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| 1 | SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade显示文摘Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both in vitro and in vivo. However, whether SHP099-mediated SHP2 inhibition retards tumor growth in vivo via anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line is insensitive to SHP099.Consequently, SHP099 minimally affected CT-26 tumor growth in immuno-deficient nude mice, but significantly decreased the tumor burden in CT-26 tumor-bearing mice with intact immune system.SHP099 augmented anti-tumor immunity, as shown by the elevated proportion of CD8tIFN-γtT cells and the upregulation of cytotoxic T-cell related genes including Granzyme B andPerforin, which decreased the tumor load. In addition, tumor growth in mice with SHP2-deficient T-cells was markedly slowed down because of enhanced anti-tumor responses. Finally, the combination of SHP099 and antiPD-1 antibody showed a higher therapeutic efficacy than either monotherapy in controlling tumor growthin two colon cancer xenograft models, indicating that these agents complement each other. Our study suggests that SHP2 inhibitor SHP099 is a promising candidate drug for cancer immunotherapy. | Mingxia Zhao Wenjie Guo Yuanyuan Wu Chenxi Yang Liang Zhong Guoliang Deng Yuyu Zhu Wen Liu Yanhong Gu Yin Lu Lingdong Kong Xiangbao Meng Qiang Xu Yang Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 18 |
| 2 | Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury显示文摘 | Fang, Fei Yang, Yuyu Yuan, Zhibin Gao, Yuqi Zhou, Jiliang Chen, Qi Xu, Yong | 2011 | 南京医科大学学报(自然科学版)2011，31，6： | 12 |
| 3 | Potential influence of water level changes on energy flows in a lake food web显示文摘Large seasonal water-level fluctuations may influence isotopic signatures of primary producers and the types and amounts of these potential food sources accessible to aquatic fauna of Poyang Lake,the largest freshwater lake in China.In this study,the isotopic signatures of primary producers and consumers were determined,stable carbon and nitrogen isotope analysis and mixing models were combined to investigate the influence of water levels on the diet and isotopic composition of Poyang Lake fish and invertebrates.Five potential food sources (seston,benthic organic matter,aquatic macrophytes,attached algae,and terrestrial plants),4 species of invertebrates,and 10 species of fish were collected from the lake area during dry and wet seasons between January 2009 and April 2010.The δ 13C values of invertebrates and most fish were within the range of δ 13C values of the potential food sources for both seasons.The δ 13C values of invertebrates and most fish were lower in the dry season than in the wet season,whereas the δ 15N values exhibited different patterns for different species.Mixing models indicated that the most important food sources for common lake fauna were seston in the dry season and aquatic macrophytes and terrestrial plants in the wet season.The fauna were more omnivorous in the wet season than in the dry season.The food web dynamics of Poyang Lake are strongly influenced by changes in the abundance and accessibility of different basal food sources that occur because of seasonal flood pulses.The trophic links within the aquatic communities of Poyang Lake are modified by water-level fluctuations. | WANG YuYu YU XiuBo LI WenHua XU Jun CHEN YuWei FAN Na | 2011 | Chinese Science Bulletin2011，56，26： | 11 |
| 4 | Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing显示文摘Many human genetic diseases,including Hutchinson-Gilford progeria syndrome(HGPS),are caused by single point mutations.HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene.Base editors(BEs)composed of a cytidine deaminase fused to CRISPR/Cas9 nickase are highly efficient at inducing C to T base conversions in a programmable manner and can be used to generate animal disease models with single amino-acid substitutions.Here,we generated the first HGPS monkey model by delivering a BE mRNA and guide RNA(gRNA)targeting the LMNA gene via microinjection into monkey zygotes.Five out of six newborn monkeys carried the mutation specifically at the target site.HGPS monkeys expressed the toxic form of lamin A,progerin,and recapitulated the typical HGPS phenotypes including growth retardation,bone alterations,and vascular abnormalities.Thus,this monkey model genetically and clinically mimics HGPS in humans,demonstrating that the BE system can efficiently and accurately generate patient-specific disease models in non-human primates. | Fang Wang Weiqi Zhang Qiaoyan Yang Yu Kang Yanling Fan Jingkuan Wei Zunpeng Liu Shaoxing Dai Hao Li Zifan Li Lizhu Xu Chu Chu Jing Qu Chenyang Si Weizhi Ji Guang-Hui Liu Chengzu Long Yuyu Niu | 2020 | Protein & Cell2020，11，11： | 11 |
| 5 | Global land-surface air temperature change based on the new CMA GLSAT data set显示文摘The China Meteorological Administration(CMA)has recently developed a new global monthly homogenized land-surface air temperature data set.Based on this data set,we reanalyzed the change in global annual mean land-surface air temperature(LSAT)during three time periods(1901–2014,1979–2014 and 1998–2014).The results show that the linear trends of global annual mean LSAT were 0.104°C/decade,0.247°C/decade and 0.098°C/decade for the three periods,respectively.The trends were statistically significant except for the period 1998–2014,the period that | Xiubao Sun Guoyu Ren Wenhui Xu Qingxiang Li Yuyu Ren | 2017 | Science Bulletin2017，62，4： | 10 |
| 6 | Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice显示文摘Metabolic syndrome is a clustering of metabolic disorder with unclear molecular mechanism.Increasing studies have found that the pathogenesis and progression of metabolic syndrome are closely related to inflammation.Here,we report celastrol,a traditional Chinese medicine,can improve high fat diet-induced metabolic syndrome through suppressing resistin-induced inflammation.Mechanistically,celastrol binds to adenylyl cyclase associated protein 1(CAP1)and inhibits the interaction between CAP1 and resistin,which restrains the cyclic adenylate monophosphate(cAMP)-protein kinase A(PKA)-nuclear factor kappa-B(NF-kB)signaling pathway and ameliorates high fat diet-induced murine metabolic syndrome.Knockdown of CAP1 in macrophages abrogated the resistin-mediated inflammatory activity.In contrast,overexpression of CAP1 in macrophages aggravated inflammation.Taken together,our study identifies celastrol,which directly targets CAP1 in macrophages,might be a promising drug candidate for the treatment of inflammatory metabolic diseases,such as metabolic syndrome. | Yuyu Zhu Ning Wan Xinni Shan Guoliang Deng Qiang Xu Hui Ye Yang Sun | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 9 |
| 7 | Doping bioactive elements into a collagen scaffold based on synchronous self-assembly/mineralization for bone tissue engineering显示文摘Pure collagen is biocompatible but lacks inherent osteoinductive,osteoimmunomodulatory and antibacterial activities.To obtain collagen with these characteristics,we developed a novel methodology of doping bioactive elements into collagen through the synchronous self-assembly/mineralization(SSM)of collagen.In the SSM model,amorphous mineral nanoparticles(AMN)(amorphous SrCO3,amorphous Ag3PO4,etc.)stabilized by the polyampholyte,carboxymethyl chitosan(CMC),and collagen molecules were the primary components under acidic conditions.As the pH gradually increased,intrafibrillar mineralization occurred via the self-adaptive interaction between the AMNs and the collagen microfibrils,which were self-assembling;the AMNs wrapped around the microfibrils became situated in the gap zones of collagen and finally transformed into crystals.Srdoped collagen scaffolds(Sr-CS)promoted in vitro cell proliferation and osteogenic differentiation of rat bone marrow mesenchymal stromal cells(rBMSCs)and synergistically improved osteogenesis of rBMSCs by altering the macrophage response.Ag-doped collagen scaffolds(Ag-CS)exhibited in vitro antibacterial effects on S.aureus,as well as cell/tissue compatibility.Moreover,Sr-CS implanted into the calvarial defect of a rat resulted in improved bone regeneration.Therefore,the SSM model is a de novo synthetic strategy for doping bioactive elements into collagen,and can be used to fabricate multifunctional collagen scaffolds to meet the clinical challenges of encouraging osteogenesis,boosting the immune response and fighting severe infection in bone defects. | Huanhuan Liu Mingli Lin Xue Liu Ye Zhang Yuyu Luo Yanyun Pang Haitao Chen Dongwang Zhu Xue Zhong Shiqing Ma Yanhong Zhao Qiang Yang Xu Zhang | 2020 | Bioactive Materials2020，5，4： | 6 |
| 8 | Analysis on Nutrient Compositions and Nutritional Quality of Lota lota( Linnaeus) Muscle显示文摘In order to evaluate the nutritional quality of Lota lota(Linnaeus) muscle,the common nutrient components,amino acid composition and fatty acid composition in muscle of wild Lota lota(captured in Hailang reaches of Mudan River) were determined by routine methods. The results showed that the contents of moisture,crude protein,crude fat and ash were 81. 82%,15. 93%,0. 44% and 1. 06% in fresh muscle of Lota lota,respectively. Totally 17 amino acids,including seven kinds of essential amino acids(EAA),were detected in dry muscle of Lota lota(Linnaeus),accounting for 72. 43% of total dry muscle. The content of EAA was 29. 82%,accounting for 41. 17% of TAA,meeting the amino acid composition of high-quality protein standard required by Food and Agriculture Organization /Word Health Organization(FAO /WHO). There were four delicious amino acids(DAA) in dry muscle,accounting for 28. 34% of total dry weight.The percentage of DAA to TAA was 39. 13% in dry muscle. The contents of C20:5n- 3(EPA) and C22:6n- 3(DHA) in dry muscle were 8. 65% and 20. 32%respectively,which were significantly higher than that of the artificially cultured fish species,such as Oxyeleotris marmorata(EPA:2. 24%,DHA:4. 74%),Spinibarbus sinensis(EPA:0. 87%,DHA:3. 08%) and Glossogobius giuris(EPA: 3. 94%,DHA: 8. 10%). Based on the amino acids score(AAS) and chemical score(CS),the first limited amino acid in Lota lota(Linnaeus) was sulfur-containing amino acid(methionine + cysteine). The essential amino acids index(EAAI) of Lota lota(Linnaeus) was 62.58. It is concluded that Lota lota(Linnaeus) is abundant in amino acids and high-unsaturated fatty acids,and rational in composition of amino acids. Thus,Lota lota(Linnaeus) is a high quality freshwater fish with high nutritional value and health value,possessing good exploitation and utilization prospects. | Xu Gefeng Wang Yuyu Bai Qingli Li Xiaolong Jia Zhonghe | 2014 | Animal Husbandry and Feed Science2014，6，4： | 5 |
| 9 | Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression显示文摘Myocardial infarction triggers massive biochemical changes, even cardiac cell death. Endoplasmic reticulum stress is involved in the pathology of myocardial infarction-mediated apoptosis. In the present study, myocardial cell line H9c2 cells were treated with cobalt chloride(CoCl_2) to induce hypoxia. Isoproterenol was used for two successive days to induce myocardial infarction in SD rats. The cardioprotective effect of olive leaf extract(OLE) and its main constituent hydroxytyrosol and the underlying mechanisms were evaluated. The results showed that hydroxytyrosol markedly protected H9c2 cells against CoCl_2-induced apoptosis. Hydroxytyrosol could reduce the mRNA and protein expression of GRP78 and CHOP induced by CoCl_2 in vitro. In vivo, the decreased ejection fraction and fractional shortening, increased heart weight/body ratio, the formation of infarction, disordered cardiac muscle fibers and infiltration of inflammatory cells induced by isoproterenol could be significantly ameliorated by pretreatment with OLE for a month. Similarly, OLE could also reverse the increase of GRP78 and CHOP expression induced by isoproterenol. Therefore, OLE and hydroxytyrosol exert a cardioprotective effect through endoplasmic reticulum stress, which could be a new target for the prevention and treatment of cardiovascular diseases. | Lixing Wu Yuyu Xu Zhijian Yang Qing Feng | 2018 | The Journal of Biomedical Research2018，32，5： | 4 |
| 10 | New opportunities and challenges of natural products research:When target identification meets single-cell multiomics显示文摘Natural products, and especially the active ingredients found in traditional Chinese medicine(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in TCM. As such,traditional remedies provide shortcuts for the development of original new drugs in China, and increasing numbers of natural products are showing great therapeutic potential in various diseases. This paper reviews the molecular mechanisms of action of natural products from different sources used in the treatment of inflammatory diseases and cancer, introduces the methods and newly emerging technologies used to identify and validate the targets of natural active ingredients, enumerates the expansive list of TCM used to treat inflammatory diseases and cancer, and summarizes the patterns of action of emerging technologies such as single-cell multiomics, network pharmacology, and artificial intelligence in the pharmacological studies of natural products to provide insights for the development of innovative natural product-based drugs. Our hope is that we can make use of advances in target identification and singlecell multiomics to obtain a deeper understanding of actions of mechanisms of natural products that will allow innovation and revitalization of TCM and its swift industrialization and internationalization. | Yuyu Zhu Zijun Ouyang Haojie Du Meijing Wang Jiaojiao Wang Haiyan Sun Lingdong Kong Qiang Xu Hongyue Ma Yang Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 3 |
| 11 | MXene based mechanically and electrically enhanced film for triboelectric nanogenerator显示文摘The development of triboelectric nanogenerator(TENG)technology which can directly convert ambient mechanical energy into electric energy may affect areas from green energy harvesting to emerging wearing electronics.And,the material of triboelectric layer is critical to the mechanical robustness and electrical output characteristics of the TENGs.Herein,a MXene enhanced electret polytetrafluoroethylene(PTFE)film with a high mechanical property and surface charge density is developed.The MXene/PTFE composite film was synthesized by spraying and annealing treatment.With the doping of MXene,the crystallinity of composite film could be tuned,leading to an enhancement in the tensile property of 450%and reducing the wear volume about 80%in the friction test.Furthermore,the as-fabricated TENG with this composite film outputs 397 V of open-circuit voltage,21µA of short-circuit current,and 232 nC of transfer charge quantity,which are 4,6,and 6 times higher than that of the TENG made by pure PTFE film,respectively.Therefore,this work provides a creative strategy to simultaneously improve the mechanical property and electrical performance of the TENGs,which have great potential in improving device stability under a complex mechanical environment. | Yuyu Gao Guoxu Liu Tianzhao Bu Yaoyao Liu Youchao Qi Yanting Xie Shaohang Xu Weili Deng Weiqing Yang Chi Zhang | 2021 | Nano Research2021，14，12： | 2 |
| 12 | Raindrop energy-powered autonomous wireless hyetometer based on liquid-solid contact electrification显示文摘Triboelectric nanogenerators(TENGs)can directly harvest energy via solid-liquid interface contact electrification,making them very suitable for harvesting raindrop energy and as active rainfall sensors.This technology is promising for realizing a fully self-powered system for autonomous rainfall monitoring combined with energy harvesting/sensing.Here,we report a raindrop energy-powered autonomous rainfall monitoring and wireless transmission system(R-RMS),in which a raindrop-TENG(R-TENG)array simultaneously serves as a raindrop energy harvester and rainfall sensor.At a rainfall intensity of 71 mm/min,the R-TENG array can generate an average short-circuit current,open-circuit voltage,and maximum output power of 15 pA,1800 V,and 325 pW,respectively.The collected energy can be adjusted to act as a stable 2.5 V direct-current source for the whole system by a power management circuit.Meanwhile,the R-TENG array acts as a rainfall sensor,in which the output signal can be monitored and the measured data are wirelessly transmitted.Linder a rainfall intensity of 71 mm/min,the R-RMS can be continuously powered and autonomously transmit rainfall data once every 4 min.This work has paved the way for raindrop energy-powered wireless hyetometers,which have exhibited broad prospects in unattended weather monitoring,field surveys,and the Internet of Things. | Chaoqun Xu Xianpeng Fu Chengyu Li Guoxu Liu Yuyu Gao Youchao Qi Tianzhao Bu Yuanfen Chen Zhong Lin Wang Chi Zhang | 2022 | Microsystems & Nanoengineering2022，8，2： | 2 |
| 13 | A comparison of the mechanical properties of fibers spun from different carbon nanotubes显示文摘 | Jingjing Jia Jingna Zhao Geng Xu Jiangtao Di Zhenzhong Yong Yuyu Tao Chao Fang Zuoguang Zhang Xiaohua Zhang Lianxi Zheng Qingwen Li | 2010 | Carbon2010，，4： | 1 |
| 14 | Study on Obstacles to Continuous Cropping of Vegetables and Soil Remediation Technology显示文摘Firstly,this paper analyzes the cause of obstacles to continuous cropping of vegetables,and then introduces the soil ecological remediation technology used for overcoming obstacles to continuous cropping of vegetables. Finally,this paper analyzes the effect of applying soil ecological remediation technology in overcoming obstacles to continuous cropping of vegetables. | Pingsheng FAN Gang CHEN Deli XU Weimin FENG Yuyu LU Anqin GUAN | 2016 | Asian Agricultural Research2016，8，2： | 1 |
| 15 | Systematic Analysis of Gene Expression in Western Flower Thrip( Frankliniella occidentalis Pergande ) before and after Infection with Impatiens Necrotic Spot Virus(INSV)显示文摘Impatiens necrotic spot virus( INSV) is an important plant virus identified in recent years. Western flower thrip( Frankliniella occidentalis) has been confirmed to be the most efficient vector for INSV. In the present study,Illumina's second-generation sequencing technique was used to determine the variation in gene expression at the transcriptome level in western flower thrip before and after infection with INSV. By aligning 168 188 unigenes of western flower thrip to the NCBI protein database,47 558 unigenes were annotated,accounting for 28. 27% of the total. Species classification revealed that 58. 7% of the annotated unigenes of western flower thrip did not match any other species,and 15. 4% of had a match in Zootermopsis navadensis,12. 4% in Mus musculus,7. 3% in Mustela putorius,3. 4% in Theileria parva,and 2. 7% in Tribolium castaneum. By analyzing DEGs between INSV-free and INSV-carrying western flower thrips,we found that 11 genes were upregulated,and 9 genes were downregulated in western flower thrip after INSV infection. In addition,cell cycle and ubiquitin-proteasome pathway in western flower thrip were significantly infected by INSV infection. | Jiani LIU Shengguang XU Yuyu ZHANG Zebin CHEN Rong LU Lei YU | 2017 | Agricultural Biotechnology2017，6，5： | 1 |
| 16 | The point-of-care-testing of nucleic acids by chip, cartridge and paper sensors显示文摘Point-of-care nucleic acid testing(POCNAT) has played an important role in the outbreak of infectious diseases(e.g., COVID-19) over recent years. POCNAT aims to realize the rapid, simple and automatic detection of nucleic acid. Thanks to the development of manufacturing technology, electronic information technology, artificial intelligence technology, and biological information technology in recent years, the development of the POCNAT device has led to significant advancement. Instead of the normal nucleic acid detection methods used in the laboratory, some novel experimental carriers have been applied, such as chips, cartridges and papers. The application of these experimental carriers has realized the automation and integration of nucleic acid detection. The entire process of nucleic acid detection is normally divided into three steps(nucleic acid extraction, target amplification and signal detection). All of the reagents required by the process can be pre-stored on these experimental carriers, without unnecessary manual operation. Furthermore, all of the processes are carried out in this experimental carrier, with the assistance of a specific control device. Although they are complicated to manufacture and precise in design,their application provides a significant step forwards in nucleic acid detection and realizes the integration of nucleic acid detection. This technology has great potential in the field of point-of-care molecular diagnostics in the future. This paper focuses on the relevant content of these experimental carriers. | Yuyue Xu Tao Wang Zhu Chen Lian Jin Zuozhong Wu Jinqu Yan Xiaoni Zhao Lei Cai Yan Deng Yuan Guo Song Li Nongyue He | 2021 | Chinese Chemical Letters2021，32，12： | 1 |
| 17 | Determination of trace amounts of lead, arsenic, nickel and cobalt in high-purity iron oxide pigment by inductively coupled plasma atomic emission spectrometry after iron matrix removal with extractant-contained resin 显示文摘 | Xu Yuyu Zhou Jianfeng Wang Guoxin et el | 2007 | Analytica Chimica Acta2007，584，1： | 1 |
| 18 | Surface-tuned two-dimension MXene scaffold for highly reversible zinc metal anode显示文摘Zinc metal has aroused increasing interest as anode material of Zn-based batteries for their energy storage application.However,the uneven Zn stripping/plating processes induce severe dendrite growth,leading to low Coulombic efficiency and safety hazards.Herein,a surface-tuned two-dimensional(2D)MXene Ti_(3)C_(2)Tx scaffold as a robust skeleton is developed to facilitate the uniform Zn stripping/plating.The Ti_(3)C_(2)Tx with high electrical conductivity and unique structure provides fast ionic-transport paths,promising even Zn2+stripping/plating processes.With suppressed Zn dendrite growth and uniform nucleation,the proposed 2D Ti_(3)C_(2)Tx scaffold for Zn metal anode delivers a low voltage hysteresis of 63 m V and long lifespan over 280 h.This surface-tuned engineering strategy demonstrates the potential application of Zn anode with MXene skeleton for next-generation Zn-based batteries. | Xiaoyu Liu Yongzheng Fang Pengcheng Liang Jiahao Xu Bo Xing Kai Zhu Yuyu Liu Jiujun Zhang Jin Yi | 2021 | Chinese Chemical Letters2021，32，9： | 1 |
| 19 | Circular migration, or permanent stay? Evidence from China’s rural–urban migration显示文摘 | Feng Hu Zhaoyuan Xu Yuyu Chen | 2010 | China Economic Review2010，，1： | 1 |
| 20 | SHP2-mediated mitophagy boosted by lovastatin in neuronal cells alleviates parkinsonism in mice显示文摘Dear Editor,The loss of PINK1/Parkin-dependent mitochondrial clearance causes loss of dopaminergic neurons in the substantia nigra and contributes to the pathogenesis of Parkinson's disease(PD).Several kinases were reported to regulate the ubiquitin E3 ligase activity of Parkin through phosphorylation but the involvement of protein tyrosine phosphatase(PTPase)for Parkin activity remains elusive. | Wen Liu Meijing Wang Lihong Shen Yuyu Zhu Hongyue Ma Bo Liu Liang Ouyang Wenjie Guo Qiang Xu Yang Sun | 2021 | Signal Transduction and Targeted Therapy2021，6，2： | 1 |
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