle could home to the injured myocardium,restore the local immunity,and efficiently deliver microRNA-1Ob to cardiomyocytes,which could reduce the activation of Hippo-YAP pathway mediated by excessive cytokines and exert the best proliferative effect of miR-1Ob.This combination therapy could finally improve cardiac function and mitigate ventricular remodeling.Consequently,this work offers a combination strategy of immunity modulation and proliferative molecule delivery to boost cardiac regeneration after injury. | Qiaozi Wang Yanan Song Jinfeng Gao Qiyu Li Jing Chen Yifang Xie Zhengmin Wang Haipeng Tan Hongbo Yang Ning Zhang Juying Qian Zhiqing Pang Zheyong Huang Junbo Ge | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 0 |
| 19 | The feasibility of antitumor drugs chemosensitivity testing by flow cytometry显示文摘Objective: To investigate the feasibility of chemosensitivity testing of antitumor drugs by flow cytometry in clinical applications so as to provide experimental and theoretical basis for the establishment of a novel antitumor drugs sensitivity testing and the screening of particular antitumor drugs. Methods: Detect the apoptosis rate of 12 cases of Molt-4 cell line, 57 cases of fresh clinical gastrointestinal tumor cells by Sub-G1 and Annexin V assay of flow cytometry under the effects of antitumor drugs at different times and the outcomes were compared with the ones of the MTT (3-(4,5-dimethylthiazolyl-2) -2,5-diphenyltetrazolium bromide) assay. Results: The lethality of drugs on Molt-4 cell, clinical gastrointestinal tumor cells had a positive correlation with the acting time of antidrugs by employing Annexin V, Sub-G1 and MTT assay. Drug-incurring maximum lethality of Annexin V assay was higher than MTT colorimetric assay, that of Sub-G1 was lower than MTT assay, the virtual times of Annexin V and Sub-G1 assay were obviously earlier than that of MTT colorimetric assay. Conclusion: Annexin V and Sub-G1 assay of flow cytometry can be taken as potent protocols testing anti-tumor drug chemosensitivity. Annexin V assay is featured by more sensitive, concise, reliable compared with the classical chemosensitivity testing assay of MTT colorimetric assay and it possesses clinical applied value. | Jing Yao Jianhong Wu Daxing Xie Xiaolan Li Deding Tao Junbo Hu Jianping Gong | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 0 |
| 20 | From n-alkane to polyacetylene on Cu(110):Linkage modulation in chain growth显示文摘Direct coupling or transformation of inert alkanes based on the selective C-H activation is of great importance for both chemistry and chemical engineering.Here,we report the coupling of polyenes that are transformed from n-dotriacontane(n-C_(22)H_(66))through on-surface cascade dehydrogenation on Cu(110)surface,leading to the formation of polyacetylene(PA).Three distinct linkages have been resolved by scanning tunneling microscope(STM)and noncontact atomic force microscope(nc-AFM).Apart from the α-type linkage which is the stemless coupling of the terminal C-C double bond in trans-configuration,β-and γ-type linkages appear as knots or defects which are,in fact,the C-C couplings in cis-configurations.Interestingly,the“defects”can be effectively suppressed by adjusting the surface coverage,thus making it of general interest for uniform structure modulation. | Zhengming Hao Junjie Zhang Miao Xie Xuechao Li Lina Wang Ye Liu Kaifeng Niu Junbo Wang Luying Song Tao Cheng Haiming Zhang Lifeng Chi | 2022 | Science China Chemistry2022，65，4： | 0 |
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