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| 1 | Mesoporous silica nanoparticles for drug and gene delivery显示文摘Mesoporous silica nanoparticles(MSNs) are attracting increasing interest for potential biomedical applications. With tailored mesoporous structure, huge surface area and pore volume,selective surface functionality, as well as morphology control, MSNs exhibit high loading capacity for therapeutic agents and controlled release properties if modified with stimuli-responsive groups, polymers or proteins. In this review article, the applications of MSNs in pharmaceutics to improve drug bioavailability, reduce drug toxicity, and deliver with cellular targetability are summarized. Particularly,the exciting progress in the development of MSNs-based effective delivery systems for poorly soluble drugs, anticancer agents, and therapeutic genes are highlighted. | Yixian Zhou Guilan Quan Qiaoli Wu Xiaoxu Zhang Boyi Niua Biyuan Wu Ying Huang Xin Pan Chuanbin Wu | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 31 |
| 2 | Role of pyroptosis in inflammation and cancer显示文摘Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures,resulting in the release of cellular contents that can activate strong inflammatory and immune responses.Pyroptosis,an innate immune response,can be triggered by the activation of inflammasomes by various influencing factors.Activation of these inflammasomes can induce the maturation of caspase-1 or caspase-4/5/11,both of which cleave gasdermin D to release its N-terminal domain,which can bind membrane lipids and perforate the cell membrane.Here,we review the latest advancements in research on the mechanisms of pyroptosis,newly discovered influencing factors,antitumoral properties,and applications in various diseases.Moreover,this review also provides updates on potential targeted therapies for inflammation and cancers,methods for clinical prevention,and finally challenges and future directions in the field. | Xiang Wei Feng Xie Xiaoxue Zhou Yuchen Wu Haiyan Yan Ting Liu Jun Huang Fangwei Wang Fangfang Zhou Long Zhang | 2022 | Cellular & Molecular Immunology2022，19，9： | 11 |
| 3 | Investigation of influence of coal properties on dense-phase pneumatic conveying at high pressure显示文摘Experiments of dense-phase pneumatic conveying of pulverized coal using nitrogen were carried out in a test facility at pressures of up to 3.7 MPa to study the effects of coal type, particle size and moisture content on flow characteristics. The Jenike shear test and scanning electron microscopy (SEM) were employed to provide a better understanding of effects of the material properties on flow characteristics. Two kinds of pulverized coals, Yanzhou and Datong, with similar particle size, moisture content and density, were used in the test. Pressure drop increases with increasing the particle size at similar solid-gas ratio, superficial velocity and pressure in the receiving hopper, and pressure drops through different test sections decrease firstly and then rise with increasing the conveying velocity for the same particle size, mass flow rate and pressure in the receiving hopper. The flowability of pulverized coal decreases with increasing the moisture content in the range from 3.24% to 8.18%. Unconfined yield strength (UYS) increases and flow function (FF) decreases with increasing the moisture content. Results of the shearing tests are consistent with the results of the conveying study. Pressure drops through different test sections are discussed and analyzed. | Cai Liang Xiaoxu Xie Pan Xu Xiaoping Chen Changsui Zhao Xin Wu | 2012 | Particuology2012，10，3： | 8 |
| 4 | Intracellular and Extracellular Phosphatidylinositol 3-Phosphate Produced by Phytophthora Species Is Important for Infection显示文摘Phytophthora 病原体生产的 RxLR 受动器被建议了把 3 磷酸盐(PtdIns (3 ) P ) 绑在 phosphatidylinositol 调停他们的 translocation 进主人房间或到增加他们在 planta 的稳定性。因为在植物的 PtdIns (3 ) P 的层次是低的,我们检验了 Phytophthora 种类是否可以生产 PtdIns (3 ) 支持感染的 P。我们观察了 P 特定的 GFP 生物传感器能绑在 P 的那 PtdIns (3 ) 。parasitica 和 P。sojae hyphae 短暂地在 Nicotiana benthamiana 的感染期间离开 secreting 生物传感器,建议 hyphae 暴露了 PtdIns (3 ) 他们的血浆膜上的 P 或分泌 PtdIns (3 ) P。phosphatidylinositol 3-kinases (PI3K ) 的 Silencing 基因,有 LY294002 的处理,或 PtdIns (3 ) 的表示由 P 的 P 有约束力的蛋白质。sojae 在大豆上减少了病原体的毒力,显示综合病原体的 PtdIns (3 ) P 为完整的毒力被要求。PtdIns (3 ) 的分泌物 P 有约束力的蛋白质或由 N 的 PI3P-5-kinase。benthamiana 叶子显著地由 P 增加了抵抗的水平到感染。parasitica 和 P。capsici。一起,我们的结果支持假设那 Phytophthora 种生产外部 PtdIns (3 ) 帮助感染的 P,例如支持 RxLR 受动器的入口进宿主细胞。我们的结果源于 P。sojae RxLR 受动器 Avr1b 证实 N 终点和这个受动器的 C 终点能绑 PtdIns (3 ) P。 | Shan Lu | 2013 | Molecular Plant2013，6，5： | 7 |
| 5 | Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase(AMPK)-dependent pathway显示文摘Obesity is a worldwide epidemic. Promoting browning of white adipose tissue(WAT)contributes to increased energy expenditure and hence counteracts obesity. Here we show that cordycepin(Cpn), a natural derivative of adenosine, increases energy expenditure, inhibits weight gain, improves metabolic profile and glucose tolerance, decreases WAT mass and adipocyte size, and enhances cold tolerance in normal and high-fat diet-fed mice. Cpn markedly increases the surface temperature around the inguinal WAT and turns the inguinal fat browner. Further investigations show that Cpn induces the development of brown-like adipocytes in inguinal and, to a less degree, epididymal WAT depots. Cpn also increases the expression of uncoupling protein 1(UCP1) and other thermogenic genes in WAT and3T3-L1 differentiated adipocytes, in which AMP-activated protein kinase(AMPK) plays an important role. Our results provide novel insights into the function of Cpn in regulating energy balance, and suggest a potential utility of Cpn in the treatment of obesity. | Guihong Qi Yue Zhou Xiaopo Zhang Jiaqi Yu Xin Li Xiaoxue Cao Chongming Wu Peng Guo | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 6 |
| 6 | Impact of global change on transmission of human infectious diseases显示文摘Global change,which refers to large-scale changes in the earth system and human society,has been changing the outbreak and transmission mode of many infectious diseases.Climate change affects infectious diseases directly and indirectly.Meteorological factors including temperature,precipitation,humidity and radiation influence infectious disease by modulating pathogen,host and transmission pathways.Meteorological disasters such as droughts and floods directly impact the outbreak and transmission of infectious diseases.Climate change indirectly impacts infectious diseases by altering the ecological system,including its underlying surface and vegetation distribution.In addition,anthropogenic activities are a driving force for climate change and an indirect forcing of infectious disease transmission.International travel and rural-urban migration are a root cause of infectious disease transmission.Rapid urbanization along with poor infrastructure and high disease risk in the rural-urban fringe has been changing the pattern of disease outbreaks and mortality.Land use changes,such as agricultural expansion and deforestation,have already changed the transmission of infectious disease.Accelerated air,road and rail transportation development may not only increase the transmission speed of outbreaks,but also enlarge the scope of transmission area.In addition,more frequent trade and other economic activities will also increase the potential risks of disease outbreaks and facilitate the spread of infectious diseases. | WU XiaoXu TIAN HuaiYu ZHOU Sen CHEN LiFan XU Bing | 2014 | Science China Earth Sciences2014，57，2： | 6 |
| 7 | Ficolin A exacerbates severe H1N1 influenza virus infection-induced acute lung immunopathological injury via excessive complement activation显示文摘Severe pandemic influenza A(H1N1)2009 virus(pH1N1)infection causes significant morbidity and mortality.We and other groups have reported that immunopathological damage induced by excessive pulmonary inflammation plays a critical role in the pathogenesis of severe pneumonia and provides novel strategies for the treatment of severe influenza infection[1–3].The complement system plays critical roles in both innate and adaptive immunity by activating the classical,alternative and lectin pathways[4]. | Xu Wu Linlin Bao Ziqi Hu Duoduo Yao Fengdi Li Hui Li Xiaoxue Xu Yunqing An Xi Wang Bin Cao Xulong Zhang | 2021 | Cellular & Molecular Immunology2021，18，9： | 6 |
| 8 | Effectiveness of Catch-Up Vaccinations after COVID-19 Containment--China,2020显示文摘Introduction:In the early stages of the coronavirus disease 2019(COVID-19)epidemic in China,the highest level of public health emergency response(Level 1 Response)was launched in all province-level administrative divisions(PLADs)across the country.Provision of vaccination services was selectively suspended due to the physical distancing and gathering restrictions required of Level 1 Response.The purpose of this paper is to evaluate the impact of COVID-19 on vaccination services and the effectiveness of selective vaccination service suspension and catch-up vaccinations in China.Methods:Vaccine doses administered,routine vaccination coverage levels,catch-up vaccine doses administered,and coverage levels after the catch-up campaign were determined from individual vaccination records in sampled clinics,standard routine immunization administrative coverage reports,and catch-up vaccination activity reports submitted by PLADs between October 2019 and October 2020.Results:National Immunization Program(NIP)and non-NIP vaccine doses administered in sampled clinics decreased by 80% and 90%,respectively,compared with doses administered before the COVID-19 pandemic.Coverage with the birth dose of hepatitis B vaccine(HepB1)and the Bacillus Calmette-Guérin vaccine(BCG)—two vaccinations recommended to continue throughout the epidemic due to their timecritical nature—were maintained at over 85%,while coverage of other NIP vaccines decreased to below 60%by February 2020.Catch-up vaccination coverage of the 29 PLADs,excluding Xinjiang and Xizang(Tibet),began in April 2020 and exceeded 90%;Hubei catch-up coverage was 95% by October 2020.Conclusions and Implications for Public Health Practice:The COVID-19 pandemic had a great impact on China’s vaccination services.During the epidemic and time of local transmission of the coronavirus,HepB1,BCG,rabies vaccine for postexposure prophylaxis,and tetanus antitoxin(TAT)for wound prophylaxis were maintained at high levels.Of the 69 million vaccine doses postponed during the time of local transmission of the coronavirus,94% were administered in the catch-up campaign.China’s pandemic immunization practices may provide evidence for other countries’immunization programs. | Jing Wu Wenzhou Yu Lei Cao Lingsheng Cao Lance Rodewald Jiakai Ye Yifan Song Li Li Xiaoxue Liu Ning Wen Fuzhen Wang Lixin Hao Yixing Li Hui Zheng Keli Li Chao Ma Dan Wu Yanmin Liu Guomin Zhang Zhijie An Huaqing Wang Zundong Yin | 2020 | China CDC weekly2020，2，50： | 6 |
| 9 | Contemporary trends on expenditure of hospital care on total cancer and its subtypes in China during 2008-2017显示文摘Objective:To describe the contemporary trends in total,inpatient,and outpatient expenditure on major subtypes of cancer in different classifications of hospitals in China's Mainland.Methods:Home page of Inpatient Medical Records(HIMRs)and Hospital Annual Reports(HARs)were used to estimate hospital care expenditure on cancer.Inpatient payments and their share of cancer were calculated with the top-down method.Kriging spatial interpolation methods were used at the county level and summed at the province level.Outpatient expenditure was estimated with inpatient expenditure and the ratios of outpatient to inpatient payments in specialized cancer hospitals,stratified by province.Total expenditure on cancer was the sum of both payments.Log-linear regression was applied to estimate annual percentage change(APC)of expenditure.Results:Total expenses for cancer of Chinese residents reached up to 304.84 billion Chinese Yuan(CNY)in2017,accounting for 5.8%of the total health expenses(THE).After adjusting for consumer price index(CPI),medical expenses for cancer have increased from 63.30 billion CNY in 2008 to 249.56 billion CNY in 2017[APC:15.2%,95%confidence interval(95%CI):13.4%-17.0%].The APC was slightly higher than THE around 2013,while was lower after 2013.During 2008-2017,the ratio of inpatient to outpatient costs for cancer decreased from4.3:1 to 3.8:1.The inpatient payments for cancer mainly happened in grade 3 general hospitals,East China,and among lung,colorectal,and stomach cancer;while the fastest increase was found in West China,and among thyroid,prostate,and colorectal cancer.Conclusions:During 2008-2017,the rapid growth trend of medical expenses for cancer has been effectively controlled with the continuous deepening of medical reform and improvements of residents’health care.More attention should be paid to potential increases of medical costs caused by technological progress and demand release.Socialized and multi-channel insurance financing modes should be explored in the future. | Yue Cai Wanqing Chen Xiaoxu Wang Xue Xia Xiang Cui Shiyong Wu Jinghua Li | 2021 | Chinese Journal of Cancer Research2021，33，5： | 5 |
| 10 | Review of cavity optomechanics in the weak-coupling regime: from linearization to intrinsic nonlinear interactions显示文摘Recently, cavity optomechanics has become a rapidly developing research field exploring the coupling between the optical field and mechanical oscillation. Cavity optomechanical systems were predicted to exhibit rich and nontrivial effects due to the nonlinear optomechanical interaction. However, most progress during the past years have focused on the linearization of the optomechanical interaction, which ignored the intrinsic nonlinear nature of the optomechanical coupling. Exploring nonlinear optomechanical interaction is of growing interest in both classical and quantum mechanisms, and nonlinear optomechanical interaction has emerged as an important new frontier in cavity optomechanics. It enables many applications ranging from single-photon sources to generation of nonclassical states. Here, we give a brief review of these developments and discuss some of the current challenges in this field. | XIONG Hao SI LiuGang LV XinYou YANG XiaoXue WU Ying | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，5： | 5 |
| 11 | Effect of sodium ions in synthesis of titanium silicalite-1 on its catalytic performance for cyclohexanone ammoximation显示文摘 | Pengxu YAO Yaquan WANG Teng ZHANG Shuhai WANG Xiaoxue WU | 2014 | Frontiers of Chemical Science and Engineering2014，8，2： | 5 |
| 12 | Effects of End-Bend and Curved Blades on the Flow Field and Loss of a Compressor Linear Cascade in the Design Condition显示文摘Curved blade and end-bend blade are considered as effective passive control methods for improving the aerodynamic performance of a compressor cascade,and their applicability also needs to be further studied.A highly-loaded compressor linear cascade in the design condition was taken as the research objective in this paper.Numerical simulation was used to study the positive and negative effects of these methods on the flow loss of the cascade by redistributing the vortex structures.Results show that:the curved blade could reduce the flow loss to 2.55%,while the end-bend blade and the end-bend+curved blade increase it to 10.58%and 2.19%,respectively.The positive effect of the curved blade weakens the strength and scale of Concentrated Shedding Vortex(CSV),which accounts for 59.2%of the total flow loss.The negative effect of the end-bend blade exacerbates the low-energy fluid clusters from the end wall and wake into CSV.Finally,the end-bend+curved blade can take their own strengths,but it enhances the twisting motion of Passage Vortex(PV)and CSV,which makes it fail to reduce the flow loss.Therefore,the positive and negative effects of these methods on the flow loss of a compressor cascade are much clearer.In addition,we also predict the potential danger of the end-bend blade in the negative incidence conditions and provides some suggestion for future study. | KAN Xiaoxu WU Wanyang YANG Ling ZHONG Jingjun | 2019 | Journal of Thermal Science2019，28，4： | 4 |
| 13 | Up-regulation of P2X7 Receptors Contributes to Spinal Microglial Activation and the Development of Pain Induced by BmK-I显示文摘Previous work has demonstrated that the sensitization of spinal neurons and microglia is important in the development of pain behaviors induced by BmK I,a Na^+ channel activator and a major peptide component of the venom of the scorpion Buthus martensi Karsch(BmK).We found that the expression of P2X7 receptors(P2X7Rs)was up-regulated in the ipsilateral spinal dorsal horn after BmK I injection in rats.P2X7R was selectively localized in microglia but not astrocytes or neurons.Similarly,interleukin 1β(IL-1β)was selectively up-regulated in microglia in the spinal dorsal horn after BmK I injection.Intrathecal injection of P2X7R antagonists largely reduced BmK I-induced spontaneous and evoked pain behaviors,and the up-regulation of P2X7R and IL-1β in the spinal cord.These data suggested that the up-regulation of P2X7Rs mediates microglial activation in the spinal dorsal horn,and therefore contributes to the development of BmK I-induced pain. | Jingjing Zhou Xiaoxue Zhang You Zhou Bin Wu Zhi-Yong Tan | 2019 | Neuroscience Bulletin2019，35，4： | 4 |
| 14 | Quality assessment of Chrysanthemum indicum Flower by simultaneous quantification of six major ingredients using a single reference standard combined with HPLC fingerprint analysis显示文摘Chrysanthemum indicum Flower is usually consumed as functional food. This paper described an improved total quality assessment method for Chrysanthemum indicum Flower by simultaneous quantitation using a single standard to determine multi-components method combined with high performance liquid chromatography fingerprint analysis. Six main components of Chrysanthemum indicum Flower including two flavonoids and four phenolic acids were simultaneously quantified using linarin as the internal reference standard. The method was fully validated with respect to linearity, precision, accuracy, robustness and stability.The validated method was successfully applied to the analysis of thirty three batches of Chrysanthemum indicum Flower samples. Under the same chromatographic conditions, fingerprint analysis in combination with Similarity analysis and principal component analysis was performed to identify the samples from different regions. In general, an effective assessment using a single standard to determinate multi-components method combined with fingerprint analysis make the reliable qualitation and quantitation analysis of Chrysanthemum indicum Flower available. | Jiao He Xiaoxue Wu Yali Kuang Tianyang Wang Kaishun Bi Qing Li | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，2： | 3 |
| 15 | A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery显示文摘SARS-CoV-2 causes the pandemic of COVID-19 and no effective drugs for this disease are available thus far.Due to the high infectivity and pathogenicity of this virus,all studies on the live virus are strictly confined in the biosafety level 3(BSL3)laboratory but this would hinder the basic research and antiviral drug development of SARS-CoV-2 because the BSL3 facility is not commonly available and the work in the containment is costly and laborious.In this study,we constructed a reverse genetics system of SARS-CoV-2 by assembling the viral cDNA in a bacterial artificial chromosome(BAC)vector with deletion of the spike(S)gene.Transfection of the cDNA into cells results in the production of an RNA replicon that keeps the capability of genome or subgenome replication but is deficient in virion assembly and infection due to the absence of S protein.Therefore,such a replicon system is not infectious and can be used in ordinary biological laboratories.We confirmed the efficient replication of the replicon by demonstrating the expression of the subgenomic RNAs which have similar profiles to the wild-type virus.By mutational analysis of nsp12 and nsp14,we showed that the RNA polymerase,exonuclease,and cap N7 methyltransferase play essential roles in genome replication and sgRNA production.We also created a SARS-CoV-2 replicon carrying a luciferase reporter gene and this system was validated by the inhibition assays with known anti-SARS-CoV-2 inhibitors.Thus,such a one-plasmid system is biosafe and convenient to use,which will benefit both fundamental research and development of antiviral drugs. | Yun-Yun Jin Hanwen Lin Liu Cao Wei-Chen Wu Yanxi Ji Liubing Du Yiling Jiang Yanchun Xie Kuijie Tong Fan Xing Fuxiang Zheng Mang Shi Ji-An Pan Xiaoxue Peng Deyin Guo | 2021 | Virologica Sinica2021，36，5： | 2 |
| 16 | The RALF1-FERONIA complex interacts with and activates TOR signaling in response to low nutrients显示文摘Target of rapamycin(TOR)kinase is an evolutionarily conserved major regulator of nutrient metabolism and organismal growth in eukaryotes.In plants,nutrients are remobilized and reallocated between shoots and roots under low-nutrient conditions,and nitrogen and nitrogen-related nutrients(e.g.,amino acids)are key upstream signals leading to TOR activation in shoots under low-nutrient conditions.However,how these forms of nitrogen can be sensed to activate TOR in plants is still poorly understood.Here we report that the Arabidopsis receptor kinase FERON IA(FER)interacts with the TOR pathway to regulate nutrient(nitrogen and amino acid)signaling under low-nutrient conditions and exerts similar metabolic effects in response to nitrogen deficiency.We found that FER and its partner,RPM1-induced protein kinase(RIPK),interact with the TOR/RAPTOR complex to positively modulate TOR signaling activity.During this process,the receptor complex FER/RIPK phosphorylates the TOR complex component RAPTOR1B.The RALF1 peptide,a ligand of the FER/RIPK receptor complex,increases TOR activation in the young leaf by enhancing FER-TOR interactions,leading to promotion of true leaf growth in Arabidopsis under lownutrient conditions.Furthermore,we showed that specific amino acids(e.g.,Gin,Asp,and Gly)promote true leaf growth under nitrogen-deficient conditions via the FER-TOR axis.Collectively,our study reveals a mechanism by which the RALF1-FER pathway activates TOR in the plant adaptive response to low nutrients and suggests that plants prioritize nutritional stress response over RALF1-mediated inhibition of cell growth under low-nutrient conditions. | Limei Song Guoyun Xu Tingting Li Huina Zhou Qinlu Lin Jia Chen Long Wang Dousheng Wu Xiaoxu Li Lifeng Wang Sirui Zhu Feng Yu | 2022 | Molecular Plant2022，15，7： | 2 |
| 17 | Application of a new wind driving force model in soil wind erosion area of northern China显示文摘The shear stress generated by the wind on the land surface is the driving force that results in the wind erosion of the soil.It is an independent factor influencing soil wind erosion.The factors related to wind erosivity,known as submodels,mainly include the weather factor(WF)in revised wind erosion equation(RWEQ),the erosion submodel(ES)in wind erosion prediction system(WEPS),as well as the drift potential(DP)in wind energy environmental assessment.However,the essential factors of WF and ES contain wind,soil characteristics and surface coverings,which therefore results in the interdependence between WF or ES and other factors(e.g.,soil erodible factor)in soil erosion models.Considering that DP is a relative indicator of the wind energy environment and does not have the value of expressing wind to induce shear stress on the surface.Therefore,a new factor is needed to express accurately wind erosivity.Based on the theoretical basis that the soil loss by wind erosion(Q)is proportional to the shear stress of the wind on the soil surface,a new model of wind driving force(WDF)was established,which expresses the potential capacity of wind to drive soil mass in per unit area and a period of time.Through the calculations in the typical area,the WDF,WF and DP are compared and analyzed from the theoretical basis,construction goal,problem-solving ability and typical area application;the spatial distribution of soil wind erosion intensity was concurrently compared with the spatial distributions of the WDF,WF and DP values in the typical area.The results indicate that the WDF is better to reflect the potential capacity of wind erosivity than WF and DP,and that the WDF model is a good model with universal applicability and can be logically incorporated into the soil wind erosion models. | ZOU Xueyong LI Huiru LIU Wei WANG Jingpu CHENG Hong WU Xiaoxu ZHANG Chunlai KANG Liqiang | 2020 | Journal of Arid Land2020，12，3： | 2 |
| 18 | Ascorbate peroxidase 1 confers resistance to southern corn leaf blight in maize显示文摘Southern corn leaf blight (SCLB), caused by Bipolarismaydis, is one of the most devastatingdiseases affecting maize production. However,only one SLCB resistance gene, conferring partialresistance, is currently known, underscoring theimportance of isolating new SCLB resistancerelatedgenes. Here, we performed a comparativeproteomic analysis and identified 258 proteinsshowing differential abundance during the maizeresponse to B. maydis. These proteins included anascorbate peroxidase (Zea mays ascorbate peroxidase1 (ZmAPX1)) encoded by a gene locatedwithin the mapping interval of a previously identifiedquantitative trait locus associated with SCLBresistance. ZmAPX1 overexpression resulted inlower H_(2)O_(2) accumulation and enhanced resistanceagainst B. maydis. Jasmonic acid (JA)contents and transcript levels for JA biosynthesisand responsive genes increased in ZmAPX1-overexpressing plants infected with B. maydis,whereas Zmapx1 mutants showed the oppositeeffects. We further determined that low levels of H_(2)O_(2) are accompanied by an accumulation of JAthat enhances SCLB resistance. These resultsdemonstrate that ZmAPX1 positively regulatesSCLB resistance by decreasing H_(2)O_(2) accumulationand activating the JA-mediated defensesignaling pathway. This study identified ZmAPX1as a potentially useful gene for increasing SCLBresistance. Furthermore, the generated datamay be relevant for clarifying the functions ofplant APXs. | Jinghua Zhang Xingmeng Jia Guan-Feng Wang Shijun Ma Shunxi Wang Qin Yang Xueyan Chen Yuqian Zhang Yajing Lyu Xiaoxu Wang Jiawei Shi Yangtao Zhao Yanhui Chen Liuji Wu | 2022 | Journal of Integrative Plant Biology2022，64，6： | 2 |
| 19 | Postzygotic single-nucleotide mosaicisms in whole-genome sequences of clinically unremarkable individuals显示文摘 | August Y Huang Xiaojing Xu Adam Y Ye Qixi Wu Linlin Yan Boxun Zhao Xiaoxu Yang Yao He Sheng Wang Zheng Zhang Bowen Gu Han-Qing Zhao Meng Wang Hua Gao Ge Gao Zhichao Zhang Xiaoling Yang Xiru Wu Yuehua Zhang Liping Wei | 2014 | Cell Research2014，24，11： | 2 |
| 20 | The Pumilio RNA-binding protein APUM24 regulates seed maturation by fine-tuning the BPM-WRI1 module in Arabidopsis显示文摘Pumilio RNAbindingproteinsparticipateinmes-senger RNA(mRNA)degradation and t ranslational repression,but their roles in plant development are largely unclear.Here,we show that Arabidopsis PUMILIO PROTEIN24(APUM24),an atypical Pumiliohomology domaincontaining protein,plays an im-portant part in regulating seed maturation,a major stage of plant development.APUM24 is strongly expressed in maturing seeds.Reducing APUM24 expression resulted in abnormal seed maturation,wrinkled seeds,and lower seed oil contents,and APUM24 knockdown resulted in lower levels of WRINKLED 1(WRI1),a key transcription factor con-trolling seed oil accumulation,and lower expression of WRI1 target genes.APUM24 reduces the mRNA stability of BTB/POZMATH(BPM)family genes,thus decreasing BPM protein levels.BPM is responsible for the 26S proteasomemediated degradation of WRI1 and has important functions in plant growth and development.The 3′untranslated regions of BPM family genes contain putative Pumilio response elements(PREs),which are bound by APUM24.Re-duced BPM or increased WRI1 expression rescued the decient seed maturation of apum242 knock-down mutants,and APUM24 overexpression re-sulted in increased seed size and weight.Therefore,APUM24 is crucial to seed maturation through its action as a positive regulatornetuning the BPMWRI1 module,making APUM24 apromising target for breeding strategies to increase crop yields. | Ruihua Huang Mengling Liu Guanping Gong Pingzhi Wu Barunava Patra Ling Yuan Hongting Qin Xiaoxu Wang Guohe Wang Huimei Liao Lu Gao Chengwei Yang Hongqing Li Shengchun Zhang | 2021 | Journal of Integrative Plant Biology2021，63，7： | 2 |
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