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| 1 | Current perspectives on in vitro maturation and its effects on oocyte genetic and epigenetic profiles显示文摘In vitro maturation(IVM), the maturation in culture of immature oocytes, has been used in clinic for more than 20 years.Although IVM has the specific advantages of low cost and minor side effects over controlled ovarian stimulation, the prevalence of IVM is less than 1% of routine in vitro fertilization and embryo transfer techniques in many reproductive centers. In this review, we searched the MEDLINE database for all full texts and/or abstract articles published in English with content related to oocyte IVM mainly between 2000 and 2016. Many different aspects of the IVM method may influence oocyte potential,including priming, gonadotrophin, growth factors, and culture times. The culture conditions of IVM result in alterations in the oocyte or cumulus cell transcriptome that are not observed under in vivo culture conditions. Additionally, epigenetic modifications, such as DNA methylation or acetylation, are also different between in vitro and in vivo cultured oocytes. In sum,current IVM technique is still not popular and requires more systematic and intensive research to improve its effects and applications. This review will help point our problems, supply evidence or clues for future improving IVM technique, thus assist patients for fertility treatment or preservation as an additional option. | Cuiling Lu Yaoyao Zhang Xiaoying Zheng Xueling Song Rui Yang Jie Yan Huailiang Feng Jie Qiao | 2018 | Science China(Life Sciences)2018，61，6： | 10 |
| 2 | Stochastic modeling the effect of wind gust on dust entrainment during sand storm显示文摘After the passage of a cold front,spring in northern China the outbreak of strong wind is often accompanied by dust emissions.Owing to the coherent structure of wind gust,dust particles can effectively overcome the systematic descending air motion and penetrate into the middle and upper levels of the atmospheric boundary layer,and then propagate further and diffuse into the troposphere where ascending air motion prevails.Here,we consider the coherent structure of wind gust in LS models,and construct a model suitable for the dust entrainment under the dust-storm canopy.With the parameter of gust,we simulate the dust entrainment during dust storms,and test that the coherent structures of wind gust make the sand particles to reach the upper of the boundary layer. | CHENG XueLing ZENG QingCun HU Fei | 2012 | Chinese Science Bulletin2012，57，27： | 10 |
| 3 | Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness显示文摘In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness(DOCs). In this paper, an oddball paradigm with two types of frequencydeviant stimulus(standard stimuli were pure tones of 1000 Hz; small deviant stimuli were pure tones of 1050 Hz; large deviant stimuli were pure tones of 1200 Hz) was applied to elicit mismatch negativity(MMN) in 30 patients with DOCs diagnosed using the JFK Coma Recovery ScaleRevised(CRS-R). The results showed that the peak amplitudes of MMN elicited by both large and small deviant stimuli were significantly different from baseline.In terms of the spatial properties of MMN, a significant interaction effect between conditions(small and large deviant stimuli) and electrode nodes was centered at the frontocentral area. Furthermore, correlation coefficients were calculated between MMN amplitudes and CRS-R scores for each electrode among all participants to generate topographic maps. Meanwhile, a significant negative correlation between the MMN amplitudes elicited by large deviant stimuli and the CRS-R scores was also found at the frontocentral area. In consequence, our results combine the above spatial properties of MMN in patients with DOCs,and provide a more precise location(frontocentral area) at which to evaluate the correlation between clinical electrophysiological assessment and the level of consciousness. | Xiaoyu Wang Rao Fu Xiaoyu Xia Xueling Chen Han Wu Nicole LANDi Ken Pugh Jianghong He Fengyu Cong | 2018 | Neuroscience Bulletin2018，34，4： | 9 |
| 4 | Experimental and numerical investigation on the thermal and mechanical behaviours of thermal barrier coatings exposed to CMAS corrosion显示文摘Calcium-magnesium-alumino-silicate(CMAS)corrosion is a critical factor which causes the failure of thermal barrier coating(TBC).CMAS attack significantly alters the temperature and stress fields in TBC,resulting in their delamination or spallation.In this work,the evolution process of TBC prepared by suspension plasma spraying(SPS)under CMAS attack is investigated.The CMAS corrosion leads to the formation of the reaction layer and subsequent bending of TBC.Based on the observations,a corrosion model is proposed to describe the generation and evolution of the reaction layer and bending of TBC.Then,numerical simulations are performed to investigate the corrosion process of free-standing TBC and the complete TBC system under CMAS attack.The corrosion model constructs a bridge for connecting two numerical models.The results show that the CMAS corrosion has a significant influence on the stress field,such as the peak stress,whereas it has little influence on the steady-state temperature field.The peak of stress increases with holding time,which increases the risk of the rupture of TBC.The Mises stress increases nonlinearly along the thick direction of the reaction layer.Furthermore,in the traditional failure zone,such as the interface of the top coat and bond coat,the stress obviously changes during CMAS corrosion. | Dongxu LI Peng JIANG Renheng GAO Fan SUN Xiaochao JIN Xueling FAN | 2021 | Journal of Advanced Ceramics2021，10，3： | 9 |
| 5 | Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders显示文摘Human genetic adaptation to high altitudes(>2500 m)has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified,largely owing to the lack of deep-genome sequencing data available to previous studies.Here,w e build a list of putative adaptive variants,including 63 missense,7 loss-of-function;1,298 evolutionarily conserved variants and 509 expression quantitative traits loci.Notably,the top signal of selection is located in TMEM 247,a transmembrane protein-coding gene.The Tibetan version of TMEM 247 harbors one high-frequency(76.3%)missense variant,rsl 16983452(c.248C>T;p.Ala83Val);with the T allele derived from archaic ancestry and carried by>94%of Tibetans but absent or in low frequencies(<3%)in non-Tibetan populations.The rsl 16983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p=5.78×10^-5),red blood cell count(p=5.72×10^-7)and hematocrit(p=2.57×10^-6).In particular,TMEM247-rs 116983452 shows greater effect size and better predicts the phenotypic outcome than any E P A S1 variants in association with adaptive traits in Tibetans.Modeling the interaction between TM£M247-rsl 16983452 and EPAS1 variants indicates weak but statistically significant epistatic effects.Our results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism. | Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu | 2019 | National Science Review2019，6，6： | 9 |
| 6 | Fabrication and Characterization of Gecko-inspired Dry Adhesion, Superhydrophobicity and Wet Self-cleaning Surfaces显示文摘 | Yongchao Zhang Shuxin Qu Xiang Cheng Xueling Gao Xia Guo | 2016 | Journal of Bionic Engineering2016，13，1： | 8 |
| 7 | Acupotomy versus sodium hyaluronate for treatment of knee osteoarthritis in rabbits显示文摘OBJECTIVE: To investigate the possible advantages of acupotomy over sodium hyaluronate injection for the treatment of knee osteoarthritis(KOA).METHODS: Twenty rabbits were divided randomly into four groups(n = 5 in each): a control group,model group, acupotomy group, and sodium hyaluronate injection group. The model, acupotomy,and sodium hyaluronate groups underwent anterior cruciate ligament transection plus partial medial meniscectomy. Sodium hyaluronate injection and acupotomy were administered to the respective groups from weeks 5 to 8, and samples of the tibial plateau and medial condyle of the femur were collected in week 9. Vascular endothelial growth factor(VEGF) expression was assessed in cartilage and subchondral bone by immunohistochemical staining.RESULTS: Articular cartilage degeneration was less pronounced in the acupotomy compared with the model and sodium hyaluronate groups. VEGF expression levels in cartilage and subchondral bone were increased in the model group compared with the control group(P < 0.01), and acupotomy had a more pronounced therapeutic effect than sodium hyaluronate injection(P < 0.01).CONCLUSION: Acupotomy and sodium hyaluronate injection may both reduce degeneration in the cartilage and subchondral bone in KOA based on the results from a rabbit model, but acupotomy improved the histopathology and reduced the VEGF content more effectively than sodium hyaluronate injection, probably by reducing venous stasis and intraosseous pressure. Acupotomy may improve KOA by lowering VEGF. | Ding Yu Yuan Xueling Wang Yongcheng Wang Aiyuan Shi Xian Wang Lu Daniela Litscher Ingrid Gaischek Irmgard Th.Lippe Gerhard Litscher | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 8 |
| 8 | DYNAMIC MECHANICAL BEHAVIOR OF 6061 AL ALLOY AT ELEVATED TEMPERATURES AND DIFFERENT STRAIN RATES显示文摘The compressive stress-strain relationships of 6061Al alloy over wide temperatures and strain rates are investigated. The dynamic impact experiments are performed using an improved high temperature split Hopkinson pressure bar apparatus. The experimental results are compared with those obtained by the modified Johnson-Cook constitutive model. It is found that the dynamic mechanical behavior depends sensitively on temperature under relatively low strain rates or on strain rate at relatively high temperatures. The good agreement indicates that it is valid to adopt the parameter identification method and the constitutive model to describe and predict the mechanical response of materials. | Xueling Fan Tao Suo Qin Sun Tiejun Wang | 2013 | Acta Mechanica Solida Sinica2013，26，2： | 7 |
| 9 | Simulation of wind gust structure in the atmospheric boundary layer with Lattice Boltzmann Method显示文摘Cold fronts occur in northern East Asia during winter and spring.After cold frontal passage,airflow is downward and accompa-nying strong winds fluctuate significantly;this is termed wind gusts.Analysis of observation data shows that wind gust structure has coherent characteristics.This is important for entrainment of spring dust storms into the upper boundary layer,where they are transported great distances.The Lattice Boltzmann Method(LBM) is a computational fluid technique based on the Boltzmann transport equation.The LBM has been used to study complex motion such as turbulence,because it describes motion at the micro level.In this paper,Large eddy simulation is introduced in the LBM,enabling simulation of turbulent flow in the atmospheric boundary layer.The formation and development of wind gusts are simulated,and a coherent structure with a combination of wave and vortex is obtained.This explains the mechanism of soil erosion and sand entrainment by the coherent structure of wind gusts. | CHENG XueLing HU Fei ZENG QingCun | 2012 | Chinese Science Bulletin2012，57，10： | 7 |
| 10 | Effects of Sini San used alone and in combination with fluoxetine on central and peripheral 5-HT levels in a rat model of depression显示文摘OBJECTIVE: To investigate the effects of Sini San and fluoxetine on the levels of central and peripheral 5-HT in a rat model of depression, and provide new insight into the treatment of depression with integrated Chinese-Western Medicine.METHODS: A rat model of depression was established by chronic mild stress(CMS). Model rats received either Sini San, fluoxetine, a combination of the two drugs, or no drug treatment. Healthy naive rats were used as controls. Open field and sucrose preference tests were used to assess depression-like behavior. ELISA and immunohistochemistry were used to determine central and peripheral levels of 5-HT.RESULTS: In the group with no drug treatment,central 5-HT expression decreased while peripheral5-HT concentrations increased as CMS continued.Four weeks after CMS, Sini San alone was less effective in reducing depression-like behavior than fluoxetine alone or in combination with Sini San,but combined use was more effective than fluoxetine alone. Eight weeks after CMS, Sini San alone or in combination with fluoxetine was more effective in reducing depression-like behavior than fluoxetine alone. Furthermore Sini San and fluoxetine used alone or in combination notably increased central 5-HT expression and decreased peripheral 5-HT levels in the rat model.CONCLUSION:The results of the present study indicate that there is a synergistic action between the two medicines in the treatment of depression. Sini San exhibited a relatively long lag before its effects were observed; however, by eight weeks the Traditional Chinese Medicine appeared at least as effective as fluoxetine. We suggest that Sini San can replace fluoxetine in the later stages of depression treatment to minimize side effects observed with long-term fluoxetine administration. | Yubo Li Yuxiu Sun Xueling Ma Xiaoxing Xue Wenting Zhang Zhiqian Wu Yulin Ouyang Jianxin Chen Weiming Wang Shuzhen Guo Wei Wang | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 11 | Morphometric measurement of the patella on 3D model reconstructed from CT scan images for the southern Chinese population显示文摘 | Shang Peng Zhang Linan Hou Zengtao Bai Xueling Ye Xin Xu Zhaobin Huang Xu | 2014 | Chinese Medical Journal2014，，1： | 6 |
| 12 | The Relationship Between the Gut Microbiome and Neurodegen-erative Diseases显示文摘Many recent studies have shown that the gut microbiome plays important roles in human physiology and pathology.Also,microbiome-based therapies have been used to improve health status and treat diseases.In addition,aging and neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s disease,have become topics of intense interest in biomedical research.Several researchers have explored the links between these topics to study the potential pathogenic or therapeutic effects of intestinal microbiota in disease.But the exact relationship between neurodegenerative diseases and gut microbiota remains unclear.As technology advances,new techniques for studying the microbiome will be developed and refined,and the relationship between diseases and gut microbiota will be revealed.This article summarizes the known interactions between the gut microbiome and neurodegenerative diseases,highlighting assay techniques for the gut microbiome,and we also discuss the potential therapeutic role of microbiome-based therapies in diseases. | Xueling Zhu Bo Li Pengcheng Lou Tingting Dai Yang Chen Aoxiang Zhuge Yin Yuan Lanjuan Li | 2021 | Neuroscience Bulletin2021，37，10： | 6 |
| 13 | ON (∈,∈ ∨q)-FUZZY FILTERS OF BL-ALGEBRAS显示文摘作者介绍() 的观点模糊布尔(含蓄,积极含蓄,;奇妙) 在 BL 代数学的过滤器,在这些概括模糊过滤器上介绍一些描述,;在这些概括模糊过滤器之中描述关系。它被证明那在 BL 代数学的模糊过滤器是的() 布尔(含蓄) 如果;仅当它两个都是积极的含蓄;奇妙。 | Xueling MA Jianming ZHAN | 2008 | Journal of Systems Science & Complexity2008，21，1： | 5 |
| 14 | Cloning of the full-length gene of activin receptor-interacting protein2a and characterization of its interaction with ActR Ⅱ A显示文摘为了调查细胞内部的信号 transduction 的机制,由 activin 受体调停了,编码新奇 activin 的全身的基因交往受体的 protein2a (ARIP2a ) 从一个老鼠大脑 cDNA 图书馆被识别。ARIP2a 和 ARIP2 和在导致 activin 的 RAW264 的 ARIP2 的序列。7 房间被比较,并且在 ARIP2a 和 ActRIIA 之间的相互作用被证实。序列分析表明除了 99 th 氨基酸。RT-PCR 试金证明 ARIP2a mRNA 高度在大脑,垂体和睾丸被表示,并且中等在胰和卵巢,但是在另外的纸巾无法发现。而, ARIP2 mRNA 广泛地在我们测试了的所有老鼠纸巾被散布。而且, ARIP2a mRNA 的表示显著地在刺激 activin 的 RAW264 被减少。7 个房间;然而, ARIP2 mRNA 的表示被增加。另外,在 ARIP2a 之间的相互作用和 activin 类型 IIA 受体(ActRIIA ) 被哺乳动物的二混血儿的试金和下拉试金进一步表明。总起来说,那些结果显示尽管 ARIP2a 对 ARIP2 相应,他们在到 activin 的织物分发和回答是不同的。ARIP2a 能也与 activin 类型 II 受体(ActRIIA ) 交往被哺乳动物的 two-hybird 试金和下拉试金进一步表明。总起来说,那些结果显示尽管 ARIP2a 对 ARIP2 相应,他们在到 activin 的织物分发和回答是不同的。ARIP2a 能也作为 ARIP 家庭的一篇小说与 activin 类型 II 受体交往。 | CUI Xueling TAI Guixiang ZHANG Hongjun FANG Lin LIU Zhonghui | 2007 | Progress in Natural Science:Materials International2007，17，2： | 5 |
| 15 | Activin A maintains cerebral cortex neuronal survival and increases voltage-gated Na^+ neuronal current显示文摘Activin A,which was first described in 1986,has been shown to maintain hippocampal neuronal survival.Activin A increases intracellular free Ca2+ via L-type Ca2+ channels.Our previous study showed that activin A promotes neurite growth of dorsal root ganglia in embryonic chickens and inhibits nitric oxide secretion.The present study demonstrated for the first time that activin A could maintain cerebral cortex neuronal survival in vitro for a long period,and that activin A was shown to increase voltage-gated Na+ current(INa) in Neuro-2a cells,which was recorded by patch clamp technique.The present study revealed a novel mechanism for activin A,as well as the influence of activin A on neurons by regulating expressions of vasoactive intestine peptide and inducible nitric oxide synthase. | Jingyan Ge Yinan Wang Haiyan Liu Fangfang Chen Xueling Cui Zhonghui Liu | 2010 | Neural Regeneration Research2010，5，19： | 4 |
| 16 | Hard state of the urban canopy layer turbulence and its self-similar multiplicative cascade models显示文摘It is found by experiment that under the thermal convection condition, the temperature fluctuation in the urban canopy layer turbulence has the hard state character, and the temperature difference between two points has the exponential probability density function distribution. At the same time, the turbulent energy dissipation rate fits the log-normal distribution, and is in accord with the hypothesis proposed by Kolmogorov in 1962 and lots of reported experimental results. In this paper, the scaling law of hard state temperature n order structure function is educed by the self-similar multiplicative cascade models. The theory formula is Sn = n/3μ{n(n+6)/72+[2lnn!-nln2]/2ln6}, and μ Is intermittent exponent. The formula can fit the experimental results up to order 8 exponents, is superior to the predictions by the Kolmogorov theory, the β And log-normal model. | HU Fei CHENG Xueling ZHAO Songnian QUAN Lihong | 2005 | Science China Earth Sciences2005，48，z2： | 4 |
| 17 | Direct Effects of Activin A on the Activation of Mouse Macrophage RAW264.7 Cells显示文摘Macrophages play critical roles in innate immune and acquired immune via secreting pro-inflammatory mediators, phagocytosing microorganisms and presenting antigens. Activin A, a member of transforming growth factor β (TGF-β) superfamily, is produced by macrophages and microglia cells. In this study, we reported a direct effect of activin A as a pro-inflammatory factor on mouse macrophage cell line RAW264.7 cells. Our data revealed that activin A could not only increase IL-1β and IL-6 production from RAW264.7 cells, but also promote pinocytic and phagocytic activities of RAW264.7 cells. In addition, activin A obviously up-regulated MHC II expression on the surface of RAW264.7 cells, whereas did not influence MHC I expression. Activin A also enhanced CD80 expression, which is a marker of activated macrophages, but did not influence RAW264.7 cell proliferation. These data suggest that activin A may regulate primary macrophage-mediated innate and acquired immune response via promoting the activation of rest macrophages. | Jingyan Ge Yinan Wang Ye Feng Haiyan Liu Xueling Cui Guixiang Tai Zhonghui Liu | 2009 | Cellular & Molecular Immunology2009，6，2： | 4 |
| 18 | Seismic hazard assessment of the Three Gorges Project显示文摘Seismic monitoring data for the past 50 years in the Three Gorges Reservoir area show that the reservoir head area is a typical weak seismic region with low seismicity before impoundment and that the epicenters were concentrated in the east and west sides of the Zigui Basin,most of which were natural tectonic earthquakes.After impoundment,the seismic activity shifted to the segment between Badong and Zigui along the Yangtze River,mainly within 5 km of the reservoir bank.The seismogenesis was categorized into four types:Karst collapse earthquakes,earthquakes caused by Karst gas explosion,mining tunnel collapse earthquakes,and rock (terrane) slip earthquakes,all of which are related to the lithology,structure,and tectonics of near-surface geological bodies of the area.Compared with the seismicity before impoundment,the seismic frequency increase was remarkable,with most of the magnitudes below Ms2.0.Therefore,the intensity of the earthquakes remained at a low level.On November 22,2008,a magnitude 4.1 earthquake,the largest earthquake recorded since impoundment,occurred in Quyuan Town,Zigui County.The intensity and PGA of reservoir-induced earthquakes are higher than those of tectonic earthquakes with equal magnitude,but the peak intensity of reservoir-induced earthquakes is not likely to go beyond that of the estimated range from earlier studies. | Yao Yunsheng Wang Qiuliang Li Jinggang Shen Xueling Kong Yuyang | 2013 | Geodesy and Geodynamics2013，4，2： | 4 |
| 19 | The enhanced protective effects of salvianic acid A: A functionalized nanoparticles against ischemic stroke through increasing the permeability of the blood-brain barrier显示文摘Ischemic stroke is the leading cause of disability and death worldwide. Currently, the only proven treatment for ischemic stroke is restoring the cerebral blood supply. In addition, some of the tissue is damaged during the subsequent reperfusion because of the overproduction of reactive oxygen species (ROS). Furthermore, antioxidant therapies have shown promise in preclinical studies for the treatment of ischemia-reperfusion injury. However, their therapeutic efficacy has been limited because of their low bioavailability in brain. To resolve this issue, we synthesized ROS-responsive, fan-shaped dendrimer nanoparticles (NPs) and conjugated them with a blood-brain barrier (BBB)-targeting peptide, COG1410, and salvianic acid A (SA), which is an effective antioxidant in ischemic stroke. The BBB targeting peptide acts as a ligand of the nanocarrier system and penetrates the BBB through the endocytosis of the ligand receptor. The results showed that T-SA-NPs not only target and accumulate in the infarct area, they also reduce over 2 times of the infarct area and reverse the behavioral deficits in MCAO mice, which illustrates that these NPs have an effective therapeutic effect on the ischemic stroke. In addition, these NPs had no toxicity in any organs of the body. Importantly, the present study provides an alternative strategy for delivering antioxidants to the brain and achieving targeted therapy of ischemic stroke. | Yaru Li Xiaojie Zhang Zhifeng Qi Xueling Guo Xiaopeng Liu Wenjuan Shi Yang Liu Libo Du | 2020 | Nano Research2020，13，10： | 4 |
| 20 | Effective and precise adenine base editing n mouse zygotes显示文摘 | Puping Liang Hongwei Sun Xiya Zhang Xiaowei Xie Jinran Zhang Yaofu Bai Xueling Ouyang Shengyao Zhi Yuanyan Xiong Wenbin Ma Dan Liu Junjiu Huang Zhou Songyang | 2018 | Protein & Cell2018，9，9： | 4 |
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