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| 1 | RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor I in Arabidopsis thaliana显示文摘RGF1,分泌的肽荷尔蒙,戏在 Arabidopsis 在根分裂组织开发给角色调音。以前的研究显示功能的 RGF1 需要是在由 tyrosylprotein sulfotransferase 的酷氨酸残余的 sulfated 并且 RGF1 主要经由二个下游的抄写因素调整根分裂组织活动,过多 1 (PLT1 ) 并且 PLT2。然而,细胞外的 RGF1 怎么被一个植物房间察觉,是不清楚的。用基因途径,我们发现了充满白氨酸的重复的 clade 像受体的 kinases,指定了为 RGF1 感觉迟钝 1 (RGI1 ) 到 RGI5,用作 RGF1 的受体。二独立 rgi1 rgi2 rgi3 rgi4 rgi5 五倍的异种与分裂组织的一种小尺寸显示一致的短主要的根显型。四倍的异种显示出的 rgi1 rgi2 rgi3 rgi4 到 RGF1 的显著地减少的敏感,和五倍的异种对 RGF1 完全感觉迟钝。PLT1 和 PLT2 的表示在五倍的异种是几乎无法发现的。一个 RGI2 倡导者极大地在五倍的异种驾驶的 PLT2 的宫外的表示救了它的根分裂组织缺点。RGI 之一, RGI1,随后详细生物化学地被分析。在 vitro 点弄污和下拉,分析显示 RGI1 能身体上与 RGF1 交往。RGF1 的外长的申请能快速并且同时导致 RGI1 的 phosphorylation 和 ubiquitination,显示 RGI1 能察觉并且 transduce RGF1 肽信号。然而,激活的 RGI1 多半很快被翻。这些结果表明那 RGI,充当 RGF1 的受体,在在 Arabidopsis thaliana 的 RGF1-PLT-mediated 根分裂组织开发的戏必需品角色。 | Yang Ou Xiaoting Lu Quaner Zi Qingqing Xun Jingjie Zhang Yujun Wu Hongyong Shi Zhuoyun Wei Baolin Zhao Xiaoyue Zhang Kai He Xiaoping Gou Chuanyou Li Jia Li | 2016 | Cell Research2016，26，6： | 18 |
| 2 | Lira-YOLO: a lightweight model for ship detection in radar images显示文摘For the detection of marine ship objects in radar images, large-scale networks based on deep learning are difficult to be deployed on existing radar-equipped devices. This paper proposes a lightweight convolutional neural network, LiraNet, which combines the idea of dense connections, residual connections and group convolution, including stem blocks and extractor modules.The designed stem block uses a series of small convolutions to extract the input image features, and the extractor network adopts the designed two-way dense connection module, which further reduces the network operation complexity. Mounting LiraNet on the object detection framework Darknet, this paper proposes Lira-you only look once(Lira-YOLO), a lightweight model for ship detection in radar images, which can easily be deployed on the mobile devices. Lira-YOLO's prediction module uses a two-layer YOLO prediction layer and adds a residual module for better feature delivery. At the same time, in order to fully verify the performance of the model, mini-RD, a lightweight distance Doppler domain radar images dataset, is constructed. Experiments show that the network complexity of Lira-YOLO is low, being only 2.980 Bflops, and the parameter quantity is smaller, which is only 4.3 MB. The mean average precision(mAP) indicators on the mini-RD and SAR ship detection dataset(SSDD) reach 83.21% and 85.46%, respectively,which is comparable to the tiny-YOLOv3. Lira-YOLO has achieved a good detection accuracy with less memory and computational cost. | ZHOU Long WEI Suyuan CUI Zhongma FANG Jiaqi YANG Xiaoting DING Wei | 2020 | Journal of Systems Engineering and Electronics2020，31，5： | 12 |
| 3 | Effects of metabolizable energy and crude protein levels on laying performance,egg quality and serum biochemical indices of Fengda-1 layers显示文摘This study was conducted to investigate the effects of dietary ME and CP levels on laying performance, egg quality and serum biochemical indices of Fengda-1 layers. In a 2 × 3 factorial arrangement, 2,400 Fengda-1 layers(32 wk of age) were randomly assigned to 6 experimental diets with 2,650 and 2,750 kcal of ME/kg of diet, each containing 14.50%, 15.00% and 15.50% CP, respectively. Each dietary treatment was replicated 5 times, and feed and water were provided ad libitum. The trial lasted for 10 wk, including a2-week acclimation period and an 8-week experimental period. Our results showed that ADFI decreased as the ME level of diet increased from 2,650 to 2,750 kcal/kg(P< 0.05). Layers fed diets with 2,750 kcal/kg ME exhibited higher mortality than those fed with 2,650 kcal/kg ME(P < 0.05). Birds fed with 14.50% and15.00% CP had higher egg production(EP) and egg mass(EM) than those fed with 15.50% CP(P < 0.05).Yolk color increased as the ME level of the diet increased from 2,650 to 2,750 kcal/kg, however, the eggshell thickness decreased(P < 0.05). Serum concentrations of uric acid and triglyceride in layers fed diets with 2,750 kcal/kg ME were higher than those fed diets with 2,650 kcal/kg ME(P < 0.05). There was no significant interaction between ME and CP on laying performance, egg quality, or serum biochemical indices(P > 0.05). Based on the data under the experimental conditions, the optimal dietary ME and CP levels of Fengda-1 layers are 2,650 kcal/kg and 15.00%(33 to 41 wk of age). | Yang Ding Xingchen Bu Nannan Zhang Lanlan Li Xiaoting Zou | 2016 | Animal Nutrition2016，，2： | 11 |
| 4 | Methane emissions from rice fields under continuous straw return in the middle-lower reaches of the Yangtze River显示文摘A three-year experiment was conducted in the middle-lower reaches of the Yangtze River in China to study the influence of continuous wheat straw return during the rice season and continuous rice straw return in wheat on methane (CH 4 ) emissions from rice fields in which, the rice-wheat rotation system is the most dominant planting pattern. The field experiment was initiated in October 2009 and has continued since the wheat-growing season of that year. The analyses for the present study were conducted in the second (2011) and third (2012) rice growing seasons. Four treatments, namely, the continuous return of wheat straw and rice straw in every season (WR), of rice straw but no wheat straw return (R), of wheat straw but no rice straw return (W) and a control with no straw return (CK), were laid out in a randomized split-plot design. The total seasonal CH 4 emissions ranged from 107.4 to 491.7 kg/ha (2011) and 160.3 to 909.6 kg/ha (2012). The increase in CH 4 emissions for treatments WR and W were 289% and 230% in the second year and 185% and 225% in the third year, respectively, in relation to CK. We observed less methane emissions in the treatment R than in CK by 14%-43%, but not statistically significant. Treatment R could increase rice productivity while no more CH 4 emission occurs. The difference in the total CH 4 emissions mainly related to a difference in the methane flux rate during the first 30-35 days after transplant in the rice growing season, which was caused by the amount of dissolved oxygen in paddy water and the amount of reducible soil materials. | Pengfu Hou Ganghua Li Shaohua Wang Xin Jin Yiming Yang Xiaoting Chen Chengqiang Ding Zhenghui Liu Yanfeng Ding | 2013 | Journal of Environmental Sciences2013，25，9： | 10 |
| 5 | Preparation of Ultrafine TATB and the Technology for Crystal Morphology Control显示文摘极其细小的 1,3,5-triamino-2,4,6-trinitrobenzene (TATB ) 被在与象表面活化剂的范畴和剂量那样的谷物尺寸和晶体形态学控制的靠近的关系中使用溶剂和非溶剂方法,和影响因素准备了,到非溶剂的溶剂的卷比率也在这份报纸被考虑了。它证明这些因素在结晶化过程期间在水晶形态学,粒子尺寸和凝块上有显著效果。由使用 0.095%( 集体百分比) 离子的表面活化剂(S) 作为添加剂并且用作为落下的设备喂设备的水花落下, 1.06 g TATB 原料从 30 ~ 50 nm 与谷物尺寸被精制了进免费跑的椭圆体和球形的 TATB 谷物。由使用 0.014%( 集体百分比) 是的非离子的表面活化剂(P) 添加剂,有 50 nm 的粒子直径并且与狭窄的粒子尺寸分发的球形的 TATB 谷物也被获得了。它被 TATB 的极其细小的粒子最好加热抵抗平均和它的 5 秒点火点的描述显示出被 7.5 K 推进。 | Yang,Li Ren,Xiaoting Li,Tiecheng Wang,Shiwei Zhang,Tonglai | 2012 | Chinese Journal of Chemistry2012，30，2： | 8 |
| 6 | A readily monitored and controllable hydrothermal system for the facile,cost-effective transformation of FGD gypsum to calcium sulfate hemihydrate whiskers显示文摘The controllable transformation of flue gas desulfurization(FGD)gypsum to calcium sulfate hemihydrate(HH)whiskers under facile,readily monitored,and cost-effective hydrothermal conditions could play a vital role in the preparation of high quality HH whiskers and improve our understanding of the transformation process.This work assessed the conversion of FGD gypsum to HH whiskers in 5×10^(-4)mol/L H_(2)SO_(4)and 1.5 wt%CuCl_(2)at 120℃while determining the effects of temperature as well as H_(2)SO_(4)and CuCl_(2)concentrations on transformation kinetics.The preparation of HH whiskers was found to involve a solution-mediated transformation from the dihydrate(DH)to theα-HH.This transition was determined to proceed via a dissolution crystallization mechanism,the rate of which was controlled by nucleation and growth of the HH whiskers.An autocatalytic kinetic model was established based on variations in the HH whiskers mole fraction over time,and this model accurately fit the experimental data with R2=0.990.Increasing the temperature or H_(2)SO_(4)concentration accelerated the transformation by modifying the super-saturation and water activity in the reaction solution,while increasing the CuCl_(2)concentration had the opposite effect.The hydrothermal conditions had an important effect on the transformation from FGD gypsum to HH whiskers. | Bolun Cao Xiao Wang Xiaoting Zhang Biao Jin Zhuoyue Xu Xueping Liu Wei Zhang Liushuan Yang | 2021 | Particuology2021，19，1： | 8 |
| 7 | Effect of electroacupuncture on chemotherapy-induced peripheral neuropathy in patients with malignant tumor:a single-blinded,randomized controlled trial显示文摘OBJECTIVE:To evaluate the effect of electroacupuncture on chemotherapy-induced peripheral neuropathy(CIPN), quality of life and immune status of patients with malignant tumors.METHODS:From Jan, 2013 to May, 2014, 37 patients with malignant tumors were included in this prospective single-blinded study, and randomized to receive either electroacupuncture or acupuncture treatment on basis of chemotherapy.The chemotherapy was continued for 2 courses as previous before the treatments, with 21 days as a course of treatment.Patients received acupuncture and electroacupuncture once per day starting at the day before chemotherapy for consecutive 7 days followed by 14 days off, with 21 days as a course of treatment, and continued for two courses of treatment.Then CIPN, traditional Chinese clinical symptoms,quality of life and immune status were all evaluated for each patient prior treatment and after two courses of treatment.RESULTS:The gender, age, cancer species as well as incidence(83.3% vs 84.2%) and grades of CIPN before treatments were all similar in patients receiving acupuncture or electroacupuncture(all P >0.05).After treatments, most patients with peripheral neuropathy were cured by two courses of electroacupuncture(84.2% vs 21.1%), whereas the other group of patients had similar incidences of peripheral neuropathy compared with prior-acupuncture(83.3% vs 72.2%).Besides, patients receiving electroacupuncture had lower incidence of peripheral neuropathy than those receiving acupuncture treatment(χ~2= 9.745, P = 0.002).The grades of peripheral neuropathy were significantly different in the two groups post-treatment(χ~2= 13.983, P =0.007).The total effective rates for traditional Chinese clinical symptoms were 16.7% and 84.2% in acupuncture and electroacupuncture groups, respectively(Z =-4.239, P < 0.001).The electroacupuncture treatment provided a more satisfactory life for patients compared with acupuncture(Z =-4.76, P < 0.001).Both electroacupuncture and acupuncture had no effects on immune function.CONCLUSION:Electroacupuncture could alleviate CIPN, and improve traditional Chinese clinical symptoms and quality of life, but did not affect immune function. | Zhang Shiqiang Wu Tingting Zhang Haisheng Yang Yun Jiang Haiyan Cao Shengcheng Xie Fang Xia Xiaoting Lü Junqiang Zhong Yi | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 7 |
| 8 | Structural characteristic and formation mechanism of hemihydrate calcium sulfate whiskers prepared using FGD gypsum显示文摘Hemihydrate calcium sulfate whiskers(HH-CSWs)were hydrothermally synthesized in a sulfuric acid solution at 120℃ for different holding times(20,40,and 60 min).The phase structures and morphologies were characterized by XRD and SEM,respectively.The XRD pattern of the sample under 60 min was refined via the Rietveld fitting method.The structure models of the HH-CSW sample under a 60-min holding time was established based on Rietveld fitting results.No difference in the positions of diffraction peaks was determined.The as-prepared holding time increased the intensity and aspect ratio of the diffraction peaks of both samples.In the prepared HH-CSW structure,Ca-O polyhedron is a 12-sided polyhedron similar to that in the gypsum structure;the Ca atom is located in two positions in the one-unit cell;the H_(2)O channel along the c-axis similar is O-shaped and bigger than that in hexagonal and monoclinic CaSO_(4)·0.5H_(2)O structures.Therefore,although the prepared HH-CSW crystals’structure are similar to that of the reported hexagonal and monoclinic CaSO_(4)·0.5H_(2)O structures,they are not the same.The formation mechanism of HH-CSW from flue gas desulfurization(FGD)gypsum is discussed based on the analysis of gypsum structure. | Xiaoting Zhang Lingwei Ran Xiao Wang Biao Jin Jianwu Zhang Shanying Li Liushuan Yang | 2022 | Particuology2022，20，3： | 7 |
| 9 | Geological and geochemical characteristics of Middle Jurassic granites in Bengbu uplift, Southeast of North China craton显示文摘1 Introduction The early formation and evolution of the North China craton has been widely concerned by scientists.The Bengbu uplift belt is located in the southeast of the craton,theresearch degree of the belt is relatively low and received increasing attention from many scholars in recent years.Through the author’s practical work and combined | Kang Congxuan Yang Xianzhong Cai Yitao Zong Wen Zhu Xiaoting | 2017 | Acta Geologica Sinica(English Edition)2017，91，S1： | 5 |
| 10 | An antioxidant system through conjugating superoxide dismutase onto metal-organic framework for cardiac repair显示文摘Acute myocardial infarction(AMI)remains a dominant origin of morbidity,mortality and disability worldwide.Increases in reactive oxygen species(ROS)are key contributor to excessive cardiac injury after AMI.Here we developed an immobilized enzyme with Superoxide Dismutase(SOD)activity cross-link with Zr-based metal-organic framework(ZrMOF)(SOD-ZrMOF)for mitigate ROS-caused injury.In vitro and in vivo evidence indicates that SOD-ZrMOF exhibits excellent biocompatibility.By efficiently scavenging ROS and suppressing oxidative stress,SOD-ZrMOF can protect the function of mitochondria,reduce cell death and alleviate inflammation.More excitingly,long-term study using an animal model of AMI demonstrated that SOD-ZrMOF can reduce the infarct area,protect cardiac function,promote angiogenesis and inhibit pathological myocardial remodeling.Therefore,SOD-ZrMOF holds great potential as an efficacious and safe nanomaterial treatment for AMI. | Jiacheng Guo Zhenzhen Yang Yongzheng Lu Chunyan Du Chang Cao Bo Wang Xiaoting Yue Zenglei Zhang Yanyan Xu Zhen Qin Tingting Huang Wei Wang Wei Jiang Jinying Zhang Junnan Tang | 2022 | Bioactive Materials2022，7，4： | 4 |
| 11 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 12 | Rapid, automated, and reliable antimicrobial susceptibility test from positive blood culture by CAST‐R显示文摘Antimicrobial susceptibility tests(ASTs)are pivotal in combating multidrug resistant pathogens,yet they can be time‐consuming,labor‐intensive,and unstable.Using the AST of tigecycline for sepsis as the main model,here we establish an automated system of Clinical Antimicrobials Susceptibility Test Ramanometry(CAST‐R),based on D2O‐probed Raman microspectroscopy.Featuring a liquid robot for sample pretreatment and a machine learning‐based control scheme for data acquisition and quality control,the 3‐h,automated CAST‐R process accelerates AST by>10‐fold,processes 96 paralleled antibiotic‐exposure reactions,and produces high‐quality Raman spectra.The Expedited Minimal Inhibitory Concentration via Metabolic Activity is proposed as a quantitative and broadly applicable parameter for metabolism‐based AST,which shows 99%essential agreement and 93%categorical agreement with the broth microdilution method(BMD)when tested on 100 Acinetobacter baumannii isolates.Further tests on 26 clinically positive blood samples for eight antimicrobials,including tigecycline,meropenem,ceftazidime,ampicillin/sulbactam,oxacillin,clindamycin,vancomycin,and levofloxacin reveal 93%categorical agreement with BMD‐based results.The automation,speed,reliability,and general applicability of CAST‐R suggest its potential utility for guiding the clinical administration of antimicrobials. | Pengfei Zhu Lihui Ren Ying Zhu Jing Dai Huijie Liu Yuli Mao Yuandong Li Yuehui He Xiaoshan Zheng Rongze Chen Xiaoting Fu Lili Zhang Lijun Sun Yuanqi Zhu Yuetong Ji Bo Ma Yingchun Xu Jian Xu Qiwen Yang | 2022 | mLife2022，1，3： | 3 |
| 13 | Early inoculation with caecal fermentation broth alters small intestine morphology,gene expression of tight junction proteins in the ileum,and the caecal metabolomic profiling of broilers显示文摘Background:The establishment of stable microbiota in early life is beneficial to the individual.Changes in the intestinal environment during early life play a crucial role in modulating the gut microbiota.Therefore,early intervention to change the intestinal environment can be regarded as a new regulation strategy for the growth and health of poultry.However,the effects of intestinal environmental changes on host physiology and metabolism are rarely reported.This study was conducted to investigate the effects of early inoculation with caecal fermentation broth on small intestine morphology,gene expression of tight junction proteins in the ileum,and cecum microbial metabolism of broilers.Results:Our data showed that early inoculation with caecal fermentation broth could improve intestine morphology.The small intestine villus height was significantly increased(P<0.05)in the intervened broilers compared to the control group,especially on day 28.A similar result was observed in the ratio of villus height to crypt depth(P<0.05).Meanwhile,we found early inoculation significantly increased(P<0.05)the expression levels of zonula occludens-1(ZO1)on days 14 and 28,claudin-1(CLDN1)on day 28,whereas the gene expression of claudin-2(CLDN2)was significantly decreased(P<0.05)on days 14 and 28.Gas chromatography time-of-flight/mass spectrometry(GC-TOF/MS)technology was further implemented to systematically evaluate the microbial metabolite profiles.Principal component analysis(PCA)and orthogonal partial least squares discriminant analysis(OPLS-DA)displayed a distinct trend towards separation between the fermentation broth group(F group)and the control group(C group).The differentially expressed metabolites were identified,and they were mainly functionally enriched in beta-alanine metabolism and biosynthesis of unsaturated fatty acids.In addition,1,3-diaminopropane was selected as a key biomarker that responded to early inoculation with caecal fermentation broth.Conclusions:These results provide insight into intestinal metabolomics and confirm that early inoculation with caecal fermentation broth can be used as a potential strategy to improve intestinal health of broilers. | Yujie Gong Wenrui Xia Xueting Wen Wentao Lyu Yingping Xiao Hua Yang Xiaoting Zou | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 3 |
| 14 | Herbal formula of Bushen Jianpi(补肾健脾方)combined with sorafenib inhibits hepatocellular carcinoma growth by promoting cell apoptosis and blocking the cell cycle显示文摘OBJECTIVE:To investigate the efficacy of an herbal formula of Bushen Jianpi(补肾健脾方,BSJP)combined with sorafenib on hepatocellular carcinoma(HCC)in vitro and in vivo,and to study the underlying mechanisms of action.METHODS:BSJP,a mixture of 12 raw herbs,was extracted in 70%alcohol/30%water and freeze-dried into a powder.The in vitro effects of BSJP alone,sorafenib alone,and their combination on cell survival,apoptosis,and cell cycle distribution were evaluated in HCC cell lines HCCLM3,HepG2,and SMMC-7721.The expression of B-cell lymphoma-2(Bcl-2),caspase-3,and caspase-9 in HCCLM3 cells was measured using Western blots after drug administration.The in vivo effects of BSJP and sorafenib were evaluated in a tumor surgical resection model using 4-week old male athymic BALB/c nude mice injected with HCCLM3 cells.Immunohistochemical analysis of tumor tissues was performed to evaluate the effects of BSJP alone,sorafenib alone,and their combination on the expression of caspase-3,caspase-9,and Bcl-2.RESULTS:BSJP decreased the survival rate of HCC cell lines,and the combination of BSJP and sorafenib further decreased the survival rate.BSJP significantly promoted cell apoptosis and blocked cell-cycle progression in HCCLM3,HepG2,and SMMC-7721 cells in a dose-dependent manner.Furthermore,the administration of BSJP and sorafenib inhibited the growth of HCCLM3 cell xenografts in nude mice,with no reduction in body weight.In vivo and in vitro experiments showed that BSJP combined with sorafenib could significantly decrease the expression of Bcl-2.CONCLUSION:Our findings suggest that the herbal formula of BSJP is a potential HCC antitumor agent. | ZHOU Zhangjie LIU Xinhua WU Tingting QUE Zujue WU Zhonghua WU Weizhong FU Shujuan ZHANG Shiqiang YANG Yun JIANG Haiyan XIA Xiaoting LV Junqiang DU Boqian LI Yun LU Tao ZHANG Zhihui ZHONG Yi | 2021 | Journal of Traditional Chinese Medicine2021，41，2： | 3 |
| 15 | RGF1-RGI1,a Peptide-Receptor Complex,Regulates Arabidopsis Root Meristem Development via a MAPK Signaling Cascade显示文摘Root growth is maintained by the continuous division of cells in the apical meristem.ROOT MERISTEM GROWTH FACTOR 1(RGF1)is a critical peptide hormone regulating root stem cell niche maintenance.Previous studies discovered that five closely related leucine-rich repeat receptor-like protein kinases(LRRRLKs),named RGF1 INSENSITIVES(RGIs)or RGF1 RECEPTORS(RGFRs),are able to perceive the RGF1 signal and redundantly control root stem cell niche maintenance.RGF1 regulates root meristem activity mainly via two downstream transcription factors,PLETHORA 1(PLT1)and PLT2.Regulatory proteins connecting cell surface RGF1-RGI1 and nuclear PLTs,however,were not identified.Here,we report that the mitogen-activated protein(MAP)kinase kinase 4(MKK4)and MAP kinase 3(MPK3)were coimmunoprecipitated with RGI1-FLAG after Arabidopsis seedlings were treated with RGF1.Genetic and biochemical assays confirmed that MKK4 and MKK5,and their downstream targets MPK3 and MPK6,are essential RG卜dependent regulators of root meristem development.In addition,we found that the MKK4/MKK5-MPK3/MPK6 module functions downstream of YDA,a MAPKKK.Our results demonstrate that RGF1-RGI1 regulate the expression of PLT1/PLT2 via a YDA-MKK4/MKK5-MPK3/MPK6 signaling cascade. | Xiaoting Lu Hongyong Shi Yang Ou Yanwei Cui Jinke Chang Liang Peng Xiaoping Gou Kai He Jia Li | 2020 | Molecular Plant2020，13，11： | 3 |
| 16 | Anti-oxidant and anti-inflammatory activities of ultrasonicassistant extracted polyphenol-rich compounds from Sargassum muticum显示文摘Polypehnol is an important,potentially bioactive component of Sargassum muticum.In this study,ultrasonic assisted extraction of polyphenol-rich substances was performed using a 38%ethanol solution at a solid:liquid ratio of 1:30 at 68℃ for 32min,determined by single-factor and response surface methodology(RSM)optimization.The content of polyphenol was 5.66mg/g in the crude extract.Further extraction showed that the polyphenol mainly distributed in ethyl acetate(SKEE)and water phases(SKEW).The anti-oxidation test by electron spin resonance(ESR)spectrum showed that the SKEE had the strongest scavenging activity on DPPH(1,1-diphenyl-2-picrylhydrazyl)and alkyl radicals.SKEE was shown noncytotoxic but could inhibit the generation of cellular ROS,showing protective effects in H2O2 and AAPHinduced Vero cells and UV-B irradiated HaCaT cells.SKEE also signifi cantly inhibited the release of NO of LPS-induced RAW 264.7 cells.Therefore,the polyphenol-rich extracts in ethanol and ethyl acetate showed excellent anti-oxidant and anti-infl ammatory activities,which is beneficial to the development of high-value bio-substances. | YU Yuan WANG Le FU Xiaoting WANG Lei FU Xiaodan YANG Min HAN Zhenlian MOU Haijin JEON You-Jin | 2019 | Journal of Oceanology and Limnology2019，37，3： | 3 |
| 17 | Urinary analysis reveals high Alternaria mycotoxins exposure in the general population from Beijing, China显示文摘Alternaria mycotoxins are of concern due to its adverse health effect, they affect various cereal crops and grain-based food along with modified forms that contribute to overall exposure. This study aimed to determine the frequency and level of exposure to Alternaria mycotoxins(tenuazonic acid, TeA;alternariol, AOH;alternariol monomethyl ether, AME;tentoxin, TEN;and altenuene, ALT) in human urine from Beijing adults. A total of 2212 urine samples were collected and analyzed for five mycotoxins using LC–ESI–MS/MS. More than98% of the samples had at least one Alternaria mycotoxin detected. Among the mycotoxins,AME had the highest detection rate(96.0%), followed by TeA(70.5%). The calculated average daily intake values of AME(12.5 ng/kg b.w.) was 5 times the TTC value(2.5 ng/kg b.w.) set by the EFSA, indicating the potential health risks associated with mycotoxins. Immediate attention and subsequent actions should be taken to identify the sources of mycotoxins and the corresponding exposure pathways to humans in the investigated regions. | Xiaoting Qiao Gang Li Jing Zhang Jing Du Yunjia Yang Jie Yin Hui Li Jie Xie You Jiang Xiang Fang Xinhua Dai Bing Shao | 2022 | Journal of Environmental Sciences2022，34，8： | 3 |
| 18 | Enhanced multimodal luminescence and ultrahigh stability Eu^(3+)-doped CsPbBr_(3) glasses for X-ray detection and imaging显示文摘As an emerging scintillation material,metal halide perovskite(CsPbX3)has been deemed the most potentially valuable candidate in X-ray detection and medical imaging.Nevertheless,it is a continuing challenge to implement efficient radioluminescence(RL)with high radiation stability and moisture resistance.Moreover,the optimized luminescence properties and excellent uniformity of CsPbX3 glass are also key points for obtaining perfect X-ray images.Herein,we have successfully precipitated Eu^(3+)-doped CsPbBr_(3)nanocrystals(NCs)with improved photoluminescence quantum yield(≈58.6%)because partial Eu^(3+)entered the perovskite lattice in a robust borosilicate glass matrix by in situ crystallization.The small amount of Eu addition made the lattice of NCs shrink and promoted uniform distribution of CsPbBr_(3)NCs in the glass,which effectively reduced the light scattering of the sample.Subsequently,multimodal RL intensity of the CsPbBr_(3)/CsPbBr_(3):xEu NCs glasses(CPB-0Eu/CPB-xEu)as a function of X-ray dose rate showed a superlinear relationship to the benefit of obtaining satisfactory X-ray images.Also,the outstanding radiation stability and water resistance of CPB-xEu were confirmed due to the protection of the robust glass matrix.Finally,an X-ray imaging system using a CPB-xEu scintillator was constructed,and the spring in the opaque sample was legibly detected under the motivation of X-rays,indicating that CsPbX3 glasses possess extensive application prospects in terms of X-ray detection and medical imaging. | YAO TONG QIN WANG HENG YANG XIAOTING LIU ENROU MEI XIAOJUAN LIANG ZHIJUN ZHANG WEIDONG XIANG | 2021 | Photonics Research2021，9，12： | 2 |
| 19 | Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt/GSK-β/β-catenin signaling and epithelial–mesenchymal transition显示文摘 | Bin Zhang Yan Yang Xiaoting Shi Wanyu Liao Min Chen Alfred Sze-Lok Cheng Hongli Yan Cheng Fang Shu Zhang Guifang Xu Shanshan Shen Shuling Huang Guangxia Chen Ying Lv Tingsheng Ling Xiaoqi Zhang Lei Wang Yuzheng Zhuge Xiaoping Zou | 2014 | Cancer Letters2014，，： | 2 |
| 20 | New efficient method for dynamic modeling and?simulation of flexible multibody systems moving in?plane显示文摘 | Bao Rong Xiaoting Rui Guoping Wang Fufeng Yang | 2010 | Multibody System Dynamics2010，，2： | 1 |
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