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| 1 | A novel m6A reader Prrc2a controls oligodendroglial specification and myelination显示文摘While N6-methyladenosine (m6A), the most abundant internal modification in eukaryotic mRNA, is linked to cell differentiation and tissue development, the biological significance of m6A modification in mammalian glial development remains unknown. Here, we identify a novel m6A reader, Prrc2a (Proline rich coiled-coil 2A), which controls oligodendrocyte specification and myelination. Nestin-Cre-mediated knockout of Prrc2a induces significant hypomyelination, decreased lifespan, as well as locomotive and cognitive defects in a mouse model. Further analyses reveal that Prrc2a is involved in oligodendrocyte progenitor cells (OPCs) proliferation and oligodendrocyte fate determination. Accordingly, oligodendroglial-lineage specific deletion of Prrc2a causes a similar phenotype of Nestin-Cre-mediated deletion. Combining transcriptome-wide RNA-seq, m6A-RIP-seq and Prrc2a RIP-seq analysis, we find that Olig2 is a critical downstream target gene of Prrc2a in oligodendrocyte development. Furthermore, Prrc2a stabilizes Olig2 mRNA through binding to a consensus GGACU motif in the Olig2 CDS (coding sequence) in an m6A-dependent manner. Interestingly, we also find that the m6A demethylase, Fto, erases the m6A modification of Olig2 mRNA and promotes its degradation. Together, our results indicate that Prrc2a plays an important role in oligodendrocyte specification through functioning as a novel m6A reader. These findings suggest a new avenue for the development of therapeutic strategies for hypomyelination-related neurological diseases. | Rong Wu Ang Li Baofa Sun Jian-Guang Sun Jinhua Zhang Ting Zhang Yusheng Chen Yujie Xiao Yuhao Gao Qingyang Zhang Jun Ma Xin Yang Yajin Liao Wei-Yi Lai Xiaolong Qi Shukun Wang Yousheng Shu Hai-Lin Wang Fengchao Wang Yun-Gui Yang Zengqiang Yuan | 2019 | Cell Research2019，29，1： | 32 |
| 2 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 3 | The Coix Genome Provides Insights into Panicoideae Evolution and Papery Hull Domestication显示文摘Coix is a grass crop domesticated as early as the Neolithic era.It is still widely cultivated for both highly nutritional food and medicinal use.However,the genetic study and breeding of this crop are hindered by the lack of a sequenced genome.Here,we report de novo sequencing and assembly of the 1619-Mb genome of Coix,and annotation of 75.39%repeats and 39629 protein-coding genes.Comparative genomics analysis showed that Coix is more closely related to sorghum than maize,but intriguingly only Coix and maize had a recent genome duplication event,which was not detected in sorghum.We further constructed a genetic map and mapped several important traits,especially the strength of hull.Selection of papery hull(thin:easy dehulling)from the stony hull(thick:difficult dehulling)in wild progenitors was a key step in Coix domestication.The papery hull makes seed easier to process and germinate.Anatomic and global transcriptome analysis revealed that the papery hull is a result of inhibition of cell division and wall biogenesis.We also successfully demonstrated that seed hull pressure resistance is controlled by two major quantitative trait loci(QTLs),which are associated with hull thickness and color,respectively.The two QTLs were further fine mapped within intervals of 250 kb and 146 kb,respectively.These resources provide a platform for evolutionary studies and will facilitate molecular breeding of this important crop. | Chao Guo Yanan Wang Aiguo Yang Jun He Chaowen Xiao Shanhua Lv Fengming Han Yibing Yuan Yuan Yuan Xiaolong Dong Juan Guo YawenYang-Hailan Liu Ningzhi Zuo Yaxi Hu Kangxu Zhao Zhengbo Jiang Xing Wang Tingting Jiang Yaou Sherf Moju Cao Yuan Wang Zhaobo Long Tingzhao Rong Luqi Huang Shufeng Zhou | 2020 | Molecular Plant2020，13，2： | 11 |
| 4 | Malicious code passive propagation model and vaccine distribution model of P2P networks显示文摘To fight against malicious codes of P2P networks, it is necessary to study the malicious code propagation model of P2P networks in depth. The epidemic of malicious code threatening P2P systems can be divided into the active and passive propagation models and a new passive propagation model of malicious code is proposed, which differentiates peers into 4 kinds of state and fits better for actual P2P networks. From the propagation model of malicious code, it is easy to find that quickly making peers get their patched and upgraded anti-virus system is the key way of immunization and damage control. To distribute patches and immune modules efficiently, a new exponential tree plus (ET+) and vaccine distribution algorithm based on ET+ are also proposed. The performance analysis and test results show that the vaccine distribution algorithm based on ET+ is robust, efficient and much more suitable for P2P networks. | Xiaolong Xu Ruchuan Wang Fu Xiao | 2010 | Journal of Systems Engineering and Electronics2010，21，1： | 9 |
| 5 | Seeing permeability from images: fast prediction with convolutional neural networks显示文摘Fast prediction of permeability directly from images enabled by image recognition neural networks is a novel pore-scale modeling method that has a great potential. This article presents a framework that includes (1) generation of porous media samples,(2) computation of permeability via fluid dynamics simulations,(3) training of convolutional neural networks (CNN) with simulated data, and (4) validations against simulations. Comparison of machine learning results and the ground truths suggests excellent predictive performance across a wide range of porosities and pore geometries, especially for those with dilated pores. Owning to such heterogeneity, the permeability cannot be estimated using the conventional Kozeny–Carman approach. Computational time was reduced by several orders of magnitude compared to fluid dynamic simulations. We found that, by including physical parameters that are known to affect permeability into the neural network, the physics-informed CNN generated better results than regular CNN. However, improvements vary with implemented heterogeneity. | Jinlong Wu Xiaolong Yin Heng Xiao | 2018 | Science Bulletin2018，63，18： | 8 |
| 6 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 7 | miR-145 improves metabolic inflammatory disease through multiple pathways显示文摘Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. | Min He Nan Wu Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 7 |
| 8 | Synchrotron radiation-based Fourier-transform infrared spectromicroscopy for characterization of the protein/peptide distribution in single microspheres显示文摘The present study establishes a visualization method for the measurement of the distribution and localization of protein/peptide constituents within a single poly-lactide-co-glycolide(PLGA) microsphere using synchrotron radiation–based Fourier-transform infrared spectromicroscopy(SR-FTIR).The representative infrared wavenumbers specific for protein/peptide(Exenatide) and excipient(PLGA) were identified and chemical maps at the single microsphere level were generated by measuring and plotting the intensity of these specific bands.For quantitative analysis of the distribution within microspheres,Matlab software was used to transform the map file into a 3D matrix and the matrix values specific for the drug and excipient were extracted.Comparison of the normalized SR-FTIR maps of PLGA and Exenatide indicated that PLGA was uniformly distributed,while Exenatide was relatively non-uniformly distributed in the microspheres.In conclusion,SR-FTIR is a rapid,nondestructive and sensitive detection technology to provide the distribution of chemical constituents and functional groups in microparticles and microspheres. | Manli Wang Xiaolong Lu Xianzhen Yin Yajun Tong Weiwei Peng Li Wu Haiyan Li Yan Yang Jingkai Gu Tiqiao Xiao Min Chen Jiwen Zhang | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 5 |
| 9 | Graphene-plasmon polaritons: From fundamental properties to potential applications显示文摘 | Sanshui Xiao Xiaolong Zhu Bo-Hong Li N. Asger Mortensen | 2016 | Frontiers of physics2016，11，2： | 2 |
| 10 | Flexible cation-based threshold selector for resistive switching memory integration显示文摘Emerging resistive switching random access memory(RRAM), considered as the most promising candidate of flash memory, is favorable for in flexible electronic system. However, in high density flexible crossbar RRAM array, crosstalk issue that currents from the neighboring unselected cell lead to failure of write and read operations, still keeps a main bottleneck. Therefore, flexible selector compatible with the flexibility of the RRAM array should be focused on to configure one selector-one resistor(1 S1 R) system,which is immune to crosstalk issue. In this paper, flexible cation-based threshold switching(TS) selectors(Pt/Ag/Hf O_2/Pt/Ti/parylene) are fabricated and the compressive performance is studied systematically.The device shows excellent bidirectional volatile TS characteristics, including high selectivity ratio(10~9), low operating voltages(|VTH|<1 V), ultra-low leakage current(~10^(-13) A) and good flexibility. The successful demonstration of the wire connected 1 S1 R unit comprising this flexible selector and one bipolar resistor cell indicates the great potential of this cation-based selector to restrain the crosstalk issue in a large flexible RRAM array. | Xiaolong ZHAO Rui WANG Xiangheng XIAO Congyan LU Facai WU Rongrong CAO Changzhong JIANG Qi LIU | 2018 | Science China(Information Sciences)2018，61，6： | 2 |
| 11 | c-Fos enhances the survival of thymocytes during positive selection by upregulating Bcl-2显示文摘T 房间从祖先 thymocytes 被导出,哪个仅仅一个少数收到适当 TCR 信号,经历积极选择并且成熟。由于 thymocytes 的短 lifespan,为积极选择的前提是幸存。TCR 导致信号的 Bcl-2 表示被相信在断然选择 thymocytes 的幸存起一个主导的作用,但是 Bcl-2 怎么直接被调整,是未知的。这里,我们报导立即的早基因(IEG ) c-Fos 能刺激 Bcl-2 的表示,取决于在 Bcl-2 倡导者的一个特定的 AP-1-binding 地点。在 c-Fos 转基因(Fos-Tg ) 老鼠, c-Fos 绑在这个地点并且支持 Bcl-2 的表示。作为结果,展出的 Fos-Tg thymocytes 提高了幸存,和更多成熟单人赛积极(SP ) thymocytes 被产生,甚至在一个唯一的 TCR 背景上。TCR 全部剧目在 Fos-Tg 老鼠仍然保持正常。我们的结果作为在 Bcl-2 表示上发信号的 TCR 的 stimulatory 效果的调停人识别了 c-Fos。因此,作为 IEG,因为它的早反应能力, c-Fos 能快速救短命 thymocytes 的幸存在积极选择期间。我们的结果提供新奇卓见进调整断然选择 thymocytes 的幸存的机制。 | Xiaoming Wang Yafeng Zhang Gang Xiao Xiang Gao Xiaolong Liu | 2009 | Cell Research2009，19，3： | 2 |
| 12 | Exploring the Degradation Potential of Halomonas Bacteria from Oil-contaminated Marine Environment显示文摘The degradation potential of a diesel-degrading bacteria(HDMP1) isolated from the oil-contaminated marine environment was explored systematically by analyzing the environmental conditions and synergistic action with other dieseldegrading bacteria. The result indicated that HDMP1 was confirmed as a strain of Halomonas by the method of strain identification. And, HDMP1 showed good diesel degradation performance with a diesel degradation rate of up to 79.59%after 7 days. By analyzing the effect of environmental conditions on HDMP1, the best carbon and nitrogen sources were found to be lactose and peptone, respectively, at a pH value of 7.5 and a salinity of 4 g/(100 mL). Additionally, the synergistic effect of HDMP1 combined with other diesel-degrading bacteria was analyzed by orthogonal experimental design. The inocula of HDMP1, HDMP2, HDMP3 and HDMB3 were optimized, with the best results equating to 0.4%, 0.1%, 0.4% and0.9% in 100 mL of MSM, respectively, while the degradation rate of diesel was identified to be 73.5% within 5 days in the presence of optimum inocula. | Wu Yanan Liu Yingying Xue Jianliang Shi Ke Gao Yu Xiao Xiaolong | 2018 | China Petroleum Processing & Petrochemical Technology2018，20，4： | 2 |
| 13 | Geochemistry and Geochronology of Diorite in Pengshan Area of Jiangxi Province:Implications for Magmatic Source and Tectonic Evolution of Jiangnan Orogenic Belt显示文摘Magmatic activities associated with tectonic events play a significant role in understanding the evolution of an orogenic belt.The Jiangnan orogenic belt has been regarded as the collisional suture zone between the Yangtze Block and the Cathaysia Block.Although the magmatic activities during the period of intra-plate extension after the collision have been well studied in recent years,some remaining issues,including source nature and geodynamic mechanism,need to be further addressed.In this paper,based on a detailed field geological,petrological,geochemical and geochronological study,we focus our work on diorites in the Pengshan area located at the northwestern margin of the Jiangnan orogenic belt.The mineral assemblages are mainly composed of plagioclase(55 vol.%-65 vol.%)and hornblende(35 vol.%-45 vol.%).One diorite sample yields zircon^(206)Pb/^(238)U mean age of 768±8 Ma(MSWD=0.29).The diorites have enriched large ion lithophile elements(Ba,K and Rb)and incompatible elements(Th and U),and are depleted in high field-strength elements including Ta,Ti and Nb.Diorites in this study have relatively high MgO content(6.56 wt.%-7.58 wt.%,7.07 wt.%on average)and Mg number values(65-67,65.8 on average).The diorites are metaluminous,high K calc-alkaline series rocks with high contents of K_2O(1.59 wt.%-1.97 wt.%)and total alkali(Na_2O+K_2O=5.56 wt.%-6.05 wt.%).The Nd/Th ratio(4.34-5.27)is higher than that of crust-derived rocks and lower than mantle-derived rocks.The Rb/Sr ratio(0.19-0.22)is slightly lower than crust,but significantly higher than upper mantle.Based on the above geochemical and geochronological analyses,we suggest that the diorites in the Pengshan area were mainly derived from crustal materials with a small amount of mantleoriginated materials involved,and possibly produced from an extensional tectonic setting after the collision between the Yangtze Block and Cathaysia Block. | Hongfeng Shi Junpeng Wang Yuan Yao Jing Zhang Song Jin Yingxin Zhu Kang Jiang Xiaolong Tian Deng Xiao Wenbin Ning | 2020 | Journal of Earth Science2020，31，1： | 2 |
| 14 | Downregulation of the transcription factor KLF4 is required for the lineage commitment of T cells显示文摘在早 T 房间开发的 reprogramming 因素 Oct4, Sox2, c-Myc 和 Klf4 的角色不完全地被定义。这里,当早 thymic 祖先(ETP ) 区分房间进 T 时,我们证明 Klf4 是其表情是 downregulated 的唯一的 reprogramming 因素。当 T 房间系承诺发生时,在未遂祖先的 Klf4 的强制表示严重地主要在 DN2-to-DN3 转变损害了 T 房间开发并且在早 T 房间开发与关键函数影响了许多基因的抄写,包括涉及 microenvironmental 发信号的基因( IL-7Rα ;),槽口目标基因( Deltex1 )或禁止的基因( Bcl11a , SpiB ,和 Id1 )。在 Tcrb 地点的 thymocytes 和重新整理的幸存面对强制 Klf4 表示被损害。在在 Klf4 转基因的老鼠的 DN1-to-DN2 和 DN2-to-DN3 转变的缺点不能被 TCR transgene 的介绍救,但是被恢复 IL-7Rα 的表示部分救;。因此,我们的数据显示 Klf4 的 downregulation 是为 T 房间系承诺的一个前提。 | Xiaomin Wen Haifeng Liu Gang Xiao Xiaolong Liu | 2011 | Cell Research2011，21，12： | 2 |
| 15 | First passage Markov decision processes with constraints and varying discount factors显示文摘这份报纸与多限制,州依赖者的折扣因素,和可能无界的费用在可数的州、紧缩的 Borel 行动空格集中于分离时间的 Markov 决定处理的第一个段落(DTMDP ) 的抑制 optimality 问题(警察) 。借助于一条政策的一项所谓的职业措施的性质,我们证明抑制 optimality 问题等价于一(无限维) 职业的集合上的线性编程与一些限制测量,并且因此在合适的条件下面证明一条最佳的政策的存在。用在抑制 optimality 问题和线性编程之间的等价,而且,我们为有限状态和行动的盒子获得一条最佳的政策的一种准确形式。作为一个例子,最后,一个控制排队系统被给说明我们的结果。 | Xiao WU Xiaolong ZOU Xianping GUO | 2015 | Frontiers of Mathematics in China2015，10，4： | 2 |
| 16 | Intercalating Ultrathin MoO_3 Nanobelts into MXene Film with Ultrahigh Volumetric Capacitance and Excellent Deformation for High-Energy-Density Devices显示文摘The restacking hindrance of MXene films restricts their development for high volumetric energy density of flexible supercapacitors toward applications in miniature,portable,wearable or implantable electronic devices.A valid solution is construction of rational heterojunction to achieve a synergistic property enhancement.The introduction of spacers such as graphene,CNTs,cellulose and the like demonstrates limited enhancement in rate capability.The combination of currently reported pseudocapacitive materials and MXene tends to express the potential capacitance of pseudocapacitive materials rather than MXene,leading to low volumetric capacitance.Therefore,it is necessary to exploit more ideal candidate materials to couple with MXene for fully expressing both potentials.Herein,for the first time,high electrochemically active materials of ultrathin MoO3 nanobelts are intercalated into MXene films.In the composites,MoO3 nanobelts not only act as pillaring components to prevent restacking of MXene nanosheets for fully expressing the MXene pseudocapacitance in acidic environment but also provide considerable pseudocapacitive contribution.As a result,the optimal M/MoO3 electrode not only achieves a breakthrough in volumetric capacitance(1817 F cm-3 and 545 F g-1),but also maintains good rate capability and excellent flexibility.Moreover,the corresponding symmetric supercapacitor likewise shows a remarkable energy density of 44.6 Wh L-1(13.4 Wh kg-1),rendering the flexible electrode a promising candidate for application in high-energy-density energy storage devices. | Yuanming Wang Xue Wang Xiaolong Li Rong Liu Yang Bai Huanhao Xiao Yang Liu Guohui Yuan | 2020 | Nano-Micro Letters2020，12，9： | 2 |
| 17 | A comparison on the phytoremediation ability of triazophos by different macrophytes显示文摘The strategy of choosing suitable plants should receive great performance in phytoremediation of surface water polluted by triazophos(O,O-diethyl-O-(1-phenyl-1,2,4-triazol-3-base) sulfur phosphate, TAP), which is an organophosphorus pesticide widespread applied for agriculture in China and moderately toxic to higher animal and fish. The tolerance, uptake, transformation and removal of TAP by twelve species of macrophytes were examined in a hydroponic system and a comprehensive score(CS) of five parameters(relative growth rate(RGR), biomass, root/shoot ratio, removal capacity(RC), and bio-concentration factor(BCF)) by factor analysis was employed to screen the potential macrophyte species for TAP phytoremediation. The results showed that Thalia dealbata, Cyperus alternifolius, Canna indica and Acorus calamus had higher RGR values, indicating these four species having stronger growth capacity under TAP stress. The higher RC loading in Iris pseudacorus and Cyperus rotundus were 42.11 and 24.63 μg/(g fw·day), respectively. The highest values of BCF occurred in A. calamus(1.17), and TF occurred in Eichhornia crassipes(2.14). Biomass and root/shoot ratio of plant showed significant positive correlation with first-order kinetic constant of TAP removal in the hydroponic system, indicating that plant biomass and root system play important roles in remediation of TAP. Five plant species including C. alternifolius, A. calamus, T. dealbata, C. indica and Typha orientalis, which owned higher CS, would be potential species for TAP phytoremediation of contaminated water bodies. | Zhu Li Huiping Xiao Shuiping Cheng Liping Zhang Xiaolong Xie Zhenbin Wu | 2014 | Journal of Environmental Sciences2014，26，2： | 2 |
| 18 | Natural astaxanthin enhanced antioxidant capacity and improved semen quality through the MAPK/Nrf2 pathway in aging layer breeder roosters显示文摘Background:Natural astaxanthin(ASTA)has strong antioxidant properties and has been widely used as a health product to improve human health.However,the effects of ASTA on the reproductive performance of aging roosters have been poorly studied.We aimed to investigate the effects of dietary ASTA on semen quality and antioxidant capacity in aging roosters and to explore the potential mechanism of semen quality change via antioxidation defense system.Methods:In the present study,9653-week-old Jinghong No.1 layer breeder roosters were fed a corn-soybean meal basal diet containing 0,25,50,or 100 mg/kg ASTA for 6 weeks.Results:Semen quality in the ASTA groups remarkably improved than that in the control group,and antioxidant activities,the abilities to scavenge hydroxyl radicals and superoxide anions,increased gradually with ASTA addition(P<0.05).In addition,the mRNA levels of antioxidant enzymes as well as the mRNA and protein levels of the mitogen-activated protein kinase(MAPK)and nuclear factor-erythroid 2-related factor 2(Nrf2)were markedly increased in the 50-100 mg/kg ASTA group(P<0.05).Conclusions:Collectively,these results demonstrate that dietary ASTA may improve semen quality by increasing antioxidant enzyme activities and the ability to scavenge hydroxyl radicals,which may be related to upregulation of the MAPK/Nrf2 pathway. | Shan Gao Nuo Heng Fang Liu Yong Guo Yu Chen Liang Wang Hemin Ni Xihui Sheng Xiangguo Wang Kai Xing Longfei Xiao Xiaolong Qi | 2022 | Journal of Animal Science and Biotechnology2022，13，2： | 2 |
| 19 | miR-193b Regulates Mcl-1 in Melanoma显示文摘 | Jiamin Chen Xiao Zhang Cindy Lentz Marie Abi-Daoud Geneviève C. Paré Xiaolong Yang Harriet E. Feilotter Victor A. Tron | 2011 | The American Journal of Pathology2011，，5： | 1 |
| 20 | MicroRNA-193b Represses Cell Proliferation and Regulates Cyclin D1 in Melanoma显示文摘 | Jiamin Chen Harriet E. Feilotter Geneviève C. Paré Xiao Zhang Joshua G.W. Pemberton Cherif Garady Dulcie Lai Xiaolong Yang Victor A. Tron | 2010 | The American Journal of Pathology2010，，5： | 1 |
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