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| 1 | Homology-mediated end joining-based targeted integration using CRISPR/Cas9显示文摘 | Yao, Xuan Wang, Xing Hu, Xinde Liu, Zhen Liu, Junlai Zhou, Haibo Shen, Xiaowen Wei, Yu Huang, Zijian Ying, Wenqin Wang, Yan Nie, Yan-Hong Zhang, Chen-Chen Li, Sanlan Cheng, Leping Wang, Qifang Wu, Yan Huang, Pengyu Sun, Qiang Shi, Linyu Yang, Hui | 2017 | Cell Research2017，27，6： | 28 |
| 2 | Effects of O3/Cl2 disinfection on corrosion and opportunistic pathogens growth in drinking water distribution systems显示文摘The effects of O_3/Cl_2 disinfection on corrosion and the growth of opportunistic pathogens in drinking water distribution systems were studied using annular reactors(ARs).The corrosion process and most probable number(MPN) analysis indicated that the higher content of iron-oxidizing bacteria and iron-reducing bacteria in biofilms of the AR treated with O_3/Cl_2 induced higher Fe_3O_4 formation in corrosion scales.These corrosion scales became more stable than the ones that formed in the AR treated with Cl_2 alone.O_3/Cl_2 disinfection inhibited corrosion and iron release efficiently by changing the content of corrosion-related bacteria.Moreover,ozone disinfection inactivated or damaged the opportunistic pathogens due to its strong oxidizing properties.The damaged bacteria resulting from initial ozone treatment were inactivated by the subsequent chlorine disinfection.Compared with the AR treated with Cl_2 alone,the opportunistic pathogens M.avium and L.pneumophila were not detectable in effluents of the AR treated with O_3/Cl_2,and decreased to(4.60 ± 0.14) and(3.09 ± 0.12) log10(gene copies/g corrosion scales) in biofilms,respectively.The amoeba counts were also lower in the AR treated with O_3/Cl_2.Therefore,O_3/C_l2 disinfection can effectively control opportunistic pathogens in effluents and biofilms of an AR used as a model for a drinking water distribution system. | Haibo Wang Chun Hu Suona Zhang Lizhong Liu Xueci Xing | 2018 | Journal of Environmental Sciences2018，30，11： | 11 |
| 3 | One-year survey of opportunistic premise plumbing pathogens and free-living amoebae in the tap-water of one northern city of China显示文摘In this study, qPCR was used to quantify opportunistic premise plumbing pathogens(OPPPs) and free-living amoebae in 11 tap water samples collected over four seasons from a city in northern China. Results demonstrated that the average numbers of gene copies of Legionella spp. and Mycobacterium spp. were significantly higher than those of Aeromonas spp.(p < 0.05). Legionella spp. and Mycobacterium spp. were 100%(44/44) positively detected while P. aeruginosa and Aeromonas spp. were 79.54%(35/44) and 77.27%(34/44) positively detected. Legionella pneumophila was only detected in 4 samples(4/44), demonstrating its occasional occurrence. No Mycobacterium avium or Naegleria fowleri was detected in any of the samples. The average gene copy numbers of target OPPPs were the highest in summer,suggesting seasonal prevalence of OPPPs. Average gene copy numbers of OPPPs in the taps of low-use-frequency were higher than in taps of high-use-frequency, but the difference was not significant for some OPPPs(p > 0.05). Moderate negative correlations between the chlorine concentration and the gene copy numbers of OPPPs were observed by Spearman analysis(rsranged from -0.311 to -0.710, p < 0.05). However, no significant correlations existed between OPPPs and AOC, BDOC, or turbidity. Moderate positive correlations were observed between the target microorganisms, especially for Acanthamoeba spp., through Spearman analysis(p < 0.05). Based on our studies, it is proposed that disinfectant concentration, season, taps with different-use frequency, OPPP species, and potential microbial correlations should be considered for control of OPPPs in tap water. | Lizhong Liu Xueci Xing Chun Hu Haibo Wang | 2019 | Journal of Environmental Sciences2019，31，3： | 9 |
| 4 | Thermal Transfer During the Activation Process in LiSi/FeS2 Thermal Batteries显示文摘 | KANG Bo ZHANG Wenli LIN Haibo XING Yonghui ZHAO Jinfeng WANG Yan | 2016 | Chemical Research in Chinese Universities2016，32，4： | 6 |
| 5 | Characterization of bacterial community and iron corrosion in drinking water distribution systems with O3-biological activated carbon treatment显示文摘Bacterial community structure and iron corrosion were investigated for simulated drinking water distribution systems(DWDSs) composed of annular reactors incorporating three different treatments: ozone, biologically activated carbon and chlorination(O_3-BAC-Cl_2);ozone and chlorination(O3-Cl_2); or chlorination alone(Cl_2). The lowest corrosion rate and iron release, along with more Fe_3O_4 formation, occurred in DWDSs with O_3-BAC-Cl_2 compared to those without a BAC filter. It was verified that O_3-BAC influenced the bacterial community greatly to promote the relative advantage of nitrate-reducing bacteria(NRB)in DWDSs. Moreover, the advantaged NRB induced active Fe(III) reduction coupled to Fe(II) oxidation, enhancing Fe_3O_4 formation and inhibiting corrosion. In addition, O_3-BAC pretreatment could reduce high-molecular-weight fractions of dissolved organic carbon effectively to promote iron particle aggregation and inhibit further iron release. Our findings indicated that the O_3-BAC treatment, besides removing organic pollutants in water, was also a good approach for controlling cast iron corrosion and iron release in DWDSs. | Xueci Xing Haibo Wang Chun Hu Lizhong Liu | 2018 | Journal of Environmental Sciences2018，30，7： | 4 |
| 6 | Antioxidative stress-induced damage in cochlear explants显示文摘The imbalance of reactive oxygen species and antioxidants is considered to be an important factor in the cellular injury of the inner ear. At present, great attention has been placed on oxidative stress. However,little is known about fighting oxidative stress. In the current study, we evaluated antioxidant-induced cochlear damage by applying several different additional antioxidants. To determine whether excessive antioxidants can cause damage to cochlear cells, we treated cochlear explants with 50 m M M40403, a superoxide dismutase mimetic, 50 m M coenzyme Q-10, a vitamin-like antioxidant, or 50 m M d-methionine, an essential amino acid and the important antioxidant glutathione for 48 h. Control cochlear explants without the antioxidant treatment maintained their normal structures after incubation in the standard serum-free medium for 48 h, indicating the maintenance of the inherent oxidative and antioxidant balance in these cochlear explants. In contrast, M40403 and coenzyme Q-10-treated cochlear explants displayed significant hair cell damage together with slight damage to the auditory nerve fibers.Moreover, d-methiodine-treated explants exhibited severe damage to the surface structure of hair cells and the complete loss of the spiral ganglion neurons and their peripheral fibers. These results indicate that excessive antioxidants are detrimental to cochlear cells, suggesting that inappropriate dosages of antioxidant treatments can interrupt the balance of the inherent oxidative and antioxidant capacity in the cell. | Dalian Ding Jianghui Zhang Fang Liu Peng Li Weidong Qi Yazhi Xing Haibo Shi Haiyan Jiang Hong Sun Shankai Yin Richard Salvi | 2020 | Journal of Otology2020，15，1： | 3 |
| 7 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | 2013 (9881)2013，，9881： | 2 |
| 8 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 9 | Nanoparticles assembled by aptamers and crystal violet for arsenic(Ⅲ) detection in aqueous solution based on a resonance Rayleigh scattering spectral assay显示文摘 | WU Yuangen ZHAN Shenshan XING Haibo | 2012 | Nanoscale2012，4，21： | 1 |
| 10 | Constructing ECOC based on confusion matrix for multiclass learning problems显示文摘In the pattern recognition field, error-correcting output codes(ECOC) are a powerful tool to fuse any number of binary classifiers to model multiclass problems, and the research of encoding based on data is attracting more and more attention. In this paper, we are going to propose a new encoding method for constructing subclass Error-Correcting Output Codes, which was first introduced by Escalera et al. To achieve this goal, we first obtain the correlation between each pair of classes with the help of confusion matrix. Then,we select the most easily separated subclasses for classification by following Fisher's principle. At last, we were able to obtain binary partitions based on subclasses. After finishing this work, a new data-driven coding matrixSubclass ECOC will be achieved. Experimental results on University of California Irvine data sets and three kinds of high resolution range profile data sets with logistic linear classifier and support vector machine as the binary classifiers show that our approach can provide a better performance and the robustness of classification with a little longer but acceptable code length. | Jindeng ZHOU Yun YANG Mingjie ZHANG Haibo XING | 2016 | Science China(Information Sciences)2016，59，1： | 1 |
| 11 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 12 | Effect of F-Rich Fluids on the A-Type Magmatism and Related Metal Mobilization:New Insights from the Fogang-Nankunshan-Yajishan Igneous Rocks in Southeast China显示文摘About 45%of tungsten,~20%of tin,and~9%of fluorite of known world reserves are associated with Late Mesozoic igneous rocks,Southeast(SE)China.Here we demonstrate that Fogang granite,the largest inland batholith,is mainly of A2-type that is commonly found in post-orogenic settings and experienced plate subduction induced metasomatism.In contrast,the Yajishan syenite and Nankunshan granite intruding the Fogang granite~20 Ma later are of A1-type formed in intraplate settings.We found that F-rich fluid fractionation,which could make the decline of Ga/Al ratio,total(Nb+Y+Ce+Zr)and Zr concentrations,Nb/Ta and Zr/Hf ratios,leads to chemical variations of a few Fogang granites changing from A2-type to highly fractionated or I-and S-type granitoids.Crystal and Frich fluid fractionations,as well as crustal contamination most likely derived from the Fogang granite,result in some Nankunshan granites developing from A1-type into A2-type.These late-or post-magmatic processes should be taken into account carefully when discriminating the petrogenetic types of igneous rocks,especially for the A2-type suites.Combining with the distribution of 180-140 Ma A1-and A2-type igneous rocks,rare metal deposits,and fluorite deposits in SE China,we highlight the significant role of slab-released F-rich fluids in formation of A-type suites and subsequent chemical differentiation and rare metal and fluorine mineralization.A model of flat-slab northeastward rollback is thus proposed,in which the subduction front reached somewhere near Fogang and then started to roll back at~165 Ma.The inland Jurassic granites of SE China represent a unique locality for formation of A-type suites and their associated mineralization.These granites are not anorogenic,but they are the result of slab rollback from a flat slab,founding of that slab at shallow levels,and metasomatism of by F-rich fluids related to slab heating by the asthenosphere. | Xing Ding Koulin Su Haibo Yan Jinlong Liang Weidong Sun | 2022 | Journal of Earth Science2022，33，3： | 1 |
| 13 | Impact of Soil Management on Organic Carbon Content and Aggregate Stability显示文摘 | Haibo Li Xiaozeng Han Feng Wang Yunfa Qiao Baoshan Xing | 2007 | Communications in Soil Science and Plant Analysis (-)2007，，13： | 1 |
| 14 | 1B50-1, a mAb Raised against Recurrent Tumor Cells, Targets Liver Tumor-Initiating Cells by Binding to the Calcium Channel α2δ1 Subunit显示文摘 | Wei Zhao Limin Wang Haibo Han Kemin Jin Na Lin Ting Guo Yangde Chen Heping Cheng Fengmin Lu Weigang Fang Yu Wang Baocai Xing Zhiqian Zhang | 2013 | Cancer Cell2013，，： | 1 |
| 15 | Structural origin of magnetic softening in a Fe-based amorphous alloy upon annealing显示文摘The underlying structural origin of magnetic properties is still elusive in Fe-based amorphous alloys.In this study,distinctive soft magnetic properties were developed in Fe_(76)Si_(9)B_(10)P_(5)amorphous ribbons through systematic design of annealing process.Combining with synchrotron radiation,high-resolution transmission electron microscopy and first principle ab initio molecular dynamic simulation,it is found that the atomic structural evolution both in short range order and medium range order is responsible for the magnetic softness at proper annealing temperature.In short range,formation of separated and densely coordinated Fe-metalloid clusters is instigated to adapt energy minimization,resulting in strengthening of ferromagnetic exchange interaction locally.In medium range,a homogeneous exchangecoupling from the uniformly strong and weak ferromagnetic regions is generated,which significantly weakens magnetic heterogeneity and leads to the excellent magnetic softness.Our findings may provide an effective/promising pathway to modulate the magnetic properties for Fe-based amorphous alloys,and give a comprehensive and quantitative understanding of the structure-properties relationship in amorphous materials. | Xing Tong Yan Zhang Yaocen Wang Xiaoyu Liang Kai Zhang Fan Zhang Yuanfei Cai Haibo Ke Gang Wang Jun Shen Akihiro Makino Weihua Wang | 2022 | Journal of Materials Science & Technology2022，，1： | 1 |
| 16 | Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome显示文摘 | Yu Chen Weifeng Liang Shigui Yang Nanping Wu Hainv Gao Jifang Sheng Hangping Yao Jianer Wo Qiang Fang Dawei Cui Yongcheng Li Xing Yao Yuntao Zhang Haibo Wu Shufa Zheng Hongyan Diao Shichang Xia Yanjun Zhang Kwok-Hung Chan Hoi-Wah Tsoi Jade Lee-Lee Teng We | 2013 | The Lancet2013，，9881： | 1 |
| 17 | Trends in heavy ion interaction with plasma显示文摘 | Yongtao Zhao Zhanghu Hu Rui Cheng Yuyu Wang Haibo Peng Alexander Golubev Xiaoan Zhang Xia Lu Dacheng Zhang Xianming Zhou Xing Wang Ge Xu Jieru Ren Yongfeng Li Yu Lei Yuanbo Sun Jiangtao Zhao Tieshan Wang Younian Wang Guoqing Xiao | 2012 | Laser and Particle Beams2012，，： | 1 |
| 18 | 1B50-1, a mAb Raised against Recurrent Tumor Cells, Targets Liver Tumor-Initiating Cells by Binding to the Calcium Channel α2δ1 Subunit显示文摘 | Wei Zhao Limin Wang Haibo Han Kemin Jin Na Lin Ting Guo Yangde Chen Heping Cheng Fengmin Lu Weigang Fang Yu Wang Baocai Xing Zhiqian Zhang | 2013 | Cancer Cell2013，，4： | 1 |
| 19 | O_3-BAC-Cl_2: A multi-barrier process controlling the regrowth of opportunistic waterborne pathogens in drinking water distribution systems显示文摘Simulated drinking water distribution system(DWDS) treated with O_3-BAC-Cl_2(ozonebiological activated carbon-chlorine) was constructed to study its effects on the regrowth of five typical opportunistic pathogens(OPs). It was found that O_3-BAC-Cl_2 could significantly reduce the regrowth of target OPs in the effluents of DWDS compared with Cl_2 and O_3-Cl_2 with the same residual chlorine levels. However, the effect of O_3-BAC-Cl_2 on the average numbers of target OPs gene markers in the biofilms of DWDS was not apparent, suggesting that OPs in the biofilms of DWDS were tolerant to the upstream disinfection process. The quantification of target OPs in the BAC-filter column demonstrated that OPs decreased with the increase of depth, which was likely due to the organic nutrient gradient and microbial competition inside the BAC-filter. Increase in the ozone dose could further reduce the OPs at the bottom of the BAC-filter. Spearman correlation analysis demonstrated that some significant correlations existed between target microorganisms, suggesting potential microbial ecological relationships. Overall, our results demonstrated that the BAC-filter may act as a 'battlefield'suppressing the OPs through microbial competition. O_3-BAC-Cl_2 could be an effective multibarrier process to suppress the proliferation of OPs in the bulk water of DWDS. However, OPs protected by the biofilms of DWDS should receive further attention because OPs may be detached and released from the biofilms. | Lizhong Liu Xueci Xing Chun Hu Haibo Wang | 2019 | Journal of Environmental Sciences2019，31，2： | 1 |
| 20 | Thin buffer layer assist carbon-modifying separator for long-life lithium metal anodes显示文摘The guided Li dendrite growth by carbon-modifying separator is believed to be an effective strategy for enhancing life of lithium metal batteries(LMBs).However,the weak adhesions,as well as the large interface impedance between the smooth separator and the carbon functional layer(CFL) lead to an easily peeling of the CFL after repetitive cycles.Herein,we propose a promising solution by an inserting thin buffer layer(TBL) to strengthen the adhesion between CFL and separator as a double modifying layer(C-TBL) of the LMBs separator,which greatly improves the stability of the CFL and provides an effective Li metal anode protection.Owing to the sufficient ionic conductivity,chemical stability and strong adhesion to the separator of the TBL,it can avoid the failure of the CFL functionality with small interface impedance.Moreover,the CFL effectively reduces localized flux of Li+ through its abundant pores.The Li/Li cell with C-TBL separator displays the Li dendrite-free and stable cycling performance for at least 1500 h.When LiFePO_(4)(LFP) is employed as the cathode electrode,the assembled full cell with C-TBL separator shows the excellent rate performance and outstanding cycling capability.Our study builds a stable Li+conducting 'bridge' between the functional layer and the separator in stabilizing Li metal anode,and provides a fresh idea of the artificial separator of LMBs. | Jiaqi Li Hongsheng Jia Haibo Li Xing Zhao Guiru Sun Zhiyong Chang Lei Li Ming Jin Zhao Wang Ming Feng | 2021 | Journal of Energy Chemistry2021，30，6： | 0 |
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