|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014显示文摘Background:H7N9 continues to cause human infections and remains a pandemic concern.Understanding the economic impacts of this novel disease is important for making decisions on health resource allocation,including infectious disease prevention and control investment.However,there are limited data on such impacts.Methods:Hospitalized laboratory-confirmed H7N9 patients or their families in Jiangsu Province of China were interviewed.Patients’direct medical costs of hospitalization were derived from their hospital bills.A generalized linear model was employed to estimate the mean direct medical costs of patients with different characteristics.Results:The mean direct cost of hospitalization for H7N9 was estimated to be¥71060(95%CI,48180–104820),i.e.,US$10996(95%CI,7455–16220),and was¥12060(US$1861),¥136120(US$21001)and¥218610(US$33728)for those who had mild or severe symptoms or who died,respectively.The principal components of the total fees differed among patients with different disease severity,although medication fees were always the largest contributors.Disease severity,proportion of reimbursement and family member monthly average income were identified as the key factors that contributed to a patient’s direct medical cost of hospitalization.Conclusions:The direct medical costs of hospitalized patients with H7N9 are significant,and far surpass the annual per capita income of Jiangsu Province,China.The influencing factors identified should be taken into account when developing related health insurance policies and making health resource allocation.Trial registration:Not applicable.This is a survey study with no health care intervention implemented on human participants. | Xiang Huo Li-Ling Chen Lei Hong Lun-Hui Xiang Fen-Yang Tang Shan-Hui Chen Qiang Gao Cong Chen Qi-gang Dai Chuan-Wu Sun Ke Xu Wen-Jun Dai Xian Qi Chang-Cheng Li Hui-Yan Yu Yin Zhou Hao-Di Huang Xing-Yang Pan Chang-sha Xu Ming-Hao Zhou Chang-Jun Bao | 2016 | Infectious Diseases of Poverty2016，5，1： | 10 |
| 2 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 3 | Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis显示文摘Disturbance of macrophage-associated lipid metabolism plays a key role in atherosclerosis.Crosstalk between autophagy deficiency and inflammation response in foam cells(FCs) through epigenetic regulation is still poorly understood. Here, we demonstrate that in macrophages, oxidized lowdensity lipoprotein(ox-LDL) leads to abnormal crosstalk between autophagy and inflammation,thereby causing aberrant lipid metabolism mediated through a dysfunctional transcription factor EB (TFEB)-P300-bromodomain-containing protein 4(BRD4) axis. ox-LDL led to macrophage autophagy deficiency along with TFEB cytoplasmic accumulation and increased reactive oxygen species generation. This activated P300 promoted BRD4 binding on the promoter regions of inflammatory genes, consequently contributing to inflammation with atherogenesis. Particularly, ox-LDL activated BRD4-dependent super-enhancer associated with liquid-liquid phase separation(LLPS) on the regulatory regions of inflammatory genes. Curcumin(Cur) prominently restored FCs autophagy by promoting TFEB nuclear translocation, optimizing lipid catabolism, and reducing inflammation. The consequences of P300 and BRD4 on super-enhancer formation and inflammatory response in FCs could be prevented by Cur. Furthermore, the anti-atherogenesis effect of Cur was inhibited by macrophage-specific Brd4 overexpression or Tfeb knock-out in Apoe knock-out mice via bone marrow transplantation. The findings identify a novel TFEB-P300-BRD4 axis and establish a new epigenetic paradigm by which Cur regulates autophagy, inhibits inflammation, and decreases lipid content. | Xuesong Li Ruigong Zhu Hong Jiang Quanwen Yin Jiaming Gu Jiajing Chen Xian Ji Xuan Wu Haiping Fu Hui Wang Xin Tang Yuanqing Gao Bingjian Wang Yong Ji Hongshan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 4 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 5 | 文化研究:西方与中国显示文摘在世纪之交的中国人文学界 ,文化研究与文化批评正呈现出强劲的发展势头与崭新的学术面貌 ,这为中国人文学术的知识创新提供了某种值得关注的可能性。但同时也应看到 ,中国当代文化研究在处理西方文化理论与中国文化实践的关系时 ,依然存在机械照搬西方理论以宰割中国经验事实的倾向 ;没有充分注意到西方文化理论与中国现实语境的有机融合与良性互动 ,这就使得中国的文化研究在准确把握本土的问题 ,并在此基础上建构适应于本土的研究范式时 ,存在着严重缺陷。这里刊发的一组笔谈 。 | Jin Yuanpu Tao Dongfeng Chen Xiaoming Zhou Xian Yin Hong · | 2000 | 中国社会科学2000，，6： | 2 |
| 6 | Tab engineering-mediated resistance of flexible lithium-ion batteries for high output current显示文摘Flexible lithium-ion batteries(LIBs) have received tremendous interest because they can provide essential flexible power for the emerging wearable electronics.However,the realization of the flexibility of LIBs is often related to flexible substrates with high electrical resistance,which results in voltage loss of the battery and is unfavorable for their practical applications.In this work,we demonstrated the use of tab engineering to mediate the resistance of flexible batteries for high current output.The resistance of the obtained pouch cell can be decreased sharply and the output current can be significantly increased by a continuous tab with desirable power and energy density.The surprising performance of the flexible LIBs allows the tab on the current collector providing enough channels for electron transfer,thus enabling electrons to be transferred quickly and enhancing the electrochemical reaction kinetics.Such a flexible battery with sufficient output current could possibly solve some of the most critical problems for their practical applications in wearable electronics. | Shi Kui Jia Bin Ze Yang Chao Feng Zhao Zhi Yong Zhang Yan Hong Yin Xian Bin Liu Ying Yan Hu Zi Ping Wu | 2021 | Journal of Energy Chemistry2021，30，7： | 1 |
| 7 | Non-canonical STING-PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response显示文摘Inflammation-driven endothelial dysfunction is the major initiating factor in atherosclerosis,while the underlying mechanism remains elusive.Here,we report that the non-canonical stimulator of interferon genes(STING)-PKR-like ER kinase(PERK)pathway was significantly activated in both human and mice atherosclerotic arteries.Typically,STING activation leads to the activation of interferon regulatory factor 3(IRF3)and nuclear factor-kappa B(NF-κB)/p65,thereby facilitating IFN signals and infammation.In contrast,our study reveals the activated non-canonical STING-PERK pathway increases scaffold protein bromodomain protein 4(BRD4)expression,which encourages the formation of super-enhancers on the proximal promoter regions of the proinflammatory cytokines,thereby enabling the transactivation of these cytokines by integrating activated IRF3 and NF-κB via a condensation process.Endothelium-specific STING and BRD4 deficiency significantly decreased the plaque area and inflammation.Mechanistically,this pathway is triggered by leaked mitochondrial DNA(mtDNA)via mitochondrial permeability transition pore(mPTP),formed by voltage-dependent anion channel 1(VDAC1)oligomer interaction with oxidized mtDNA upon cholesterol oxidation stimulation.Especially,compared to macrophages,endothelial STING activation plays a more pronounced role in atherosclerosis.We propose a non-canonical STING-PERK pathway-dependent epigenetic paradigm in atherosclerosis that integrates IRF3,NF-κB and BRD4 in inflammatory responses,which provides emerging therapeutic modalities for vascular endothelial dysfunction. | Xuesong Li Xiang Chen Longbin Zheng Minghong Chen Yunjia Zhang Ruigong Zhu Jiajing Chen Jiaming Gu Quanwen Yin Hong Jiang Xuan Wu Xian Ji Xin Tang Mengdie Dong Qingguo Li Yuanqing Gao Hongshan Chen | 2023 | Acta Pharmaceutica Sinica B2023，13，12： | 1 |
| 8 | Morphological Influence of Molybdenum Disulfide on the Tribological Properties of Rapeseed Oil显示文摘 | Ze Yin Xu Kun Hong Hu Cheng Liang Han Xian Guo Hu Yu Fu Xu | 2013 | Tribology Letters2013，，3： | 1 |
| 9 | Synthesis of 3 or 4-Substituted Pyridine-2, 6-Dicarboxylic Acid显示文摘Various 4-alkoxypyridine-2, 6-dicarboxylic acids were synthesized starting from 2,6- lutidine.Through aldol condensation and Michael addition, various 4-arylpyridine-2, 6-dicarboxylic acids were synthesized starting from aromatic aldehydes and 2-acetylfuran. | Xian Hong YIN Man Ya YANG Hua Hong SHI Lian Quan GU(Chemistry Department, Zhongshan University. Guangzhou 510275)(Chemistry Department, Guangxin University for Nationalities, Nanning 530006) | 1999 | Chinese Chemical Letters1999，10，11： | 1 |
| 10 | A high‐throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography–tandem mass spectrometry显示文摘 | Chong‐Zhen Qin Xian Ren Zhi‐Rong Tan Yao Chen Ji‐Ye Yin Jing Yu Jian Qu Hong‐Hao Zhou Zhao‐Qian Liu | 2014 | Chromatogr2014，，2： | 1 |
| 11 | Sorafenib suppresses postsurgical recurrence and metastasis of hepatocellular carcinoma in an orthotopic mouse model显示文摘 | Yu‐Xiong Feng Tao Wang Yue‐Zhen Deng Pengyuan Yang Jing‐Jing Li Dong‐Xian Guan Fan Yao Yin‐Qiu Zhu Ying Qin Hui Wang Nan Li Meng‐Chao Wu Hong‐Yang Wang Xiao‐Fan Wang Shu‐Qun Cheng Dong Xie | 2011 | Hepatology2011，，2： | 1 |
| 12 | ELECTRODEPOSITION OP Ba-K-Bi-O AND Ba-K-M-Bi-O (M=Rb, Pb AND La) SINGLE CRYSTALS显示文摘ELECTRODEPOSITIONOPBa-K-Bi-OANDBa-K-M-Bi-O(M=Rb,PbANDLa)SINGLECRYSTALS￥LiangZhongZHAO;JinBiaoZHANG;WeiHuaWANGShiHongLIU;DaoBe... | Liang Zhong ZHAO Jin Biao ZHANG Wei Hua WANG Shi Hong LIU Dao Ben ZHU(Institute of Chemistry ,Academia Sinica, Beijing 100080)Bo YIN Jin Wei LI Zhong Xian ZHAO(Institute of Physics ,Academia Sinica, Beijing 100080) | 1994 | Chinese Chemical Letters1994，5，7： | 0 |
| 13 | Advances in nuclear detection and readout techniques显示文摘“A Craftsman Must Sharpen His Tools to Do His Job,”said Confucius.Nuclear detection and readout techniques are the foundation of particle physics,nuclear physics,and particle astrophysics to reveal the nature of the universe.Also,they are being increasingly used in other disciplines like nuclear power generation,life sciences,environmental sciences,medical sciences,etc.The article reviews the short history,recent development,and trend of nuclear detection and readout techniques,covering Semiconductor Detector,Gaseous Detector,Scintillation Detector,Cherenkov Detector,Transition Radiation Detector,and Readout Techniques.By explaining the principle and using examples,we hope to help the interested reader underst and this research field and bring exciting information to the community. | Rui He Xiao‑Yang Niu Yi Wang Hong‑Wei Liang Hong‑Bang Liu Ye Tian Hong‑Lin Zhang Chao‑Jie Zou Zhi‑Yi Liu Yun‑Long Zhang Hai‑Bo Yang Ju Huang Hong‑Kai Wang Wei‑Jia Han Bei Cao Gang Chen Cong Dai Li‑Min Duan Rui‑Rui Fan Fang‑Fa Fu Jian‑Hua Guo Dong Han Wei Jiang Xian‑Qin Li Xin Li Zhuo‑Dai Li Yu‑Tie Liang Shun Liao De‑Xu Lin Cheng‑Ming Liu Guo‑Rui Liu Jun‑Tao Liu Ze Long Meng‑Chen Niu Hao Qiu Hu Ran Xiang‑Ming Sun Bo‑Tan Wang Jia Wang Jin‑Xiang Wang Qi‑Lin Wang Yong‑Sheng Wang Xiao‑Chuan Xia Hao‑Qing Xie He‑Run Yang Hong Yin Hong Yuan Chun‑Hui Zhang Rui‑Guang Zhao Ran Zheng Cheng‑Xin Zhao | 2023 | Nuclear Science and Techniques2023，34，12： | 0 |
| 14 | Synthesis of Terpyridine Derivatives Containing β-Cyclodextrin显示文摘A novel b-cyclodextrin-based terpyridine derivatives has been prepared by the coupling of 4-(4-bromomethyl phenyl)- 2, 2:6, 2-terpyridine with mono-6-hydroxy permethylated b- cyclodextrin. The cyclodextrin dimmer appending a 4-phenyl-2,2:6,2- terpyridine spacer on the primary faces was synthesized by reaction of 4-phenyl-2,2:6,2-terpyridine-6,6-dicarbonitrile with an excess of 6-deoxy-6-O-tosyl-b-cyclodextrin. | Xian Hong YIN* Department of Chemistry, Guangxi University for Nationalities, Nanning 530006 | 2003 | Chinese Chemical Letters2003，14，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员