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| 1 | CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization显示文摘Despite the diverse etiologies of drug-induced liver injury(DILI),innate immunity activation is a common feature involved in DILI progression.However,the involvement of innate immunity regulation in inflammation resolution and liver regeneration in DILI remains obscure.Herein,we identified the chemokine CCL5 as a central mediator of innate immunity regulation in the pathogenesis of DILI.First,we showed that serum and hepatic CCL5 levels are elevated in both DILI patients and an APAP-induced liver injury(AILI)mouse model.Interestingly,both nonparenchymal cells and stressed hepatocytes are cell sources of CCL5 induction in response to liver injury.Functional experiments showed that CCL5 deficiency has no effect on the early phase of AILI but promotes liver repair in the late phase mainly by promoting inflammation resolution and liver regeneration,which are associated with an increased number of hepatic M2 macrophages.Mechanistically,CCL5 can directly activate M1 polarization and impede M2 polarization through the CCR1-and CCR5-mediated activation of the MAPK and NF-κB pathways.We then showed that CCL5 inhibition mediated by either a CCL5-neutralizing antibody or the antagonist Met-CCL5 can greatly alleviate liver injury and improve survival in an AILI mouse model.Our data demonstrate CCL5 induction during DILI,identify CCL5 as a novel innate immunity regulator in macrophage polarization,and suggest that CCL5 blockage is a promising therapeutic strategy for the treatment of DILI. | Meng Li Xuehua Sun Jie Zhao Lei Xia Jichang Li Min Xu Bingrui Wang Han Guo Chang Yu Yueqiu Gao Hailong Wu Xiaoni Kong Qiang Xia | 2020 | Cellular & Molecular Immunology2020，17，7： | 13 |
| 2 | Effects of mepiquat chloride on yield and main properties of cottonseed under different plant densities显示文摘Background:Cottonseed oil and protein content as well as germination traits are major indicators of seed quality.However,the responses of these indicators to plant density and mepiquat chloride(MC)are still uncertain.To investigate plant density and MC effects on cotto nseed yield and main quality parameters,we con ducted a twoyear field experiment including four plant densities(1.35,2.55,3.75 and 4.95 plants·m^-2)and two closes of MC(0 and 135g·hm^-2)in Dafeng,Jiangsu Province,in 2013 and 2014.Results:The application of MC reduced plant height,fruit branch length and fruiting branch number under different plant densities,resulting in a lower and more compact plant canopy.Cottonseed yield showed a nonlinear increase as plant density increasing and achieved the highest value at 3.75 plants·m^-2,regardless of MC application.No significant interactio ns were found between plant density and MC for cotton seed yield and quality parameters.The 100-seed weight,cottonseed oil content and vigor index significantly decreased as plant density increased,while these parameters significantly increased with MC applying under different plant densities.Seed vigor index was positively correlated with 100-seed weight and seed oil con tent across different plant densities and MC treatments.Conclusions:Thus,application of MC could realize a win-win situation between cottonseed yield and main quality parameters under various densities;and plant density of 3.75 plants·m^-2 combined with 135 g·hm^-2 of MC applying is optimal for high cottonseed yield and quality in this cotton production area. | ZHAO Wenqing YAN Qiang YANG Hongkun YANG Xiaoni WANG Leran CHEN Binglin MENG Yali ZHOU Zhiguo | 2019 | Journal of Cotton Research2019，2，2： | 3 |
| 3 | The point-of-care-testing of nucleic acids by chip, cartridge and paper sensors显示文摘Point-of-care nucleic acid testing(POCNAT) has played an important role in the outbreak of infectious diseases(e.g., COVID-19) over recent years. POCNAT aims to realize the rapid, simple and automatic detection of nucleic acid. Thanks to the development of manufacturing technology, electronic information technology, artificial intelligence technology, and biological information technology in recent years, the development of the POCNAT device has led to significant advancement. Instead of the normal nucleic acid detection methods used in the laboratory, some novel experimental carriers have been applied, such as chips, cartridges and papers. The application of these experimental carriers has realized the automation and integration of nucleic acid detection. The entire process of nucleic acid detection is normally divided into three steps(nucleic acid extraction, target amplification and signal detection). All of the reagents required by the process can be pre-stored on these experimental carriers, without unnecessary manual operation. Furthermore, all of the processes are carried out in this experimental carrier, with the assistance of a specific control device. Although they are complicated to manufacture and precise in design,their application provides a significant step forwards in nucleic acid detection and realizes the integration of nucleic acid detection. This technology has great potential in the field of point-of-care molecular diagnostics in the future. This paper focuses on the relevant content of these experimental carriers. | Yuyue Xu Tao Wang Zhu Chen Lian Jin Zuozhong Wu Jinqu Yan Xiaoni Zhao Lei Cai Yan Deng Yuan Guo Song Li Nongyue He | 2021 | Chinese Chemical Letters2021，32，12： | 1 |
| 4 | The genomic and bulked segregant analysis of Curcuma alismatifolia revealed its diverse bract pigmentation显示文摘Compared with most flowers where the showy part comprises specialized leaves(petals)directly subtending the reproductive structures,most Zingiberaceae species produce showy“flowers”through modifications of leaves(bracts)subtending the true flowers throughout an inflorescence.Curcuma alismatifolia,belonging to the Zingiberaceae family,a plant species originating from Southeast Asia,has become increasingly popular in the flower market worldwide because of its varied and esthetically pleasing bracts produced in different cultivars.Here,we present the chromosome-scale genome assembly of C.alismatifolia“Chiang Mai Pink”and explore the underlying mechanisms of bract pigmentation.Comparative genomic analysis revealed C.alismatifolia contains a residual signal of whole-genome duplication.Duplicated genes,including pigment-related genes,exhibit functional and structural differentiation resulting in diverse bract colors among C.alismatifolia cultivars.In addition,we identified the key genes that produce different colored bracts in C.alismatifolia,such as F3′5'H,DFR,ANS and several transcription factors for anthocyanin synthesis,as well as chlH and CAO in the chlorophyll synthesis pathway by conducting transcriptomic analysis,bulked segregant analysis using both DNA and RNA data,and population genomic analysis.This work provides data for understanding the mechanism of bract pigmentation and will accelerate breeding in developing novel cultivars with richly colored bracts in C.alismatifolia and related species.It is also important to understand the variation in the evolution of the Zingiberaceae family. | Xuezhu Liao Yuanjun Ye Xiaoni Zhang Dan Peng Mengmeng Hou Gaofei Fu Jianjun Tan Jianli Zhao Rihong Jiang Yechun Xu Jinmei Liu Jinliang Yang Wusheng Liu Luke RTembrock Genfa Zhu Zhiqiang Wu | 2022 | aBIOTECH2022，3，3： | 1 |
| 5 | RF and field measurements of the SSC-LINAC RFQ显示文摘The 53.667 MHz continuous-wave heavy ion RFQ has been designed and manufactured for the SSC-LINAC project.This four-rod RFQ accelerates ions with maximum mass to charge ratio of 7 from 3.728 keV/u to 143 keV/u.Measurements have been carried out to check the RF performance of the cavity and the quality of the electric field.The S11 of the power coupler is adjusted to better than-44 dB,and the Q0 of the cavity is 6440.The quality of the electric field is evaluated by the perturbation method.The measurement procedure and data analysis will be discussed in detail.The error due to gravity of the perturbation bead has been corrected by averaging the fields in different quadrants.As a result,the unflatness of the electric field is±2.5%,and the dipole field component distributes from 0%to 20%in different longitudinal positions,which indicates the asymmetry of the quadrupole field.The unflatness of the quadrupole field distribution represents a good agreement with the simulation results.High power RF test and beam commissioning of the RFQ are on schedule in early 2014. | LIU Ge LU YuanRong YIN XueJun ZHANG XiaoHu DU Heng JIANG PeiYong LI ZhongShan LI XiaoNi HE Yuan WANG Zhi GAO ShuLi YANG YaQing ZHU Kun YAN XueQing CHEN JiaEr YUAN YouJin XIA JiaWen ZHAO HongWei | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，7： | 0 |
| 6 | A high-quality Bougainvillea genome provides new insights into evolutionary history and pigment biosynthetic pathways in the Caryophyllales显示文摘Bougainvillea is a perennial ornamental shrub that is highly regarded in ornamental horticulture around the world.However,the absence of genome data limits our understanding of the pathways involved in bract coloration and breeding.Here,we report a chromosome-level assembly of the giga-genome of Bougainvillea×buttiana‘Mrs Butt’,a cultivar thought to be the origin of many other Bougainvillea cultivars.The assembled genome is∼5 Gb with a scaffold N50 of 151756278 bp and contains 86572 genes which have undergone recent whole-genome duplication.We confirmed that multiple rounds of whole-genome multiplication have occurred in the evolutionary history of the Caryophyllales,reconstructed the relationship in the Caryophyllales at whole genome level,and found discordance between species and gene trees as the result of complex introgression events.We investigated betalain and anthocyanin biosynthetic pathways and found instances of independent evolutionary innovations in the nine different Caryophyllales species.To explore the potential formation mechanism of diverse bract colors in Bougainvillea,we analyzed the genes involved in betalain and anthocyanin biosynthesis and found extremely low expression of ANS and DFR genes in all cultivars,which may limit anthocyanin biosynthesis.Our findings indicate that the expression pattern of the betalain biosynthetic pathway did not directly correlate with bract color,and a higher expression level in the betalain biosynthetic pathway is required for colored bracts.This improved understanding of the correlation between gene expression and bract color allows plant breeding outcomes to be predicted with greater certainty. | Lan Lan Huiqi Zhao Suxia Xu Shenglong Kan Xiaoni Zhang Weichao Liu Xuezhu Liao Luke RTembrock Yonglin Ren Wayne Reeve Jun Yang Zhiqiang Wu | 2023 | Horticulture Research2023，10，8： | 0 |
| 7 | 重离子存环CSRe上相对论能量类锂O^(5+)离子激光冷却实验研究显示文摘Laser cooling is one of the most promising techniques to achieve high phase-space densities or even crystalline beams for relativistic heavy ion beams at storage rings[1].Based on the success of laser cooling of C^(3+) at the ESR[2,3],and the experience of test laser cooling experiments at the CSRe[4],laser cooling of lithium-like O^(5+) ion beams with an relativistic energy of 275.7 MeV/u was achieved for the first time at the heavy-ion storage ring CSRe in Lanzhou,China.In the experiment,a CW laser system with a wavelength of 220 nm was used to match the optical transition of 2s1=2-2p1=2 of O^(5+)ions.In order to cool the relativistic ion beams with only one counterpropagating CW laser,the ion beams were bunched by applying a sinusoidal voltage to the RF-buncher system.Fig. | Wang Hanbing Wen Weiqiang Huang Zhongkui Zhang Dacheng Chen Dongyang Zhang Hongyi Hai Bang Zhao Dongmei Zhu Xiaolong Li Xiaoni Li Jie Mao lijun Mao Ruishi Zhao Tiecheng Wu Junxia Yin Dayu Yang Jiancheng Yuan Youjin Ma Xinwen | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 8 | 6-2 Recent Progress of the SSC-Linac显示文摘SSC-Linac[1] as the injector for the Separated Sector Cyclotron (SSC), is being constructed at national labo-ratory Heavy Ion Research Facility at Lanzhou (HIRFL). The injection and extraction energy are 3.7 keV/u and1.025 MeV/u, respectively. Fig. 1 shows the front end section of the SSC-Linac. The high charges state continuswave (CW) 4-rod RFQ has been designed and fabricated for some years. From the end of 2013, the commissioningof the RFQ was performed and the beam test was carried out in April 2014. In this paper the experiment resultwill be presented. | Yin Xuejun Yuan Youjin Zhang Xiaohu Lu Wang Du Heng Li Xiaoni Jiang Peiyong Li Zhongcan Wang Haonin Yang Yaqing Ma Lizhen Xu Zhe Zhang Xuezhen Sun Liangting Yao Qinggao Meng Jun Cai Guozhu He Yuan Zhao Hongwei Xia Jiawen Liu Ge Lu Yuanrong Zhu Kun Gao Shuli Yan Xueqing Chen Jiaer | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 9 | Hydrological cycle research by D&^(18)O tracing in small watershed in the loess hilly region显示文摘The objective of this study was to determine the mechanisms of the hydrologic cycle in the loess area in China.Sixty eight water samples from precipitation,soil water of the 0-4 m layer,surface water in the valley,ground water(spring and well)were collected and the Deuterium(D)and Oxygen-18(^(18)O)of these water samples were analyzed to interpret the relationship among those waters in the watershed in the loess hilly region during 2005-2009.The results show that:the D&^(18)O of precipitation in Yangou was consistent with that of Xi,an,apparently the north migration of water vapor in Xi^an;according to the correlations among the differential waters in D&^(18)O,confirmed that precipitation recharge could account for most of the sources of valley flow,with part of the recharge water going to soil water recharge.The D&^(18)O of groundwater were very close to that of precipitation,likely the soil preferential flow was dominant in groundwater recharge although the infiltration had a certain lag.Under the influence of rainfall and evaporation,the response of the soil moisture profile,and its D&^(18)O profile were different.The soil moisture had the strong influenced layer in the 60-160 cm range,a weak impacted layer in 60 l60 cm,and a stable layer below l60 cm.It was shown that the soil evaporation depth could be up to l60 cm because the D&^(18)O changed in that depth.The study could increase our understanding of the magnitude and pattern of the hydrologic cycle,which should improve water resources management in the watershed scale. | Xu Xuexuan Zhao Jiaona Zhang Xiaoni | 2013 | International Soil and Water Conservation Research2013，1，3： | 0 |
| 10 | Sympatric or micro-allopatric speciation in a glacial lake?Genomic islands support neither显示文摘Apparent cases of sympatric speciation may actually be due to micro-allopatric or micro-parapatric speciation.One way to distinguish between these models is to examine the existence and nature of genomic islands of divergence,wherein divergent DNA segments are interspersed with low-divergence segments.Such islands should be rare or absent under micro-allopatric speciation but common in cases of speciation with gene flow.Sympatric divergence of endemic fishes is known from isolated saline,crater,postglacial,and ancient lakes.Two morphologically distinct cyprinid fishes,Gymnocypris eckloni scoliostomus(GS)and G.eckloni eckloni(GE),in a small glacial lake on the Qinghai-Tibet Plateau,Lake Sunmcuo,match the biogeographic criteria of sympatric speciation.In this study,we examined genome-wide variation in 46individuals from these two groups.The divergence time between the GS and GE lineages was estimated to be 20-60 Kya.We identified 54 large genomic islands(≥100 kb)of speciation,which accounted for 89.4%of the total length of all genomic islands.These islands harboured divergent genes related to olfactory receptors and olfaction signals that may play important roles in food selection and assortative mating in fishes.Although the genomic islands clearly indicated speciation with gene flow and rejected micro-allopatric speciation,they were too large to support the hypothesis of sympatric speciation.Theoretical and recent empirical studies suggested that continual gene flow in sympatry should give rise to many small genomic islands(as small as a few kilobases in size).Thus,the observed pattern is consistent with the extensive evidence on parapatric speciation,in which adjacent habitats facilitate divergent selection but also permit gene flow during speciation.We suggest that many,if not most,of the reported cases of sympatric speciation are likely to be micro-parapatric speciation. | Ning Sun Liandong Yang Fei Tian Honghui Zeng Ziwen He Kai Zhao Cheng Wang Minghui Meng Chenguang Feng Chengchi Fang Wenqi Lv Jing Bo Yongtao Tang Xiaoni Gan Zuogang Peng Yiyu Chen Shunping He | 2022 | National Science Review2022，9，12： | 0 |
| 11 | CSRe上激光冷却实验准备:测量^(3)C子的寿命和比例显示文摘Laser cooling is the most promising method to achieve high phase-space densities,even crystalline beams for relativistic heavy ion at storage rings[1].While a pure ion beam is usually desirable for laser cooling experiments to avoid spurious heating effects by any non-cooled ion species,we have found the C^(3+) ion beams produced by an Electron Cyclotron Resonance(ECR)ion source to be mixed with a significant fraction of O^(4+),because these two ions have almost the same mass-to-charge ratio and could not be separated by the analyzing magnets.Therefore,both ion species were injected into the CSRe and present during all experiments. | Wang Hanbing Wen Weiqiang Huang Zhongkui Zhang Dacheng Hai Bang Zhu Xiaolong Zhao Dongmei Li Jie Li Xiaoni Mao lijun Mao Ruishi Yang Jiancheng Yuan Youjin Ma Xinwen Laser Cooling Collaboration | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 12 | 3-3 Preparation for Laser Cooling of Relativistic Li-like 16O5+Ion Beams at the CSRe显示文摘Laser cooling of relativistic heavy ion beams at storage rings is one of the most promising techniques to reach high phase-space densities and achieve a phase transition,an ordered beam,or even a crystalline beam.Compared with the established cooling schemes at storage rings,such as electron cooling and stochastic cooling,laser cooling rate is expected to be much higher and laser-cooled ion beams could reach ultra-low temperatures(~mK).The preparation of laser cooling of 280 MeV/u 16O^5+ion beams at the experimental cooler storage ring CSRe is in progress at the Institute of Modern Physics[1],Chinese Academy of Sciences. | Wen Weiqiang Wang Hanbing Huang Zhongkui Zhang Dacheng Hai Bang Zhu Xiaolong Zhao Dongmei Yang Jie Li Xiaoni Li Jie Mao Ruishi Mao Lijun Yang Jiancheng Yuan Youjin Ma Xinwen | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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