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| 1 | Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement显示文摘Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City,China,by January 30,2020,a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China.Among the confirmed cases,1527 were severe cases,171 had recovered and been discharged at home,and 213 died.And among these cases,a total of 28 children aged from 1 month to 17 years have been reported in China.For standardizing prevention and management of 2019-nCoV infections in children,we called up an experts' committee to formulate this experts' consensus statement.This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections.The present consensus statement summarizes current strategies on diagnosis,treatment,and prevention of 2019-nCoV infection in children. | Kunling Shen Yonghong Yang Tianyou Wang Dongchi Zhao Yi Jiang Runming Jin Yuejie Zheng Baoping Xu Zhengde Xie Likai Lin Yunxiao Shang Xiaoxia Lu Sainan Shu Yan Bai Jikui Deng Min Lu Leping Ye Xuefeng Wang Yongyan Wang Liwei Gao | 2020 | World Journal of Pediatrics2020，16，3： | 56 |
| 2 | Function of Ca^(2+)-/calmodulin-dependent protein kinase Ⅳ in Ca^(2+)-stimulated neuronal signaling and behavior显示文摘The activity of Ca2+/calmodulin-dependent protein kinase IV(Ca MKIV) is sensitive to activity-dependent changes in the level of intracellular Ca2+.Following neuronal stimulation,the activation of Ca MKIV may trigger synaptic modifications and transcriptional responses,both of which are involved in regulating cognitive and emotional behavior.Here,we used Ca MKIV knockout(KO) neurons and mice to examine the function of Ca MKIV in Ca2+-stimulated intracellular signaling and animal behavior,respectively.Following NMDA receptor activation or membrane depolarization,the up-regulation of CREB(c AMP responsive element binding protein) and its target gene Bdnf(brain-derived neurotrophic factor) was intact in cortical neurons obtained from Ca MKIV KO mice.Ca MKIV KO mice displayed severe impairment in contextual fear memory but normal locomotor activity and anxiety level in the contextual training chamber.Although Ca MKIV KO mice showed normal memory in the standard passive avoidance task,they were defective in learning the temporal dissociative passive avoidance task.As indicated by the light/dark test and marble-burying test data,Ca MKIV KO mice showed less anxiety and normal perseveration.In the voluntary wheel-running test,Ca MKIV KO mice showed normal running time and distance but higher maximal running speed.Our results demonstrate the function of Ca MKIV in regulating different forms of fear memory,anxiety,and certain aspect of motor function. | SONG ZiXiang CHEN Qi DING Qi ZHENG Fei LI ChengWei XU LePing WANG HongBing | 2015 | Science China(Life Sciences)2015，58，1： | 6 |
| 3 | Preparation of Spherical FePO4 by Chemical Co-precipitation Combined with Spray-Drying显示文摘Well-shaped spherical agglomerates of FePO4 particles were prepared by a novel method:chemical co-precipitation combined with spray-drying.Tap density analysis,Brunauer-Emmett-Teller analysis,characterizations of X-ray diffraction,scanning electron microscopy,and transmission electron microscopy confirmed that the micron-sized spherical agglomerates with high specific surface area and high tap density were composed of the uniform nano-sized particles.The effects of pH and reaction time on the morphology of the FePO4 particles were investigated by experimental and theoretical analyses.The analyses revealed that amorphous FePO4 was responsible for forming a well-shaped spherical agglomerate,and the ideal spherical particles were obtained at pH 3.The reaction time also played a significant role in controlling the size and surface morphology of the FePO4 particles,and smooth spherical FePO4 particles were obtained at a reaction time of 6 h.By this novel method,poly-porous spherical iron phosphate particles were prepared,which can be used with high efficiency in some special fields,especially as a precursor for synthesizing LiFePO4 and catalysts. | Leping Dang Hongtao Zhang Xin Xu Xiaojun Lang | 2020 | Transactions of Tianjin University2020，26，1： | 3 |
| 4 | Effects of Formulation Parameters and Process Variables on the Properties of Granules Obtained by Reactive Granulation显示文摘In this work, granulation between dodecyl-benzenesulfonic acid and sodium carbonate was investigated in a laboratory-scale high shear mixer. The effects offormulation parameters and process variables, including primary carbonate size, binder content, impeller speed, and operating temperature, were correlated to the properties ofthe product granules. Design ofexperiment and analysis ofvariance were combined to analyze the experimentaldata, and results showed that larger granule sizes with fewer fine particles can be obtained by employing higher binder contents and larger sodium carbonate sizes. The shear force ofthe impeller can extensively break oversized granules. The binder content exerted a contrasting effect on the flowability ofgranules formed with two kinds ofsodium carbonate, likely because ofdifferences in the liquid saturation ofthe solids. The dissolution rate determined by in-line size analysis showed that high binder contents were beneficialto dissolution performance, and the relationships between Hunter color and tested parameters were evaluated. The results ofthis work can be used as a reliable guidance for process controland optimization in powder detergent manufacturing. | Leping Dang Xiaojun Lang Xu Li Hongyuan Wei | 2018 | Transactions of Tianjin University2018，24，3： | 2 |
| 5 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 6 | CXCL12-induced upregulation of FOXM1 expression promotes human glioblastoma cell invasion显示文摘 | Shengwen Wang Shanyi Zhang Junliang Li Xinke Xu Yinlun Weng Meiguang Zheng Leping Ouyang Fangcheng Li | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 7 | The damage assessment of marine oil spill pollution using Back-Propagation neu- ral network显示文摘 | Zhou Junfeng Xu Leping | 2011 | Energy Procedia2011，11，： | 1 |
| 8 | Adenovirus-mediated transfection with glucose transporter 3 suppresses PC12 cell apoptosis following ischemic injury显示文摘In this study,we investigated the effects of adenovirus-mediated transfection of PC12 cells with glucose transporter 3 after ischemic injury.The results of flow cytometry and TUNEL showed that exogenous glucose transporter 3 significantly suppressed PC12 cell apoptosis induced by ischemic injury.The results of isotopic scintiscan and western blot assays showed that,the glucose uptake rate was significantly increased and nuclear factor kappaB expression was significantly decreased after adenovirus-mediated transfection of ischemic PC12 cells with glucose transporter 3.These results suggest that adenovirus-mediated transfection of cells with glucose transporter 3 elevates the energy metabolism of PC12 cells with ischemic injury,and inhibits cell apoptosis. | Junliang Li Xinke Xu Shanyi Zhang Meiguang Zheng Zhonghua Wu Yinlun Weng Leping Ouyang Jian Yu Fangcheng Li | 2012 | Neural Regeneration Research2012，7，17： | 1 |
| 9 | Regime Map of Dry Neutralization Agglomeration Process Containing Non-Reactive Ingredient on a Laboratory Scale显示文摘This study described a regime map for dry neutralization agglomeration. Based on the map, the effects of selected key parameters, such as ingredient composition, operation temperature, agitation speed, and size of Na_2CO_3 particles, were investigated using a laboratory-scale mixer, and properties of the agglomeration product were analyzed, including particle size distribution, Hunter color, and flowability. Torque curves evolving during the process were correlated with the system flowability. Three distinguishable regimes were indicated, dry, wet, and transitional, and the agitation speed was found to have a different influence on the agglomeration process for the three regimes. Furthermore, the influence of temperature on reactive agglomeration significantly differed from that in agglomeration processes in which the binder was non-reactive. | Leping Dang Xu Li Jinsheng Fu Xiaojun Lang Hongyuan Wei | 2019 | Transactions of Tianjin University2019，25，1： | 1 |
| 10 | Haploidentical hematopoietic stem cell transplantation may improve long-term survival for children with high-risk T-cell acute lymphoblastic leukemia in first complete remission显示文摘Background: The role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in children with high-risk (HR) T-cell acute lymphoblastic leukemia (T-ALL) in first complete remission (CR1) is still under evaluation. Moreover, relapse is the main factor affecting survival. This study aimed to explore the effect of allo-HSCT (especially haploidentical HSCT [haplo-HSCT]) on improving survival and reducing relapse for HR childhood T-ALL in CR1 and the prognostic factors of childhood T-ALL in order to identify who could benefit from HSCT.Methods: A total of 74 newly diagnosed pediatric T-ALL patients between January 1, 2012 and June 30, 2018 were enrolled in this retrospective study. Patients were stratified into the low-risk chemotherapy cohort (n = 16), HR chemotherapy cohort (n = 31), and HR transplant cohort (n = 27). Characteristics, survival outcomes, and prognostic factors of all patients were then analyzed.Results: Patient prognosis in the HR chemotherapy cohort was significantly worse than that in the low-risk chemotherapy cohort (5-year overall survival [OS]: 58.5%vs. 100%,P = 0.003;5-year event-free survival [EFS]: 54.1%vs. 83.4%,P = 0.010;5-year cumulative incidence of relapse [CIR]: 45.2%vs. 6.3%,P = 0.011). In HR patients, allo-HSCT improved the 5-year EFS and CIR compared to that of chemotherapy (5-year EFS: 80.1%vs. 54.1%,P = 0.041;5-year CIR: 11.6%vs. 45.2%,P = 0.006). The 5-year OS was higher in the HR transplant cohort than that in the HR chemotherapy cohort (81.0%vs. 58.5%,P = 0.084). Minimal residual disease re-emergence was an independent risk factor for 5-year OS, EFS, and CIR;age ≥10 years was an independent risk factor for OS and EFS;and high white blood cell count was an independent risk factor for EFS and CIR.Conclusion: Allo-HSCT, especially haplo-HSCT, could effectively reduce relapse of children with HR T-ALL in CR1. | Zhang Yongzhan Bai Lu Cheng Yifei Lu Aidong Wang Yu Wu Jun Zhang Xiaohui Zuo Yingxi Xu Lanping Jia Yueping Huang Xiaojun Zhang Leping | 2022 | Chinese Medical Journal2022，，8： | 1 |
| 11 | Preparation and modification of N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride nanoparticle as a protein carrier显示文摘 | Xu Yongmei DuYumin Huang Ronghua Gao Leping | 2003 | Biomaterials2003，29，11： | 1 |
| 12 | Uncertainty Analysis in CFD for Resistance显示文摘基于数字在 CFD (计算液体动力学) 作为无常的三个主要因素被拿的统计,第一边界层的厚度,骚乱模型和房间的拉丁方形的设计。壳的全部的抵抗被计算,在壳附近的流动地被 CFD 方法模仿。然后,壳抵抗上的无常因素的影响被回归分析与整修网孔讨论并且搅乱网孔。通过一系列计算和分析,最佳的计算方法被提出,并且计算的相关参数是坚定的。第三,不同速度的全部的抵抗被使用这些二种格子计算,它在对试验性的结果的好同意。最后,根据 ITTC 推荐了过程,在 CFD 的无常分析被格子的三个集合与一致精炼比率 rG = 与全部的抵抗的数字结果执行 2。当时,修改抵抗与试验性的结果相比,它改进了抵抗预言的精确性。 | WANG Zhongcheng LIU Xiaoyu ZHANG Shenglong XU Leping ZHOU Peilin | 2017 | Journal of Shipping and Ocean Engineering2017，7，5： | 0 |
| 13 | Assessing environmental impact:Micro-energy network optimization in a Chinese industrial park显示文摘Micro-energy systems contribute significantly to environmental improvement by reducing dependence on power grids through the utilization of multiple renewable energy sources.This study quantified the environmental impact of a micro-energy network system in an industrial park through a life cycle assessment using the operation of the micro-energy network over a year as the functional unit and“cradle-to-gate”as the system boundary.Based on the baseline scenario,a natural gas generator set was added to replace central heating,and the light pipes were expanded to constitute the optimized scenario.The results showed that the key impact categories for both scenarios were global warming,fine particulate matter formation,human carcinogenic toxicity,and human non-carcinogenic toxicity.The overall environmental impact of the optimized scenario was reduced by 68%compared to the baseline scenario.A sensitivity analysis of the key factors showed that electricity from the power grid was the key impact factor in both scenarios,followed by central heating and natural gas.Therefore,to reduce the environmental impact of network systems,it is necessary to further optimize the grid power structure.The research approach can be used to optimize micro-energy networks and evaluate the environmental impact of different energy systems. | Guanzhun Cao Chuan Feng Tong Li Hongjuan Zhang Xiaoyao Guo Wen Li Yanshuang Jia Leping Chen Yuan Xu Qingsong Wang Guifang Chen Xueliang Yuan | 2024 | Chinese Journal of Population,Resources and Environment2024，22，1： | 0 |
| 14 | Microstructure and Hot Deformation Behavior of Mg-9Al-3Si-0.375Sr-0.78Y Alloy显示文摘Using Gleeble-3500 thermal simulator,the high temperature plastic deformation behavior and microstructure evolution of Mg-9Al-3Si-0.375Sr-0.78Y alloy are investigated at the temperature of 523 K?673 K and the strain rate of 10^(-3)s^(-1) 10 s^(-1).True strain-true stress curves show the characteristics of the typical dynamically recrystallization process.The Arrhenius constitutive equation of the hyperbolic model is established.The average activation energy and the strain rate sensitivity index are,respectively,221.578 kJ·mol^(-1) and 0.137.The result shows that theα-Mg phase exhibits dynamic recrystallization (DRX)characteristics obviously.But no DRX occurs in the β-Mg_(17)Al_(12) phase.Hot deformation does not affect the primary Mg_(2)Si phase.Under the conditions of low temperature (523 K?673 K) and high strain rate(1 s^(-1) 10 s^(-1)),the flow instability and macro-defects such as crack appear in the specimens.However,there are finer recrystallization grains.Under the conditions of high temperature(≥673 K)or low strain rate,the microstructure of the alloy shows good homogeneity.The size of the primary Mg_(2)Si phase is uniform,the size of the β-Mg_(17)Al_(12) phase is small,and the distribution of the β-Mg_(17)Al_(12) phase is uniform. | CHEN Leping ZHANG Lianteng XU Yong ZHOU Quan | 2022 | 上海航天(中英文)2022，39，1： | 0 |
| 15 | Visualization of Wormlike Micelle Fluid Flow in a Mixing Tank显示文摘In this study,particle image velocimetry was applied to investigate flow fields of wormlike micelle(WLM) fluids in a mixing tank equipped with a four-blade,down-pumping,pitched blade turbine. First,the rheology of WLM fluids was investigated,and the Carreau model was utilized to describe their apparent viscosity. Then,the effects of the rotation speeds and rheological properties on the flow fields were studied using different WLM fluids at different rotation speeds. The results revealed that with increasing Reynolds number,the discharge angle decreases and the carven size increases. Furthermore,elastic effects of WLM fluids lead to a more curved flow and a smaller carven. | Hongyuan Wei Jieliang Lu Chong Gu Kate Xu Boonho Ng Leping Dang | 2018 | Transactions of Tianjin University2018，24，4： | 0 |
| 16 | Abnormal glycosylated hemoglobin as a predictive factor for glucose metabolism disorders in antipsychotic treatment显示文摘The aim of this study was to observe the changes in glucose metabolism after antipsychotic(APS)therapy,to note the influencing factors,as well as to discuss the relationship between the occurrence of glucose metabolism disorders of APS origin and abnormal glycosylated hemoglobin(HbA1c)levels.One hundred and fifty-two patients with schizophrenia,whose fasting plasma glucose(FPG)and 2-h plasma glucose(2hPG)in the oral glucose tolerance test(2HPG)were normal,were grouped according to the HbA1c levels,one normal and the other abnormal,and were randomly enrolled into risperidone,clozapine and chlorpromazine treatment for six weeks.The FPG and 2hPG were measured at the baseline and at the end of the study.In the group with abnormal HbA1c and clozapine therapy,2HPG was higher after the study[(9.5±1.8)mmol/L]than that before the study[(7.2±1.4)mmol/L]and the difference was statistically significant(P<0.01).FPG had no statistically significant difference before and after the study in any group(P>0.05).HbA1c levels and drugs contributing to 2HPG at the end of study had statistical cross-action(P<0.01).In the abnormal HbA1c group,2HPG after the study was higher in the clozapine treatment group[(9.5±1.8)mmol/L]than in the risperidone treatment group[(7.4±1.7)mmol/L]and the chlorpromazine treatment group[(7.3±1.6)mmol/L].The differences were statistically significant(P<0.01).In the normal HbA1c group there was no statistically significant difference before and after the study in any group(P>0.05).2HPG before[(7.1±1.6)mmol/L]and after the study[(8.1±1.9)mmol/L]was higher in the abnormal HbA1c group than in the normal HbA1c group[(6.2±1.4)mmol/L vs(6.5±1.4)mmol/L]with the difference being statistically significant(P<0.01 vs P<0.001).As compared with normal HbA1c group,the relative risk(RR)of glucose metabolism disease occurrence was 4.7 in the abnormal HbA1c group with the difference being statistically significant(P<0.001).Patients with abnormal HbA1c are more likely to have a higher risk of having glucose metabolism disorders after APS treatment. | XU Leping JI Juying DUAN Yiyang SHI Hui ZHANG Bin SHAO Yaqin SUN Jian | 2007 | Frontiers of Medicine2007，1，3： | 0 |
| 17 | Carbon footprint accounting for cigar production processes: A life cycle assessment perspective显示文摘Although the tobacco industry is a significant contributor to energy consumption and carbon emissions its negative environmental impact has received inadequate attention globally.Cigarette factories are a key link in the tobacco industry’s production chain,and using data provided by a cigarette factory in China we conduct a life cycle assessment to account for the carbon footprint of cigar production in cigarette factories.The results of the assessment show that factory air conditioning is the most important contributor to the environmental load of the cigar manufacturing process,while electricity is the key factor that contributes the greatest envi‐ronmental load across all of the processes in the product life cycle.In addition,packaging,including small boxes and cigarette cartons,has a significant impact on the industry’s environmental footprint due to its use of raw materials.We find the carbon footprint of the entire production process for cigar products to be 383.59 kg CO_(2) eq.Based on our findings,we suggest ways to optimize cigar/cigarette factory processes to re‐duce carbon emissions that can help to promote sustainable development in related industries. | Guanzhun Cao Xiaoyao Guo Chuan Feng Tong Li Feng Cui Yuan Xu Shuo Yang Qingsong Wang Leping Chen Xueliang Yuan Guifang Chen | 2023 | Chinese Journal of Population,Resources and Environment2023，21，4： | 0 |
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