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| 1 | Herbgenomics: A stepping stone for research into herbal medicine显示文摘From the prehistoric era until the publishing of the Compendium of Materia Medica and the first scientific Nobel Prize in the Chinese mainland for Tu's discovery on anti-malarial tablets,each milestone and stepping stone in the developmental history of herbal medicine involved intrepid exploration,bold hypothesis formulation,and cautious verification.After thousands of years of discovery and development,herbal research has entered a new era—the era of herbgenomics.Herbgenomics combines herbal and genomic research,bridging the gap between traditional herbal medicine and cutting-edge omics studies.Therefore,it provides a general picture of the genetic background of traditional herbs,enabling researchers to investigate the mechanisms underlying the prevention and treatment of human diseases from an omics perspective. | Haoyu Hu Xiaofeng Shen Baosheng Liao Lu Luo Jiang Xu Shilin Chen | 2019 | Science China(Life Sciences)2019，62，7： | 13 |
| 2 | Global Pharmacopoeia Genome Database is an integrated and mineable genomic database for traditional medicines derived from eight international pharmacopoeias显示文摘Genomic data have demonstrated considerable traction in accelerating contemporary studies in traditional medicine. However,the lack of a uniform format and dispersed storage limits the full potential of herb genomic data. In this study, we developed a Global Pharmacopoeia Genome Database(GPGD). The database contains 34,346 records for 903 herb species from eight global pharmacopoeias(Brazilian, Egyptian, European, Indian, Japanese, Korean, the Pharmacopoeia of the People’s Republic of China, and U.S. Pharmacopoeia’s Herbal Medicines Compendium). In particular, the GPGD contains 21,872 DNA barcodes from 867 species, 2,203 organelle genomes from 674 species, 55 whole genomes from 49 species, 534 genomic sequencing datasets from 366 species, and 9,682 transcriptome datasets from 350 species. Among the organelle genomes, 534 genomes from 366 species were newly generated in this study. Whole genomes, organelle genomes, genomic fragments, transcriptomes, and DNA barcodes were uniformly formatted and arranged by species. The GPGD is publicly accessible at http://gffzzf938e9d610ce4c4ahvwwnqv6pwuu56fxn.ffgz.tsg.suse.edu.cn and serves as an essential resource for species identification, decomposition of biosynthetic pathways, and molecular-assisted breeding analysis. Thus, the database is an invaluable resource for future studies on herbal medicine safety, drug discovery, and the protection and rational use of herbal resources. | Baosheng Liao Haoyu Hu Shuiming Xiao Guanru Zhou Wei Sun Yang Chu Xiangxiao Meng Jianhe Wei Han Zhang Jiang Xu Shilin Chen | 2022 | Science China(Life Sciences)2022，65，4： | 11 |
| 3 | Treatment of multiple sclerosis by transplantation of neural stem cells derived from induced pluripotent stem cells显示文摘Multiple sclerosis(MS) is an autoimmune disease of the central nervous system(CNS), with focal T lymphocytic infiltration and damage of myelin and axons. The underlying mechanism of pathogenesis remains unclear and there are currently no effective treatments. The development of neural stem cell(NSC) transplantation provides a promising strategy to treat neurodegenerative disease. However, the limited availability of NSCs prevents their application in neural disease therapy. In this study, we generated NSCs from induced pluripotent stem cells(iPSCs) and transplanted these cells into mice with experimental autoimmune encephalomyelitis(EAE), a model of MS. The results showed that transplantation of iPSC-derived NSCs dramatically reduced T cell infiltration and ameliorated white matter damage in the treated EAE mice. Correspondingly, the disease symptom score was greatly decreased, and motor ability was dramatically rescued in the iPSC-NSC-treated EAE mice, indicating the effectiveness of using iPSC-NSCs to treat MS. Our study provides pre-clinical evidence to support the feasibility of treating MS by transplantation of iPSC-derived NSCs. | Chao Zhang Jiani Cao Xiaoyan Li Haoyu Xu Weixu Wang Libin Wang Xiaoyang Zhao Wei Li Jianwei Jiao Baoyang Hu Qi Zhou Tongbiao Zhao | 2016 | Science China(Life Sciences)2016，59，9： | 9 |
| 4 | DJ-1 is involved in the multidrug resistance of SGC7901 gastric cancer cells through PTEN/PI3K/Akt/Nrf2 pathway显示文摘Gastric cancer is a common malignancy worldwide.The occurrence of multidrug resistance(MDR)is the major obstacle for effective gastric cancer chemotherapy.In this study,the in-depth molec-ular mechanism of the DJ-1-induced MDR in SGC7901 gastric cancer cells was investigated.The results showed that DJ-1 expression level was higher in MDR variant SGC7901NCR cells than that in its parental SGC7901 cells.Moreover,DJ-1 overexpression conferred the MDR phenotype to SGC7901 cells,while DJ-1 knockdown in SGC7901NCR cells induced re-sensitization to adriamycin,vincristine,cisplatin,and 5-fluorouracil.These results suggested that DJ-1 mediated the develop-ment of MDR in SGC7901 gastric cancer cells.Importantly,further data revealed that the activation of PI3k/Akt and Nrf2 signaling pathway were required for the DJ-1-induced MDR phenotype in SGC7901 gastric cancer cells.Meanwhile,we found that Pl3k/Akt pathway was activated probably through DJ-1 directly binding to and negatively regulating PTEN,consequently resulting in Nrf2 phosphorylation and activation,and thereby inducing Nrf2-dependent P-glycoprotein(P-gp)and Bcl-2 expressions in the DJ-1-mediated MDR of SGC7901 gastric cancer cells.Overall,these results revealed that activating PTEN/PI3K/Akt/Nrf2 pathway and subsequently upregulating P-gp and Bcl-2 expression could be a critical mechanism by which DJ-1 mediates the development of MDR in SGC7901 gastric cancer cells.The new findings may be helpful for understanding the mechanisms of MDR in gastric cancer cells,prompting its further investigation as a molecular target to overcome MDR. | Lejia Qiu Zhaoxia Ma Xiaoran Li Yizhang Deng Guangling Duan Le Zhao Xingwang Xu Lin Xiao Haoyue Liu Zhengming Zhu Heping Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，11： | 5 |
| 5 | A Comparative Analysis of the Chloroplast Genomes of Four Salvia Medicinal Plants显示文摘Herbgenomics is an emerging field of traditional Chinese medicine(TCM)research and development.By combining TCM research with genomics,herbgenomics can help to establish the scientific validity of TCM and bring it into wider usage within the field of medicine.Salvia Linn.(S.Linn.)is a large genus of Labiatae that includes important medicinal plants.In this herbgenomics study,the complete chloroplast(cp)genomes of two Salvia spp.—namely,S.przewalskii and S.bulleyana,which are used as a surrogate for S.miltiorrhiza—were sequenced and compared with those of two other reported Salvia spp.—namely,S.miltiorrhiza and S.japonica.The genome organization,gene number,type,and repeat sequences were compared.The annotation results showed that both Salvia plants contain 114 unique genes,including 80 protein-coding,30 transfer RNA(tRNA),and four ribosomal RNA(rRNA)genes.Repeat sequence analysis revealed 21 forward and 22 palindromic sequences in both Salvia cp genomes,and 17 and 21 tandem repeats in S.przewalskii and S.bulleyana,respectively.A synteny comparison of the Salvia spp.cp genomes showed a high degree of sequence similarity in the coding regions and a relatively high divergence of the intergenic spacers.Pairwise alignment and single-nucleotide polymorphism(SNP)analyses found some candidate fragments to identify Salvia spp.,such as the intergenic region of the trnV–ndhC,trnQ–rps16,atpI–atpH,psbA–ycf3,ycf1,rpoC2,ndhF,matK,rpoB,rpoA,and accD genes.All of the results—including the repeat sequences and SNP sites,the inverted repeat(IR)region border,and the phylogenetic analysis—showed that S.przewalskii and S.bulleyana are extremely similar from a genetic standpoint.The cp genome sequences of the two Salvia spp.reported here will pave the way for breeding,species identification,phylogenetic evolution,and cp genetic engineering studies of Salvia medicinal plants. | Conglian Liang Lei Wang Juan Lei Baozhong Duan Weisi Ma Shuiming Xiao Haijun Qi Zhen Wang Yaoqi Liu Xiaofeng Shen Shuai Guo Haoyu Hu Jiang Xu Shilin Chen | 2019 | Engineering2019，5，5： | 5 |
| 6 | Implementation of regional Acute Stroke Care Map increases thrombolysis rates for acute ischaemic stroke in Chinese urban area in only 3 months显示文摘Background The rate of intravenous thrombolysis for acute ischaemic stroke remains low in China.We investigated whether the implementation of a citywide Acute Stroke Care Map(ASCaM)is associated with an improvement of acute stroke care quality in a Chinese urban area.Methods The ASCaM comprises 10 improvement strategies and has been implemented through a network consisting of 20 tertiary hospitals.We identified 7827 patients with ischaemic stroke admitted from April to October 2017,and 506 patients underwent thrombolysis were finally included for analysis.Results Compared with‘pre-ASCaM period’,we observed an increased rate of administration of tissue plasminogen activator within 4.5 hours(65.4% vs 54.5%;adjusted OR,1.724;95% CI 1.21 to 2.45;p=0.003)during‘ASCaM period’.In multivariate analysis models,‘ASCaM period’was associated with a significant reduction in onset-to door time(114.1±55.7 vs 135.7±58.4 min,p=0.0002)and onset-to needle time(ONT)(169.2±58.1 vs 195.6±59.3 min,p<0.0001).Yet no change was found in door-to needle time.Clinical outcomes such as symptomatic intracranial haemorrhage,favourable functional outcome(modified Rankin Scale≤2)and in-hospital mortality remained unchanged.Conclusion The implementation of ASCaM was significantly associated with increased rates of intravenous thrombolysis and shorter ONT.The ASCaM may,in proof-of principle,serve as a model to reduce treatment delay and increase thrombolysis rates in Chinese urban areas and possibly other highly populated Asian regions. | Yi Sui Jianfeng Luo Chunyao Dong Liqiang Zheng Weijin Zhao Yao Zhang Ying Xian Huaguang Zheng Bernard Yan Mark Parsons Li Ren Ying Xiao Haoyue Zhu Lijie Ren Qi Fang Yi Yang Weidong Liu Bing Xu | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 7 | Numerical Simulation of 2D Supersonic Magnetohydrodynamic Channel and Study on Hall Effect显示文摘In this research effort,numerical simulation of two-dimensional magnetohydrodynamic(MHD) channel is performed and Hall effect is studied.The computational model consists of the Navier-Stokes(N-S) equations coupled with electrical-magnetic source terms,Maxwell equations and the generalized Ohm's law.Boundary conditions for the electrical potential equation considering Hall effect are derived.To start with,the MHD channel with single-pair electrodes is studied and flow of the electric current is in accordance with physical principle.Then the MHD channel with five-pair electrodes is numerically simulated.The results show that the electrical current concentrates on the downstream of the anode and the upstream of the cathode due to Hall effect,and the flow field becomes asymmetrical.At the current value of the magnetic interaction parameter,the electrical-magnetic force affects the flow remarkably,decreasing the outlet Mach number and increasing the outlet pressure;what's more,the flow structure in the channel becomes extremely complex.Performances of MHD channels with continual electrodes and segmented electrodes are compared.The results show that performance of the MHD channel with segmented electrodes is better than that with continual electrodes with the increase of Hall parameter. | ZHENG Xiaomei LU Haoyu XU Dajun CAI Guobiao | 2011 | Chinese Journal of Aeronautics2011，24，2： | 3 |
| 8 | Progress and prospects of horizontal well fracturing technology for shale oil and gas reservoirs显示文摘By systematically summarizing horizontal well fracturing technology abroad for shale oil and gas reservoirs since the “13th Five-Year Plan”, this article elaborates new horizontal well fracturing features in 3D development of stacked shale reservoirs, small well spacing and dense well pattern, horizontal well re-fracturing, fracturing parameters optimization and cost control. In light of requirements on horizontal well fracturing technology in China, we have summarized the technological progress in simulation of multi-fracture propagation, horizontal well frac-design, electric-drive fracturing equipment, soluble tools and low-cost downhole materials and factory-like operation. On this basis, combined with the demand analysis of horizontal well fracturing technology in the “14th Five-Year Plan” for unconventional shale oil and gas, we suggest strengthening the research and development in the following 7 aspects:(1) geology-engineering integration;(2) basic theory and design optimization of fracturing for shale oil and gas reservoirs;(3) development of high-power electric-drive fracturing equipment;(4) fracturing tool and supporting equipment for long horizontal section;(5) horizontal well flexible-sidetracking drilling technology for tapping remaining oil;(6) post-frac workover technology for long horizontal well;(7) intelligent fracturing technology. | LEI Qun XU Yun CAI Bo GUAN Baoshan WANG Xin BI Guoqiang LI Hui LI Shuai DING Bin FU Haifeng TONG Zheng LI Tao ZHANG Haoyu | 2022 | Petroleum Exploration and Development2022，49，1： | 3 |
| 9 | Experimental investigation on the nanoindentation viscoelastic constitutive model of quartz and kaolinite in mudstone显示文摘The creep behaviors in deep underground engineering structures,especially in soft rocks,have a remarkable impact on the long-term stability of the excavations,which finally leads to the high risk and failure of it.Accordingly,it is essential to recognize the time-dependent deformation through the investigation of this phenomenon.In this study,the creep behaviors of soft rocks were examined to help understand the underlying mechanism of the extended time-dependent deformation.Due to the limited results about the time-dependent properties of the constituents of the rock that reveal their heterogeneity,the targeting nanoindentation technique(TNIT),was adopted to investigate the viscoelastic characteristics of kaolinite and quartz in a two-constituent mudstone sample.The TNIT consists of identifications of mineralogical ingredients in mudstone and nanoindentation experiments on each identified constituent.After conducting experiments,the unloading stages of the typical indentation curves were analyzed to calculate the hardness and elastic modulus of both elements in mudstone.Additionally,the 180 s load-holding stages with the peak load of 50 mN were transformed into the typical creep strain-time curves for fitting analysis by using the Kelvin model,the standard viscoelastic model,and the extended viscoelastic model.Fitting results show that the standard viscoelastic model not only can perfectly express the nanoindentation creep behaviors of both kaolinite and quartz but also can produce suitable constants used to measure their creep parameters.The creep parameters of kaolinite are much smaller than that of quartz,which causes the considerable time-dependent deformation of the soft mudstone.Eventually,the standard viscoelastic model was also verified on the quartz in a sandstone sample. | Changlun Sun Guichen Li Mohamed Elgharib Gomah Jiahui Xu Haoyu Rong | 2021 | International Journal of Coal Science & Technology2021，8，5： | 2 |
| 10 | Case study of small scale polytropic index in the central plasma sheet显示文摘This paper studies the effective polytropic index in the central plasma sheet(CPS) by using the method of Kartalev et al.(2006), which adopts the denoising technique of Haar wavelet to identify the homogeneous MHD Bernoulli integral(MBI) and has been frequently used to study the polytropic relation in the solar wind. We chose the quiet CPS crossing by Cluster C1 during the interval 08:51:00–09:19:00 UT on 03 August 2001. In the central plasma sheet, thermal pressure energy per unit mass is the most important part in MBI, and kinetic energy of fluid motion and electromagnetic energy per unit mass are less important. In the MBI, there are many peaks, which correspond to isothermal or near isothermal processes. The interval lengths of homogenous MBI regions are generally less than 1 min. The polytropic indexes are calculated by linearly fitting the data of lnp and lnn within a 16 s window, which is shifted forward by 8 s step length. Those polytropic indexes with |R|≥0.8(R is the correlation coefficient between lnp and lnn) and p-value≤0.1 in the homogeneous regions are almost all in the range of [0, 1]. The mean and median effective polytropic indexes with high R and low p-value in homogeneous regions are 0.34 and 0.32 respectively, which are much different from the polytropic index obtained by traditional method(?trad=?0.15). This result indicates that the CPS is not uniform even during quiet time and the blanket applications of polytropic law to plasma sheet may return misleading value of polytropic index. The polytropic indexes in homogeneous regions with a high correlation coefficient basically have good regression significance and are thus credible. These results are very important to understand the energy transport in magnetotail in the MHD frame. | PANG XueXia CAO JinBin LIU WenLong MA YuDuan LU HaoYu YANG JunYing LI LiuYuan LIU Xu WANG Jing WANG TieYan YU Jiang | 2015 | Science China Earth Sciences2015，58，11： | 2 |
| 11 | Seasonal variations in the plant diet of the Chinese Monal revealed by fecal DNA metabarcoding analysis显示文摘The Chinese Monal(Lophophorus thuysii)is an alpine-obligate galliform species of global conservation priority.It has been listed as a first class protected wildlife species in China,requiring conservation actions during the 14 th Five-Year Plan period.However,the diet composition of Chinese Monal and its seasonal variations have rarely been studied,constraining the effective conservation of the species.Here,we investigated the plant diet composition of the Chinese Monal and its seasonal variations using a DNA metabarcoding approach on fecal samples.We collected 190 fecal samples of the Chinese Monals from the central Qionglai Mountains located in China,and analyzed the plant diet of this species using a DNA metabarcoding approach.Taxonomic profiling of higher plants in the fecal samples was performed using the second internal transcribed spacer(ITS2)amplicon.Downstream analyses,including rarefaction curves,nonmetric multidimensional scaling(NMDS)and permutational multivariate analysis of variance(PERMANOVA),were used to explore the seasonal variations in diet composition.The Chinese Monal foraged a wide range of plant recipes composed of 35 families and 83 genera throughout the year,with Brassicaceae,Apiaceae,and Poaceae as the dominant families,and Cardamine as the dominant genus.The species consumed plants from 62 genera from 28 families during the breeding season(n=81)and 66 genera from 31 families during the non-breeding season(n=109).Further,the plant diet composition significantly varied between the breeding and non-breeding seasons,especially for the frequency of occurrence and relative read abundances at genus level.Our study analyzed the plant diet of the Chinese Monal at a high resolution for the first time,and the results revealed that the seasonal variations in its plant diet composition was adapted to plant phenology and foraging strategy.Fritillaria species,a previously confirmed important food resource for the Chinese Monal,were not detected in any fecal samples,potentially due to overharvesting of Fritillaria bulbs for Traditional Chinese Medicine.Therefore,we highly recommend further restriction of herb gathering in Chinese Monal habitats to facilitate the conservation of this endangered species.Altogether,our study enriches essential ecological information for the Chinese Monal and also provides insights into conservation management for this endangered species. | Bin Wang Yun Li Guiquan Zhang Jian Yang Cao Deng Haoyu Hu Long Zhang Xiaoqin Xu Caiquan Zhou | 2022 | Avian Research2022，13，2： | 2 |
| 12 | Stability analysis of surrounding rock mass in underground powerhouse considering damage effect of microfractures显示文摘A high-precision microseismic(MS)monitoring system was built to monitor surrounding rock microfractures in the underground powerhouse on the left bank of Shuangjiangkou Hydropower Station.The surrounding rock damage area with spatiotemporal clustering of MS activities was studied for qualitative analysis of the damage mechanism of surrounding rock microfractures,based on the source parameters of MS events.The surrounding rock microfracture scale characterized by the source radius of MS events was considered to establish the constitutive relation.MS information was imported into the model for numerical analysis using fast Lagrangian analysis of continuain 3 dimensions(FLAC^(3D)).The results indicated that the numerical simulation results considering MS damage can better reflect the actual situation of the field.The surrounding rock microfractures mainly showed mixed failure characteristics.Shear failures appeared in localized areas while the fracture scale of sections from K0e33 m to K0e15 m on the vault was large.The deformation increment caused by microfracture damage in the shallow surrounding rock of the top arch accounted for 10%e13%,and the stress decrement in the surrounding rock caused by microfracture damage accounted for about 10%. | Peiwei Xiao Haoyu Mao Bo Qian Biao Li Xingguo Yang Nuwen Xu | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，4： | 2 |
| 13 | Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes显示文摘Various biotin-modified liposomes incorporated with docetaxel(DTX) were prepared to study the effect of surface biotin density on the pharmacokinetic profile of the liposome. Four types of liposomes such as PEG modified liposome(PDL), 0.5%(mol) biotin modified liposome(0.5 BDL), 1%(mol) biotin modified liposome(1 BDL) and 2%(mol) biotin modified liposome(2 BDL) were prepared using thin film dispersion method. The prepared liposomes were characterized by measuring encapsulation efficiency(EE), particle size, Zeta-potential, physical stability and drug release profiles in vitro. MTT assay was performed to elevate the cytotoxicity of liposomes on MCF-7 cells. In vivo evaluation was further performed to investigate the effect of biotin surface density on the pharmacokinetic profiles. All the prepared liposomes exhibited high encapsulation efficiency, small particle size, narrow particle distribution and sustained release profiles in vitro. In MTT assay, 0.5 BDL showed largest tumor cell toxicity, compared with DTX solution. All liposomes containing DTX showed prolonged blood circulation in vivo, and 0.5 BDL showed the longest circulation time among the biotin modified liposome. Surface modification of liposome had a negative impact on the circulation of liposomes in the blood, which needs to be considered when designing the ligand mediated targeting delivery systems. A proper amount of biotin liposome with 0.5% molar ratio is expected to produce the best anti-tumor effect. | Chun Chu Ping Xu Haoyue Zhao Qing Chen Dawei Chen Haiyang Hu Xiuli Zhao Mingxi Qiao | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 2 |
| 14 | in vitro study of DNA interaction with trichlorobenzenes by spectroscopic and voltammetric techniques显示文摘 | SHEN Haoyu SHAO Xiaoli XU Hua ct al | 2011 | Int J Electrochem Sci2011，6，3： | 1 |
| 15 | Solubility determination and thermodynamic modeling of bis-2-hydroxyethyl terephthalate(BHET)in different solvents显示文摘Studies on the degradation process of waste polyethylene terephthalate(PET)have become increasingly mature,but there are relatively few studies on the separation of degradation products.The products contain many components and the separation of which is difficult.Therefore,the study on phase equilibrium thermodynamics of bis-2-hydroxyethyl terephthalate(BHET)is of great theoretical significance and practical value to provide basic data for the BHET crystallization separation.In this work,the degraded products were purified and characterized.The solubility of BHET in methanol,ethanol,ethylene glycol,water and the mixture of ethylene glycol+water were determined by static method.The experimental results were correlated with different models,such as ideal solution(IS)model,λh equation,Apelblat equation and NRTL model.Based on the van’t Hoff equation,the mixing Gibbs energy,enthalpy and entropy were calculated.From this work,the basic data which can be used to guide the crystallization process of BHET were obtained,including solubility data,correlation model and thermodynamic properties. | Haoyu Yao Dongxia Yan Xingmei Lu Qing Zhou Yinan Bao Junli Xu | 2022 | Chinese Journal of Chemical Engineering2022，35，5： | 1 |
| 16 | Nanocrystalline aluminum and iron: Mechanical behavior at quasi-static and high strain rates, and constitutive modeling显示文摘 | Akhtar S. Khan Yeong S. Suh Xu Chen Laszlo Takacs Haoyue Zhang | 2005 | International Journal of Plasticity2005，，2： | 1 |
| 17 | Occurrence, Prevention and Control of Cryphalus eriobotryae, a New Devastating Pest of Loquat显示文摘A devastating trunk beetle has been found in Baisha loquat in Dongshan Town, Wuzhong District, Suzhou City in recent years. It is iden-tified as a new insect species, Cryphalus eriobotryae, belonging to Scolytinae, Curculionidae, Coleoptera. So far, loquat is known as the unique host of C. eriobotryae, and trees of 20-30 years old or 3-4 years old are all attacked by the insect. Holes drilled by adults with the diameter of about0.8 mm and sores(ate by adults) with the diameter of 1 mm are found on bark and trunk of damaged trees. Three-dimensional channels in 3-4 layers are formed in cortex, which are filled with insect dung. The phloem turns black-brown in late stage, and loses transport function, resulting in plant death and a great impact on loquat production and industrial development. During the occurrence period of C. eriobotryae from April to November,the damaged trunks and branches should be sprayed with 48% chlorpyrifos EC or 5% imidacloprid EC 100 times dilution once every 10 d for con-tinuous 2-3 times, and various states of the insect could be killed. If the phloem is damaged in the early and middle stages and does not turn black and brown completely, the plant could grow new cortex to realize recovery. | Li Haoyu Yang Daqiang Cai Ping Xu Chunming | 2019 | Plant Diseases and Pests2019，10，3： | 1 |
| 18 | Electrostatic assembly functionalization of poly(γ-glutamic acid)for biomedical antibacterial applications显示文摘Poly(γ-glutamic acid)(γ-PGA)has been found widespread applications in biomedical field because of its excellent water solubility,biocompatibility,and bioactivity.Herein,a water-insoluble γ-PGA antibacterial compound is facilely fabricated via one-pot electrostatic assembly of γ-PGA with cationic ethyl lauroyl arginate(ELA).The functionalized γ-PGA compound(γ-PGA-ELA)ethanol solution can facilely produce colorless and transparent coatings on various inorganic,metal,and polymeric substrates,especially for the lumen of slender catheters(length up to 2 m,and inner diameter down to 1 mm).The functionalized γ-PGA coating presents remarkable antibacterial efficacy in vitro and in vivo.In addition,the γ-PGA compound is used as antibacterial additives of polyolefin via melting extrusion,and the asprepared antibacterial polyolefin demonstrates advantageous antibacterial efficacy.More importantly,the functionalized γ-PGA coating exhibit good hemocompatibility,low cytotoxicity,and satisfactory histocompatibility.The as-proposed γ-PGA compound has a great potential to serve as a safe and multifunctional antibacterial candidate to combat biomedical devices-related infections. | Xiaodan Wang Hengchong Shi Haoyu Tang Huan Yu Qiuyan Yan Huawei Yang Xu Zhang Shifang Luan | 2020 | Journal of Materials Science & Technology2020，59，24： | 1 |
| 19 | Sound radiation of a functionally graded material cylindrical shell in water by mobility method显示文摘Based on the fundamental dynamic equations of functionally graded material (FGM) cylindrical shell, this paper investigates the sound radiation of vibrational FGM shell in water by mobility method. This model takes into account the exterior fluid loading due to the sound press radiated by the FGM shell. The FGM cylindrical shell was excited by a harmonic line radial force uniformly distributing along the generator. The FGM shell equations of motion, the Helmholtz equation in the exterior fluid medium and the continuity equation at fluid-shell interface are used in this vibroacoustic problem. The expressions of sound radiation efficiency and sound field of the FGM shell have been derived by mobility method. Radiation efficiency, modal mobility and the directivity pattern of the sound field are solved numerically. In particular, radiation efficiency and directivity pattern with various power law index are analyzed. | Buqing Xu,1,2, ) Shaopu Yang,3, and Haoyu Li1, 1)Department of Engineering Mechanics, Shijiazhuang Tiedao University, Shijiazhuang 050043, China 2)Provincial Laboratory of Traffic Safety and Control of Hebei, Shijiazhuang Tiedao University, Shijiazhuang 050043, China 3)Shijiazhuang Tiedao University, Shijiazhuang 050043, China | 2011 | Theoretical & Applied Mechanics Letters2011，1，6： | 1 |
| 20 | 50th anniversary of artemisinin:From the discovery to allele-aware genome assembly of Artemisia annua显示文摘Over the past half century,the fight against malaria has been a resounding success mainlydue to thediscoveryof artemisinin.According to the World Health Organization(WHO),morbidity and mortality due to malaria have been cut by half since the promotion of artemisinin-based combination therapy(WHO,2020). | Jiang Xu Baosheng Liao Ling Yuan Xiaofeng Shen Xuejiao Liao Jigang Wang Haoyu Hu Zhihai Huang Li Xiang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 1 |
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