|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Plant Prime Editors Enable Precise Gene Editing in Rice Cells显示文摘Genome editing is revolutionizing plant research and crop breeding.Sequence-specific nucleases(SSNs)such as zinc finger nuclease(ZFN)and TAL effector nuclease(TALEN)have been used to create site-specific DNA double-strand breaks and to achieve precise DNA modifications by promoting homology-directed repair(HDR)(Steinert et al.,2016;Voytas,2013).Later,RNA-guided SSNs such as CRISPR-Cas9,Cas12a,Cas12b,and their variants were applied for genome editing in plants(Li et al.,2013;Nekrasov et alM 2013;Tang et al.,2017;Zhong et al.,2019;Ming et al.,2020;Tang et al.,2019).However,HDR relies on simultaneous delivery of SSNs and DNA donors,which has been challenging in plants(Steinert et al.,2016;Zhang et aL,2019).Another challenge for realizing efficient HDR in plants is that DNA repair favors nonhomologous end joining(NHEJ)pathways over HDR in most cell types(Puchta,2005;Qi et al.,2013). | Xu Tang Simon Sretenovic Qiurong Ren Xinyu Jia Mengke Li Tingting Fan Desuo Yin Shuyue Xiang Yachong Guo Li Liu Xuelian Zheng Yiping Qi Yong Zhang | 2020 | Molecular Plant2020，13，5： | 20 |
| 2 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 3 | Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration显示文摘Articular cartilage defect repair is a problem that has long plagued clinicians.Although mesenchymal stem cells(MSCs)have the potential to regenerate articular cartilage,they also have many limitations.Recent studies have found that MSC-derived exosomes(MSC-Exos)play an important role in tissue regeneration.The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix(ACECM)scaffold and to explore the underlying mechanism.The results of in vitro experiments show that human umbilical cord Wharton’s jelly MSC-Exos(hWJMSC-Exos)can promote the migration and proliferation of bone marrow-derived MSCs(BMSCs)and the proliferation of chondrocytes.We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype.The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model.This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response,which may be a promoting factor for osteochondral regeneration.In addition,microRNA(miRNA)sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage.We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis.In summary,this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. | Shuangpeng Jiang Guangzhao Tian Zhen Yang Xiang Gao Fuxin Wang Juntan Li Zhuang Tian Bo Huang Fu Wei Xinyu Sang Liuqi Shao Jian Zhou Zhenyong Wang Shuyun Liu Xiang Sui Quanyi Guo Weimin Guo Xu Li | 2021 | Bioactive Materials2021，6，9： | 11 |
| 4 | Nitrate in shallow groundwater in typical agricultural and forest ecosystems in China,2004-2010显示文摘The nitrate-nitrogen(NO 3-N) concentrations from shallow groundwater wells situated in 29 of the Chinese Ecosystem Research Network field stations,representing typical agroand forest ecosystems,were assessed using monitoring data collected between 2004 and 2010.Results from this assessment permit a national scale assessment of nitrate concentrations in shallow groundwater,and allow linkages between nitrate concentrations in groundwater and broad land use categories to be made.Results indicated that most of the NO 3--N concentrations in groundwater from the agroand forest ecosystems were below the Class 3 drinking water standard stated in the Chinese National Standard:Quality Standard for Ground Water(≤ 20 mg/L).Over the study period,the average NO 3--N concentrations were significantly higher in agro-ecosystems(4.1 ± 0.33 mg/L) than in forest ecosystems(0.5 ± 0.04 mg/L).NO 3-N concentrations were relatively higher(> 10 mg N /L) in 10 of the 43 wells sampled in the agricultural ecosystems.These elevated concentrations occurred mainly in the Ansai,Yucheng,Linze,Fukang,Akesu,and Cele field sites,which were located in arid and semiarid areas where irrigation rates are high.We suggest that improvements in N fertilizer application and irrigation management practices in the arid and semi-arid agricultural ecosystems of China are the key to managing groundwater nitrate concentrations. | Xinyu Zhang Zhiwei Xu Xiaomin Sun Wenyi Dong Deborah Ballantine | 2013 | Journal of Environmental Sciences2013，25，5： | 10 |
| 5 | Optimization and test for spraying parameters of cotton defoliant sprayer显示文摘Boom sprayer is widely used in large farm crops because of its high working efficiency and favorable spraying effect.But there are still some problems in cotton defoliant spraying in Xinjiang,China.Cotton is planted in a high density in Xinjiang,the row space is(10+66)cm,leaves in two adjacent rows are seriously overlapped,the lower leavers are poorly sprayed,so the defoliation effect is poor,and the cotton quality is degraded.To solve this problem and improve the defoliant droplets coverage on the cotton canopy,the original boom spraying was modified,and the spraying pardameters was optimized by the central combination test and design concept of Box-Behnken based on a single-factor test.A quadratic polynomial model of droplets coverage was created by using working parameters including horizontal spraying boom height,hang boom height and nozzles angle as the influential factors and the mean droplets coverage on cotton canopy as the target function,and the effectiveness of mode and interaction of factors were analyzed.The model was optimized and analyzed using the regression analysis method and response surface analysis method of software Design-Expert 7.0.0,and the optimal combination of spraying parameters was obtained.The results showed that the droplets coverage on cotton canopy were influenced by boom height,sprayer height and angled nozzles sequentially from large to small,and the optimal combination of spraying parameters was under horizontal spraying boom height of 134 cm,hang spraying boom height of 27.5 cm and nozzles angle of 21°.The mean droplets coverage of experimental value and predicted value on cotton canopy were 19.6%and 20.43%respectively in such conditions,and the relative error to the estimated value on the model was–4.25%.The research result can provide a reference for further optimizing the spraying parameters of cotton defoliant sprayer. | Qin Weicai Xue Xinyu Cui Longfei Zhou Qingqing Xu Zhufeng Chang Feilong | 2016 | International Journal of Agricultural and Biological Engineering2016，9，4： | 9 |
| 6 | Genome-wide Dissection of Co-selected UV-B Responsive Pathways in the UV-B Adaptation of Qingke显示文摘Qingke (Tibetan hulless barley) has long been cultivated and exposed to long-term and strong UV-B radiation on the Tibetan Plateau, which renders it an ideal species for elucidating novel UV-B responsive mechanisms in plants. Here we report a comprehensive metabolite profiling and metabolite-based genome-wide association study (mGWAS) using 196 diverse qingke and barley accessions. Our results demonstrated both constitutive and induced accumulation, and common genetic regulation, of metabolites from different branches of the phenylpropanoid pathway that are involved in UV-B protection. A total of 90 significant mGWAS loci for these metabolites were identified in barley-qingke differentiation regions, and a number of high-level metabolite trait alleles were found to be significantly enriched in qingke, suggesting co-selection of various phenylpropanoids. Upon dissecting the entire phenylpropanoid pathway, we identified some key determinants controlling natural variation of phenylpropanoid content, including three novel proteins, a flavone C-pentosyltransferase, a tyramine hydroxycinnamoyl acyltransferase, and a MYB transcription factor. Our study, furthermore, demonstrated co-selection of both constitutive and induced phenylpropanoids for UV-B protection in qingke. | Xingquan Zeng Hongjun Yuan Xuekui Dong Meng Peng Xinyu Jing Qijun Xu Tang Tang Yulin Wang Sang Zha Meng Gao Congzhi Li Chujin Shu Zexiu Wei Wangmu Qimei Yuzhen Basang Jiabu Dunzhu Zeqing Li Lijun Bai Jian Shi Zhigang Zheng Sibin Yu Alisdair R.Fernie Jie Luo Tashi Nyima | 2020 | Molecular Plant2020，13，1： | 9 |
| 7 | Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2显示文摘Host cellular receptors play key roles in the determination of virus tropism and pathogenesis.However,little is known about SARS-CoV-2 host receptors with the exception of ACE2.Furthermore,ACE2 alone cannot explain the multi-organ tropism of SARS-CoV-2 nor the clinical differences between SARS-CoV-2 and SARS-CoV,suggesting the involvement of other receptor(s).Here,we performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike(S)protein.Twelve proteins,including ACE2,ASGR1,and KREMEN1,were identified with diverse S-binding affinities and patterns.ASGR1 or KREMEN1 is sufficient for the entry of SARS-CoV-2 but not SARS-CoV in vitro and in vivo.SARS-CoV-2 utilizes distinct ACE2/ASGR1/KREMEN1(ASK)receptor combinations to enter different cell types,and the expression of ASK together displays a markedly stronger correlation with virus susceptibility than that of any individual receptor at both the cell and tissue levels.The cocktail of ASK-related neutralizing antibodies provides the most substantial blockage of SARS-CoV-2 infection in human lung organoids when compared to individual antibodies.Our study revealed an interacting host receptome of SARS-CoV-2,and identified ASGR1 and KREMEN1 as alternative functional receptors that play essential roles in ACE2-independent virus entry,providing insight into SARS-CoV-2 tropism and pathogenesis,as well as a community resource and potential therapeutic strategies for further COVID-19 investigations. | Yunqing Gu Jun Cao Xinyu Zhang Hai Gao Yuyan Wang Jia Wang Juan He Xiaoyi Jiang Jinlan Zhang Guanghui Shen Jie Yang Xichen Zheng Gaowei Hu Yuanfei Zhu Shujuan Du Yunkai Zhu Rong Zhang Jianqing Xu Fei Lan Di Qu Guoliang Xu Yun Zhao Dong Gao Youhua Xie Min Luo Zhigang Lu | 2022 | Cell Research2022，32，1： | 8 |
| 8 | A High-Resolution Earth’s Gravity Field Model SGG-UGM-2 from GOCE,GRACE,Satellite Altimetry,and EGM2008显示文摘This paper focuses on estimating a new high-resolution Earth’s gravity field model named SGG-UGM-2 from satellite gravimetry,satellite altimetry,and Earth Gravitational Model 2008(EGM2008)-derived gravity data based on the theory of the ellipsoidal harmonic analysis and coefficient transformation(EHA-CT).We first derive the related formulas of the EHA-CT method,which is used for computing the spherical harmonic coefficients from grid area-mean and point gravity anomalies on the ellipsoid.The derived formulas are successfully evaluated based on numerical experiments.Then,based on the derived least-squares formulas of the EHA-CT method,we develop the new model SGG-UGM-2 up to degree 2190 and order 2159 by combining the observations of the Gravity Field and Steady-State Ocean Circulation Explorer(GOCE),the normal equation of the Gravity Recovery and Climate Experiment(GRACE),marine gravity data derived from satellite altimetry data,and EGM2008-derived continental gravity data.The coefficients of degrees 251–2159 are estimated by solving the block-diagonal form normal equations of surface gravity anomalies(including the marine gravity data).The coefficients of degrees 2–250 are determined by combining the normal equations of satellite observations and surface gravity anomalies.The variance component estimation technique is used to estimate the relative weights of different observations.Finally,global positioning system(GPS)/leveling data in the mainland of China and the United States are used to validate SGG-UGM-2 together with other models,such as European improved gravity model of the earth by new techniques(EIGEN)-6C4,GECO,EGM2008,and SGG-UGM-1(the predecessor of SGG-UGM-2).Compared to other models,the model SGG-UGM-2 shows a promising performance in the GPS/leveling validation.All GOCE-related models have similar performances both in the mainland of China and the United States,and better performances than that of EGM2008 in the mainland of China.Due to the contribution of GRACE data and the new marine gravity anomalies,SGG-UGM-2 is slightly better than SGG-UGM-1 both in the mainland of China and the United States. | Wei Liang Jiancheng Li Xinyu Xu Shengjun Zhang Yongqi Zhao | 2020 | Engineering2020，6，8： | 8 |
| 9 | Effect of wall boundary condition on CFD simulation of CFB risers显示文摘The effect of solid-phase wall boundary condition on the numerical simulation of gas-solid flow in CFB risers containing FCC particles was investigated using the two-fluid model incorporating the kinetic theory of granular flow.Both the Gidaspow drag model and the EMMS-based drag model were used.The Johnson and Jackson(1987) wall boundary condition was applied to describe the interaction between particles and wall.Based on the experimental system of Li and Kwauk(1994),parametric studies of specularity coefficient(φ=1.0,0.6,0.0005,0.00005,0) and particle-wall restitution coefficient(e_w=0.6,0.9,0.95,0.99,0.999) were performed to evaluate their effects on axial voidage profile,solids flux,meso-scale and heterogeneous structures.Simulation results showed that solid-phase wall boundary condition had little effect on axial voidage profile when the Gidaspow drag model was used.However,the specularity coefficient φ had a pronounced influence on flow behavior when the EMMS-based drag model was used,and a small specularity coefficient(φ=0.00005,0) could result in better agreement with experimental data.The particle-wall restitution coefficient e_w plays but a minor role in the holistic flow characteristics. | Xinyu Zhou Jinsen Gao Chunming Xu Xingying Lan | 2013 | Particuology2013，11，5： | 6 |
| 10 | Scalable microfabrication of three-dimensional porous interconnected graphene scaffolds with carbon spheres for high-performance all carbon-based micro-supercapacitors显示文摘As one of the most important micro energy storage devices(MESDs),graphene-based micro-supercapacitors(G-MSCs)possess the advantages of excellent flexibility,long cycle life,affordability and high reliability.In most cases,constructing three-dimensional(3D)graphene networks is widely utilized to promote the permeation of electrolyte and enhance the utilization of active materials.In this work,conventional freeze-drying process is utilized in the fabrication of G-MSCs to constitute 3D interconnected networks micro-electrodes,and further by regulating the composition of inks,carbon spheres(CSs)at different mass loadings are introduced into the graphene scaffolds to further increase the active sites of the micro-electrodes.The fabricated all carbon-based MSC with the optimal mass loading of CSs(0.406 mg cm^(-2))exhibits a high specific areal capacitance of 17.01mF cm^(-2)at the scan rate of 10mV s^(-1)and a capacitance retention of 93.14%after 10000 cycles at the scan rate of 500 mV s^(-1).The proposed microfabrication process is facile and fully compatible with modern microtechnologies and will be highly suitable for large-scale production and integration. | Yiming Chen Minghao Guo Liang He Wei Yang Lin Xu Jiashen Meng Xiaocong Tian Xinyu Ma Qiang Yu Kaichun Yang Xufeng Hong Liqiang Mai | 2019 | Journal of Materiomics2019，5，2： | 6 |
| 11 | A brief introduction to the FUTang Updating medical REcords(FUTURE)database显示文摘Introduction Futang Research Center of Pediatric Development(FRCPD),the first nonprofit social service organization engaging in pediatric research in China,was founded in May 2013.Until August 2021,FRCPD has 40 tertiary children’s hospitals,accounting for about 65.6%of all national public children’s hospitals,which was reported to be 61 in China Health Statistical Yearbook(2020).The hospitals are distributed in 30 provinces,autonomous regions,and municipalities(except for Tibet autonomous region),and most of them are in the capital of the province,forming a broad frontline representing the best quality of health care for the diagnosis and treatment of children’s disease in China.Based on the idea of sharing,FRCPD realized the exchange of experts,medical resources,research findings,educational events,preventive strategies,and management experiences among members.In the long run,FRCPD aims to continuously promote the quality of healthcare and medical service capability for children in China. | Xinyu Wang Yueping Zeng Jian Tian Hui Xu Fei Song Yongli Guo Xin Xu Guoshuang Feng Xin Ni | 2021 | Pediatric Investigation2021，5，3： | 6 |
| 12 | WFRFT modulation recognition based on HOC and optimal order searching algorithm显示文摘A hybrid carrier(HC) scheme based on weighted-type fractional Fourier transform(WFRFT) has been proposed recently.While most of the works focus on HC scheme's inherent characteristics, little attention is paid to the WFRFT modulation recognition.In this paper, a new theory is provided to recognize the WFRFT modulation based on higher order cumulants(HOC). First, it is deduced that the optimal WFRFT received order can be obtained through the minimization of 4 th-order cumulants, C_(42). Then, a combinatorial searching algorithm is designed to minimize C_(42).Finally, simulation results show that the designed scheme has a high recognition rate and the combinatorial searching algorithm is effective and reliable. | LIANG Yuan DA Xinyu WU Jialiang XU Ruiyang ZHANG Zhe LIU Hujun | 2018 | Journal of Systems Engineering and Electronics2018，29，3： | 6 |
| 13 | Nitrogen pollution and source identification of urban ecosystem surface water in Beijing显示文摘 | Yufen REN Zhiwei XU Xinyu ZHANG Xiaoke WANG Xiaomin SUN D. J. BALLANTINE Shengzhong WANG | 2014 | Frontiers of Environmental Science & Engineering2014，8，1： | 6 |
| 14 | Modulating the threshold voltage of oxide nanowire field-effect transistors by a Ga^+ ion beam显示文摘在这份报纸,我们报导一个方法改变 SnO 的阀值电压<潜水艇class=“ a-plus-plus ”> 2 并且在里面<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”>由 Ga 的 3 只 nanowire 晶体管<啜class=“ a-plus-plus ”>+离子照耀。不同于在更早的报告的结果, SnO 的阀值电压<潜水艇class=“ a-plus-plus ”> 2 并且在里面<潜水艇class=“ a-plus-plus ”> 2 O <潜水艇class=“ a-plus-plus ”>在在 Ga 以后的否定的门电压方向的 3 nanowire 地效果晶体管(联邦货物税)移动<啜class=“ a-plus-plus “>+离子照耀。更小的阀值电压,由 Ga 完成了 < 啜 class= “ a-plus-plus ” >+ 离子照耀,为高效、低电压的操作被要求。阀值电压移动能被归因于 Ga 引起的表面缺点的降级 < 啜 class= “ a-plus-plus ” >+ 离子照耀。在照耀以后,当前的开/关比率稍微衰退,但是离 10 仍然靠近 < 啜 class= “ a-plus-plus ” > 6 。结果显示那 Ga < 啜 class= “ a-plus-plus ” >+ 离子横梁照耀在改进氧化物 nanowire 联邦货物税的表演起一个重要作用。 | Wenqing Li Lei Liao Xiangheng Xiao Xinyue Zhao Zhigao Dai Shishang Guo Wei Wu Ying Shi Jinxia Xu Feng Ren Changzhong Jiang | 2014 | Nano Research2014，7，11： | 5 |
| 15 | Natural Heritage Value of Xinjiang Tianshan and Global Comparative Analysis显示文摘Xinjiang Tianshan is a serial natural property that has been nominated for World Heritage status.This paper presents a systematically comprehensive and comparative analysis of the heritage resources of Xinjiang Tianshan according to the World Heritage criteria.Its biological,ecological and aesthetic values,which are of global importance, are documented.It is concluded that Xinjiang Tianshan meets the world heritage criteria(vii)and (ix).Xinjiang Tianshan is compared with other mountain world heritage sites,mountains in Central Asia,the Tianshan Mountains outside China,and with the protected areas of the Tianshan Mountains on the Tentative List for World Heritage Sites,so as to provide objective data for the world heritage application. | XU Xiaoliang YANG Zhaoping Adayi Saiken Shao Rui LIU Xinyu | 2012 | Journal of Mountain Science2012，9，2： | 5 |
| 16 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 17 | Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain显示文摘Peripheral nerve injury could lead to chronic neuropathic pain.Understanding transcriptional changes induced by nerve injury could provide fundamental insights into the complex pathogenesis of neuropathic pain.Gene expression profiles of dorsal root ganglia(DRG)in neuropathic pain condition have been studied.However,little is known about transcriptomic changes in individual DRG neurons after peripheral nerve injury. | Kaikai Wang Sashuang Wang Yan Chen Dan Wu Xinyu Hu Yingjin Lu Liping Wang Lan Bao Changlin Li Xu Zhang | 2021 | Cell Research2021，31，8： | 5 |
| 18 | A GOCE only gravity model GOSG01S and the validation of GOCE related satellite gravity models显示文摘We compile the GOCE-only satellite model GOSG01 S complete to spherical harmonic degree of 220 using Satellite Gravity Gradiometry(SGG) data and the Satellite-to-Satellite Tracking(SST) observations along the GOCE orbit based on applying a least-squares analysis.The diagonal components(V_(xx),V_(yy),V_(zz)) of the gravitational gradient tensor are used to form the system of observation equations with the band-pass ARMA filter.The point-wise acceleration observations(a_x,a_y,a_z) along the orbit are used to form the system of observation equations up to the maximum spherical harmonic degree/order 130.The analysis of spectral accuracy characteristics of the newly derived gravitational model GOSG01 S and the existing models GOTIM04 S,GODIR04S,GOSPW04 S and JYY_GOCE02S based on their comparison with the ultrahigh degree model EIGEN-6C2 reveals a significant consistency at the spectral window approximately between 80 and 190 due to the same period SGG data used to compile these models.The GOCE related satellite gravity models GOSG01 S,GOTIM05S,GODIR05 S,GOTIM04S,GODIR04 S,GOSPW04S,JYY_-GOCE02 S,EIGEN-6C2 and EGM2008 are also validated by using GPS-leveling data in China and USA.According to the truncation at degree 200,the statistic results show that all GGMs have very similar differences at GPS-leveling points in USA,and all GOCE related gravity models have better performance than EGM2008 in China.This suggests that all these models provide much more information on the gravity field than EGM2008 in areas with low terrestrial gravity coverage.And STDs of height anomaly differences in China for the selected truncation degrees show that GOCE has improved the accuracy of the global models beyond degree 90 and the accuracies of the models improve from 24 cm to 16 cm.STDs of geoid height differences in USA show that GOSGOIS model has best consistency comparing with GPSleveling data for the frequency band of the degree between 20 and 160. | Xinyu Xu Yongqi Zhao Tilo Reubelt Robert Tenzer | 2017 | Geodesy and Geodynamics2017，8，4： | 5 |
| 19 | Biogenic carbonate formation and sedimentation in the Xisha Islands: evidences from living Halimeda显示文摘A recent island survey reveals that the Xuande Atoll and the Yongle Atoll in the Xisha Islands can be classified into one of two systems: the depleted atoll system and growth atoll system; the survey also indicates that the decreased area of several shoals is an unbearable burden for the Xisha Islands, of which the largest island area is 2.13 km2 and the minimum elevation is 1.4 m. According to a survey on the ecological characteristics of Halimeda in the Laolongtou breaker zone of Shidao Island in the Xisha Islands, the green and white living Halimeda are collected,the isotopic ages of 14 C contained in the Halimeda are shown to be 27 years and 55 years, respectively, and carbonate mainly occurs in five types, i.e., luster, segment, sand, sand grain, and marl in the formation. The Halimeda segments mainly provide the carbonate sediments of long-term biogenic deposits in the reef environment and the annual productivity per area is 60–100 g/m2; the characteristics of the microstructure of the Halimeda are analyzed, the aragonite raphide carbonate is deposited and enriched in the cortexes, medullas and cysts, and the Halimeda generally contain major elements such as C, O, Ca, Cl, Mg, K, Na, S and Al, and are rich in trace elements such as tellurium(Te), rhodium(Rh) and strontium. It is believed that the Halimeda grow slowly,including the biotic community of reef corals in the reef areas, thus they possess an environmental remediation capacity, but it takes much time to remedy the environment, and it is necessary to make the law to protect the diversity and vulnerability of the Xisha marine ecology, the ecology of the reef community and the island environment in a scientific way. As indicated in the survey, under the background of global warming and sea-level rise, the discovery of large amounts of Halimeda in the Laolongtou sea area is significant for the natural increase of the depleted atoll system of the Xuande Atoll, while the Halimeda segments represent the primary form of the fossil Halimeda, of which the species can be identified and preserved in great numbers under geological conditions. The Miocene was discovered in large amounts in the Xichen-1 well, therefore the study on the characteristics and mechanism of Halimeda carbonate sediments plays a pivotal role in the formation and construction of organic reefs in the South China Sea as well as oil and gas exploration. | XU Hong ZHAO Xinwei EBERLI G.P. LIU Xinyu ZHU Yurui CAI Ying LUO Wei YAN Guijing ZHANG Bolin WEI Kai SHI Jian | 2015 | Acta Oceanologica Sinica2015，34，4： | 4 |
| 20 | Impact of National Centralized Drug Procurement Policy on Antiviral Utilization and Expenditure for Hepatitis B in China显示文摘Background and Aims:The National Centralized Drug Procurement(NCDP)policy was launched in China's Mainland in April 2019,with entecavir(ETV)and tenofovir disoproxil fumarate(TDF)being included in the procurement list.We conducted the current study to investigate the impact of the NCDP policy on the utilization and expenditures of antiviral therapy for chronic hepatitis B(CHB)in China.Methods:Procurement records,including monthly purchase volume,expenditure,and price of nucleos(t)ide analogs(NAs),were derived from the National Healthcare Security Administration from April 2018 to March 2021.The changes in volumes and expenditures of the first-line NAs and bid-winning products were calculated.The effects of price,volume,and structure related to drug expenditure were calculated by the Addis and Magrini(AM)Index System Analysis.Results:The purchase volume of NAs significantly increased from 134.3 to 318.3 million DDDs,whereas the expenditure sharply decreased from 1,623.41 to 490.43 million renminbi(RMB)or 241.94 to 73.09 million US dollars(USD).The proportions of firstline NAs rose from 72.51%(ETV:69.00%,TDF:3.51%)to 94.97%(ETV:77.42%,TDF:17.55%).AM analysis showed that the NCDP policy decreased the expenditure of all NAs(S=0.91)but increased that of the first-line NAs in the bidwinning list(S=1.13).Assuming the population size of CHB patients remains stable and a compliance rate of≥75%,the proportion of CHB patients receiving first-line antiviral therapy would increase from 6.36–8.48%to 11.56–15.41%.Conclusions:The implementation of the NCDP policy significantly increased the utilization of first-line NAs for CHB patients at a lower expenditure.The findings provided evidence for optimizing antiviral therapy strategy and allocating medical resources in China. | Xinyu Zhao Min Li Hao Wang Xiaoqian Xu Xiaoning Wu Yameng Sun Canjian Ning Bingqiong Wang Shuyan Chen Hong You Jidong Jia Yuanyuan Kong | 2022 | Journal of Clinical and Translational Hepatology2022，10，3： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员