|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | Surface Active Sites on Co_(3)O_(4) Nanobelt and Nanocube Model Catalysts for CO Oxidation显示文摘CO oxidation has been performed on Co_(3)O_(4) nanobelts and nanocubes as model catalysts.The Co_(3)O_(4) nanobelts which have a predominance of exposed{011}planes are more active than Co_(3)O_(4) nanocubes with exposed{001}planes.Temperature programmed reduction of CO shows that Co_(3)O_(4) nanobelts have stronger reducing properties than Co_(3)O_(4) nanocubes.The essence of shape and crystal plane effect is revealed by the fact that turnover frequency of Co3+sites of{011}planes on Co_(3)O_(4) nanobelts is far higher than that of{001}planes on Co_(3)O_(4) nanocubes. | Linhua Hu Keqiang Sun Qing Peng Boqing Xu Yadong Li | 2010 | Nano Research2010，3，5： | 21 |
| 3 | Raman lasing and Fano lineshapes in a packaged fiber-coupled whispering-gallery-mode microresonator显示文摘We report Raman lasing and the optical analog of electromagnetically-induced-transparency(EIT) in a whispering-gallery-mode(WGM) microtoroid resonator embedded in a low refractive index polymer matrix together with a tapered fiber coupler. The microtoroid resonator supports both single mode and multimode Raman lasing with low power thresholds. Observations of Fano and EIT-like phenomena in a packaged microresonator will enable high resolution sensors and can be used in networks where slow-light effect is needed. These results will open up new possibilities for portable, robust, and stable WGM microlasers and resonator-based sensors for applications in various environments. | Guangming Zhao Sahin Kaya Ozdemir Tao Wang Linhua Xu Eshan King Gui-Lu Long Lan Yang | 2017 | Science Bulletin2017，62，12： | 6 |
| 4 | Chinese expert consensus on the management of chimeric antigen receptor T cell therapy-associated coagulopathy显示文摘Chimeric antigen receptor T-cell(CAR-T)therapy has greatly improved the disease remission rate and long-term survival rate of patients with relapsed/refractory hematological malignancies.[1-3]Currently,several commercial CAR-T products are available in the market and numerous CAR-T clinical trials have been conducted.Attention should be paid to the safety of CAR-T therapy.The main adverse effects of CAR-T therapy are cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS).[4] | Heng Mei Fangping Chen Yue Han Ming Hou He Huang Xiaojun Huang Yuhua Li Aibin Liang Qifa Liu Ting Niu Jun Peng Wenbin Qian Yongping Song Jianxiang Wang Ying Wang Depei Wu Kailin Xu Linhua Yang Renchi Yang Lei Zhang Liansheng Zhang Xi Zhang Xiaohui Zhang Weili Zhao Weidong Han Yu Hu | 2022 | Chinese Medical Journal2022，，14： | 4 |
| 5 | Influence of Anion Types on the Electrodeposition Healing Effect of Concrete Cracks显示文摘With the zinc salt and magnesium salt solutions, the influence of anion types on the electrodeposition healing effect of concrete cracks was investigated, four parameters such as rate of weight gain, surface coating, crack closure, and crack filling depth were measured, and the mineral composition and appearance of electrodeposits in the cracks were analyzed. The experimental results demonstrate that the electrodeposition healing effect is the best by adopting ZnSO4 and MgSO4 solutions. The mineral composition of electrodeposits in the cracks does not change with the anion types. The most particles of ZnO crystal appear as fusiform by using zinc salt solutions. If we selected MgSO4 solution, the Mg(OH)2 crystal was porous honeycomb. The electrodeposits present as flake structure while the other magnesium salt solutions were adopted. | 储洪强 JIANG Linhua XU Ning XIOANG Chuansheng | 2012 | Journal of Wuhan University of Technology(Materials Science)2012，27，6： | 2 |
| 6 | Reversible adhesion surface coating proppant显示文摘Proppant is a key material in the hydraulic fracturing process,which has been widely used in unconventional oil exploitation.Normal proppants are easy to sedimentate and accumulate at the entrance of shale fracture,which will block the diversion of water,oil and gas.Coated proppants(CPs) are fabricated by coating resin on normal ceramic proppants through a simple method,which is dramatically enhanced the supporting properties in shale fracture and easy to scale up.Compared with uncoated ceramic proppants,the self-suspension ability of CPs is ~11 times higher,which are able to migrate and distribute farther and deeper inside the fracture.At the same time,Coating enhanced the 23.7% of adhesive force in maximum,which makes the CPs easier to adhere on the fracture surface to supportthe shale fracture.Besides,the liquid conductivity of CPs is 60% higher than uncoated ceramic proppants at13.6 MPa pressure.This method is expected to fabricated varieties of proppantsfor shale fracture supporting to improve the exploration of unconventional oil and gas resources. | Quan Xu Fan Fan Zhaohui Lu Mao Sheng Shouceng Tian Ye Zhang Linhua Pan Yang Zhou | 2021 | Chinese Chemical Letters2021，32，1： | 2 |
| 7 | 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy显示文摘Immune thrombocytopenia(ITP)is an acquired disease characterized by isolated thrombocytopenia,which is one of the most common causes of thrombocytopenia during pregnancy.Women with ITP who have severe thrombocytopenia are at an increased risk for life-threatening obstetric complications.Therefore,we established this consensus statement on the diagnosis and management of ITP during pregnancy(detailed information is available in the Supplementary File,http://gffzz16e312a87a7141a5hoocp0obxc6w66kqw.ffgz.tsg.suse.edu.cn/A978). | Zhang Xiaohui Chen Fangping Chen Xiequn Cheng Yunfeng Fang Meiyun Feng Jianming Fu Haixia Gao Hong Han Yue He Aili Hou Ming Hu Yu Huang Ruibin Huang Wenrong Jing Zhicheng Kong Peiyan Liang Aibin Liang Meiying Liu Daihong Liu Junling Liu Lin Liu Xiaowei Ma Liangming Mei Heng Ni Heyu Niu Ting Peng Jun Qiao Jianlin Ren Jinhai Song Yongping Tang Liang V Tong Tong Wang Shaoyuan Wang Xin Wang Zhao Wei Hui Wu Depei Wu Guangsheng Xu Caigang Xu Xue Xu Yajing Yang Linhua Yang Renchi Yang Tonghua Yin Chenghong Yu Li Zhang Guangsen Zhang Lei Zhang Liansheng Zhang Xi Zhao Weili Zhao Yongqiang Zhou Daobin Zhou Hu Zhou Zeping Zhu Tienan Wang Jianliu Huang Xiaojun | 2022 | Chinese Medical Journal2022，，8： | 2 |
| 8 | Influence of de- tection methods on chloride threshold value for the corrosion of steel reinforcement显示文摘 | XU Jinxia JIANG Linhua WANG Jingxiang | 2009 | Construction and Building Materi- als2009，23，5： | 1 |
| 9 | Releases of bound chlorides from chloride-admixed plain and blended cement pastes subjected to sulfate attacks显示文摘 | XU Jinxia ZHANG Changkuan JIANG Linhua | 2013 | Construction and Building Ma- terials2013，，45： | 1 |
| 10 | Mapping Domain- and Age-Specific Functional Brain Activity for Children’s Cognitive and Affective Development显示文摘The human brain undergoes rapid development during childhood,with significant improvement in a wide spectrum of cognitive and affective functions.Mapping domain-and age-specific brain activity patterns has important implications for characterizing the development of children’s cognitive and affective functions.The current mainstay of brain templates is primarily derived from structural magnetic resonance imaging(MRI),and thus is not ideal for mapping children’s cognitive and affective brain development.By integrating task-dependent functional MRI data from a large sample of 250 children(aged 7 to 12)across multiple domains and the latest easy-to-use and transparent preprocessing workflow,we here created a set of age-specific brain functional activity maps across four domains:attention,executive function,emotion,and risky decision-making.Moreover,we developed a toolbox named Developmental Brain Functional Activity maps across multiple domains that enables researchers to visualize and download domain-and age-specific brain activity maps for various needs.This toolbox and maps have been released on the Neuroimaging Informatics Tools and Resources Clearinghouse website(http://gffzza9adc041c78b4b3bhoocp0obxc6w66kqw.ffgz.tsg.suse.edu.cn/projects/dbfa).Our study provides domain-and age-specific brain activity maps for future developmental neuroimaging studies in both healthy and clinical populations. | Lei Hao Lei Li Menglu Chen Jiahua Xu Min Jiang Yanpei Wang Linhua Jiang Xu Chen Jiang Qiu Shuping Tan Jia-Hong Gao Yong He Sha Tao Qi Dong Shaozheng Qin | 2021 | Neuroscience Bulletin2021，37，6： | 1 |
| 11 | Preliminary investigations of antioxidation of Dihydromyrieetin in polymers显示文摘 | Qiukai Zheng Linli Xu Linhua Zhu | 2010 | Bull Mater Sei2010，33，3： | 1 |
| 12 | Influence of N,N'-dimethylaminoethanol as an inhibitor on the chloride threshold level for corrosion of steel reinforcement显示文摘 | Xu Jinxia Jiang Linhua Xing Feng | 2010 | Mater Corros2010，61，9： | 1 |
| 13 | Influence of detection methods on chloride threshold value for the corrosion of steel reinforcement显示文摘 | Xu Jinxia Jiang Linhua Wang Jingxiang | 2009 | Constr Build Mater2009，23，5： | 1 |
| 14 | Influence of CaCI2 and NaCI from different sources on chloride threshold value for the corrosion of steel reinforcement in concrete显示文摘 | XU Jinxia JIANG Linhua WANG Weilun | 2011 | Construction and Building Materials2011，25，2： | 1 |
| 15 | Influence of chloride salt type on threshold level of reinforcement corro- sion in simulated concrete pore solutions显示文摘 | JIANG Linhua HUANG Guohong XU Jinxia | 2012 | Construction and Building Materials2012，30，5： | 1 |
| 16 | Relea- ses of bound chlorides from chloride-admixed plain and blen- ded cement pastes subjected to sulfate attacks显示文摘 | XU Jinxia ZHANG Changkuan JIANG Linhua | 2013 | Construc- tion and Building Materials2013，45，： | 1 |
| 17 | Influence of N, N'-dimethylaminoethanol as an inhibitor on the chloride threshold level for corrosion of steel reinforcement 显示文摘 | XU Jinxia JIANG Linhua XING F | | Materials and Corrosion-Werkstoffe Und Korrosion0，61，9： | 1 |
| 18 | Chloride threshold value for reinforcement corrosion in concrete with additions of silica fume or fly ash显示文摘 | XU Jinxia JIANG Linhua WANG Weilun | 2011 | Magazine of Concrete Research2011，63，12： | 1 |
| 19 | A CODEBOOK COMPENSATIVE VOICE MORPHING ALGORITHM BASED ON MAXIMUM LIKELIHOOD ESTIMATION显示文摘This paper presents an improved voice morphing algorithm based on Gaussian Mixture Model(GMM) which overcomes the traditional one in the terms of overly smoothed problems of the converted spectral and discontinuities between frames.Firstly, a maximum likelihood estimation for the model is introduced for the alleviation of the inversion of high dimension matrixes caused by traditional conversion function.Then, in order to resolve the two problems associated with the baseline, a codebook compensation technique and a time domain medial filter are applied.The results of listening evaluations show that the quality of the speech converted by the proposed method is significantly better than that by the traditional GMM method, and the Mean Opinion Score(MOS) of the converted speech is improved from 2.5 to 3.1 and ABX score from 38% to 75%. | Xu Ning Yang Zhen Zhang Linhua | 2009 | Journal of Electronics(China)2009，26，3： | 1 |
| 20 | Influence of N, N'-dimethylaminoethanol as an inhibitor on the chloride threshold level for corrosion of steel reinforcement 显示文摘 | Xu Jinxia Jiang Linhua Xing Fujian | 2009 | Materials and Corrosion2009，60，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员